Antibody Information
General Information of This Antibody
| Antibody ID | ANI0XHYAA |
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|---|---|---|---|---|---|---|
| Antibody Name | Cetuximab Fab (conjugate to glycan residues) |
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Humanized IgG1-kappa |
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| Antigen Name | Epidermal growth factor receptor (EGFR) |
Antigen Info | ||||
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
Cetux Fab-vc-MMAE [Investigative]
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
0.01 nM
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High EGFR expression (EGFR+++/++) | ||
| Method Description |
Cells were incubated with a serial dilution of conjugate, and a mixture of conjugate and excess, unconjugated anti-EGFR. After 4 days of continuous treatment with conjugates, cell viability was determined using Cell Titer Glo reagent.
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| In Vitro Model | Glioblastoma | U-87MG cells | CVCL_0022 | ||
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