Antigen Information

General Information of This Antigen
Antigen ID
TAR0OVWVF
Antigen Name
Myeloid cell surface antigen CD33 (CD33)
Gene Name
CD33
Gene ID
945
Synonym
SIGLEC3; Sialic acid-binding Ig-like lectin 3;gp67;CD_antigen=CD33
Sequence
MPLLLLLPLLWAGALAMDPNFWLQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSPVHGYW
FREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDNGSYFFRM
ERGSTKYSYKSPQLSVHVTDLTHRPKILIPGTLEPGHSKNLTCSVSWACEQGTPPIFSWL
SAAPTSLGPRTTHSSVLIITPRPQDHGTNLTCQVKFAGAGVTTERTIQLNVTYVPQNPTT
GIFPGDGSGKQETRAGVVHGAIGGAGVTALLALCLCLIFFIVKTHRRKAARTAVGRNDTH
PTTGSASPKHQKKSKLHGPTETSSCSGAAPTVEMDEELHYASLNFHGMNPSKDTSTEYSE
VRTQ

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Family
Immunoglobulin family
Function
Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP- 2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K.

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Uniprot Entry
CD33_HUMAN
HGNC ID
HGNC:1659
KEGG ID
hsa:945
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
018 (CD33)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2024222841A1 ADC55
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
 [1]
019 (CD33)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2024222841A1 ADC56
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
 [1]
 ADC Info 
WO2024222841A1 ADC65
B63
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Ala-PABC
 [1]
020 (CD33)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2024222841A1 ADC57
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
 [1]
021 (CD33)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2024222841A1 ADC58
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
 [1]
022 (CD33)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2024222841A1 ADC59
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
 [1]
 ADC Info 
WO2024222841A1 ADC66
B63
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Ala-PABC
 [1]
15G15.3 LC K149C
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN106714844B ADC-110
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
 [2]
 ADC Info 
CN106714844B ADC-115
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
CN106714844B-ADC-115-linker
 [2]
 ADC Info 
CN106714844B ADC-139
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Ethylmaleimide linker
 [2]
A recombinant anti-CD33 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
DXC007
Tub255
Microtubule (MT)
Undisclosed
Anti-CD3 single-chain Fv
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
DT390 anti-CD3sFv immunotoxin
DT390
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 [3]
Anti-CD33
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
US12186310B2-34
Undisclosed
Undisclosed
Undisclosed
 [4]
 ADC Info 
US12186310B2-48
Undisclosed
Undisclosed
Undisclosed
 [4]
Anti-CD33 (US12186310B2)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
US12186310B2-8
Undisclosed
Undisclosed
Undisclosed
 [4]
 ADC Info 
US12186310B2-9
Undisclosed
Undisclosed
Undisclosed
 [4]
Anti-CD33 AB1
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-CD33 AB1 Compound (Ia)
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Ia) linker
 [5]
 ADC Info 
Anti-CD33 AB1 Compound (Ib)
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Ib) linker
 [5]
 ADC Info 
Anti-CD33 AB1 Compound (Ic)
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Ic) linker
 [5]
 ADC Info 
Anti-CD33 AB1 Compound (Id)
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Id) linker
 [5]
 ADC Info 
Anti-CD33 AB1 Compound (Ie)
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Ie) linker
 [5]
 ADC Info 
Anti-CD33 AB1 Compound (If)
NeoDegrader P6
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (If) linker
 [5]
 ADC Info 
Anti-CD33 AB1 Compound (Ig)
NeoDegrader P2
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Ig) linker
 [5]
 ADC Info 
Anti-CD33 AB1 Compound (Ih)
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Ih) linker
 [5]
 ADC Info 
Anti-CD33 AB1 Compound (Ii)
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Ii) linker
 [5]
 ADC Info 
Anti-CD33 AB1 Compound (Ij)
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Ij) linker
 [5]
 ADC Info 
Anti-CD33 AB1 Compound (Ik)
NeoDegrader P14
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Ik) linker
 [5]
 ADC Info 
Anti-CD33 AB1 Compound (Il)
NeoDegrader P14
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Il) linker
 [5]
