Antigen Information

General Information of This Antigen (ID: TAR0UYFIF)
Antigen Name
Epidermal growth factor receptor (EGFR)
Gene Name
EGFR
Gene ID
1956
Synonym
ERBB; ERBB1; HER1; Proto-oncogene c-ErbB-1;Receptor tyrosine-protein kinase erbB-1
Sequence
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED
SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN
TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
APQSSEFIGA

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Family
Tyr protein family
Function
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin- binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration. Plays a role in enhancing learning and memory performance. Plays a role in mammalian pain signaling (long-lasting hypersensitivity).

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Uniprot Entry
EGFR_HUMAN
HGNC ID
HGNC:3236
KEGG ID
hsa:1956
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
1711/425 scFv-SNAP
 Antibody Info 
ADC Name Payload Target Linker ADC Info
1711 (scFv)-SNAP-AuriF [1]
Auristatin F
Microtubule (MT)
BG based linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
P1-528mAb [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
P2-528mAb [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
P3-528mAb [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
37218930 2P3-528mAb [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CoP-528mAb [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2024105205A1 2g-981 [3]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 3g-981 [3]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 4g-981 [3]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 5g-981 [3]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 6g-981 [3]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 7g-981 [3]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 8g-981 [3]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 14g-981 [3]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
9G8-7D12-Fc
 Antibody Info 
ADC Name Payload Target Linker ADC Info
S7 ADC [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
9G8-7D12-Fc with E430G
 Antibody Info 
ADC Name Payload Target Linker ADC Info
S7-E430G ADC [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
AbA-vcMMAE [5]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-EGFR Ab1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Ab1-mcMMAF [6]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-EGFR Ab3
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Ab3-mcMMAF [6]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-EGFR AbA
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AbA-vcMMAE [6]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
AbA-mcMMAE [6]
Monomethyl auristatin E
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Anti-EGFR antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
SYS6010
JS-1
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
BB-1705
Eribulin
Microtubule (MT)
Mal-PEG2-Val-Cit-PABC
 ADC Info 
ABBV-637
BCL-xL inhibitor
Bcl-2-like protein 1 (BCL2L1)
Undisclosed
 ADC Info 
ALX2004
TOP1 inhibitor
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
HMPL-A580
HM5041609
PI3K; PIKK
A cleavable linker
 ADC Info 
Anti-EGFR huFc
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HuFc-MMAE [7]
Monomethyl auristatin E
Microtubule (MT)
Gly3-Val-Cit-PABC
 ADC Info 
Anti-EGFR IgG1 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HLX42
TOP1 inhibitor
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
anti-EGFR IgG4 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-hEGFR (IgG4)-ABNO-DM-1: E4-AD [8]
Mertansine DM1
Microtubule (MT)
ABNO Linker
 ADC Info 
Anti-EGFR mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-EGFR-Sulfo-SMCC-DM1 [9]
Mertansine DM1
Microtubule (MT)
Sulfo-SMCC
 ADC Info 
Anti-EGFR-Ala-Ala-IGN [10]
Indolinobenzodiazepine dimer
Human Deoxyribonucleic acid (hDNA)
Ala-Ala dipeptide
 ADC Info 
Anti-EGFR-Val-Gln-IGN [10]
Indolinobenzodiazepine dimer
Human Deoxyribonucleic acid (hDNA)
Val-Gln dipeptide linker
 ADC Info 
EGFR-ADC 13a [11]
PBD dimer 14a
Human Deoxyribonucleic acid (hDNA)
Adipic acid-Val-Ala-PABC
 ADC Info 
EGFR-ADC 13b [11]
PBD dimer 14b
Human Deoxyribonucleic acid (hDNA)
Adipic acid-Val-Ala-PABC
 ADC Info 
EGFR-ADC 13c [11]
PBD dimer 14c
Human Deoxyribonucleic acid (hDNA)
Adipic acid-Val-Ala-PABC
 ADC Info 
WO2023124537A1+ADC1 [12]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
DBCO-VC-PAB
 ADC Info 
WO2023124537A1+ADC2 [12]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
DBCO-VC-PAB
 ADC Info 
WO2023124537A1+ADC3 [12]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
DBCO-VC-PAB
 ADC Info 
Anti-EGFR mAb 40H3
 Antibody Info 
ADC Name Payload Target Linker ADC Info
40H3-Tesirine [13]
SG3199
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
 ADC Info 
40H3-MCVCPAB-MMAE [13]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
40H3-CL2A-SN38 [13]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 ADC Info 
40H3-SMCC-DM1 [13]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
40H3-Deruxtecan [13]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
Anti-EGFR mAb hR3-YTE
 Antibody Info 
ADC Name Payload Target Linker ADC Info
SHR-A1307 [14]
SHR152852
Microtubule (MT)
L2-MC
 ADC Info 
Anti-EGFR mAb LA22
 Antibody Info 
ADC Name Payload Target Linker ADC Info
LA22-MMC [15]
Mitomycin C
Human Deoxyribonucleic acid (hDNA)
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
 ADC Info 
Anti-EGFR mAb rat IgG2a
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-EGFR-PEG4-Mal-DM1 [16]
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 ADC Info 
Antibody molecule C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
US20220378928A1 C-11 [17]
US20220378928A1 C-11 Payload
Undisclosed
US20220378928A1 C-11 Linker
 ADC Info 
US20220378928A1 C-20 [17]
US20220378928A1 C-11 Payload
Undisclosed
US20220378928A1 C-20 Linker
 ADC Info 
US20220378928A1 C-21 [17]
US20220378928A1 C-11 Payload
Undisclosed
US20220378928A1 C-21 Linker
 ADC Info 
US20220378928A1 C-23 [17]
US20220378928A1 C-11 Payload
Undisclosed
US20220378928A1 C-23 Linker
 ADC Info 
US20220378928A1 C-24 [17]
US20220378928A1 C-11 Payload
Undisclosed
US20220378928A1 C-24 Linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
MYK-3 [18]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
BA03-MC-MMAE [18]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
BA03-MCC-MMAE [18]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Becotatug
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Becotatug vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
C4-MMAE [19]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
Cet-4S-2M [20]
CN108853514B-Cet-4S-2M-payload
Undisclosed
CN108853514B-Cet-4S-2M-linker
 ADC Info 
Cet-8E [20]
CN108853514B-Cet-8E-payload
