Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0AKIIU
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|---|---|---|---|---|---|---|
| ADC Name |
SM001
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| Synonyms |
SM001
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| Organization |
Nanjing University of Chinese Medicine.; Chinese Academy of Sciences.
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| Drug Status |
Investigative
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| Antibody Name |
undisclosed
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| Antigen Name |
Nectin-4 (NECTIN4)
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Antigen Info | ||||
| Payload Name |
Exatecan
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Payload Info | ||||
| Therapeutic Target |
DNA topoisomerase 1 (TOP1)
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Target Info | ||||
| Linker Name |
Undisclosed
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| Conjugate Type |
Re-bridge disulfide via bis (vinylsulfonyl)piperazines (BVP).
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General Information of The ADMET Data Related to This ADC(2027 Update)
Absorption
| Standard Type | Value | Units | Description | Reference |
|---|---|---|---|---|
| Time to Maximum Concentration (Tmax) | 0.542±0.502 | h |
PK parameters in cynomolgus monkeys after a single intravenous infusion of SM001 (10 mg/kg).
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[1] |
| Maximum Observed Concentration (Cmax) | 247±31.5 | ug/mL |
PK parameters in cynomolgus monkeys after a single intravenous infusion of SM001 (10 mg/kg).
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[1] |
| Area Under the Concentration-Time Curve (AUC) | 25500±3580 | h*ug/mL |
PK parameters in cynomolgus monkeys after a single intravenous infusion of SM001 (10 mg/kg), AUC0-t.
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[1] |
Distribution
| Standard Type | Value | Units | Description | Reference |
|---|---|---|---|---|
| Area Under the Concentration-Time Curve (AUC) | 25500±3580 | h*ug/mL |
PK parameters in cynomolgus monkeys after a single intravenous infusion of SM001 (10 mg/kg), AUC0-t.
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[1] |
| Volume of Distribution (Vd) | 50±7.77 | mL/kg |
PK parameters in cynomolgus monkeys after a single intravenous infusion of SM001 (10 mg/kg).
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[1] |
Metabolism
| Standard Type | Value | Units | Description | Reference |
|---|---|---|---|---|
| Area Under the Concentration-Time Curve (AUC) | 25500±3580 | h*ug/mL |
PK parameters in cynomolgus monkeys after a single intravenous infusion of SM001 (10 mg/kg), AUC0-t.
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[1] |
Excretion
| Standard Type | Value | Units | Description | Reference |
|---|---|---|---|---|
| Area Under the Concentration-Time Curve (AUC) | 25500±3580 | h*ug/mL |
PK parameters in cynomolgus monkeys after a single intravenous infusion of SM001 (10 mg/kg), AUC0-t.
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[1] |
| Elimination Half-Life (t1/2) | 87.6±9 | h |
PK parameters in cynomolgus monkeys after a single intravenous infusion of SM001 (10 mg/kg).
|
[1] |
| Clearance (CL) | 0.397±0.0596 | mL/h/kg |
PK parameters in cynomolgus monkeys after a single intravenous infusion of SM001 (10 mg/kg).
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[1] |
References