 ADC Info 
Anti-CD33 AB1 Compound (Im)
NeoDegrader P14
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Im) linker
 [5]
Anti-CD33 Anti-ody 11A1
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CD33-CPI dimer ADC
Bicyclopentyl-seco-CBI-dimer
Human Deoxyribonucleic acid (hDNA)
AcLys-Val-Cit-PABC-DMAE
 [6]
Anti-CD33 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ABBV-787
BET degrader
Bromodomain and extra-terminal (BET)
A cleavable linker
 [7]
Anti-CD33 mAb 15G15.33
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CD33 PNU ADC2-2
CD33 PNU ADC2-2 payload
Undisclosed
CD33 PNU ADC2-2 linker
 [8]
 ADC Info 
CD33 PNU ADC3-2
CD33 PNU ADC3-2 payload
Undisclosed
CD33 PNU ADC3-2 linker
 [8]
 ADC Info 
CD33 PNU ADC4-2
CD33 PNU ADC4-2 payload
Undisclosed
CD33 PNU ADC4-2 linker
 [8]
 ADC Info 
CD33-PNU-LD1
CD33-PNU-LD1 payload
Undisclosed
CD33-PNU-LD1 linker
 [8]
 ADC Info 
CD33-PNU-LD5
CD33-PNU-LD5 payload
Undisclosed
CD33-PNU-LD5 linker
 [8]
 ADC Info 
CD33-PNU-LD6
CD33-PNU-LD6 payload
Undisclosed
CD33-PNU-LD6 linker
 [8]
 ADC Info 
CD33-PNU-LD7
CD33-PNU-LD7 payload
Undisclosed
CD33-PNU-LD7 linker
 [8]
Anti-CD33 mAb humanized 2H12
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
h2H12-Compound 1
h2H12-compound 1 payload
Undisclosed
h2H12-compound 1 linker
 [9]
 ADC Info 
h2H12-Compound 2
h2H12-compound 2 payload
Undisclosed
h2H12-compound 2 linker
 [9]
 ADC Info 
h2H12-Compound 3
h2H12-compound 3 payload
Undisclosed
h2H12-compound 3 linker
 [9]
Anti-CD33 mAb murine 2H12
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
m2H12-Compound 1
m2H12-compound 1 payload
Undisclosed
m2H12-compound 1 linker
 [9]
 ADC Info 
m2H12-Compound 2
m2H12-compound 2 payload
Undisclosed
m2H12-compound 2 linker
 [9]
 ADC Info 
m2H12-Compound 3
m2H12-compound 3 payload
Undisclosed
m2H12-compound 3 linker
 [9]
anti-CD33-11A1-v1417- (K290C)- (K334C) and CD33-11A1-v1417- (K334C)- (K392C) mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
H- (A114C)-#6
Undisclosed
Undisclosed
Undisclosed
 [10]
 ADC Info 
H- (A114C)-#7
Undisclosed
Undisclosed
Undisclosed
 [10]
 ADC Info 
H- (A114C)-#10
Undisclosed
Undisclosed
Undisclosed
 [10]
 ADC Info 
H- (A114C)-#11
Undisclosed
Undisclosed
Undisclosed
 [10]
 ADC Info 
H- (A114C)-#14
Undisclosed
Undisclosed
Undisclosed
 [10]
 ADC Info 
H- (A114C)-#19
H- (A114C)-#19 Payload
Undisclosed
H- (A114C)-#19 Linker
 [10]
 ADC Info 
H- (A114C)-#26
H- (A114C)-#19 Payload
Undisclosed
H- (A114C)-#26 Linker
 [10]
 ADC Info 
H- (kK183C)-#26
H- (A114C)-#19 Payload
Undisclosed
H- (A114C)-#26 Linker
 [10]
 ADC Info 
H- (E380C)-#26
H- (A114C)-#19 Payload
Undisclosed
H- (A114C)-#26 Linker
 [10]
 ADC Info 
H- (A114C)-#30
H- (A114C)-#30 Payload
Undisclosed
H- (A114C)-#30 Linker
 [10]
 ADC Info 
H- (E380C)-#30
H- (A114C)-#30 Payload
Undisclosed
H- (A114C)-#30 Linker
 [10]
 ADC Info 
H- (A114C)-#35
H- (A114C)-#19 Payload
Undisclosed
H- (A114C)-#35 Linker
 [10]
 ADC Info 
CD33-11A1-v1417 (K290C)- (K334C)-#39
CD33-11A1-v1417 (C)-#39 Payload
Undisclosed
CD33-11A1-v1417 (C)-#39 Linker
 [10]
 ADC Info 
CD33-11A1-v1417 (K334C)- (K392C)-#39
CD33-11A1-v1417 (C)-#39 Payload
Undisclosed
CD33-11A1-v1417 (C)-#39 Linker
 [10]
 ADC Info 
H- (A114C)-#43
H- (A114C)-#30 Payload
Undisclosed
H- (A114C)-#43 Linker
 [10]
 ADC Info 
H- (A114C)-#46
H- (A114C)-#30 Payload
Undisclosed
H- (A114C)-#43 Linker
 [10]
 ADC Info 
H- (A114C)-#52
H- (A114C)-#30 Payload
Undisclosed
H- (A114C)-#43 Linker
 [10]
 ADC Info 
H- (A114C)-#58
H- (A114C)-#30 Payload
Undisclosed
H- (A114C)-#43 Linker
 [10]
 ADC Info 
H- (A114C)-#66
H- (A114C)-#30 Payload
Undisclosed
H- (A114C)-#66 Linker
 [10]
Anti-CD33AB
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-CD33AB-Compound (Ia)
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33AB-Compound (Ia) linker
 [11]
 ADC Info 
Anti-CD33AB-Compound (Ib)
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33AB-Compound (Ib) linker
 [11]
 ADC Info 
Anti-CD33AB-Compound (Ic)
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33AB-Compound (Ic) linker
 [11]
 ADC Info 
Anti-CD33AB-Compound (Ie)
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33AB-Compound (Ie) linker
 [11]
 ADC Info 
Anti-CD33AB-Compound (Ih)
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33AB-Compound (Ih) linker
 [11]
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP1
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP5
