Antigen Information

General Information of This Antigen (ID: TAR0OVWVF)
Antigen Name
Myeloid cell surface antigen CD33 (CD33)
Gene Name
CD33
Gene ID
945
Synonym
SIGLEC3; Sialic acid-binding Ig-like lectin 3;gp67;CD33
Sequence
MPLLLLLPLLWAGALAMDPNFWLQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSPVHGYW
FREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDNGSYFFRM
ERGSTKYSYKSPQLSVHVTDLTHRPKILIPGTLEPGHSKNLTCSVSWACEQGTPPIFSWL
SAAPTSLGPRTTHSSVLIITPRPQDHGTNLTCQVKFAGAGVTTERTIQLNVTYVPQNPTT
GIFPGDGSGKQETRAGVVHGAIGGAGVTALLALCLCLIFFIVKTHRRKAARTAVGRNDTH
PTTGSASPKHQKKSKLHGPTETSSCSGAAPTVEMDEELHYASLNFHGMNPSKDTSTEYSE
VRTQ

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Family
Immunoglobulin family
Function
Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially recognizes and binds alpha-2,3- and more avidly alpha-2,6-linked sialic acid-bearing glycans. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP- 2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. One of the repressive effect of CD33 on monocyte activation requires phosphoinositide 3-kinase/PI3K.

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Uniprot Entry
CD33_HUMAN
HGNC ID
HGNC:1659
KEGG ID
hsa:945
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
018 (CD33)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2024222841A1 ADC55 [1]
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
 ADC Info 
019 (CD33)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2024222841A1 ADC56 [1]
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
 ADC Info 
WO2024222841A1 ADC65 [1]
B63
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Ala-PABC
 ADC Info 
020 (CD33)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2024222841A1 ADC57 [1]
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
 ADC Info 
021 (CD33)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2024222841A1 ADC58 [1]
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
 ADC Info 
022 (CD33)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2024222841A1 ADC59 [1]
(S)B19
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
OXDc-VA-PAB (PEG)
 ADC Info 
WO2024222841A1 ADC66 [1]
B63
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
Mc-Val-Ala-PABC
 ADC Info 
15G15.3 LC K149C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106714844B ADC-110 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
 ADC Info 
CN106714844B ADC-115 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
CN106714844B-ADC-115-linker
 ADC Info 
CN106714844B ADC-139 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Ethylmaleimide linker
 ADC Info 
A recombinant anti-CD33 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
DXC007
Tub255
Microtubule (MT)
Undisclosed
 ADC Info 
Anti-CD3 single-chain Fv
 Antibody Info 
ADC Name Payload Target Linker ADC Info
DT390 anti-CD3sFv immunotoxin [3]
DT390
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 ADC Info 
Anti-CD33
 Antibody Info 
ADC Name Payload Target Linker ADC Info
US12186310B2-34 [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12186310B2-48 [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-CD33 (US12186310B2)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
US12186310B2-8 [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12186310B2-9 [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-CD33 AB1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-CD33 AB1 Compound (Ia) [5]
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Ia) linker
 ADC Info 
Anti-CD33 AB1 Compound (Ib) [5]
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Ib) linker
 ADC Info 
Anti-CD33 AB1 Compound (Ic) [5]
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Ic) linker
 ADC Info 
Anti-CD33 AB1 Compound (Id) [5]
