Antibody Information
General Information of This Antibody
| Antibody ID | ANI0PPQZY |
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|---|---|---|---|---|---|---|
| Antibody Name | huAb18v10 |
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Humanized IgG1-kappa |
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| Antigen Name | CD276 antigen (CD276) |
Antigen Info | ||||
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
huAb18v10-CZ [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
0.57 nM
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Positive CD276 expression (CD276 +++/++) | ||
| Method Description |
Humanized chAb18 variants were conjugated to the CZ synthon and tested for cytotoxicity in HCC38 cell line.
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| In Vitro Model | Breast ductal carcinoma | HCC38 cells | CVCL_1267 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
0.57 nM
|
Positive CD276 expression (CD276 +++/++) | ||
| Method Description |
The anti-tumor activity of these ADCs was tested in cytotoxicity assaysusing the HCC38 cell line. IC50 values were determined by quantitating viable cells using a CellTiter-Glo luminescent assay.
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| In Vitro Model | Breast ductal carcinoma | HCC38 cells | CVCL_1267 | ||
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