Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0GAVVD
ADC Name
CD276 mAb-MMAF/IMQ
Synonyms
CD276 mAb-MMAF/IMQ
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Organization
National Cancer Institute (NCI)
Drug Status
Investigative
Structure
Antibody Name
Hu276 mAb
  Antibody Info 
Antigen Name
CD276 antigen (CD276)
  Antigen Info 
Payload Name
Monomethyl auristatin F
  Payload Info 
Payload Name
imiquimod
  Payload Info 
Linker Name
DBM linker
  Linker Info 
Conjugate Type
Random conjugation through reduced inter-chain cysteines.
General Information of The ADMET Data Related to This ADC(2027 Update)
Absorption
Click To Hide/Show 1 Absorption Data Related to This Level
Standard Type Value Units Description Reference
Maximum Observed Concentration (Cmax) 21.39-93.37 ug/mL
The PK parameters were assessed using 4T1 xenografted BALB/cJ models.
 [1]
Excretion
Click To Hide/Show 1 Excretion Data Related to This Level
Standard Type Value Units Description Reference
Elimination Half-Life (t1/2) 1.21-2.99 day
The PK parameters were assessed using 4T1 xenografted BALB/cJ models.
 [1]
References
Ref 1 A Dual-Payload Antibody-Drug Conjugate Targeting CD276/B7-H3 Elicits Cytotoxicity and Immune Activation in Triple-Negative Breast Cancer