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Id) linker
 ADC Info 
Anti-CD33 AB1 Compound (Ie) [5]
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Ie) linker
 ADC Info 
Anti-CD33 AB1 Compound (If) [5]
NeoDegrader P6
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (If) linker
 ADC Info 
Anti-CD33 AB1 Compound (Ig) [5]
NeoDegrader P2
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Ig) linker
 ADC Info 
Anti-CD33 AB1 Compound (Ih) [5]
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Ih) linker
 ADC Info 
Anti-CD33 AB1 Compound (Ii) [5]
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Ii) linker
 ADC Info 
Anti-CD33 AB1 Compound (Ij) [5]
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Ij) linker
 ADC Info 
Anti-CD33 AB1 Compound (Ik) [5]
NeoDegrader P14
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Ik) linker
 ADC Info 
Anti-CD33 AB1 Compound (Il) [5]
NeoDegrader P14
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Il) linker
 ADC Info 
Anti-CD33 AB1 Compound (Im) [5]
NeoDegrader P14
Protein cereblon (CRBN)
Anti-CD33 AB1 Compound (Im) linker
 ADC Info 
Anti-CD33 Anti-ody 11A1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD33-CPI dimer ADC [6]
Bicyclopentyl-seco-CBI-dimer
Human Deoxyribonucleic acid (hDNA)
AcLys-Val-Cit-PABC-DMAE
 ADC Info 
Anti-CD33 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ABBV-787 [7]
BET degrader
Bromodomain and extra-terminal (BET)
A cleavable linker
 ADC Info 
Anti-CD33 mAb 15G15.33
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD33 PNU ADC2-2 [8]
CD33 PNU ADC2-2 payload
Undisclosed
CD33 PNU ADC2-2 linker
 ADC Info 
CD33 PNU ADC3-2 [8]
CD33 PNU ADC3-2 payload
Undisclosed
CD33 PNU ADC3-2 linker
 ADC Info 
CD33 PNU ADC4-2 [8]
CD33 PNU ADC4-2 payload
Undisclosed
CD33 PNU ADC4-2 linker
 ADC Info 
CD33-PNU-LD1 [8]
CD33-PNU-LD1 payload
Undisclosed
CD33-PNU-LD1 linker
 ADC Info 
CD33-PNU-LD5 [8]
CD33-PNU-LD5 payload
Undisclosed
CD33-PNU-LD5 linker
 ADC Info 
CD33-PNU-LD6 [8]
CD33-PNU-LD6 payload
Undisclosed
CD33-PNU-LD6 linker
 ADC Info 
CD33-PNU-LD7 [8]
CD33-PNU-LD7 payload
Undisclosed
CD33-PNU-LD7 linker
 ADC Info 
Anti-CD33 mAb humanized 2H12
 Antibody Info 
ADC Name Payload Target Linker ADC Info
h2H12-Compound 1 [9]
h2H12-compound 1 payload
Undisclosed
h2H12-compound 1 linker
 ADC Info 
h2H12-Compound 2 [9]
h2H12-compound 2 payload
Undisclosed
h2H12-compound 2 linker
 ADC Info 
h2H12-Compound 3 [9]
h2H12-compound 3 payload
Undisclosed
h2H12-compound 3 linker
 ADC Info 
Anti-CD33 mAb murine 2H12
 Antibody Info 
ADC Name Payload Target Linker ADC Info
m2H12-Compound 1 [9]
m2H12-compound 1 payload
Undisclosed
m2H12-compound 1 linker
 ADC Info 
m2H12-Compound 2 [9]
m2H12-compound 2 payload
Undisclosed
m2H12-compound 2 linker
 ADC Info 
m2H12-Compound 3 [9]
m2H12-compound 3 payload
Undisclosed
m2H12-compound 3 linker
 ADC Info 
anti-CD33-11A1-v1417- (K290C)- (K334C) and CD33-11A1-v1417- (K334C)- (K392C) mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
H- (A114C)-#6 [10]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
H- (A114C)-#7 [10]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
H- (A114C)-#10 [10]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
H- (A114C)-#11 [10]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
H- (A114C)-#14 [10]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
H- (A114C)-#19 [10]
H- (A114C)-#19 Payload
Undisclosed
H- (A114C)-#19 Linker
 ADC Info 
H- (A114C)-#26 [10]
H- (A114C)-#19 Payload
Undisclosed
H- (A114C)-#26 Linker
 ADC Info 
H- (kK183C)-#26 [10]
H- (A114C)-#19 Payload
Undisclosed
H- (A114C)-#26 Linker
 ADC Info 
H- (E380C)-#26 [10]
H- (A114C)-#19 Payload
Undisclosed
H- (A114C)-#26 Linker
 ADC Info 
H- (A114C)-#30 [10]
H- (A114C)-#30 Payload
Undisclosed
H- (A114C)-#30 Linker
 ADC Info 
H- (E380C)-#30 [10]
