General Information of This Antibody-drug Conjugate (ID: DRG0CBLIJ)
ADC Name
BGB-C354
Synonyms
BGB-C354
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Organization
BeiGene (Originator)
Drug Status
Phase 1 (discontinued)
Drug-to-Antibody Ratio
~8
Antibody Name
Anti-B7H3 antibody
 Antibody Info 
Antigen Name
CD276 antigen (CD276)
 Antigen Info 
Payload Name
TOP1 inhibitor
 Payload Info 
Payload Target
DNA topoisomerase 1 (TOP1)
 Target Info 
Linker Name
A cleavable linker
 Linker Info 
Conjugate Type
Undisclosed
2027 Update
The disease landscape of This ADC
2027 Update
The clinical trial pipelines of This ADC
Indication Phase 1 Phase 2 Phase 3 Approved
Unspecific solid tumor
1 Trials
Trial ID
NCT06422520; EudraCT2024-513280-11; CTR20243757; ChiCTR2400091198