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP6
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417-kN92S-H16-D55A- K222R-hGl-LP7
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP8
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP9
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP11
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP12
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP13
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP18
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP19
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417 kN92S-H16-D55A- K222R-hGl- (Q)_AcLysValCitPABC _LP21
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417 kN92S-H16-D55A- K222R-hGl- (Q)_AcLysValCitPABC_LP25
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417 kN92S-H16-D55A- K222R-hGl (Q)_AcLysValCitPABC _LP26
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417 kN92S-H16-D55A- K222R-hGl- (Q)_AcLysValCitPABC _LP27
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417 kN92S-H16-D55A- K222R-hGl- (Q)_AcLysValCitPABC _LP28
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417 kN92S-H16-D55A- K222R-hGl- (Q)_AcLysValCitPABC _LP29
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417 kN92S-H16-D55A- K222R-hGl- (Q)_AcLysValCitPABC _LP33
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417 kN92S-H16-D55A- K222R-hGl- (Q)_AcLysValCitPABC _LP34
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417 kN92S-H16-D55A- K222R-hGl- (Q)_AcLysValCitPABC _LP35
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417 kN92S-H16-D55A- K222R-hGl- (Q)_AcLysValCitPABC _LP36
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP39
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP40
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP41
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP42
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP43
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP44
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP45
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP46
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP47
Undisclosed
Undisclosed
Undisclosed
 [12]
CD33-11A1-v1417-H7C-hGl
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CD33-11A1-v1417- H7C-hGl-LP19
Undisclosed
Undisclosed
Undisclosed
 [12]
CD33-11A1-v1417-hG1- (C)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
US11365263B2 ADC#4
US11365263B2 ADC#6 payload
Undisclosed
US11365263B2 ADC#6 linker
 [13]
CD33-11A1-v1417-K334C-hG1- (C334)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
US11365263B2 ADC#6
US11365263B2 ADC#6 payload
Undisclosed
US11365263B2 ADC#6 linker
 [13]
CD33-11A1-v1417-K334C-K392C-hG1- (C334 + C392)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
US11365263B2 ADC#5
US11365263B2 ADC#6 payload
Undisclosed
US11365263B2 ADC#6 linker
 [13]
CD33-11A1-v1417-kK183C-hGl
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CD33-11A1-v1417- kK183C-hGl-LP2
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- kK183C-hGl-LP48
Undisclosed
Undisclosed
Undisclosed
 [12]
CD33-11A1-v1417-LCQ05-H16-K222R-hG1
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CD33-11A1-v1417- LCQ05-H16-K222R- hG1-LP1
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- LCQO5-H16-K222R- hGl-LP13
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- LCQO5-H16-K222R- hGl-LP14
Undisclosed
Undisclosed
Undisclosed
 [12]
 ADC Info 
CD33-11A1-v1417- LCQ05-H16-K222R- hGl-LP19
Undisclosed
Undisclosed
Undisclosed
 [12]
CD33-A Anti-ody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CD33-A Antibody-Compound (X)
CD33-A Antibody-Compound (X) payload
Undisclosed
CD33-A Antibody-Compound (X) linker
 [14]
 ADC Info 
CD33-A Antibody-Compound (XI)
CD33-A Antibody-Compound (XI) payload
Undisclosed
CD33-A Antibody-Compound (XI) linker
 [14]
 ADC Info 
CD33-A Antibody-Compound (XIV)
CD33-A Antibody-Compound (XIV) payload
Undisclosed
CD33-A Antibody-Compound (XIV) linker
 [14]
 ADC Info 
CD33-A Antibody-Compound (XVIII)
CD33-A Antibody-Compound (XVIII) payload
Undisclosed
CD33-A Antibody-Compound (XVIII) linker
 [14]
 ADC Info 
CD33-A Antibody-Compound (Ie)
CD33-A Antibody-Compound (Ie) payload
Undisclosed
CD33-A Antibody-Compound (Ie) linker
 [14]
 ADC Info 
CD33-A Antibody-Compound (XIX)
CD33-A Antibody-Compound (XIX) payload
Undisclosed
CD33-A Antibody-Compound (XIX) linker
 [14]
 ADC Info 