H- (A114C)-#30 Payload
Undisclosed
H- (A114C)-#30 Linker
 ADC Info 
H- (A114C)-#35 [10]
H- (A114C)-#19 Payload
Undisclosed
H- (A114C)-#35 Linker
 ADC Info 
CD33-11A1-v1417 (K290C)- (K334C)-#39 [10]
CD33-11A1-v1417 (C)-#39 Payload
Undisclosed
CD33-11A1-v1417 (C)-#39 Linker
 ADC Info 
CD33-11A1-v1417 (K334C)- (K392C)-#39 [10]
CD33-11A1-v1417 (C)-#39 Payload
Undisclosed
CD33-11A1-v1417 (C)-#39 Linker
 ADC Info 
H- (A114C)-#43 [10]
H- (A114C)-#30 Payload
Undisclosed
H- (A114C)-#43 Linker
 ADC Info 
H- (A114C)-#46 [10]
H- (A114C)-#30 Payload
Undisclosed
H- (A114C)-#43 Linker
 ADC Info 
H- (A114C)-#52 [10]
H- (A114C)-#30 Payload
Undisclosed
H- (A114C)-#43 Linker
 ADC Info 
H- (A114C)-#58 [10]
H- (A114C)-#30 Payload
Undisclosed
H- (A114C)-#43 Linker
 ADC Info 
H- (A114C)-#66 [10]
H- (A114C)-#30 Payload
Undisclosed
H- (A114C)-#66 Linker
 ADC Info 
Anti-CD33AB
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-CD33AB-Compound (Ia) [11]
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33AB-Compound (Ia) linker
 ADC Info 
Anti-CD33AB-Compound (Ib) [11]
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33AB-Compound (Ib) linker
 ADC Info 
Anti-CD33AB-Compound (Ic) [11]
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33AB-Compound (Ic) linker
 ADC Info 
Anti-CD33AB-Compound (Ie) [11]
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33AB-Compound (Ie) linker
 ADC Info 
Anti-CD33AB-Compound (Ih) [11]
NeoDegrader P1
Protein cereblon (CRBN)
Anti-CD33AB-Compound (Ih) linker
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP1 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP5 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP6 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417-kN92S-H16-D55A- K222R-hGl-LP7 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP8 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP9 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP11 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP12 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP13 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP18 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP19 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417 kN92S-H16-D55A- K222R-hGl- (Q)_AcLysValCitPABC _LP21 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417 kN92S-H16-D55A- K222R-hGl- (Q)_AcLysValCitPABC_LP25 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417 kN92S-H16-D55A- K222R-hGl (Q)_AcLysValCitPABC _LP26 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417 kN92S-H16-D55A- K222R-hGl- (Q)_AcLysValCitPABC _LP27 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417 kN92S-H16-D55A- K222R-hGl- (Q)_AcLysValCitPABC _LP28 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417 kN92S-H16-D55A- K222R-hGl- (Q)_AcLysValCitPABC _LP29 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417 kN92S-H16-D55A- K222R-hGl- (Q)_AcLysValCitPABC _LP33 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417 kN92S-H16-D55A- K222R-hGl- (Q)_AcLysValCitPABC _LP34 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417 kN92S-H16-D55A- K222R-hGl- (Q)_AcLysValCitPABC _LP35 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417 kN92S-H16-D55A- K222R-hGl- (Q)_AcLysValCitPABC _LP36 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP39 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP40 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP41 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP42 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP43 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP44 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP45 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP46 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- kN92S-H16-D55A- K222R-hGl-LP47 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417-H7C-hGl
