Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)

ADC ID	DRG0ERFMZ
ADC Name	CN118001423A ADC2
Synonyms	ADC2 Click to Show/Hide
Organization	HANGZHOU ADCORIS BIOPHARMA CO LTD
Drug Status	Investigative
Drug-to-Antibody Ratio	8
Structure
	3D MOL	2D MOL
Antibody Name	undisclosed
Antigen Name	Nectin-4 (NECTIN4)		Antigen Info
Payload Name	CN118001423A+ADC2+payload		Payload Info
Linker Name	CN118001423A+ADC1+Linker		Linker Info
Conjugate Type	DBCO-Azide Click Chemistry Conjugation

General Information of The Activity Data Related to This ADC

Revealed Based on the Cell Line Data

Click To Hide/Show 5 Activity Data Related to This Level

Standard Type	Value	Units	Cell Line	Disease Model
Half Maximal inhibitory Concentration (lC50)	< 50	nM	CVCL_0419	Breast adenocarcinoma
Half Maximal inhibitory Concentration (lC50)	≈ 50≈200	nM	CVCL_1728	Mouse melanoma
Half Maximal inhibitory Concentration (lC50)	≈ 50≈200	nM	CVCL_0031	Invasive breast carcinoma
Half Maximal inhibitory Concentration (lC50)	< 50	nM	CVCL_0395	Prostate carcinoma
Half Maximal inhibitory Concentration (lC50)	< 50	nM	CVCL_0186	Pancreatic ductal adenocarcinoma

Full List of Activity Data of This Antibody-drug Conjugate

Revealed Based on the Cell Line Data

Click To Hide/Show 5 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal inhibitory Concentration (lC50)	< 50 nM	High NECTIN4 expression (NECTIN4 +++)
Method Description	A Cell line test on MDA-MB-468
In Vitro Model	Breast adenocarcinoma	MDA-MB-468 cells		CVCL_0419
Experiment 2 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal inhibitory Concentration (lC50)	≈ 50≈200 nM	High NECTIN4 expression (NECTIN4 +++)
Method Description	A Cell line test on SW-780
In Vitro Model	Mouse melanoma	SW-780 cells		CVCL_1728
Experiment 3 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal inhibitory Concentration (lC50)	≈ 50≈200 nM	High NECTIN4 expression (NECTIN4 +++)
Method Description	A Cell line test on MCF-7
In Vitro Model	Invasive breast carcinoma	MCF-7 cells		CVCL_0031
Experiment 4 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal inhibitory Concentration (lC50)	< 50 nM	High NECTIN4 expression (NECTIN4 +++)
Method Description	A Cell line test on LNCAP
In Vitro Model	Prostate carcinoma	LNCaP cells		CVCL_0395
Experiment 5 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Half Maximal inhibitory Concentration (lC50)	< 50 nM	High NECTIN4 expression (NECTIN4 +++)
Method Description	A Cell line test on BxPC-3
In Vitro Model	Pancreatic ductal adenocarcinoma	BxPC-3 cells		CVCL_0186

References

Ref 1	Hydrophilic anti-Nectin-4 antibody-drug conjugates and their preparation methods and uses