CD33-A Antibody-Compound (Ii)
CD33-A Antibody-Compound (Ii) payload
Undisclosed
CD33-A Antibody-Compound (Ii) linker
 [14]
 ADC Info 
CD33-A Antibody-Compound (XLI)
CD33-A Antibody-Compound (XLI) payload
Undisclosed
CD33-A Antibody-Compound (XLI) linker
 [14]
 ADC Info 
CD33-A Antibody-Compound (XVI)
CD33-A Antibody-Compound (XIX) payload
Undisclosed
CD33-A Antibody-Compound (XIX) linker
 [14]
 ADC Info 
CD33-A Antibody-Compound (XL)
CD33-A Antibody-Compound (XL) payload
Undisclosed
CD33-A Antibody-Compound (XL) linker
 [14]
 ADC Info 
CD33-A Antibody-Compound (XLIII)
CD33-A Antibody-Compound (XLIII) payload
Undisclosed
CD33-A Antibody-Compound (XLIII) linker
 [14]
 ADC Info 
CD33-A Antibody-Compound (XLII)
CD33-A Antibody-Compound (XLII) payload
Undisclosed
CD33-A Antibody-Compound (XLII) linker
 [14]
 ADC Info 
CD33-A Antibody-Compound (XV)
CD33-A Antibody-Compound (XV) payload
Undisclosed
CD33-A Antibody-Compound (XV) linker
 [14]
CD33-B Anti-ody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CD33-B Antibody-Compound (X)
CD33-B Antibody-Compound (X) payload
Undisclosed
CD33-B Antibody-Compound (X) linker
 [14]
 ADC Info 
CD33-B Antibody-Compound (XI)
CD33-B Antibody-Compound (XI) payload
Undisclosed
CD33-B Antibody-Compound (XI) linker
 [14]
 ADC Info 
CD33-B Antibody-Compound (XIV)
CD33-B Antibody-Compound (XIV) payload
Undisclosed
CD33-B Antibody-Compound (XIV) linker
 [14]
 ADC Info 
CD33-B Antibody-Compound (XVIII)
CD33-B Antibody-Compound (XVIII) payload
Undisclosed
CD33-B Antibody-Compound (XVIII) linker
 [14]
 ADC Info 
CD33-B Antibody-Compound (Ie)
CD33-B Antibody-Compound (Ie) payload
Undisclosed
CD33-B Antibody-Compound (Ie) linker
 [14]
 ADC Info 
CD33-B Antibody-Compound (XIX)
CD33-B Antibody-Compound (XIX) payload
Undisclosed
CD33-B Antibody-Compound (XIX) linker
 [14]
 ADC Info 
CD33-B Antibody-Compound (Ii)
CD33-B Antibody-Compound (Ii) payload
Undisclosed
CD33-B Antibody-Compound (Ii) linker
 [14]
 ADC Info 
CD33-B Antibody-Compound (XLI)
CD33-B Antibody-Compound (XLI) payload
Undisclosed
CD33-B Antibody-Compound (XLI) linker
 [14]
 ADC Info 
CD33-B Antibody-Compound (XVI)
CD33-B Antibody-Compound (XIX) payload
Undisclosed
CD33-B Antibody-Compound (XIX) linker
 [14]
 ADC Info 
CD33-B Antibody-Compound (XL)
CD33-B Antibody-Compound (XL) payload
Undisclosed
CD33-B Antibody-Compound (XL) linker
 [14]
 ADC Info 
CD33-B Antibody-Compound (XLIII)
CD33-B Antibody-Compound (XLIII) payload
Undisclosed
CD33-B Antibody-Compound (XLIII) linker
 [14]
 ADC Info 
CD33-B Antibody-Compound (XLII)
CD33-B Antibody-Compound (XLII) payload
Undisclosed
CD33-B Antibody-Compound (XLII) linker
 [14]
 ADC Info 
CD33-B Antibody-Compound (XV)
CD33-B Antibody-Compound (XV) payload
Undisclosed
CD33-B Antibody-Compound (XV) linker
 [14]
CD33-C Anti-ody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CD33-C Antibody-Compound (X)
CD33-C Antibody-Compound (X) payload
Undisclosed
CD33-C Antibody-Compound (X) linker
 [14]
 ADC Info 
CD33-C Antibody-Compound (XI)
CD33-C Antibody-Compound (XI) payload
Undisclosed
CD33-C Antibody-Compound (XI) linker
 [14]
 ADC Info 
CD33-C Antibody-Compound (XIV)
CD33-C Antibody-Compound (XIV) payload
Undisclosed
CD33-C Antibody-Compound (XIV) linker
 [14]
 ADC Info 
CD33-C Antibody-Compound (XVIII)
CD33-C Antibody-Compound (XVIII) payload
Undisclosed
CD33-C Antibody-Compound (XVIII) linker
 [14]
 ADC Info 
CD33-C Antibody-Compound (Ie)
CD33-C Antibody-Compound (Ie) payload
Undisclosed
CD33-C Antibody-Compound (Ie) linker
 [14]
 ADC Info 
CD33-C Antibody-Compound (XIX)
CD33-C Antibody-Compound (XIX) payload
Undisclosed
CD33-C Antibody-Compound (XIX) linker
 [14]
 ADC Info 
CD33-C Antibody-Compound (Ii)
CD33-C Antibody-Compound (Ii) payload
Undisclosed
CD33-C Antibody-Compound (Ii) linker
 [14]
 ADC Info 
CD33-C Antibody-Compound (XLI)
CD33-C Antibody-Compound (XLI) payload
Undisclosed
CD33-C Antibody-Compound (XLI) linker
 [14]
 ADC Info 
CD33-C Antibody-Compound (XVI)
CD33-C Antibody-Compound (XIX) payload
Undisclosed
CD33-C Antibody-Compound (XIX) linker
 [14]
 ADC Info 
CD33-C Antibody-Compound (XL)
CD33-C Antibody-Compound (XL) payload
Undisclosed
CD33-C Antibody-Compound (XL) linker
 [14]
 ADC Info 
CD33-C Antibody-Compound (XLIII)
CD33-C Antibody-Compound (XLIII) payload
Undisclosed
CD33-C Antibody-Compound (XLIII) linker
 [14]
 ADC Info 
CD33-C Antibody-Compound (XLII)
CD33-C Antibody-Compound (XLII) payload
