Antibody Information
General Information of This Antibody
Antibody ID | ANI0VLZLL |
|||||
---|---|---|---|---|---|---|
Antibody Name | Fv-LDP-D3 |
|||||
Synonyms |
Cetuximab Fv+the apoprotein of lidamycin+the third domain of human serum albumin
Click to Show/Hide
|
|||||
Antibody Type | Monoclonal antibody (mAb) |
|||||
Antibody Subtype | Humanized IgG1-kappa |
|||||
Antigen Name | Epidermal growth factor receptor (EGFR) |
Antigen Info |
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
Fv-LDP-D3-AE [Investigative]
Discovered Using Cell Line-derived Xenograft Model
Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 64.00% (Day 28) | High EGFR expression (EGFR+++) | ||
Method Description |
KYSE150 cells (5 10 6 cells/200 L) suspended in PBS were inoculated subcutaneously into the right armpit of athymic mice. When the tumor volume reached about 80mm3, nude mice were randomized into two groups (n=6, per group), a control group and a Fv-LDP-D3-AE (0.2 mg/kg) group. The drug treatment group was given by tail vein injection once a week for two consecutive weeks.
Click to Show/Hide
|
||||
In Vivo Model | Esophageal squamous cell carcinoma CDX model | ||||
In Vitro Model | Esophageal squamous cell carcinoma | KYSE-150 cells | CVCL_1348 | ||
Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 73.00% (Day 28) | High EGFR expression (EGFR+++) | ||
Method Description |
KYSE150 cells (5 10 6 cells/200 L) suspended in PBS were inoculated subcutaneously into the right armpit of athymic mice. When the tumor volume reached about 80mm3, nude mice were randomized into two groups (n=6, per group), a control group and a Fv-LDP-D3-AE (0.25 mg/kg) group. The drug treatment group was given by tail vein injection once a week for two consecutive weeks.
Click to Show/Hide
|
||||
In Vivo Model | Esophageal squamous cell carcinoma CDX model | ||||
In Vitro Model | Esophageal squamous cell carcinoma | KYSE-150 cells | CVCL_1348 | ||
Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 81.00% (Day 28) | High EGFR expression (EGFR+++) | ||
Method Description |
KYSE150 cells (5 10 6 cells/200 L) suspended in PBS were inoculated subcutaneously into the right armpit of athymic mice. When the tumor volume reached about 80mm3, nude mice were randomized into two groups (n=6, per group), a control group and a Fv-LDP-D3-AE (0.5 mg/kg) group. The drug treatment group was given by tail vein injection once a week for two consecutive weeks.
Click to Show/Hide
|
||||
In Vivo Model | Esophageal squamous cell carcinoma CDX model | ||||
In Vitro Model | Esophageal squamous cell carcinoma | KYSE-150 cells | CVCL_1348 |
Revealed Based on the Cell Line Data
Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
33.00 ng/mL
|
High EGFR expression (EGFR+++) | ||
Method Description |
The CCK8 method was used to evaluate the cytotoxicity of Fv-LDP-D3 and Fv-LDP-D3-AE in KYSE150, KYSE520, and Eca109 cells.
|
||||
In Vitro Model | Esophageal squamous cell carcinoma | KYSE-150 cells | CVCL_1348 | ||
Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
44.00 ng/mL
|
High EGFR expression (EGFR+++) | ||
Method Description |
The CCK8 method was used to evaluate the cytotoxicity of Fv-LDP-D3 and Fv-LDP-D3-AE in KYSE150, KYSE520, and Eca109 cells.
|
||||
In Vitro Model | Esophageal squamous cell carcinoma | KYSE-520 cells | CVCL_1355 | ||
Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
Efficacy Data | Half Maximal Inhibitory Concentration (IC50) |
75.00 ng/mL
|
Moderate EGFR expression (EGFR++) | ||
Method Description |
The CCK8 method was used to evaluate the cytotoxicity of Fv-LDP-D3 and Fv-LDP-D3-AE in KYSE150, KYSE520, and Eca109 cells.
|
||||
In Vitro Model | Esophageal squamous cell carcinoma | Eca-109 cells | CVCL_6898 |
References
If you find any error in data or bug in web service, please kindly report it to Dr. Shen et al.