Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0TPXXD
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| ADC Name |
CN118001423A ADC4
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| Synonyms |
ADC4
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| Organization |
HANGZHOU ADCORIS BIOPHARMA CO LTD
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| Drug Status |
Investigative
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| Drug-to-Antibody Ratio |
8
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| Structure |
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| Antibody Name |
undisclosed
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| Antigen Name |
Nectin-4 (NECTIN4)
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Antigen Info | ||||
| Payload Name |
CN118001423A+ADC4+payload
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Payload Info | ||||
| Linker Name |
CN118001423A+ADC3+Linker
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Linker Info | ||||
| Conjugate Type |
DBCO-Azide Click Chemistry Conjugation
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General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on MDA-MB-468
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| In Vitro Model | Breast adenocarcinoma | MDA-MB-468 cells | CVCL_0419 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on SW-780
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| In Vitro Model | Mouse melanoma | SW-780 cells | CVCL_1728 | ||
| Experiment 3 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | ≈ 50≈200 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on LNCAP
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| In Vitro Model | Prostate carcinoma | LNCaP cells | CVCL_0395 | ||
| Experiment 4 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | < 50 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on BxPC-3
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| In Vitro Model | Pancreatic ductal adenocarcinoma | BxPC-3 cells | CVCL_0186 | ||
| Experiment 5 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal inhibitory Concentration (lC50) | ≈ 200≈1000 nM | High NECTIN4 expression (NECTIN4 +++) | ||
| Method Description |
A Cell line test on MCF-7
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| In Vitro Model | Invasive breast carcinoma | MCF-7 cells | CVCL_0031 | ||
References