Antigen Information

General Information of This Antigen (ID: TAR0MWTFE)
Antigen Name
Nectin-4 (NECTIN4)
Gene Name
NECTIN4
Gene ID
81607
Synonym
Ig superfamily receptor LNIR;Nectin cell adhesion molecule 4;Poliovirus receptor-related protein 4
Sequence
MPLSLGAEMWGPEAWLLLLLLLASFTGRCPAGELETSDVVTVVLGQDAKLPCFYRGDSGE
QVGQVAWARVDAGEGAQELALLHSKYGLHVSPAYEGRVEQPPPPRNPLDGSVLLRNAVQA
DEGEYECRVSTFPAGSFQARLRLRVLVPPLPSLNPGPALEEGQGLTLAASCTAEGSPAPS
VTWDTEVKGTTSSRSFKHSRSAAVTSEFHLVPSRSMNGQPLTCVVSHPGLLQDQRITHIL
HVSFLAEASVRGLEDQNLWHIGREGAMLKCLSEGQPPPSYNWTRLDGPLPSGVRVDGDTL
GFPPLTTEHSGIYVCHVSNEFSSRDSQVTVDVLDPQEDSGKQVDLVSASVVVVGVIAALL
FCLLVVVVVLMSRYHRRKAQQMTQKYEEELTLTRENSIRRLHSHHTDPRSQPEESVGLRA
EGHPDSLKDNSSCSVMSEEPEGRSYSTLTTVREIETQTELLSPGSGRAEEEEDQDEGIKQ
AMNHFVQENGTLRAKPTGNGIYINGRGHLV

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Family
Nectin family
Function
Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells.