Undisclosed
CD33-C Antibody-Compound (XLII) linker
 [14]
 ADC Info 
CD33-C Antibody-Compound (XV)
CD33-C Antibody-Compound (XV) payload
Undisclosed
CD33-C Antibody-Compound (XV) linker
 [14]
CD33-D Anti-ody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CD33-D Antibody-Compound (X)
CD33-D Antibody-Compound (X) payload
Undisclosed
CD33-D Antibody-Compound (X) linker
 [14]
 ADC Info 
CD33-D Antibody-Compound (XI)
CD33-D Antibody-Compound (XI) payload
Undisclosed
CD33-D Antibody-Compound (XI) linker
 [14]
 ADC Info 
CD33-D Antibody-Compound (XIV)
CD33-D Antibody-Compound (XIV) payload
Undisclosed
CD33-D Antibody-Compound (XIV) linker
 [14]
 ADC Info 
CD33-D Antibody-Compound (XVIII)
CD33-D Antibody-Compound (XVIII) payload
Undisclosed
CD33-D Antibody-Compound (XVIII) linker
 [14]
 ADC Info 
CD33-D Antibody-Compound (Ie)
CD33-D Antibody-Compound (Ie) payload
Undisclosed
CD33-D Antibody-Compound (Ie) linker
 [14]
 ADC Info 
CD33-D Antibody-Compound (XIX)
CD33-D Antibody-Compound (XIX) payload
Undisclosed
CD33-D Antibody-Compound (XIX) linker
 [14]
 ADC Info 
CD33-D Antibody-Compound (Ii)
CD33-D Antibody-Compound (Ii) payload
Undisclosed
CD33-D Antibody-Compound (Ii) linker
 [14]
 ADC Info 
CD33-D Antibody-Compound (XLI)
CD33-D Antibody-Compound (XLI) payload
Undisclosed
CD33-D Antibody-Compound (XLI) linker
 [14]
 ADC Info 
CD33-D Antibody-Compound (XVI)
CD33-D Antibody-Compound (XIX) payload
Undisclosed
CD33-D Antibody-Compound (XIX) linker
 [14]
 ADC Info 
CD33-D Antibody-Compound (XL)
CD33-D Antibody-Compound (XL) payload
Undisclosed
CD33-D Antibody-Compound (XL) linker
 [14]
 ADC Info 
CD33-D Antibody-Compound (XLIII)
CD33-D Antibody-Compound (XLIII) payload
Undisclosed
CD33-D Antibody-Compound (XLIII) linker
 [14]
 ADC Info 
CD33-D Antibody-Compound (XLII)
CD33-D Antibody-Compound (XLII) payload
Undisclosed
CD33-D Antibody-Compound (XLII) linker
 [14]
 ADC Info 
CD33-D Antibody-Compound (XV)
CD33-D Antibody-Compound (XV) payload
Undisclosed
CD33-D Antibody-Compound (XV) linker
 [14]
CN105828840B_ADC-125 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN105828840B ADC-125
CN105828840B_ADC-125 payload
Undisclosed
CN105828840B_ADC-125 linker
 [15]
CN105828840B_ADC-127 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN105828840B ADC-127
CN105828840B_ADC-127 payload
Undisclosed
CN105828840B_ADC-127 linker
 [15]
CN105828840B_ADC-129 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN105828840B ADC-129
CN105828840B_ADC-129 payload
Undisclosed
CN105828840B_ADC-129 linker
 [15]
CN105828840B_ADC-131 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN105828840B ADC-131
CN105828840B_ADC-131 payload
Undisclosed
CN105828840B_ADC-131 linker
 [15]
CN105828840B_ADC-133 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN105828840B ADC-133
CN105828840B_ADC-133 payload
Undisclosed
CN105828840B_ADC-133 linker
 [15]
CN105828840B_ADC-137 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN105828840B ADC-137
CN105828840B_ADC-137 payload
Undisclosed
CN105828840B_ADC-137 linker
 [15]
CN105828840B_ADC-138 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN105828840B ADC-138
CN105828840B_ADC-138 payload
Undisclosed
CN105828840B_ADC-138 linker
 [15]
CN105828840B_ADC-139 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN105828840B ADC-139
CN105828840B_ADC-139 payload
Undisclosed
CN105828840B_ADC-139 linker
 [15]
Gemtuzumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Gemtuzumab ozogamicin
N-acetyl-gamma-calicheamicin
Human deoxyribonucleic acid (hDNA)
AcButDMH
 [16]
 ADC Info 
BL-M11D1
Ed-04
DNA topoisomerase 1 (TOP1)
Gly-Mal-Gly-Gly-Phe-Gly
 ADC Info 
Gemtuzumab-Compound (Ie)
NeoDegrader P1
Protein cereblon (CRBN)
Gemtuzumab-Compound (Ie) linker
 [11]
 ADC Info 
Gemtuzumab-Compound (Ie)
Gemtuzumab-Compound (Ie) payload
Undisclosed
Gemtuzumab-Compound (Ie) linker
 [14]
 ADC Info 
Gemtuzumab-ADC-24-1
Gemtuzumab-ADC-24-1 payload
Undisclosed
Gemtuzumab-ADC-24-1 linker
 [17]
 ADC Info 
Gemtuzumab-ADC-24-2
Gemtuzumab-ADC-24-2 payload
Undisclosed
Gemtuzumab-ADC-24-2 linker
 [17]
 ADC Info 
Gemtuzumab-ADC-24-3
Gemtuzumab-ADC-24-3 payload
Undisclosed
Gemtuzumab-ADC-24-3 linker
 [17]
 ADC Info 
Gemtuzumab-ADC-24-4
Gemtuzumab-ADC-24-4 payload
Undisclosed
Gemtuzumab-ADC-24-4 linker
 [17]
 ADC Info 
Gemtuzumab-ADC-24-5
Gemtuzumab-ADC-24-5 payload
Undisclosed
Gemtuzumab-ADC-24-5 linker
 [17]
 ADC Info 
Gemtuzumab-ADC-24-6