Undisclosed
CN108853514B-Cet-8E-linker
 ADC Info 
Cet-8S-4M [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Cet-4M [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Cet-8E-2M [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Cet-8s [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Cetuximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Cetuximab- (FGX16-11) [21]
FGX8-46
Human Deoxyribonucleic acid (hDNA)
Mc-Val-Ala-PABC
 ADC Info 
Hu-Alpha-EGFR-172 [22]
IMSA172
Stimulator of interferon genes protein (STING1)
Mc-Val-Cit-PABC
 ADC Info 
C-IgG-Val-Cit-MMAE [7]
Monomethyl auristatin E
Microtubule (MT)
Gly3-Val-Cit-PABC
 ADC Info 
Cetuximab-Puromycin [23]
Puromycin
Ribosome (RB)
Succinimidyl acetylthiopropionate (SATP)
 ADC Info 
Cet-DM1 [24]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
MAb-DMBA-SIL-MMAE [25]
Monomethyl auristatin E
Microtubule (MT)
DMBA-SIL
 ADC Info 
Cet-ZA ADC [26]
Zoledronic acid
Geranylgeranyl pyrophosphate synthase (GGPS1)
Undisclosed
 ADC Info 
MAb-DMBA-SIL-Dox [25]
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
DMBA-SIL
 ADC Info 
Cetuximab-Val-Cit-Dox [27]
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
Mc-Val-Cit-PABC
 ADC Info 
Erbitux-MHT-71 [28]
Auristatin F
Microtubule (MT)
MHT-71
 ADC Info 
Quinoin cetuximab immunoconjugate [29]
Quinoin
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)
N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP)
 ADC Info 
ITcetuximab [30]
Saporin
Microtubule (MT)
Undisclosed
 ADC Info 
Cet-TPL [31]
Triptolide
Nuclear factor NF-kappa-B p105 subunit (NFKB1)
N-hydroxysuccinimide based linker
 ADC Info 
Cetuximab-DNA conjugate [32]
DNA mimics
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 ADC Info 
EGFR-ADC-07 (DAR8) [33]
EGFR-ADC-07(DAR8) payload
Undisclosed
EGFR-ADC-07(DAR8) linker
 ADC Info 
EGFR-ADC-07 (DAR4) [33]
EGFR-ADC-07(DAR4) payload
Undisclosed
EGFR-ADC-07(DAR4) linker
 ADC Info 
EGFR-ADC-08 (DAR8) [33]
EGFR-ADC-08(DAR8) payload
Undisclosed
EGFR-ADC-08(DAR8) linker
 ADC Info 
EGFR-ADC-08 (DAR4) [33]
EGFR-ADC-08(DAR4) payload
Undisclosed
EGFR-ADC-08(DAR4) linker
 ADC Info 
EGFR-ADC-32 (DAR4) [33]
EGFR-ADC-32(DAR4) payload
Undisclosed
EGFR-ADC-32(DAR4) linker
 ADC Info 
Cetuximab-Comound (Ia) [34]
NeoDegrader P1
Protein cereblon (CRBN)
Cetuximab-Comound (Ia) linker
 ADC Info 
WO2017089895A1 ADC64 [35]
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC64 linker
 ADC Info 
WO2017089895A1 ADC65 [35]
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC65 linker
 ADC Info 
WO2017089895A1 ADC66 [35]
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC66 linker
 ADC Info 
WO2022078260A1 ADC-9 [36]
Ln-D2
DNA topoisomerase 1 (TOP1)
WO2022078260A1_ADC-9 linker
 ADC Info 
WO2022078260A1 ADC-10 [36]
Ln-D7
DNA topoisomerase 1 (TOP1)
WO2022078260A1_ADC-10 linker
 ADC Info 
EGFR-MMAU ADC [37]
Glucuronyl-monomethyl-auristatin E (MMAU)
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Cetux Cys-vc-MMAE [38]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Cetuximab-vc-MMAE [39]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
CTX-MMAE [40]
Monomethyl auristatin E
Microtubule (MT)
PD-Val-Cit-PABC
 ADC Info 
EGFR ADC-21 [41]
Monomethyl auristatin E
Microtubule (MT)
Vinylsulfonamide based linker 15
 ADC Info 
EGFR ADC-22 [41]
Monomethyl auristatin E
Microtubule (MT)
Vinylsulfonamide based linker 16
 ADC Info 
EGFR ADC-23 [41]
Monomethyl auristatin E
Microtubule (MT)
Vinylsulfonamide based linker 17
 ADC Info 
WO2017089890A1 ADC64 [42]
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC64 linker
 ADC Info 
WO2017089890A1 ADC65 [42]
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC65 linker
 ADC Info 
WO2017089890A1 ADC66 [42]
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC66 linker
 ADC Info 
Cetuximab-Compound 9 [43]
Mertansine DM1
Microtubule (MT)
Cetuximab-Compound 9 linker
 ADC Info 
Cetuximab-Compound 17 [43]
Mertansine DM4
Microtubule (MT)
Cetuximab-Compound 17 linker
 ADC Info 
Cetuximab-Compound 25 [43]
Monomethyl auristatin E
Microtubule (MT)
Cetuximab-Compound 25 linker
 ADC Info 
Cetuximab-Compound 31 [43]
Auristatin 0101
Microtubule (MT)
Cetuximab-Compound 31 linker
 ADC Info 
Cetuximab-Compound 36 [43]
Monomethyl auristatin E
Microtubule (MT)
Cetuximab-Compound 36 linker
 ADC Info 
Cetuximab-Compound 43 [43]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Cetuximab-Compound 43 linker
 ADC Info 
Cetuximab-Compound 49 [43]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Cetuximab-Compound 49 linker
 ADC Info 
Cetuximab-Compound 55 [43]
Mertansine DM1
Microtubule (MT)
Cetuximab-Compound 55 linker
 ADC Info 
Cetuximab-Compound 59 [43]
Mertansine DM4
Microtubule (MT)
Cetuximab-Compound 59 linker
 ADC Info 
Cetuximab-Compound 64 [43]
Monomethyl auristatin E
Microtubule (MT)
Cetuximab-Compound 64 linker
 ADC Info 
Cetuximab-Compound 69 [43]
Monomethyl auristatin E
Microtubule (MT)
Cetuximab-Compound 69 linker
 ADC Info 
Cetuximab-Compound 74 [43]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Cetuximab-Compound 74 linker
 ADC Info 
Cetuximab-Compound 75 [43]
Monomethyl auristatin E
Microtubule (MT)
Cetuximab-Compound 75 linker
 ADC Info 
Cetuximab-Compound 76 [43]
Monomethyl auristatin E
Microtubule (MT)
Cetuximab-Compound 76 linker
 ADC Info 
Cetuximab-Compound 77 [43]
Mertansine DM1
Microtubule (MT)
Cetuximab-Compound 77 linker
 ADC Info 
Cetuximab-Compound 78 [43]
Auristatin 0101
Microtubule (MT)
Cetuximab-Compound 78 linker
 ADC Info 
Cetuximab-Compound 79 [43]
Auristatin 0101
Microtubule (MT)
Cetuximab-Compound 79 linker
 ADC Info 
Cetuximab-Compound 80 [43]
Mertansine DM4
Microtubule (MT)
Cetuximab-Compound 80 linker
 ADC Info 
CN114917361A ADC-1 [44]
CN114917361A ADC-1 payload
Undisclosed
CN114917361A ADC-1 linker
 ADC Info 
CN114917361A ADC-6 [44]
CN114917361A ADC-6 payload
Undisclosed
CN114917361A ADC-6 linker
 ADC Info 
CN114917361A ADC-11 [44]
CN114917361A ADC-11 payload
Undisclosed
CN114917361A ADC-11 linker
 ADC Info 
CN114917361A ADC-13 [44]
CN114917361A ADC-13 payload
Undisclosed
CN114917361A ADC-13 linker
 ADC Info 
CN114917361A ADC-16 [44]
CN114917361A ADC-16 payload
Undisclosed
CN114917361A ADC-16 linker
 ADC Info 
CN114917361A ADC-19 [44]
CN114917361A ADC-19 payload
Undisclosed
CN114917361A ADC-19 linker
 ADC Info 
CN114917361A ADC-21 [44]
CN114917361A ADC-21 payload
Undisclosed
CN114917361A ADC-21 linker
 ADC Info 
CN114917361A ADC-25 [44]
CN114917361A ADC-25 payload
Undisclosed
CN114917361A ADC-25 linker
 ADC Info 
CN114917361A ADC-27 [44]
CN114917361A ADC-27 payload
Undisclosed
CN114917361A ADC-27 linker
 ADC Info 
CN114917361A ADC-30 [44]
CN114917361A ADC-30 payload
Undisclosed
CN114917361A ADC-30 linker
 ADC Info 
CN114917361A ADC-33 [44]
CN114917361A ADC-33 payload
Undisclosed
CN114917361A ADC-33 linker
 ADC Info 
CN114917361A ADC-36 [44]
