Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0LKQLS
|
|||||
|---|---|---|---|---|---|---|
| ADC Name |
SG11202408662TA ADC-C7
|
|||||
| Synonyms |
ADC-C7
Click to Show/Hide
|
|||||
| Organization |
BEIGENE, LTD.
|
|||||
| Drug Status |
Investigative
|
|||||
| Drug-to-Antibody Ratio |
8.06
|
|||||
| Structure |
|
|||||
| Antibody Name |
Ifinatamab
|
Antibody Info | ||||
| Antigen Name |
CD276 antigen (CD276)
|
Antigen Info | ||||
| Payload Name |
Undisclosed
|
|||||
| Therapeutic Target |
Stimulator of interferon genes protein (STING1)
|
Target Info | ||||
| Linker Name |
Undisclosed
|
|||||
| Conjugate Type |
Random conjugation through reduced inter-chain cysteines.
|
|||||
General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 0.007 nM | Positive B7H3 expression (B7H3+++/++) | ||
| Method Description |
Adding the fresh growth-medium containing the varying concentrations of ADCs, 40ul/well
into H358, H441, H1048 and MDA-MB-487.
|
||||
| In Vitro Model | Lung small cell carcinoma, Small cell lung cancer | H1048 cells | CVCL_1453 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 0.038 nM | High B7H3 expression (B7H3 +++) | ||
| Method Description |
Adding the fresh growth-medium containing the varying concentrations of ADCs, 40ul/well
into H358, H441, H1048 and MDA-MB-487.
|
||||
| In Vitro Model | Minimally invasive lung adenocarcinoma | H358 cells | CVCL_1559 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 0.894 nM | Positive B7H3 expression (B7H3+++/++) | ||
| Method Description |
Adding the fresh growth-medium containing the varying concentrations of ADCs, 40ul/well
into H358, H441, H1048 and MDA-MB-487.
|
||||
| In Vitro Model | Lung papillary adenocarcinoma | H441 cells | CVCL_1561 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | > 100 nM | Negative B7H3 expression (B7H3-) | ||
| Method Description |
Adding the fresh growth-medium containing the varying concentrations of ADCs, 40ul/well
into H358, H441, H1048 and MDA-MB-487.
|
||||
| In Vitro Model | Breast adenocarcinoma | MDA-MB-453 cells | CVCL_0418 | ||