Antibody Information
General Information of This Antibody
| Antibody ID | ANI0MEQWJ |
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| Antibody Name | Omburtamab |
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| Organization | Memorial Sloan Kettering Cancer Center; Y-mAbs Therapeutics, Inc.; SciClone Pharmaceuticals LLC |
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| Indication | Neuroblastoma |
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| Synonyms |
8H9; Mab 8H9
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Murine IgG1-kappa |
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| Antigen Name | CD276 antigen (CD276) |
Antigen Info | ||||
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| Click to Show/Hide the Sequence Information of This Antibody | ||||||
| Heavy Chain Sequence |
QVQLQQSGAELVKPGASVKLSCKASGYTFTNYDINWVRQRPEQGLEWIGWIFPGDGSTQY
NEKFKGKATLTTDTSSSTAYMQLSRLTSEDSAVYFCARQTTATWFAYWGQGTLVTVSAAK TTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLY TLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPRDCGCKPCICTVPEVSSVFIFPP KPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREEQFNSTFRSVSE LPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTKGRPKAPQVYTIPPPKEQMAKDKVSL TCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDTDGSYFVYSKLNVQKSNWEAGNTFTC SVLHEGLHNHHTEKSLSHSPGK Click to Show/Hide
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| Heavy Chain Varible Domain |
QVQLQQSGAELVKPGASVKLSCKASGYTFTNYDINWVRQRPEQGLEWIGWIFPGDGSTQY
NEKFKGKATLTTDTSSSTAYMQLSRLTSEDSAVYFCARQTTATWFAYWGQGTLVTVSA Click to Show/Hide
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| Heavy Chain Constant Domain 1 |
AKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSD
LYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKI Click to Show/Hide
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| Heavy Chain Constant Domain 2 |
PEVSSVFIFPPKPKDVLTITLTPKVTCVVVDISKDDPEVQFSWFVDDVEVHTAQTQPREE
QFNSTFRSVSELPIMHQDWLNGKEFKCRVNSAAFPAPIEKTISKTK Click to Show/Hide
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| Heavy Chain Constant Domain 3 |
GRPKAPQVYTIPPPKEQMAKDKVSLTCMITDFFPEDITVEWQWNGQPAENYKNTQPIMDT
DGSYFVYSKLNVQKSNWEAGNTFTCSVLHEGLHNHHTEKSLSHSPGK Click to Show/Hide
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| Heavy Chain Hinge Region |
VPRDCGCKPCICTV
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| Heavy Chain CDR 1 |
GYTFTNYD
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| Heavy Chain CDR 2 |
IFPGDGST
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| Heavy Chain CDR 3 |
ARQTTATWFAY
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| Light Chain Sequence |
DIVMTQSPATLSVTPGDRVSLSCRASQSISDYLHWYQQKSHESPRLLIKYASQSISGIPS
RFSGSGSGSDFTLSINSVEPEDVGVYYCQNGHSFPLTFGAGTKLELKRADAAPTVSIFPP SSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLT LTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC Click to Show/Hide
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| Light Chain Varible Domain |
DIVMTQSPATLSVTPGDRVSLSCRASQSISDYLHWYQQKSHESPRLLIKYASQSISGIPS
RFSGSGSGSDFTLSINSVEPEDVGVYYCQNGHSFPLTFGAGTKLELK Click to Show/Hide
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| Light Chain Constant Domain |
RADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQD
SKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC Click to Show/Hide
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| Light Chain CDR 1 |
QSISDY
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| Light Chain CDR 2 |
YAS
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| Light Chain CDR 3 |
QNGHSFPLT
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Each Antibody-drug Conjugate Related to This Antibody
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