CN114917361A ADC-36 payload
Undisclosed
CN114917361A ADC-36 linker
 ADC Info 
CN114917361A ADC-39 [44]
CN114917361A ADC-39 payload
Undisclosed
CN114917361A ADC-39 linker
 ADC Info 
CN114917361A ADC-41 [44]
CN114917361A ADC-41 payload
Undisclosed
CN114917361A ADC-41 linker
 ADC Info 
CN114917361A ADC-44 [44]
CN114917361A ADC-44 payload
Undisclosed
CN114917361A ADC-44 linker
 ADC Info 
CN114917361A ADC-47 [44]
CN114917361A ADC-47 payload
Undisclosed
CN114917361A ADC-47 linker
 ADC Info 
CN114917361A ADC-50 [44]
CN114917361A ADC-50 payload
Undisclosed
CN114917361A ADC-50 linker
 ADC Info 
CN114917361A ADC-55 [44]
CN114917361A ADC-55 payload
Undisclosed
CN114917361A ADC-55 linker
 ADC Info 
CN114917361A ADC-58 [44]
CN114917361A ADC-58 payload
Undisclosed
CN114917361A ADC-58 linker
 ADC Info 
CN114917361A ADC-61 [44]
CN114917361A ADC-61 payload
Undisclosed
CN114917361A ADC-61 linker
 ADC Info 
CN114917361A ADC-64 [44]
CN114917361A ADC-64 payload
Undisclosed
CN114917361A ADC-64 linker
 ADC Info 
CN114917361A ADC-67 [44]
CN114917361A ADC-67 payload
Undisclosed
CN114917361A ADC-67 linker
 ADC Info 
CN114917361A ADC-70 [44]
CN114917361A ADC-70 payload
Undisclosed
CN114917361A ADC-70 linker
 ADC Info 
CN114917361A ADC-73 [44]
CN114917361A ADC-73 payload
Undisclosed
CN114917361A ADC-73 linker
 ADC Info 
CN114917361A ADC-76 [44]
CN114917361A ADC-76 payload
Undisclosed
CN114917361A ADC-76 linker
 ADC Info 
CN114917361A ADC-79 [44]
CN114917361A ADC-79 payload
Undisclosed
CN114917361A ADC-79 linker
 ADC Info 
CN114917361A ADC-82 [44]
CN114917361A ADC-82 payload
Undisclosed
CN114917361A ADC-82 linker
 ADC Info 
Cetuximab based antibody-drug conjugate [45]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
AGCM-22 [46]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Ala-PABC
 ADC Info 
39143910 ADC 40 [47]
Monomethyl auristatin E
Microtubule (MT)
1- (4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl (Dde) based linker
 ADC Info 
36924655 ADC 33 [48]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
Cet-CL2A-FL118 (12) [49]
Undisclosed
Undisclosed
CL2A
 ADC Info 
Cetuximab-SNS-032 ADC [50]
SNS-032
Undisclosed
Mal-Val-Ala-PAB
 ADC Info 
Dual-function antibody conjugate [51]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CMPXC [52]
Chlorin e6 (Ce6)
Undisclosed
Mal-PX linker
 ADC Info 
Cetuximab based PROTAC (CPRO) [53]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Cet-C8Pt (IV) [54]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Cet-IRDye800CW (DAR2) [55]
IRDye800CW
Undisclosed
Undisclosed
 ADC Info 
Cet-IRDye800CW (DAR7) [55]
IRDye800CW
Undisclosed
Undisclosed
 ADC Info 
Cet-IRDye800CW (DAR11) [55]
IRDye800CW
Undisclosed
Undisclosed
 ADC Info 
Cetuximab-IRDye800-AF647 [56]
IRDye800CW; AF647
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC60 [57]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 1a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 2a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 4a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 5a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 6a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 7a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 8a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 10a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 11a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 12a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 13a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 14a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 15a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 16a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 17a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 18a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 19a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 21a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 22a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 23a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 24a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 25a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 26a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 27a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 28a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 29a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 30a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 35a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 36a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 37a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 38a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 39a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 40a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 41a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 42a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 43a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12144865B2 44a [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Cex-50-5 [60]
CN112209990B+Cex-50-5+payload
Undisclosed
CN112209990B+Cex-50-5+Linker
 ADC Info 
Cex-59 [60]
CN112209990B+Cex-59+payload
Undisclosed
CN112209990B+Cex-59+Linker
 ADC Info 
Cex-70 [60]
CN112209990B+Cex-70+payload
Undisclosed
CN112209990B+Cex-70+Linker
 ADC Info 
EP4227309A4 ADC-19 [61]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
EP4227309A4 ADC-20 [61]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
Cetuximab-I-9-0.03 [62]
Cetuximab-I-45-0.7 payload
Undisclosed
Cetuximab-I-9-0.03 linker
 ADC Info 
Cetuximab-I-18-0.04 [62]
Cetuximab-I-45-0.7 payload
Undisclosed
Cetuximab-I-18-0.04 linker
 ADC Info 
Cetuximab-I-38-0.31 [62]
Cetuximab-I-45-0.7 payload
Undisclosed
Cetuximab-I-38-0.31 linker
 ADC Info 
Cetuximab-I-39-0.46 [62]
Cetuximab-I-45-0.7 payload
Undisclosed
Cetuximab-I-39-0.46 linker
 ADC Info 
Cetuximab-I-40-0.69 [62]
Cetuximab-I-45-0.7 payload
Undisclosed
Cetuximab-I-40-0.69 linker
 ADC Info 
Cetuximab-I-45-0.7 [62]
Cetuximab-I-45-0.7 payload
Undisclosed
Cetuximab-I-45-0.7 linker
 ADC Info 
AU2023279443A1 Example A3c [63]
U-031
Microtubule (MT)
AU2023279443A1, Example A3, Linker
 ADC Info 
CN113943310A ADC-19 [64]
D-D3 payload
DNA topoisomerase I (TOP1)
CN113943310A, ADC-1, Linker
 ADC Info 
CN113943310A ADC-20 [64]
D-D7 payload
DNA topoisomerase I (TOP1)
CN113943310A, ADC-1, Linker
 ADC Info 
CN118873678A ADC-19 [65]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
cetuximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-EGFR ADC [59]
3-aminophenyl-hemiasterlin
Undisclosed
DBCO Val Cit PABA linker
 ADC Info 
Cetuximab (Fc/Fab labeled with Neu5NAz)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Cetux Fc/Fab-vc-MMAE [38]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Cetuximab (LC)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Cetuximab (LC)-2i [66]
Monomethyl auristatin F