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Uniprot Entry
NECT4_HUMAN
HGNC ID
HGNC:19688
KEGG ID
hsa:81607
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
WO2022057651A1 ADC-19 [1]
WO2022057651A1 ADC-19 payload
Undisclosed
WO2022057651A1 ADC-19 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2022057651A1 ADC-20 [1]
WO2022057651A1 ADC-20 payload
Undisclosed
WO2022057651A1 ADC-20 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2022057651A1 ADC-21 [1]
WO2022057651A1 ADC-21 payload
Undisclosed
WO2022057651A1 ADC-21 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
Ab1-MMAE [2]
Monomethyl auristatin E
Microtubule (MT)
NHS-VC-PAB
 ADC Info 
Abl-Linker-DM1 [3]
Mertansine DM1
Microtubule (MT)
Undisclosed
 ADC Info 
Abl-Linker-AF [3]
CL202203715A1 AF
Undisclosed
Undisclosed
 ADC Info 
Abl-Linker-MMAF [3]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
JP2025011033A Ab1 [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20250000991A1 Ab1 ADC [5]
US20250000991A1 Ab1 ADC Payload
Undisclosed
US20250000991A1 Ab1 ADC Linker
 ADC Info 
Ab1-Linker-DM1 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Ab1-Linker-AF [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Ab1-Linker-MMAF [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
JP2025011033A Ab1JP2025011033A A [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2024107014A1 Ab2-Linker-AF 4.46 [3]
CL202203715A1 AF
Undisclosed
Undisclosed
 ADC Info 
JP2025011033A Ab2 [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20250000991A1 Ab2 ADC [5]
undisclosed
Undisclosed
US20250000991A1 Ab1 ADC Linker
 ADC Info 
Ab2-Linker-AF 4.46 [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2024107014A1 Ab3-Linker-MMAF [3]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
JP2025011033A Ab3 [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20250000991A1 Ab3 ADC [5]
undisclosed
Undisclosed
US20250000991A1 Ab1 ADC Linker
 ADC Info 
Ab3-Linker-MMAF [3]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
JP2025011033A Ab4 [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20250000991A1 Ab4 ADC [5]
undisclosed
Undisclosed
US20250000991A1 Ab1 ADC Linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
JP2025011033A Ab5 [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20250000991A1 Ab5 ADC [5]
undisclosed
Undisclosed
US20250000991A1 Ab1 ADC Linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
JP2025011033A Ab6 [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20250000991A1 Ab6 ADC [5]
undisclosed
Undisclosed
US20250000991A1 Ab1 ADC Linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
JP2025011033A Ab7 [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20250000991A1 Ab7 ADC [5]
undisclosed
Undisclosed
US20250000991A1 Ab1 ADC Linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
JP2025011033A Ab8 [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US20250000991A1 Ab8 ADC [5]
undisclosed
Undisclosed
US20250000991A1 Ab1 ADC Linker
 ADC Info 
Anti-Nectin-4 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
SBE303
TOP1 inhibitor
DNA topoisomerase 1 (TOP1)
Self-immolative OHPAS linker
 ADC Info 
Notiretatug rezetecan
SHR9265
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
SKB410
TOP1 inhibitor
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
SYS6002
Monomethyl auristatin E
Microtubule (MT)
NH2-PEG3-Val-Cit-PABC
 ADC Info 
SBT6290
TLR8 agonist
Toll-like receptor 8 (TLR8)
Undisclosed
 ADC Info 
BAT8007
Exatecan
DNA topoisomerase 1 (TOP1)
A cleavable but systemically stable linker
 ADC Info 
ADRX-0706
AP052
Microtubule (MT)
Adcentrx' proprietary linker
 ADC Info 
IPH45
Exatecan
DNA topoisomerase 1 (TOP1)
A cleavable hydrophilic linker
 ADC Info 
LY4101174
Exatecan
DNA topoisomerase 1 (TOP1)
maleimide-β-glucuronide poly-sarcosine linker
 ADC Info 
Anti-Nectin-4 IgG1 Fc-silent mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
LY4052031
LSN3889710
DNA topoisomerase 1 (TOP1)
A cleavable peptide linker
 ADC Info 
Anti-NECTIN4 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ADC2204 [6]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CN117159739A ADC7 [7]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
Bulumtatug
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Bulumtatug fuvedotin
Monomethyl auristatin E
Microtubule (MT)
IDM-Val-Cit-PBCA
 ADC Info 
Enfortumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Enfortumab vedotin [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Araris ADC [9]
Monomethyl auristatin E
Microtubule (MT)
Cathepsin B cleavable linker
 ADC Info 
WO2022057651A1 ADC-22 [1]
WO2022057651A1 ADC-22 payload
Undisclosed
WO2022057651A1 ADC-22 linker
 ADC Info 
Enfortumab-MMAE [10]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
huNb26/Nb26-Nbh
 Antibody Info 
ADC Name Payload Target Linker ADC Info
huNb26/Nb26-Nbh-MMAE [11]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
SWY2001-Ab1-LND1002 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
MW282 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Nectin-4-MMAE [13]
Monomethyl auristatin E
Microtubule (MT)
IDconnect linker
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
A-410 [14]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JS114 [15]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
HLX-44 [16]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
NTX-1105 [17]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Nectin-4 ADC (Jiangsu Hengrui) [18]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ETX-22 [19]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
N41mab-Val-Cit-MMAE [20]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
BA-3361 [21]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
SM001 [22]
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
GLR1059 [23]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
anti-nectin-4 ADC [24]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
WO2024043319A1 83 [25]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CN118001423A ADC1 [26]
CN118001423A+ADC1+payload
Undisclosed
CN118001423A+ADC1+Linker
 ADC Info 
CN118001423A ADC2 [26]
CN118001423A+ADC2+payload
Undisclosed
CN118001423A+ADC1+Linker
 ADC Info 
CN118001423A ADC3 [26]
CN118001423A+ADC3+payload
Undisclosed
CN118001423A+ADC3+Linker
 ADC Info 
CN118001423A ADC4 [26]
CN118001423A+ADC4+payload
Undisclosed
CN118001423A+ADC3+Linker
 ADC Info 
CN118001423A ADC5 [26]
CN118001423A+ADC5+payload
Undisclosed
CN118001423A+ADC5+Linker
 ADC Info 
References
Ref 1 Anti-nectin-4 antibody, conjugate including same, and application thereof; 2022-03-24.
Ref 2 Discovery of a novel highly specific, fully human PSCA antibody and its application as an antibody-drug conjugate in prostate cancer
Ref 3 Anti-basal cell adhesion molecule antibody-drug conjugate
Ref 4 Nectin-4 antibodies and antibody-drug conjugates
Ref 5 Nectin-4 antibodies and antibody-drug conjugates
Ref 6 Introduction to basic information on ADC drug ADC2204
Ref 7 Antibody-drug conjugates, their preparation methods and applications
Ref 8 FDA Approval Summary: Enfortumab Vedotin for Locally Advanced or Metastatic Urothelial Carcinoma
Ref 9 Novel peptide linker-based nectin-4 targeting ADC shows improved tolerability with long-lasting anti-tumor efficacy at low doses. Cancer Res (2023) 83 (8_Supplement): LB221.
Ref 10 NECTIN4-targeted antibody-drug conjugate is a potential therapeutic option for extramammary Paget disease
Ref 11 A humanized trivalent Nectin-4-targeting nanobody drug conjugate displays potent antitumor activity in gastric cancer
Ref 12 Pharmaceutical compositions of recombinant humanized anti-Nectin-4 monoclonal antibody-MMAE conjugates
Ref 13 A novel and promising therapeutic approach for treating pancreatic cancer: Nectin-4-targeted antibody-drug conjugates alone or combined with autophagy inhibitors
Ref 14 Introduction to basic information on ADC drug A-410.
Ref 15 Junshi Biosciences biopharmaceutical company product pipeline
Ref 16 Introduction to basic information on ADC drug HLX-44.
Ref 17 Nectin therapeutics biotechnology company product pipeline
Ref 18 Introduction to basic information on Nectin-4 ADC (Jiangsu Hengrui).
Ref 19 Emergence therapeutics product pipeline
Ref 20 Nectin-4: a new prognostic biomarker for efficient therapeutic targeting of primary and metastatic triple-negative breast cancer. Ann Oncol. 2017 Apr 1;28(4):769-776. doi: 10.1093/annonc/mdw678.
Ref 21 NextGen conditionally active biologic (CAB) anti-Nectin-4-ADC with improved stability and safety. Cancer Res (2023) 83 (7_Supplement): 1541.
Ref 22 Development of an ELISA with acidification treatment for an antibody conjugate incorporating Exatecans
Ref 23 GLR1059, next-generation nectin-4-targeted ADC with a novel mechanism-of-action payload, demonstrated significantly potent anti-tumor efficacy and reduced toxicity in preclinical evaluation
Ref 24 Combination therapy with TB511 and anti-nectin-4 antibody drug conjugate in a human pancreatic cancer mouse model
Ref 25 Antibody-drug complexes
Ref 26 Hydrophilic anti-Nectin-4 antibody-drug conjugates and their preparation methods and uses