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD33-11A1-v1417- H7C-hGl-LP19 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417-hG1- (C)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
US11365263B2 ADC#4 [13]
US11365263B2 ADC#6 payload
Undisclosed
US11365263B2 ADC#6 linker
 ADC Info 
CD33-11A1-v1417-K334C-hG1- (C334)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
US11365263B2 ADC#6 [13]
US11365263B2 ADC#6 payload
Undisclosed
US11365263B2 ADC#6 linker
 ADC Info 
CD33-11A1-v1417-K334C-K392C-hG1- (C334 + C392)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
US11365263B2 ADC#5 [13]
US11365263B2 ADC#6 payload
Undisclosed
US11365263B2 ADC#6 linker
 ADC Info 
CD33-11A1-v1417-kK183C-hGl
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD33-11A1-v1417- kK183C-hGl-LP2 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- kK183C-hGl-LP48 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417-LCQ05-H16-K222R-hG1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD33-11A1-v1417- LCQ05-H16-K222R- hG1-LP1 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- LCQO5-H16-K222R- hGl-LP13 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- LCQO5-H16-K222R- hGl-LP14 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-11A1-v1417- LCQ05-H16-K222R- hGl-LP19 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD33-A Anti-ody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD33-A Antibody-Compound (X) [14]
CD33-A Antibody-Compound (X) payload
Undisclosed
CD33-A Antibody-Compound (X) linker
 ADC Info 
CD33-A Antibody-Compound (XI) [14]
CD33-A Antibody-Compound (XI) payload
Undisclosed
CD33-A Antibody-Compound (XI) linker
 ADC Info 
CD33-A Antibody-Compound (XIV) [14]
CD33-A Antibody-Compound (XIV) payload
Undisclosed
CD33-A Antibody-Compound (XIV) linker
 ADC Info 
CD33-A Antibody-Compound (XVIII) [14]
CD33-A Antibody-Compound (XVIII) payload
Undisclosed
CD33-A Antibody-Compound (XVIII) linker
 ADC Info 
CD33-A Antibody-Compound (Ie) [14]
CD33-A Antibody-Compound (Ie) payload
Undisclosed
CD33-A Antibody-Compound (Ie) linker
 ADC Info 
CD33-A Antibody-Compound (XIX) [14]
CD33-A Antibody-Compound (XIX) payload
Undisclosed
CD33-A Antibody-Compound (XIX) linker
 ADC Info 
CD33-A Antibody-Compound (Ii) [14]
CD33-A Antibody-Compound (Ii) payload
Undisclosed
CD33-A Antibody-Compound (Ii) linker
 ADC Info 
CD33-A Antibody-Compound (XLI) [14]
CD33-A Antibody-Compound (XLI) payload
Undisclosed
CD33-A Antibody-Compound (XLI) linker
 ADC Info 
CD33-A Antibody-Compound (XVI) [14]
CD33-A Antibody-Compound (XIX) payload
Undisclosed
CD33-A Antibody-Compound (XIX) linker
 ADC Info 
CD33-A Antibody-Compound (XL) [14]
CD33-A Antibody-Compound (XL) payload
Undisclosed
CD33-A Antibody-Compound (XL) linker
 ADC Info 
CD33-A Antibody-Compound (XLIII) [14]
CD33-A Antibody-Compound (XLIII) payload
Undisclosed
CD33-A Antibody-Compound (XLIII) linker
 ADC Info 
CD33-A Antibody-Compound (XLII) [14]
CD33-A Antibody-Compound (XLII) payload
Undisclosed
CD33-A Antibody-Compound (XLII) linker
 ADC Info 
CD33-A Antibody-Compound (XV) [14]
CD33-A Antibody-Compound (XV) payload
Undisclosed
CD33-A Antibody-Compound (XV) linker
 ADC Info 
CD33-B Anti-ody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD33-B Antibody-Compound (X) [14]
CD33-B Antibody-Compound (X) payload
Undisclosed
CD33-B Antibody-Compound (X) linker
 ADC Info 
CD33-B Antibody-Compound (XI) [14]
CD33-B Antibody-Compound (XI) payload
Undisclosed
CD33-B Antibody-Compound (XI) linker
 ADC Info 
CD33-B Antibody-Compound (XIV) [14]
CD33-B Antibody-Compound (XIV) payload
Undisclosed
CD33-B Antibody-Compound (XIV) linker
 ADC Info 
CD33-B Antibody-Compound (XVIII) [14]
CD33-B Antibody-Compound (XVIII) payload