Microtubule (MT)
Cetuximab(LC)-2i linker
 ADC Info 
Cetuximab (LC)-3i [66]
Monomethyl auristatin F
Microtubule (MT)
Cetuximab(LC)-3i linker
 ADC Info 
Cetuximab (LC)-4i [66]
Monomethyl auristatin F
Microtubule (MT)
Cetuximab(LC)-4i linker
 ADC Info 
Cetuximab (LC)-6e [66]
Monomethyl auristatin E
Microtubule (MT)
Cetuximab(LC)-6e linker
 ADC Info 
Cetuximab (LC)-amanitin [66]
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Cetuximab(LC)-amanitin linker
 ADC Info 
Cetuximab (LC) G7-CVIM
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ADC14-0810 [66]
Monomethyl auristatin F
Microtubule (MT)
ADC14-0810 linker
 ADC Info 
Cetuximab (LC) G7-CVIM-3i [66]
Monomethyl auristatin F
Microtubule (MT)
Cetuximab(LC) G7-CVIM-3i linker
 ADC Info 
Cetuximab (LC) G7-CVIM-4i [66]
Monomethyl auristatin F
Microtubule (MT)
Cetuximab(LC) G7-CVIM-4i linker
 ADC Info 
Cetuximab (LC) G7-CVIM-6e [66]
Monomethyl auristatin E
Microtubule (MT)
Cetuximab(LC) G7-CVIM-6e linker
 ADC Info 
Cetuximab (LC) G7-CVIM-amanitin [66]
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Cetuximab(LC) G7-CVIM-amanitin linker
 ADC Info 
Cetuximab (LV) G7-CVIM
 Antibody Info 
ADC Name Payload Target Linker ADC Info
LCB14-0645 [66]
Monomethyl auristatin F
Microtubule (MT)
LCB14-0645 linker
 ADC Info 
Cetuximab (LV) G7-CVIM-3i [66]
Monomethyl auristatin F
Microtubule (MT)
Cetuximab(LV) G7-CVIM-3i linker
 ADC Info 
Cetuximab (LV) G7-CVIM-4i [66]
Monomethyl auristatin F
Microtubule (MT)
Cetuximab(LV) G7-CVIM-4i linker
 ADC Info 
Cetuximab (LV) G7-CVIM-6e [66]
Monomethyl auristatin E
Microtubule (MT)
Cetuximab(LV) G7-CVIM-6e linker
 ADC Info 
Cetuximab (LV) G7-CVIM-amanitin [66]
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Cetuximab(LV) G7-CVIM-amanitin linker
 ADC Info 
Cetuximab Fab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
C-Fab-MMAE [7]
Monomethyl auristatin E
Microtubule (MT)
Gly3-Val-Cit-PABC
 ADC Info 
Cetuximab Fab (conjugate to glycan residues)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Cetux Fab-vc-MMAE [38]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Demupitamab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Demupitamab-ADC-Tb5-1 [33]
Demupitamab-ADC-Tb5-1 payload
Undisclosed
Demupitamab-ADC-Tb5-1 linker
 ADC Info 
Demupitamab-ADC-Tb5-2 [33]
Demupitamab-ADC-Tb5-2 payload
Undisclosed
Demupitamab-ADC-Tb5-2 linker
 ADC Info 
Depatuxizumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Depatuxizumab mafodotin
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Depatuxizumab-ADC-Tb5-1 [33]
Depatuxizumab-ADC-Tb5-1 payload
Undisclosed
Depatuxizumab-ADC-Tb5-1 linker
 ADC Info 
Depatuxizumab-ADC-Tb5-2 [33]
Depatuxizumab-ADC-Tb5-2 payload
Undisclosed
Depatuxizumab-ADC-Tb5-2 linker
 ADC Info 
WO2017089890A1 ADC73 [42]
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC73 linker
 ADC Info 
WO2017089890A1 ADC74 [42]
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC74 linker
 ADC Info 
WO2017089890A1 ADC75 [42]
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC75 linker
 ADC Info 
JP7623413B2 ExampleADC57 [57]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7623413B2 ExampleADC58 [57]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7560255B2 ControlADC57 [67]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7560255B2 ControlADC58 [67]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Depatuxizumab S238C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ABBV-322 [68]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Mc-Val-Ala
 ADC Info 
EGFR Ab-L
 Antibody Info 
ADC Name Payload Target Linker ADC Info
RN765C [69]
Auristatin 0101
Microtubule (MT)
AcLys-Val-Cit-PABC
 ADC Info 
EGFR No.1 (L234A, L235A, L328C)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
anti-EGFR Ab No.1 (L234A, L235A, L328C)-vcMMAE [70]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
EGFR No.1 (L328C)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
anti-EGFR Ab No.1 (L328C)-vcMMAE [70]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
EGFR No.3 (L234A, L235A, L328C)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
anti-EGFR Ab No.3 (L234A, L235A, L328C)-vcMMAE [70]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ERC6 bispecific Anti-ody (fuse Anti-cotinine scFv to cetuximab CH3 domain)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Cotinine-duocarmycin [71]
Duocarmycin Sa
Human Deoxyribonucleic acid (hDNA)
Mc-Val-Cit-PABC-DMAE
 ADC Info 
ADC Name Payload Target Linker ADC Info
Fcab-1-MMAE [7]
Monomethyl auristatin E
Microtubule (MT)
Gly3-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
Fcab-2-MMAE [7]
Monomethyl auristatin E
Microtubule (MT)
Gly3-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
Fcab-3-MMAE [7]
Monomethyl auristatin E
Microtubule (MT)
Gly3-Val-Cit-PABC
 ADC Info 
Futuximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Futuximab-ADC-Tb5-1 [33]
Futuximab-ADC-Tb5-1 payload
Undisclosed
Futuximab-ADC-Tb5-1 linker
 ADC Info 
Futuximab-ADC-Tb5-2 [33]
Futuximab-ADC-Tb5-2 payload
Undisclosed
Futuximab-ADC-Tb5-2 linker
 ADC Info 
Fv-LDP-D3
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Fv-LDP-D3-AE [72]
Lidamycin
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 ADC Info 
Glyco-engineered cetuximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Cetux Cys-vc-MMAE [38]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Glyco-engineered cetuximab Fab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Glyco-cetuximab Fab-vc-MMAE [38]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Glyco-engineered cetuximab Fc/Fab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Cetux Fc/Fab-vc-MMAE [38]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
hu-alpha-EGFR(ACVC), cetuximab with A114C and V205C mutations
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Hu-Alpha-EGFR (ACVC)-172 [22]
IMSA172
Stimulator of interferon genes protein (STING1)
Mc-Val-Cit-PABC
 ADC Info 
Imgatuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Imgatuzumab-ADC-Tb5-1 [33]
Imgatuzumab-ADC-Tb5-1 payload
Undisclosed
Imgatuzumab-ADC-Tb5-1 linker
 ADC Info 
Imgatuzumab-ADC-Tb5-2 [33]
Imgatuzumab-ADC-Tb5-2 payload
Undisclosed
Imgatuzumab-ADC-Tb5-2 linker
 ADC Info 
AU2023226367A1-3c [73]
Auristatin E
Microtubule (MT)
RU20241285-3-linker
 ADC Info 
CN119630431A ADC-94 [74]
CN119630431A-ADC-82-PAYLOAD
Undisclosed
CN119630431A-ADC-82-LINKER
 ADC Info 
Laprituximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Laprituximab emtansine
DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
Laprituximab-ADC-Tb5-1 [33]
Laprituximab-ADC-Tb5-1 payload
Undisclosed
Laprituximab-ADC-Tb5-1 linker
 ADC Info 
Laprituximab-ADC-Tb5-2 [33]
Laprituximab-ADC-Tb5-2 payload
Undisclosed
Laprituximab-ADC-Tb5-2 linker
 ADC Info 
Losatuxizumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Losatuxizumab vedotin
