Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0RXZQR
ADC Name
CN119317630A ADC-C10
Synonyms
ADC-C10
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Organization
BeiGene Ltd
Drug Status
Investigative
Drug-to-Antibody Ratio
8.53
Structure
Antibody Name
Ifinatamab
  Antibody Info 
Antigen Name
CD276 antigen (CD276)
  Antigen Info 
Payload Name
DX-8951 derivative (DXd)
  Payload Info 
Therapeutic Target
DNA topoisomerase 1 (TOP1)
  Target Info 
Linker Name
CN119317630A ADC-C10 Linker
  Linker Info 
Conjugate Type
Random conjugation through reduced inter-chain cysteines.
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Click To Hide/Show 3 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Half Maximal Effective Concentration (EC50) 
66
nM
CVCL_1559
Minimally invasive lung adenocarcinoma
Half Maximal Effective Concentration (EC50) 
96
nM
CVCL_1453
Lung small cell carcinoma, Small cell lung cancer
Half Maximal Effective Concentration (EC50) 
100
nM
CVCL_1561
Lung papillary adenocarcinoma
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
Click To Hide/Show 3 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Effective Concentration (EC50)
66 nM
Method Description
Distribute the cell lines H358 (1E3/well), to 3D-96-well plates (Corning: 4520), with 80 ul/well. Incubate overnight at 37°C and 5% CO2. Detect the cell viability of H358, H441, H1048 and MDA-MB-453 cells using 3D reagent (Promega, G9683).
In Vitro Model Minimally invasive lung adenocarcinoma H358 cells CVCL_1559
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Effective Concentration (EC50)
96 nM
Method Description
Distribute the cell lines H1048 (1E3/well) to 3D-96-well plates (Corning: 4520), with 80 ul/well. Incubate overnight at 37°C and 5% CO2. Detect the cell viability of H358, H441, H1048 and MDA-MB-453 cells using 3D reagent (Promega, G9683).
In Vitro Model Lung small cell carcinoma, Small cell lung cancer H1048 cells CVCL_1453
Experiment 3 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Effective Concentration (EC50)
100 nM
Method Description
Distribute the cell lines H441 (1E3/well) to 3D-96-well plates (Corning: 4520), with 80 ul/well. Incubate overnight at 37°C and 5% CO2. Detect the cell viability of H358, H441, H1048 and MDA-MB-453 cells using 3D reagent (Promega, G9683).
In Vitro Model Lung papillary adenocarcinoma H441 cells CVCL_1561
References
Ref 1 Antibody-drug complexes