Undisclosed
CD33-B Antibody-Compound (XVIII) linker
 ADC Info 
CD33-B Antibody-Compound (Ie) [14]
CD33-B Antibody-Compound (Ie) payload
Undisclosed
CD33-B Antibody-Compound (Ie) linker
 ADC Info 
CD33-B Antibody-Compound (XIX) [14]
CD33-B Antibody-Compound (XIX) payload
Undisclosed
CD33-B Antibody-Compound (XIX) linker
 ADC Info 
CD33-B Antibody-Compound (Ii) [14]
CD33-B Antibody-Compound (Ii) payload
Undisclosed
CD33-B Antibody-Compound (Ii) linker
 ADC Info 
CD33-B Antibody-Compound (XLI) [14]
CD33-B Antibody-Compound (XLI) payload
Undisclosed
CD33-B Antibody-Compound (XLI) linker
 ADC Info 
CD33-B Antibody-Compound (XVI) [14]
CD33-B Antibody-Compound (XIX) payload
Undisclosed
CD33-B Antibody-Compound (XIX) linker
 ADC Info 
CD33-B Antibody-Compound (XL) [14]
CD33-B Antibody-Compound (XL) payload
Undisclosed
CD33-B Antibody-Compound (XL) linker
 ADC Info 
CD33-B Antibody-Compound (XLIII) [14]
CD33-B Antibody-Compound (XLIII) payload
Undisclosed
CD33-B Antibody-Compound (XLIII) linker
 ADC Info 
CD33-B Antibody-Compound (XLII) [14]
CD33-B Antibody-Compound (XLII) payload
Undisclosed
CD33-B Antibody-Compound (XLII) linker
 ADC Info 
CD33-B Antibody-Compound (XV) [14]
CD33-B Antibody-Compound (XV) payload
Undisclosed
CD33-B Antibody-Compound (XV) linker
 ADC Info 
CD33-C Anti-ody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD33-C Antibody-Compound (X) [14]
CD33-C Antibody-Compound (X) payload
Undisclosed
CD33-C Antibody-Compound (X) linker
 ADC Info 
CD33-C Antibody-Compound (XI) [14]
CD33-C Antibody-Compound (XI) payload
Undisclosed
CD33-C Antibody-Compound (XI) linker
 ADC Info 
CD33-C Antibody-Compound (XIV) [14]
CD33-C Antibody-Compound (XIV) payload
Undisclosed
CD33-C Antibody-Compound (XIV) linker
 ADC Info 
CD33-C Antibody-Compound (XVIII) [14]
CD33-C Antibody-Compound (XVIII) payload
Undisclosed
CD33-C Antibody-Compound (XVIII) linker
 ADC Info 
CD33-C Antibody-Compound (Ie) [14]
CD33-C Antibody-Compound (Ie) payload
Undisclosed
CD33-C Antibody-Compound (Ie) linker
 ADC Info 
CD33-C Antibody-Compound (XIX) [14]
CD33-C Antibody-Compound (XIX) payload
Undisclosed
CD33-C Antibody-Compound (XIX) linker
 ADC Info 
CD33-C Antibody-Compound (Ii) [14]
CD33-C Antibody-Compound (Ii) payload
Undisclosed
CD33-C Antibody-Compound (Ii) linker
 ADC Info 
CD33-C Antibody-Compound (XLI) [14]
CD33-C Antibody-Compound (XLI) payload
Undisclosed
CD33-C Antibody-Compound (XLI) linker
 ADC Info 
CD33-C Antibody-Compound (XVI) [14]
CD33-C Antibody-Compound (XIX) payload
Undisclosed
CD33-C Antibody-Compound (XIX) linker
 ADC Info 
CD33-C Antibody-Compound (XL) [14]
CD33-C Antibody-Compound (XL) payload
Undisclosed
CD33-C Antibody-Compound (XL) linker
 ADC Info 
CD33-C Antibody-Compound (XLIII) [14]
CD33-C Antibody-Compound (XLIII) payload
Undisclosed
CD33-C Antibody-Compound (XLIII) linker
 ADC Info 
CD33-C Antibody-Compound (XLII) [14]
CD33-C Antibody-Compound (XLII) payload
Undisclosed
CD33-C Antibody-Compound (XLII) linker
 ADC Info 
CD33-C Antibody-Compound (XV) [14]
CD33-C Antibody-Compound (XV) payload
Undisclosed
CD33-C Antibody-Compound (XV) linker
 ADC Info 
CD33-D Anti-ody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD33-D Antibody-Compound (X) [14]
CD33-D Antibody-Compound (X) payload
Undisclosed
CD33-D Antibody-Compound (X) linker
 ADC Info 
CD33-D Antibody-Compound (XI) [14]
CD33-D Antibody-Compound (XI) payload
Undisclosed
CD33-D Antibody-Compound (XI) linker
 ADC Info 
CD33-D Antibody-Compound (XIV) [14]
CD33-D Antibody-Compound (XIV) payload
Undisclosed
CD33-D Antibody-Compound (XIV) linker
 ADC Info 
CD33-D Antibody-Compound (XVIII) [14]
CD33-D Antibody-Compound (XVIII) payload
Undisclosed
CD33-D Antibody-Compound (XVIII) linker
 ADC Info 
CD33-D Antibody-Compound (Ie) [14]