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Losatuxzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Losatuxzumab-ADC-Tb5-1 [33]
Losatuxzumab-ADC-Tb5-1 payload
Undisclosed
Losatuxzumab-ADC-Tb5-1 linker
 ADC Info 
Losatuxzumab-ADC-Tb5-2 [33]
Losatuxzumab-ADC-Tb5-2 payload
Undisclosed
Losatuxzumab-ADC-Tb5-2 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
LR004-Val-Cit-MMAE [75]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
LR-DM1 [76]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
ADC Name Payload Target Linker ADC Info
AVID100
DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
Matuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Matuzumab-ADC-Tb5-1 [33]
Matuzumab-ADC-Tb5-1 payload
Undisclosed
Matuzumab-ADC-Tb5-1 linker
 ADC Info 
Matuzumab-ADC-Tb5-2 [33]
Matuzumab-ADC-Tb5-2 payload
Undisclosed
Matuzumab-ADC-Tb5-2 linker
 ADC Info 
Modotuximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Modotuximab-ADC-Tb5-1 [33]
Modotuximab-ADC-Tb5-1 payload
Undisclosed
Modotuximab-ADC-Tb5-1 linker
 ADC Info 
Modotuximab-ADC-Tb5-2 [33]
Modotuximab-ADC-Tb5-2 payload
Undisclosed
Modotuximab-ADC-Tb5-2 linker
 ADC Info 
mu-alpha-EGFR
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Mu-Alpha-EGFR-172 [22]
IMSA172
Stimulator of interferon genes protein (STING1)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
NC-6201 [77]
E7974
Microtubule (MT)
Undisclosed
 ADC Info 
Necitumumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Necitumumab-ADC-Tb5-1 [33]
Necitumumab-ADC-Tb5-1 payload
Undisclosed
Necitumumab-ADC-Tb5-1 linker
 ADC Info 
Necitumumab-ADC-Tb5-2 [33]
Necitumumab-ADC-Tb5-2 payload
Undisclosed
Necitumumab-ADC-Tb5-2 linker
 ADC Info 
WO2024055886A1 ADC1 [78]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024055886A1 ADC2 [78]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024055886A1 ADC3 [78]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Nimotuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Nimotuzumab-ADC-24-1 [79]
Nimotuzumab-ADC-24-1 payload
Undisclosed
Nimotuzumab-ADC-24-1 linker
 ADC Info 
Nimotuzumab-ADC-24-2 [79]
Nimotuzumab-ADC-24-2 payload
Undisclosed
Nimotuzumab-ADC-24-2 linker
 ADC Info 
Nimotuzumab-ADC-24-3 [79]
Nimotuzumab-ADC-24-3 payload
Undisclosed
Nimotuzumab-ADC-24-3 linker
 ADC Info 
Nimotuzumab-ADC-24-4 [79]
Nimotuzumab-ADC-24-4 payload
Undisclosed
Nimotuzumab-ADC-24-4 linker
 ADC Info 
Nimotuzumab-ADC-24-5 [79]
Nimotuzumab-ADC-24-5 payload
Undisclosed
Nimotuzumab-ADC-24-5 linker
 ADC Info 
Nimotuzumab-ADC-24-6 [79]
Nimotuzumab-ADC-24-6 payload
Undisclosed
Nimotuzumab-ADC-24-6 linker
 ADC Info 
Nimotuzumab-ADC-24-7 [79]
Nimotuzumab-ADC-24-7 payload
Undisclosed
Nimotuzumab-ADC-24-7 linker
 ADC Info 
Nimotuzumab-ADC-24-8 [79]
Nimotuzumab-ADC-24-8 payload
Undisclosed
Nimotuzumab-ADC-24-8 linker
 ADC Info 
Nimotuzumab-ADC-24-9 [79]
Nimotuzumab-ADC-24-9 payload
Undisclosed
Nimotuzumab-ADC-24-9 linker
 ADC Info 
Nimotuzumab-ADC-24-10 [79]
Nimotuzumab-ADC-24-10 payload
Undisclosed
Nimotuzumab-ADC-24-10 linker
 ADC Info 
Nimotuzumab-ADC-24-11 [79]
Nimotuzumab-ADC-24-11 payload
Undisclosed
Nimotuzumab-ADC-24-11 linker
 ADC Info 
Nimotuzumab-ADC-24-12 [79]
Nimotuzumab-ADC-24-12 payload
Undisclosed
Nimotuzumab-ADC-24-12 linker
 ADC Info 
Nimotuzumab-ADC-24-13 [79]
Nimotuzumab-ADC-24-13 payload
Undisclosed
Nimotuzumab-ADC-24-13 linker
 ADC Info 
Nimotuzumab-ADC-Tb5-1 [33]
Nimotuzumab-ADC-Tb5-1 payload
Undisclosed
Nimotuzumab-ADC-Tb5-1 linker
 ADC Info 
Nimotuzumab-ADC-Tb5-2 [33]
Nimotuzumab-ADC-Tb5-2 payload
Undisclosed
Nimotuzumab-ADC-Tb5-2 linker
 ADC Info 
Nimotuzumab-Compound 9 [43]
Mertansine DM1
Microtubule (MT)
Nimotuzumab-Compound 9 linker
 ADC Info 
Nimotuzumab-Compound 17 [43]
Mertansine DM4
Microtubule (MT)
Nimotuzumab-Compound 17 linker
 ADC Info 
Nimotuzumab-Compound 25 [43]
Monomethyl auristatin E
Microtubule (MT)
Nimotuzumab-Compound 25 linker
 ADC Info 
Nimotuzumab-Compound 31 [43]
Auristatin 0101
Microtubule (MT)
Nimotuzumab-Compound 31 linker
 ADC Info 
Nimotuzumab-Compound 36 [43]
Monomethyl auristatin E
Microtubule (MT)
Nimotuzumab-Compound 36 linker
 ADC Info 
Nimotuzumab-Compound 43 [43]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Nimotuzumab-Compound 43 linker
 ADC Info 
Nimotuzumab-Compound 49 [43]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Nimotuzumab-Compound 49 linker
 ADC Info 
Nimotuzumab-Compound 55 [43]
Mertansine DM1
Microtubule (MT)
Nimotuzumab-Compound 55 linker
 ADC Info 
Nimotuzumab-Compound 59 [43]
Mertansine DM4
Microtubule (MT)
Nimotuzumab-Compound 59 linker
 ADC Info 
Nimotuzumab-Compound 64 [43]
Monomethyl auristatin E
Microtubule (MT)
Nimotuzumab-Compound 64 linker
 ADC Info 
Nimotuzumab-Compound 69 [43]
Monomethyl auristatin E
Microtubule (MT)
Nimotuzumab-Compound 69 linker
 ADC Info 
Nimotuzumab-Compound 74 [43]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Nimotuzumab-Compound 74 linker
 ADC Info 
Nimotuzumab-Compound 75 [43]
Monomethyl auristatin E
Microtubule (MT)
Nimotuzumab-Compound 75 linker
 ADC Info 
Nimotuzumab-Compound 76 [43]
Monomethyl auristatin E
Microtubule (MT)
Nimotuzumab-Compound 76 linker
 ADC Info 
Nimotuzumab-Compound 77 [43]
Mertansine DM1
Microtubule (MT)
Nimotuzumab-Compound 77 linker
 ADC Info 
Nimotuzumab-Compound 78 [43]
Auristatin 0101
Microtubule (MT)
Nimotuzumab-Compound 78 linker
 ADC Info 
Nimotuzumab-Compound 79 [43]
Auristatin 0101
Microtubule (MT)
Nimotuzumab-Compound 79 linker
 ADC Info 
Nimotuzumab-Compound 80 [43]
Mertansine DM4
Microtubule (MT)
Nimotuzumab-Compound 80 linker
 ADC Info 
CN114917361A ADC-3 [44]
CN114917361A ADC-3 payload
Undisclosed
CN114917361A ADC-3 linker
 ADC Info 
Nim-CL2A-FL118 (13) [49]
Undisclosed
Undisclosed
CL2A
 ADC Info 
US12144865B2 1i [58]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Nimotuzumab derivative
 Antibody Info 
ADC Name Payload Target Linker ADC Info
DXC-004A
Tubulysin B analog
Microtubule (MT)
Undisclosed
 ADC Info 
DXC004 [80]
Tubulysin B analog
Microtubule (MT)
Undisclosed
 ADC Info 
Panitumumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CyEt-Pan-Duo [81]
DEAEA duocarmycin
Human Deoxyribonucleic acid (hDNA)
Mal-PEG4-Triazol-Cyanine cage
 ADC Info 
AVID-300 [82]
Mertansine DM1
Microtubule (MT)
Undisclosed
 ADC Info 
Panitumumab-DNA conjugate [32]
DNA mimics
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 ADC Info 
Panitumumab-ADC-Tb5-1 [33]
Panitumumab-ADC-Tb5-1 payload
Undisclosed
Panitumumab-ADC-Tb5-1 linker
 ADC Info 
Panitumumab-ADC-Tb5-2 [33]
Panitumumab-ADC-Tb5-2 payload
Undisclosed
Panitumumab-ADC-Tb5-2 linker
 ADC Info 
Panitumumab-Compound 9 [43]
Mertansine DM1
Microtubule (MT)
Panitumumab-Compound 9 linker
 ADC Info 
Panitumumab-Compound 17 [43]
Mertansine DM4
Microtubule (MT)
Panitumumab-Compound 17 linker
 ADC Info 
Panitumumab-Compound 25 [43]