Gemtuzumab-ADC-24-6 payload
Undisclosed
Gemtuzumab-ADC-24-6 linker
 [17]
 ADC Info 
Gemtuzumab-ADC-24-7
Gemtuzumab-ADC-24-7 payload
Undisclosed
Gemtuzumab-ADC-24-7 linker
 [17]
 ADC Info 
Gemtuzumab-ADC-24-8
Gemtuzumab-ADC-24-8 payload
Undisclosed
Gemtuzumab-ADC-24-8 linker
 [17]
 ADC Info 
Gemtuzumab-ADC-24-9
Gemtuzumab-ADC-24-9 payload
Undisclosed
Gemtuzumab-ADC-24-9 linker
 [17]
 ADC Info 
Gemtuzumab-ADC-24-10
Gemtuzumab-ADC-24-10 payload
Undisclosed
Gemtuzumab-ADC-24-10 linker
 [17]
 ADC Info 
Gemtuzumab-ADC-24-11
Gemtuzumab-ADC-24-11 payload
Undisclosed
Gemtuzumab-ADC-24-11 linker
 [17]
 ADC Info 
Gemtuzumab-ADC-24-12
Gemtuzumab-ADC-24-12 payload
Undisclosed
Gemtuzumab-ADC-24-12 linker
 [17]
 ADC Info 
Gemtuzumab-ADC-24-13
Gemtuzumab-ADC-24-13 payload
Undisclosed
Gemtuzumab-ADC-24-13 linker
 [17]
 ADC Info 
Gemtuzumab-Compound (Ia)
NeoDegrader P1
Protein cereblon (CRBN)
Gemtuzumab-Compound (Ia) linker
 [11]
 ADC Info 
Gemtuzumab-Compound (Ib)
NeoDegrader P1
Protein cereblon (CRBN)
Gemtuzumab-Compound (Ib) linker
 [11]
 ADC Info 
Gemtuzumab-Compound (Ic)
NeoDegrader P1
Protein cereblon (CRBN)
Gemtuzumab-Compound (Ic) linker
 [11]
 ADC Info 
Gemtuzumab-Compound (Ih)
NeoDegrader P1
Protein cereblon (CRBN)
Gemtuzumab-Compound (Ih) linker
 [11]
 ADC Info 
Gemtuzumab-Compound (X)
Gemtuzumab-Compound (X) payload
Undisclosed
Gemtuzumab-Compound (X) linker
 [14]
 ADC Info 
Gemtuzumab-Compound (XI)
Gemtuzumab-Compound (XI) payload
Undisclosed
Gemtuzumab-Compound (XI) linker
 [14]
 ADC Info 
Gemtuzumab-Compound (XIV)
Gemtuzumab-Compound (XIV) payload
Undisclosed
Gemtuzumab-Compound (XIV) linker
 [14]
 ADC Info 
Gemtuzumab-Compound (XVIII)
Gemtuzumab-Compound (XVIII) payload
Undisclosed
Gemtuzumab-Compound (XVIII) linker
 [14]
 ADC Info 
Gemtuzumab-Compound (XIX)
Gemtuzumab-Compound (XIX) payload
Undisclosed
Gemtuzumab-Compound (XIX) linker
 [14]
 ADC Info 
Gemtuzumab-Compound (Ii)
Gemtuzumab-Compound (Ii) payload
Undisclosed
Gemtuzumab-Compound (Ii) linker
 [14]
 ADC Info 
Gemtuzumab-Compound (XLI)
Gemtuzumab-Compound (XLI) payload
Undisclosed
Gemtuzumab-Compound (XLI) linker
 [14]
 ADC Info 
Gemtuzumab-Compound (XVI)
Gemtuzumab-Compound (XIX) payload
Undisclosed
Gemtuzumab-Compound (XIX) linker
 [14]
 ADC Info 
Gemtuzumab-Compound (XL)
Gemtuzumab-Compound (XL) payload
Undisclosed
Gemtuzumab-Compound (XL) linker
 [14]
 ADC Info 
Gemtuzumab-Compound (XLIII)
Gemtuzumab-Compound (XLIII) payload
Undisclosed
Gemtuzumab-Compound (XLIII) linker
 [14]
 ADC Info 
Gemtuzumab-Compound (XLII)
Gemtuzumab-Compound (XLII) payload
Undisclosed
Gemtuzumab-Compound (XLII) linker
 [14]
 ADC Info 
Gemtuzumab-Compound (XV)
Gemtuzumab-Compound (XV) payload
Undisclosed
Gemtuzumab-Compound (XV) linker
 [14]
 ADC Info 
Gemtuzumab-Compound 9
Mertansine DM1
Microtubule (MT)
Gemtuzumab-Compound 9 linker
 [18]
 ADC Info 
Gemtuzumab-Compound 17
Mertansine DM4
Microtubule (MT)
Gemtuzumab-Compound 17 linker
 [18]
 ADC Info 
Gemtuzumab-Compound 25
Monomethyl auristatin E
Microtubule (MT)
Gemtuzumab-Compound 25 linker
 [18]
 ADC Info 
Gemtuzumab-Compound 31
Auristatin 0101
Microtubule (MT)
Gemtuzumab-Compound 31 linker
 [18]
 ADC Info 
Gemtuzumab-Compound 36
Monomethyl auristatin E
Microtubule (MT)
Gemtuzumab-Compound 36 linker
 [18]
 ADC Info 
Gemtuzumab-Compound 43
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Gemtuzumab-Compound 43 linker
 [18]
 ADC Info 
Gemtuzumab-Compound 49
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Gemtuzumab-Compound 49 linker
 [18]
 ADC Info 
Gemtuzumab-Compound 55
Mertansine DM1
Microtubule (MT)
Gemtuzumab-Compound 55 linker
 [18]
 ADC Info 
Gemtuzumab-Compound 59
Mertansine DM4
Microtubule (MT)
Gemtuzumab-Compound 59 linker
 [18]
 ADC Info 
Gemtuzumab-Compound 64
Monomethyl auristatin E
Microtubule (MT)
Gemtuzumab-Compound 64 linker
 [18]
 ADC Info 
Gemtuzumab-Compound 69
Monomethyl auristatin E
Microtubule (MT)
Gemtuzumab-Compound 69 linker
 [18]
 ADC Info 
Gemtuzumab-Compound 74
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Gemtuzumab-Compound 74 linker
 [18]
 ADC Info 
Gemtuzumab-Compound 75
Monomethyl auristatin E
Microtubule (MT)
Gemtuzumab-Compound 75 linker
 [18]
 ADC Info 
Gemtuzumab-Compound 76
Monomethyl auristatin E
Microtubule (MT)
Gemtuzumab-Compound 76 linker
 [18]
 ADC Info 
Gemtuzumab-Compound 77
Mertansine DM1
Microtubule (MT)
Gemtuzumab-Compound 77 linker
 [18]
 ADC Info 
Gemtuzumab-Compound 78
