Antibody Information
General Information of This Antibody
Antibody ID | ANI0ZZTGC |
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Antibody Name | Anti-EGFR Ab1 |
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Antibody Type | Monoclonal antibody (mAb) |
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Antibody Subtype | Humanized IgG1 |
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Antigen Name | Epidermal growth factor receptor (EGFR) |
Antigen Info |
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
Ab1-mcMMAF [Investigative]
Discovered Using Cell Line-derived Xenograft Model
Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 81.39% (Day 33) | Positive EGFR expression (EGFR+++/++) | ||
Method Description |
Cells were subcutaneously inoculated at a dose of 1,000,000 cells to the right flank region of each female nude mouse (Day 0). On the day 7 of grouping, the antibody-drug conjugate was intravenously administered at doses of 3 mg/kg to thetail of each mouse.
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In Vivo Model | EBC-1 CDX model | ||||
In Vitro Model | Lung squamous cell carcinoma | EBC-1 cells | CVCL_2891 | ||
Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 86.40% (Day 55) | Positive EGFR expression (EGFR+++/++) | ||
Method Description |
Cells were subcutaneously inoculated at a dose of 1,000,000 cells to the right flank region of each female nude mouse (Day 0). On the day 7 of grouping, the antibody-drug conjugate was intravenously administered at doses of 1 mg/kg to thetail of each mouse.
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In Vivo Model | NCI-H1703 CDX model | ||||
In Vitro Model | Lung squamous cell carcinoma | NCI-H1703 cells | CVCL_1490 |
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