Monomethyl auristatin E
Microtubule (MT)
Panitumumab-Compound 25 linker
 ADC Info 
Panitumumab-Compound 31 [43]
Auristatin 0101
Microtubule (MT)
Panitumumab-Compound 31 linker
 ADC Info 
Panitumumab-Compound 36 [43]
Monomethyl auristatin E
Microtubule (MT)
Panitumumab-Compound 36 linker
 ADC Info 
Panitumumab-Compound 43 [43]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Panitumumab-Compound 43 linker
 ADC Info 
Panitumumab-Compound 49 [43]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Panitumumab-Compound 49 linker
 ADC Info 
Panitumumab-Compound 55 [43]
Mertansine DM1
Microtubule (MT)
Panitumumab-Compound 55 linker
 ADC Info 
Panitumumab-Compound 59 [43]
Mertansine DM4
Microtubule (MT)
Panitumumab-Compound 59 linker
 ADC Info 
Panitumumab-Compound 64 [43]
Monomethyl auristatin E
Microtubule (MT)
Panitumumab-Compound 64 linker
 ADC Info 
Panitumumab-Compound 69 [43]
Monomethyl auristatin E
Microtubule (MT)
Panitumumab-Compound 69 linker
 ADC Info 
Panitumumab-Compound 74 [43]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Panitumumab-Compound 74 linker
 ADC Info 
Panitumumab-Compound 75 [43]
Monomethyl auristatin E
Microtubule (MT)
Panitumumab-Compound 75 linker
 ADC Info 
Panitumumab-Compound 76 [43]
Monomethyl auristatin E
Microtubule (MT)
Panitumumab-Compound 76 linker
 ADC Info 
Panitumumab-Compound 77 [43]
Mertansine DM1
Microtubule (MT)
Panitumumab-Compound 77 linker
 ADC Info 
Panitumumab-Compound 78 [43]
Auristatin 0101
Microtubule (MT)
Panitumumab-Compound 78 linker
 ADC Info 
Panitumumab-Compound 79 [43]
Auristatin 0101
Microtubule (MT)
Panitumumab-Compound 79 linker
 ADC Info 
Panitumumab-Compound 80 [43]
Mertansine DM4
Microtubule (MT)
Panitumumab-Compound 80 linker
 ADC Info 
Pimurutamab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Pimurutamab-ADC-Tb5-1 [33]
Pimurutamab-ADC-Tb5-1 payload
Undisclosed
Pimurutamab-ADC-Tb5-1 linker
 ADC Info 
Pimurutamab-ADC-Tb5-2 [33]
Pimurutamab-ADC-Tb5-2 payload
Undisclosed
Pimurutamab-ADC-Tb5-2 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
RC68-PY-Val-Cit-PABC-MMAE [83]
Monomethyl auristatin E
Microtubule (MT)
PY-VC-PABC
 ADC Info 
RC68-Mc-Val-Cit-PABC-MMAE [83]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
SCT-200-M-1 [84]
Monomethyl auristatin E
Microtubule (MT)
CN112604004B-SCT-200-M-1-linker
 ADC Info 
SCT-200-M-2 [84]
Monomethyl auristatin E
Microtubule (MT)
CN112604004B-SCT-200-M-2-linker
 ADC Info 
SCT-200-M-3 [84]
Monomethyl auristatin E
Microtubule (MT)
CN112604004B-SCT-200-M-3-linker
 ADC Info 
SCT-200-C-1 [84]
Monomethyl auristatin E
Microtubule (MT)
CN112604004B-SCT-200-C-1-linker
 ADC Info 
SCT-200-C-2 [84]
Monomethyl auristatin E
Microtubule (MT)
CN112604004B-SCT-200-C-2-linker
 ADC Info 
SCT-200-C-3 [84]
Monomethyl auristatin E
Microtubule (MT)
CN112604004B-SCT-200-C-3-linker
 ADC Info 
SCT-200-C-4 [84]
Monomethyl auristatin E
Microtubule (MT)
CN112604004B-SCT-200-C-4-linker
 ADC Info 
SCT-200-C-5 [84]
Monomethyl auristatin E
Microtubule (MT)
CN112604004B-SCT-200-C-5-linker
 ADC Info 
SCT-200-R-1 [84]
Monomethyl auristatin E
Microtubule (MT)
CN112604004B-SCT-200-R-1-linker
 ADC Info 
SCT-200-R-2 [84]
Monomethyl auristatin E
Microtubule (MT)
CN112604004B-SCT-200-R-2-linker
 ADC Info 
Serclutamab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Serclutamab talirine
SGD-1882
Human deoxyribonucleic acid (hDNA)
Mc-Val-Ala
 ADC Info 
Serclutamab-ADC-Tb5-1 [33]
Serclutamab-ADC-Tb5-1 payload
Undisclosed
Serclutamab-ADC-Tb5-1 linker
 ADC Info 
Serclutamab-ADC-Tb5-2 [33]
Serclutamab-ADC-Tb5-2 payload
Undisclosed
Serclutamab-ADC-Tb5-2 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
SWY2110-JSSW-001 ADC [85]
Exatecan
DNA topoisomerase 1 (TOP1)
C12-1 linker
 ADC Info 
SWY2110-GGFG-DXD ADC [85]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
SWY2110-VC-MMAE ADC [85]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
SWY2111-JSSW-001 ADC [85]
Exatecan
DNA topoisomerase 1 (TOP1)
C12-1 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
SWY2112-JSSW-001 ADC [85]
Exatecan
DNA topoisomerase 1 (TOP1)
C12-1 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
SWY2113-JSSW-001 ADC [85]
Exatecan
DNA topoisomerase 1 (TOP1)
C12-1 linker
 ADC Info 
Tomuzotuximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Tomuzotuximab-ADC-Tb5-1 [33]
Tomuzotuximab-ADC-Tb5-1 payload
Undisclosed
Tomuzotuximab-ADC-Tb5-1 linker
 ADC Info 
Tomuzotuximab-ADC-Tb5-2 [33]
Tomuzotuximab-ADC-Tb5-2 payload
Undisclosed
Tomuzotuximab-ADC-Tb5-2 linker
 ADC Info 
Zalutumumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Zalutumumab-ADC-Tb5-1 [33]
Zalutumumab-ADC-Tb5-1 payload
Undisclosed
Zalutumumab-ADC-Tb5-1 linker
 ADC Info 
Zalutumumab-ADC-Tb5-2 [33]
Zalutumumab-ADC-Tb5-2 payload
Undisclosed
Zalutumumab-ADC-Tb5-2 linker
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HTI-1511 [86]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Probody drug conjugate (CytomX Therapeutics) [87]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Recombinant humanized anti-EGFR mAb-DUO-5 conjugate [88]
Duostatin 5
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 ADC Info 
PBX-003 [89]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
NS Cys-vc-MMAE [38]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
STI-A020X [90]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
EGFR-EDV-RRM1 [91]
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
 ADC Info 
WO2024043319A1 82 [92]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CN107614020A 1MB-701 [93]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CN107614020A 1MB-702 [93]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CN114786729A ADC-VII [94]
CDN-A
Undisclosed
Undisclosed
 ADC Info 
CN114786729A ADC-VIII [94]
CDN-A
Undisclosed
Undisclosed
 ADC Info 
CN114786729A ADC-IX [94]
CDN-A
Undisclosed
Undisclosed
 ADC Info 
CN114786729A ADC-X [94]
CDN-A
Undisclosed
Undisclosed
 ADC Info 
CN114786729A ADC-XI [94]
CDN-A
Undisclosed
Undisclosed
 ADC Info 
CN117731799A ADC-1 [95]
CN117731799A-ADC-1-payload
Undisclosed
CN117731799A-ADC-1-linker
 ADC Info 
CN115429890B ADC-1 [96]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
DBCO-PEG8-glu
 ADC Info 
CN115429890B ADC-2 [96]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
DBCO-Val-Cit-PABC
 ADC Info 
References
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Ref 2 RAFT Polymer-Antibody Conjugation: Squaramide Ester Chemistry Leads to Conjugates with a Therapeutic Anti-EGFR Antibody with Full Retention of Activity and Increased Tumor Uptake In Vivo
Ref 3 Antibody-drug conjugates (A2DCs) with enzymatically cleavable groups
Ref 4 A multivalent biparatopic EGFR-targeting nanobody drug conjugate displays potent anticancer activity in solid tumor models. Signal Transduct Target Ther. 2021 Sep 3;6(1):320. doi: 10.1038/s41392-021-00666-5.
