Antibody Information
General Information of This Antibody
| Antibody ID | ANI0ZBAYV |
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| Antibody Name | chAb18 |
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Chimeric IgG1-kappa |
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| Antigen Name | CD276 antigen (CD276) |
Antigen Info | ||||
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
chAb18-CZ [Investigative]
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) |
90.00%
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Positive CD276 expression (CD276 +++/++) | ||
| Method Description |
Anti-tumor activity in a mouse small celllung cancer cell line xenograft model NCI-H146, of human origin. Mice were administered 10 mg/kg of the ADC intraperitoneally IP/QDx1.
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| In Vivo Model | NCI-H146 CDX model | ||||
| In Vitro Model | Small cell carcinoma | NCI-H146 cells | CVCL_1473 | ||
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
0.28 nM
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Positive CD276 expression (CD276 +++/++) | ||
| Method Description |
Chimra IgG1 variants were conjugated to the CZ synthon and tested for cytotoxicity in HCC38 cell line.
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| In Vitro Model | Breast ductal carcinoma | HCC38 cells | CVCL_1267 | ||
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