Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0MOYWK
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| ADC Name |
HuAb3v2.9-CZ
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| Synonyms |
huAb3v2.9 CZ; huAb3v2.9CZ
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| Organization |
AbbVie, Inc.
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
2.8
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| Structure |
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| Antibody Name |
huAb3v2.9
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Antibody Info | ||||
| Antigen Name |
CD276 antigen (CD276)
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Antigen Info | ||||
| Payload Name |
Undisclosed
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| Therapeutic Target |
Stimulator of interferon genes protein (STING1)
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Target Info | ||||
| Linker Name |
huAb3v2.9-CZ linker
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| Combination Type |
AbbVie's CZ
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General Information of The Activity Data Related to This ADC
Discovered Using Cell Line-derived Xenograft Model
| Standard Type | Value | Units | Cell Line | Disease Model |
|---|---|---|---|---|
| Tumor Growth Inhibition value (TGI) |
94
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%
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NCI-H146 cells
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Small cell carcinoma
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Revealed Based on the Cell Line Data
| Standard Type | Value | Units | Cell Line | Disease Model |
|---|---|---|---|---|
| Half Maximal Inhibitory Concentration (IC50) |
2.3
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nM
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NCI-H847 cells
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Lung small cell carcinoma
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Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | 94% | Positive CD276 expression (CD276 +++/++) | ||
| Method Description |
Humanized anti-B7-H3 antibodies huAb13v1, huAb3v2.5 and huAb3v2.6 were selected to beconjugated with several Bcl-xL inhibitor payloads and were evaluated in xenograft models of small cell lung cancer (H146). The dose was 6 mg/kg/IP/QDx1.
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| In Vivo Model | H146 CDX model | ||||
| In Vitro Model | Small cell carcinoma | NCI-H146 cells | CVCL_1473 | ||
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | 2.3 nM | Positive CD276 expression (CD276 +++/++) | ||
| Method Description |
The anti-tumor activity of these ADCs was tested in cytotoxicity assaysusing the H847 cell line. IC50 values were determined by quantitating viable cells using a CellTiter-Glo luminescent assay.
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| In Vitro Model | Lung small cell carcinoma | NCI-H847 cells | CVCL_1596 | ||