Ref 5 Anti-EGFR antibodies, antibody-drug conjugates, pharmaceutical compositions and uses for treating cancer and inhibiting or reducing solid tumor growth
Ref 6 Anti-egfr antibodies and antibody drug conjugates.
Ref 7 EGFR binding Fc domain-drug conjugates: stable and highly potent cytotoxic molecules mediate selective cell killing. Biol Chem. 2021 Sep 20;403(5-6):525-534.
Ref 8 Novel tryptophan-based antibody-drug conjugate (ADC) targeting EGFR-positive lung cancer demonstrates robust antitumor efficacy by triggering immunogenic cell death
Ref 9 Anti-EGFR antibody-drug conjugate for triple-negative breast cancer therapy. Eng Life Sci. 2020 Oct 7;21(1-2):37-44. doi: 10.1002/elsc.202000027. eCollection 2021 Jan.
Ref 10 Optimizing Lysosomal Activation of Antibody-Drug Conjugates (ADCs) by Incorporation of Novel Cleavable Dipeptide Linkers. Mol Pharm. 2019 Dec 2;16(12):4817-4825. doi: 10.1021/acs.molpharmaceut.9b00696. Epub 2019 Oct 29.
Ref 11 Synthesis of Highly Potent N-10 Amino-Linked DNA-Alkylating Indolinobenzodiazepine Antibody-Drug Conjugates (ADCs). ACS Med Chem Lett. 2019 Jul 22;10(8):1211-1215. doi: 10.1021/acsmedchemlett.9b00254. eCollection 2019 Aug 8.
Ref 12 Conjugates and antibody-drug conjugates prepared therefrom
Ref 13 Antibody drug conjugates, targeting cancer-expressed EGFR, exhibit potent and specific antitumor activity. Biomed Pharmacother. 2023 Jan;157:114047.
Ref 14 Discovery of A Novel EGFR-Targeting Antibody-Drug Conjugate, SHR-A1307, for the Treatment of Solid Tumors Resistant or Refractory to Anti-EGFR Therapies. Mol Cancer Ther. 2019 Jun;18(6):1104-1114. doi: 10.1158/1535-7163.MCT-18-0854.
Ref 15 Inhibition of human tumor xenograft growth in nude mice by a conjugate of monoclonal antibody LA22 to epidermal growth factor receptor with anti-tumor antibiotics mitomycin C. Biochem Biophys Res Commun. 2006 Oct 20;349(2):816-24. doi: 10.1016/j.bbrc.2006.08.114. Epub 2006 Aug 28.
Ref 16 Therapeutic potential of nimotuzumab PEGylated-maytansine antibody drug conjugates against EGFR positive xenograft. Oncotarget. 2019 Feb 1;10(10):1031-1044. doi: 10.18632/oncotarget.26613. eCollection 2019 Feb 1.
Ref 17 A camptothecin drug and its antibody conjugate thereof
Ref 18 Antibody-drug conjugate; 2016-08-25.
Ref 19 A novel anti-HER2/EGFR bispecific antibody-drug conjugate demonstrates promising antitumor efficacy and overcomes resistance to HER2- or EGFR-targeted ADCs
Ref 20 Antibody-drug conjugates containing two different drugs
Ref 21 A new class of DNA sequence-selective G-A cross-linking antibody-drug conjugate (ADC) payloads. Cancer Res (2022) 82 (12_Supplement): 1749.
Ref 22 Tumor-targeted delivery of a STING agonist improvescancer immunotherapy. Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2214278119.
Ref 23 Conjugation of Cetuximab - Puromycin and Its Target-Specific Effect on Triple Negative Breast Cancer Cell Lines. Asian Pac J Cancer Prev. 2022 May 1;23(5):1803-1812.
Ref 24 An anti-EGFR antibody-drug conjugate overcomes resistance to HER2-targeted drugs. Cancer Lett. 2023 Feb 1;554:216024.
Ref 25 Radiation Cleaved Drug-Conjugate Linkers Enable Local Payload Release. Bioconjug Chem. 2022 Aug 17;33(8):1474-1484.
Ref 26 Targeting of colorectal cancer organoids with zoledronic acid conjugated to the anti-EGFR antibody cetuximab. J Immunother Cancer. 2022 Dec;10(12):e005660.
Ref 27 EGFR Targeted Cetuximab-Valine-Citrulline (vc)-Doxorubicin Immunoconjugates- Loaded Bovine Serum Albumin (BSA) Nanoparticles for Colorectal Tumor Therapy. Int J Nanomedicine. 2021 Mar 26;16:2443-2459. doi: 10.2147/IJN.S289228. eCollection 2021.
Ref 28 Compounds, linker-drugs and ligand-drug conjugates; 2020-06-16
Ref 29 A Novel EGFR Targeted Immunotoxin Based on Cetuximab and Type 1 RIP Quinoin Overcomes the Cetuximab Resistance in Colorectal Cancer Cells. Toxins (Basel). 2023 Jan 9;15(1):57. doi: 10.3390/toxins15010057.
Ref 30 Development of a new minimally invasive phototherapy for lung cancer using antibody-toxin conjugate. Thorac Cancer. 2023 Mar;14(7):645-653. doi: 10.1111/1759-7714.14776. Epub 2023 Jan 19.
Ref 31 Cetuximab-Triptolide Conjugate Suppresses the Growth of EGFR-Overexpressing Lung Cancers through Targeting RNA Polymerase II. Mol Ther Oncolytics. 2020 Jul 6;18:304-316. doi: 10.1016/j.omto.2020.07.001. eCollection 2020 Sep 25.
Ref 32 Aptamer-Directed Conjugation of DNA to Therapeutic Antibodies. Bioconjug Chem. 2019 Aug 21;30(8):2127-2135. doi: 10.1021/acs.bioconjchem.9b00363. Epub 2019 Jul 12.
Ref 33 Bioactive substance conjugate, preparation method therefor and use thereof; 2022-08-18.
Ref 34 Neodegrader conjugates; 2021-10-07.
Ref 35 Antibody-drug conjugates comprising branched linkers and methods related thereto; 2017-06-01.
Ref 36 Camptothecin derivative and ligand-drug conjugate thereof; 2022-04-21.
Ref 37 Hydrophilic Auristatin Glycoside Payload Enables Improved Antibody-Drug Conjugate Efficacy and Biocompatibility. Antibodies (Basel). 2018 Mar 22;7(2):15. doi: 10.3390/antib7020015.
Ref 38 MAbs. 2023 Jan-Dec;15(1):2149057. doi: 10.1080/19420862.2022.2149057.