Auristatin 0101
Microtubule (MT)
Gemtuzumab-Compound 78 linker
 [18]
 ADC Info 
Gemtuzumab-Compound 79
Auristatin 0101
Microtubule (MT)
Gemtuzumab-Compound 79 linker
 [18]
 ADC Info 
Gemtuzumab-Compound 80
Mertansine DM4
Microtubule (MT)
Gemtuzumab-Compound 80 linker
 [18]
 ADC Info 
JP7623413B2 ExampleADC46
Undisclosed
Undisclosed
Undisclosed
 [19]
 ADC Info 
IGAC-89
IG-L-18 Payload
Undisclosed
IG-L-25 linker
 [20]
gemtuzumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
IGAC-26
Smol006
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
MP-Ala-Ala-PAB
 [20]
 ADC Info 
IGAC-28
IG-L-1 Payload
Undisclosed
IG-L-1 linker
 [20]
 ADC Info 
IGAC-32
IG-L-1 Payload
Undisclosed
IG-L-1 linker
 [20]
 ADC Info 
JP7560255B2 ControlADC46
Undisclosed
Undisclosed
Undisclosed
 [21]
GM15.33 HC A118C
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN106714844B ADC-105
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
CN106714844B-ADC-105-linker
 [2]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CD33-ADC
SG3199
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 [22]
 ADC Info 
TW201803600A ADC-1
PBD
Undisclosed
Mc-Val-Ala
 [23]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
TW201803600A ADC-2
PBD
Undisclosed
Undisclosed
 [23]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
AVE9633
DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
huMy9-6 IgG1
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HuMy9-6IgG1-Compound (la) DAR 8
NeoDegrader P1
Protein cereblon (CRBN)
huMy9-6IgG1-Compound (la) DAR 8 linker
 [24]
 ADC Info 
HuMy9-6 IgG1-Compound (la) DAR 1.9
NeoDegrader P1
Protein cereblon (CRBN)
huMy9-6 IgG1-Compound (la) DAR 1.9 linker
 [24]
 ADC Info 
HuMy9-6IgG1-Compound (la) DAR3.9
NeoDegrader P1
Protein cereblon (CRBN)
huMy9-6IgG1-Compound (la) DAR3.9 linker
 [24]
 ADC Info 
HuMy9-6IgG1-Compound(la) DAR 5.5
NeoDegrader P1
Protein cereblon (CRBN)
huMy9-6IgG1-Compound(la) DAR 5.5 linker
 [24]
 ADC Info 
HuMy9-6IgG1-Compound (ld) DAR 8
NeoDegrader P1
Protein cereblon (CRBN)
huMy9-6IgG1-Compound (ld) DAR 8 linker
 [24]
huMy9-6-IgG4-S228P
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HuMy9-6-IgG4-S228P-Compound (Ia)
NeoDegrader P1
Protein cereblon (CRBN)
huMy9-6-IgG4-S228P-Compound (Ia) linker
 [11]
 ADC Info 
HuMy9-6-IgG4-S228P-Compound (Ib)
NeoDegrader P1
Protein cereblon (CRBN)
huMy9-6-IgG4-S228P-Compound (Ib) linker
 [11]
 ADC Info 
HuMy9-6-IgG4-S228P-Compound (Ic)
NeoDegrader P1
Protein cereblon (CRBN)
huMy9-6-IgG4-S228P-Compound (Ic) linker
 [11]
 ADC Info 
HuMy9-6-IgG4-S228P-Compound (Ie)
NeoDegrader P1
Protein cereblon (CRBN)
huMy9-6-IgG4-S228P-Compound (Ie) linker
 [11]
 ADC Info 
HuMy9-6-IgG4-S228P-Compound (Ih)
NeoDegrader P1
Protein cereblon (CRBN)
huMy9-6-IgG4-S228P-Compound (Ih) linker
 [11]
Lintuzumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Lintuzumab Ac-225
AC225
Undisclosed
DOTA-P-toluene isothiocyanate
 ADC Info 
Lintuzumab IgG1-Compound (la) DAR 8
NeoDegrader P1
Protein cereblon (CRBN)
Lintuzumab IgG1-Compound (la) DAR 8 linker
 [24]
 ADC Info 
Lintuzumab IgG1-Compound (ld) DAR 8
NeoDegrader P1
Protein cereblon (CRBN)
Lintuzumab IgG1-Compound (ld) DAR 8 linker
 [24]
 ADC Info 
GLK-33
Glucuronyl-monomethyl-auristatin E (MMAU)
Microtubule (MT)
Undisclosed
 [25]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
OR000213-Compound (Ia)
NeoDegrader P1
Protein cereblon (CRBN)
OR000213-Compound (Ia) linker
 [24]
 ADC Info 
OR000213-Compound(la) DAR 8
NeoDegrader P1
Protein cereblon (CRBN)
OR000213-Compound(la) DAR 8 linker
 [24]
 ADC Info 
OR000213-Compound (la) DAR 1.2
NeoDegrader P1
Protein cereblon (CRBN)
OR000213-Compound (la) DAR 1.2 linker
 [24]
 ADC Info 
OR000213-Compound(la) DAR 1.8
NeoDegrader P1
Protein cereblon (CRBN)
OR000213-Compound(la) DAR 1.8 linker
 [24]
 ADC Info 
OR000213-Compound(la) DAR 2.3
NeoDegrader P1
Protein cereblon (CRBN)
OR000213-Compound(la) DAR 2.3 linker
 [24]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
BMS-986497
SMol006
CRBN×GSPT1
β-glucuronide linker
 [26]
Thio hu Anti-CD33 GM15.33 HC A118C
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
WO2014159981A2 ADC-203
WO2014159981A2_ADC-203 payload
Undisclosed
WO2014159981A2_ADC-203 linker
 [27]
 ADC Info 
WO2014159981A2 ADC-213
WO2014159981A2_ADC-213 payload
Undisclosed
WO2014159981A2_ADC-213 linker
 [27]
 ADC Info 
WO2014159981A2 ADC-222
WO2014159981A2_ADC-222 payload
