Antibody Information

General Information of This Antibody
Antibody ID
ANI0JYTME
Antibody Name
huAb3v5
Antibody Type
Monoclonal antibody (mAb)
Antibody Subtype
Humanized IgG1-kappa
Antigen Name
CD276 antigen (CD276)
  Antigen Info 
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
huAb3v5-CZ [Investigative]
 ADC Info 
Revealed Based on the Cell Line Data
Click To Hide/Show 1 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Half Maximal Inhibitory Concentration (IC50)
0.17 nM
Positive CD276 expression (CD276 +++/++)
Method Description
The anti-tumor activity of these ADCs was tested in cytotoxicity assaysusing the HCC38 cell line. IC50 values were determined by quantitating viable cells using a CellTiter-Glo luminescent assay.
In Vitro Model Breast ductal carcinoma HCC38 cells CVCL_1267
References
Ref 1 Anti-b7-h3 antibodies and antibody drug conjugates; 2018-03-08.

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