Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0MIACF
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| ADC Name |
Cetuximab (LC) G7-CVIM-amanitin
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| Synonyms |
Cetuximab(LC) G7-CVIM amanitin
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| Organization |
LegoChem Biosciences, Inc.
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| Drug Status |
Investigative
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| Indication |
In total 3 Indication(s)
Breast cancer [ICD11:2C60-2C65]
Investigative
Lung cancer [ICD11:2C25]
Investigative
Skin squamous cell carcinoma [ICD11:2C31]
Investigative
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| Drug-to-Antibody Ratio |
2
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| Antibody Name |
Cetuximab (LC) G7-CVIM
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Antibody Info | ||||
| Antigen Name |
Epidermal growth factor receptor (EGFR)
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Antigen Info | ||||
| Payload Name |
Alpha-amanitin
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Payload Info | ||||
| Therapeutic Target |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
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Target Info | ||||
| Linker Name |
Cetuximab(LC) G7-CVIM-amanitin linker
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| Conjugate Type |
Site-specific conjugation through the CaaX sequence at the C-terminal.
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