Undisclosed
WO2014159981A2_ADC-222 linker
 [27]
 ADC Info 
WO2014159981A2 ADC-CD33-24
WO2014159981A2_ADC-CD33-24 payload
Undisclosed
WO2014159981A2_ADC-CD33-24 linker
 [27]
 ADC Info 
WO2014159981A2 ADC-CD33-25
WO2014159981A2_ADC-CD33-25 payload
Undisclosed
WO2014159981A2_ADC-CD33-25 linker
 [27]
 ADC Info 
WO2014159981A2 ADC-CD33-33
WO2014159981A2_ADC-CD33-33 payload
Undisclosed
WO2014159981A2_ADC-CD33-33 linker
 [27]
 ADC Info 
WO2014159981A2 ADC-CD33-37
WO2014159981A2_ADC-CD33-37 payload
Undisclosed
WO2014159981A2_ADC-CD33-37 linker
 [27]
 ADC Info 
WO2014159981A2 ADC-CD33-41
WO2014159981A2_ADC-CD33-41 payload
Undisclosed
WO2014159981A2_ADC-CD33-41 linker
 [27]
 ADC Info 
WO2014159981A2 ADC-CD33-44
WO2014159981A2_ADC-CD33-44 payload
Undisclosed
WO2014159981A2_ADC-CD33-44 linker
 [27]
Vadastuximab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Vadastuximab talirine
SGD-1882
Human deoxyribonucleic acid (hDNA)
Mc-Val-Ala
 ADC Info 
JP7623413B2 ExampleADC54
Undisclosed
Undisclosed
Undisclosed
 [19]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
IMGN779
DGN462
Human deoxyribonucleic acid (hDNA)
Sulfo-SPDB
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-CD33 next-generation DNA-targeting payload ADC (Pfizer)
Undisclosed
Undisclosed
Undisclosed
 [28]
 ADC Info 
Indolino-benzodiazepine antibody drug conjugate
Undisclosed
Undisclosed
Undisclosed
 [29]
 ADC Info 
Anti-CD3 single-chain immunotoxin
DT390-scFvUCHT1
Undisclosed
Undisclosed
 [30]
undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-Human CD33 BETd ADCs
BETd drug
Undisclosed
US20250000993A1 ADC Linker
 [31]
References
Ref 1 Antibody-drug conjugate
Ref 2 Anthracycline disulfide intermediates, antibody-drug conjugates and methods
Ref 3 Anti-graft-versus-host disease effect of DT390-anti-CD3sFv, a single-chain Fv fusion immunotoxin specifically targeting the CD3 epsilon moiety of the T-cell receptor. Blood. 1996 Sep 15;88(6):2342-53.
Ref 4 Antibody-drug conjugate
Ref 5 Neodegrader-anti-cd33 antibody conjugates; 2022-12-08.
Ref 6 Development of Highly Optimized Antibody-Drug Conjugates against CD33 and CD123 for Acute Myeloid Leukemia. Clin Cancer Res. 2021 Jan 15;27(2):622-631. doi: 10.1158/1078-0432.CCR-20-2149. Epub 2020 Nov 4.
Ref 7 anti-CD33/BET degrader ADC ABBV-787
Ref 8 Peptidomimetic compounds and antibody-drug conjugates thereof; 2015-09-03.
Ref 9 Cyclodextrin and antibody-drug conjugate formulations.
Ref 10 Heteroaryl sulfone-based conjugation handles, methods for their preparation, and their use in synthesizing antibody drug conjugates
Ref 11 Neodegrader conjugates; 2021-10-07.
Ref 12 Calicheamicin derivatives and antibody drug conjugates thereof
Ref 13 Bifunctional cytotoxic agents containing the CTI pharmacophore
Ref 14 Linkers for use in antibody drug conjugates; 2023-03-16.
Ref 15 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment.
Ref 16 Approval summary: gemtuzumab ozogamicin in relapsed acute myeloid leukemia
Ref 17 Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof; 2020-04-02.
Ref 18 Covalent linkers in antibody-drug conjugates and methods of making and using the same.
Ref 19 Antibody-drug complexes containing hemiasterlin derivatives
Ref 20 Isoindolinone-glutarimide antibody conjugates, and uses thereof
Ref 21 Pharmaceuticals containing antibody-drug complexes containing hemiasterin derivatives
Ref 22 KK2845, a PBD dimer-containing antibody-drug conjugate targeting TIM-3-expressing AML
Ref 23 Antibody-drug conjugates mainly based on PBD and combinations with FLT3 inhibitors
Ref 24 Neodegrader conjugates; 2021-10-07.
Ref 25 Targeting CD33+ Acute Myeloid Leukemia with GLK-33, a Lintuzumab-Auristatin Conjugate with a Wide Therapeutic Window
Ref 26 Abstract 2700: ORM-6151: A first-in-class CD33-antibody enabled GSPT1 degrader for AML
Ref 27 Pyrrolobenzodiazepines and conjugates thereof; 2015-04-09.
Ref 28 Introduction to basic information on anti-CD33 targeting next-generation DNA-targeting payload antibody-drug conjugates(Pfizer).
Ref 29 Characterization of the taxol structure-activity profile for the locus of the a-ring side-chain. Bioorg Med Chem Lett. 1994;4(12):1531-1536.
Ref 30 Expression of an anti-CD3 single-chain immunotoxin with a truncated diphtheria toxin in a mutant CHO cell line. Protein Expr Purif. 2000 Jul;19(2):304-11. doi: 10.1006/prep.2000.1255.
Ref 31 Anti-human CD33 BET degrader antibody-drug conjugates