Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ID: DRG0AOWTD)
| ADC Name |
WO2024165045A1 ADC-B
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| Synonyms |
ADC-B
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| Organization |
BEIGENE, LTD. | TSAI, CHARNG-SHENG
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
8.12
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| Antibody Name |
Ifinatamab
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Antibody Info | ||||
| Antigen Name |
CD276 antigen (CD276)
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Antigen Info | ||||
| Payload Name |
Undisclosed
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| Linker Name |
Undisclosed
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| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 0.5 nM | Low B7H3 expression (B7H3+) | ||
| Method Description |
Cells were seeded (NCI-1650 or MDA-MB-453 (2E3/well) or Capan-1 (4E3/well)) into
3D 96-well plates (Corning: 4520), 80 ul/well, and incubated at 37 °C, 5% CO2, overnight.
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| In Vitro Model | Pancreatic ductal adenocarcinoma | Capan-1 cells | CVCL_0237 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 3.9 nM | High B7H3 expression (B7H3 +++) | ||
| Method Description |
Cells were seeded (NCI-1650 or MDA-MB-453 (2E3/well) or Capan-1 (4E3/well)) into
3D 96-well plates (Corning: 4520), 80 ul/well, and incubated at 37 °C, 5% CO2, overnight.
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| In Vitro Model | Lung adenocarcinoma | NCI-H1650 cells | CVCL_1483 | ||