Ref 39 Balancing Selectivity and Efficacy of Bispecific Epidermal Growth Factor Receptor (EGFR) c-MET Antibodies and Antibody-Drug Conjugates. J Biol Chem. 2016 Nov 25;291(48):25106-25119. doi: 10.1074/jbc.M116.753491. Epub 2016 Sep 30.
Ref 40 Controlled coupling of an ultrapotent auristatin warhead to cetuximab yields a next-generation antibody-drug conjugate for EGFR-targeted therapy of KRAS mutant pancreatic cancer. Br J Cancer. 2020 Nov;123(10):1502-1512. doi: 10.1038/s41416-020-01046-6. Epub 2020 Sep 11.
Ref 41 Divinylsulfonamides enable the construction of homogeneous antibody-drug conjugates. Bioorg Med Chem. 2020 Dec 1;28(23):115793. doi: 10.1016/j.bmc.2020.115793. Epub 2020 Oct 6.
Ref 42 Conjugates comprising self-immolative groups and methods related thereto.
Ref 43 Covalent linkers in antibody-drug conjugates and methods of making and using the same.
Ref 44 Binder-wirkstoff-konjugate (adcs) und binder-prodrug-konjugate (apdcs) mit enzymatisch spaltbaren gruppen.
Ref 45 Introduction to basic information on ADC drug ADC-W-2589.
Ref 46 AGCM-22, a novel cetuximab-based EGFR-targeting antibody-drug-conjugate with highly selective anti-glioblastoma efficacy
Ref 47 Use of a Cyclic α-Alkylidene-β-Diketone as a Cleavable Linker Strategy for Antibody-Drug Conjugates
Ref 48 Phenyldivinylsulfonamides for the construction of antibody-drug conjugates with controlled four payloads
Ref 49 Design, synthesis and biological evaluation of camptothecin analogue FL118 as a payload for antibody-drug conjugates in targeted cancer therapy
Ref 50 Anti-EGFR Antibody-Drug Conjugate Carrying an Inhibitor Targeting CDK Restricts Triple-Negative Breast Cancer Growth
Ref 51 Dual-Function Antibody Conjugate-Enabled Photoimmunotherapy Complements Fluorescence and Photoacoustic Imaging of Head and Neck Cancer Spheroids
Ref 52 Synergistic Approach of Antibody-Photosensitizer Conjugate Independent of KRAS-Mutation and Its Downstream Blockade Pathway in Colorectal Cancer
Ref 53 Cetuximab-based PROteolysis targeting chimera for effectual downregulation of NSCLC with varied EGFR mutations
Ref 54 Antibody-platinum (IV) prodrugs conjugates for targeted treatment of cutaneous squamous cell carcinoma
Ref 55 Increasing the Dye Payload of Cetuximab-IRDye800CW Enables Photodynamic Therapy
Ref 56 Temporal dynamics of fluorescence and photoacoustic signals of a Cetuximab-IRDye800 conjugate in EGFR-overexpressing tumors
Ref 57 Antibody-drug complexes containing hemiasterlin derivatives
Ref 58 Antibody drug conjugates with enzymatically cleavable groups
Ref 59 Bispecific antibody-drug conjugates targeting EGFR and MUC1 and uses thereof
Ref 60 Combreta-statin derivatives and their antibody-drug conjugates
Ref 61 Deuterated camptothecin derivatives and antibody-drug conjugates thereof
Ref 62 Directed conjugation technology
Ref 63 Antibody-multidrug conjugate
Ref 64 Deuterated camptothecin derivatives and their antibody-drug conjugates
Ref 65 Antibody-drug conjugates and uses thereof
Ref 66 Compositions and methods related to anti-egfr antibody drug conjugates; 2017-03-30.
Ref 67 Pharmaceuticals containing antibody-drug complexes containing hemiasterin derivatives
Ref 68 Targeting and Efficacy of Novel mAb806-Antibody-Drug Conjugates in Malignant Mesothelioma. Pharmaceuticals (Basel). 2020 Oct 2;13(10):289. doi: 10.3390/ph13100289.
Ref 69 RN765C, a low affinity EGFR antibody drug conjugate with potent anti-tumor activity in preclinical solid tumor models. Oncotarget. 2018 Sep 11;9(71):33446-33458. doi: 10.18632/oncotarget.26002. eCollection 2018 Sep 11.
Ref 70 Antibody compositions comprising Fc mutations and site-specific conjugation properties for use in treating cancer, immunological disorders, and methods thereof
Ref 71 Bispecific anti-mPDGFR x cotinine scFv-C()-scFv fusion protein and cotinine-duocarmycin can form antibody-drug conjugate-like complexes that exert cytotoxicity against mPDGFR expressing cells. Methods. 2019 Feb 1;154:125-135. doi: 10.1016/j.ymeth.2018.10.002. Epub 2018 Oct 4.
Ref 72 A recombinant scFv antibody-based fusion protein that targets EGFR associated with IMPDH2 downregulation and its drug conjugate show therapeutic efficacy against esophageal cancer. Drug Deliv. 2022 Dec;29(1):1243-1256.
Ref 73 Antibody-drug conjugate
Ref 74 Antibody-drug conjugates
Ref 75 Excellent effects and possible mechanisms of action of a new antibody-drug conjugate against EGFR-positive triple-negative breast cancer. Mil Med Res. 2021 Dec 9;8(1):63.
Ref 76 Rational Design and Systemic Appraisal of an EGFR-Targeting Antibody-Drug Conjugate LR-DM1 for Pancreatic Cancer. J Med Chem. 2022 May 26;65(10):7141-7153. doi: 10.1021/acs.jmedchem.1c01920. Epub 2022 May 6.
Ref 77 Preclinical evaluation of NC-6201, an antibody/drug-conjugated micelle incorporating novel hemiasterlin analogue E7974.
Ref 78 Branched polyethylene glycol linkers and their uses
Ref 79 Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof; 2020-04-02.
Ref 80 DAC biotechnology company product pipeline
Ref 81 In Vivo Activation of Duocarmycin-Antibody Conjugates by Near-Infrared Light. ACS Cent Sci. 2017 Apr 26;3(4):329-337. doi: 10.1021/acscentsci.7b00026. Epub 2017 Feb 24.
Ref 82 ADC review AVID-300
Ref 83 Monomethyl auristatin E-conjugated anti-EGFR antibody inhibits the growth of human EGFR-positive non-small cell lung cancer. Cancer Chemother Pharmacol. 2019 Jul;84(1):61-72. doi: 10.1007/s00280-019-03848-9. Epub 2019 Apr 29.
Ref 84 Anti-human EGFR antibody-drug conjugates and their preparation methods and applications
Ref 85 Uses of an antibody-drug conjugate
Ref 86 Preclinical evaluation of a next-generation, EGFR targeting ADC that promotes regression in KRAS or BRAF mutant tumors. Cancer Res (2016) 76 (14_Supplement): 1217.
Ref 87 Introduction to basic information on ADC drug Probody drug conjugate (CytomX Therapeutics)
Ref 88 Introduction to basic information on recombinant humanized anti-EGFR mAb-DUO-5 conjugate(Zova Biotherapeutics/Zhejiang Hisun Pharmaceutical).
Ref 89 Pinotbio biotechnology company product pipeline
Ref 90 Sorrento therapeutics next-generation cancer therapeutics; November 2013
Ref 91 Introduction to basic information on antibody-drug nanocell conjugates(EnGeneIC Pty Ltd.).
Ref 92 Antibody-drug complexes
Ref 93 Conjugates targeting intracellular tumor-associated antigens for treatment of cancer
Ref 94 Antibody-STING agonist conjugates and their use in immunotherapy
Ref 95 An antibody-drug conjugate formulation and its preparation process
Ref 96 Conjugates and antibody-drug conjugates prepared therefrom