CD33-D Antibody-Compound (Ie) payload
Undisclosed
CD33-D Antibody-Compound (Ie) linker
 ADC Info 
CD33-D Antibody-Compound (XIX) [14]
CD33-D Antibody-Compound (XIX) payload
Undisclosed
CD33-D Antibody-Compound (XIX) linker
 ADC Info 
CD33-D Antibody-Compound (Ii) [14]
CD33-D Antibody-Compound (Ii) payload
Undisclosed
CD33-D Antibody-Compound (Ii) linker
 ADC Info 
CD33-D Antibody-Compound (XLI) [14]
CD33-D Antibody-Compound (XLI) payload
Undisclosed
CD33-D Antibody-Compound (XLI) linker
 ADC Info 
CD33-D Antibody-Compound (XVI) [14]
CD33-D Antibody-Compound (XIX) payload
Undisclosed
CD33-D Antibody-Compound (XIX) linker
 ADC Info 
CD33-D Antibody-Compound (XL) [14]
CD33-D Antibody-Compound (XL) payload
Undisclosed
CD33-D Antibody-Compound (XL) linker
 ADC Info 
CD33-D Antibody-Compound (XLIII) [14]
CD33-D Antibody-Compound (XLIII) payload
Undisclosed
CD33-D Antibody-Compound (XLIII) linker
 ADC Info 
CD33-D Antibody-Compound (XLII) [14]
CD33-D Antibody-Compound (XLII) payload
Undisclosed
CD33-D Antibody-Compound (XLII) linker
 ADC Info 
CD33-D Antibody-Compound (XV) [14]
CD33-D Antibody-Compound (XV) payload
Undisclosed
CD33-D Antibody-Compound (XV) linker
 ADC Info 
CN105828840B_ADC-125 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN105828840B ADC-125 [15]
CN105828840B_ADC-125 payload
Undisclosed
CN105828840B_ADC-125 linker
 ADC Info 
CN105828840B_ADC-127 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN105828840B ADC-127 [15]
CN105828840B_ADC-127 payload
Undisclosed
CN105828840B_ADC-127 linker
 ADC Info 
CN105828840B_ADC-129 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN105828840B ADC-129 [15]
CN105828840B_ADC-129 payload
Undisclosed
CN105828840B_ADC-129 linker
 ADC Info 
CN105828840B_ADC-131 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN105828840B ADC-131 [15]
CN105828840B_ADC-131 payload
Undisclosed
CN105828840B_ADC-131 linker
 ADC Info 
CN105828840B_ADC-133 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN105828840B ADC-133 [15]
CN105828840B_ADC-133 payload
Undisclosed
CN105828840B_ADC-133 linker
 ADC Info 
CN105828840B_ADC-137 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN105828840B ADC-137 [15]
CN105828840B_ADC-137 payload
Undisclosed
CN105828840B_ADC-137 linker
 ADC Info 
CN105828840B_ADC-138 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN105828840B ADC-138 [15]
CN105828840B_ADC-138 payload
Undisclosed
CN105828840B_ADC-138 linker
 ADC Info 
CN105828840B_ADC-139 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN105828840B ADC-139 [15]
CN105828840B_ADC-139 payload
Undisclosed
CN105828840B_ADC-139 linker
 ADC Info 
Gemtuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Gemtuzumab ozogamicin [16]
N-acetyl-gamma-calicheamicin
Human deoxyribonucleic acid (hDNA)
AcButDMH
 ADC Info 
BL-M11D1
Ed-04
DNA topoisomerase 1 (TOP1)
Gly-Mal-Gly-Gly-Phe-Gly
 ADC Info 
Gemtuzumab-ADC-24-1 [17]
Gemtuzumab-ADC-24-1 payload
Undisclosed
Gemtuzumab-ADC-24-1 linker
 ADC Info 
Gemtuzumab-ADC-24-2 [17]
Gemtuzumab-ADC-24-2 payload
Undisclosed
Gemtuzumab-ADC-24-2 linker
 ADC Info 
Gemtuzumab-ADC-24-3 [17]
Gemtuzumab-ADC-24-3 payload
Undisclosed
Gemtuzumab-ADC-24-3 linker
 ADC Info 
Gemtuzumab-ADC-24-4 [17]
Gemtuzumab-ADC-24-4 payload
Undisclosed
Gemtuzumab-ADC-24-4 linker
 ADC Info 
Gemtuzumab-ADC-24-5 [17]
Gemtuzumab-ADC-24-5 payload
Undisclosed
Gemtuzumab-ADC-24-5 linker
 ADC Info 
Gemtuzumab-ADC-24-6 [17]
Gemtuzumab-ADC-24-6 payload
Undisclosed
Gemtuzumab-ADC-24-6 linker
 ADC Info 
Gemtuzumab-ADC-24-7 [17]
Gemtuzumab-ADC-24-7 payload
Undisclosed
Gemtuzumab-ADC-24-7 linker
 ADC Info 
Gemtuzumab-ADC-24-8 [17]
Gemtuzumab-ADC-24-8 payload
Undisclosed
Gemtuzumab-ADC-24-8 linker
 ADC Info 
Gemtuzumab-ADC-24-9 [17]
Gemtuzumab-ADC-24-9 payload
Undisclosed
Gemtuzumab-ADC-24-9 linker
 ADC Info 
Gemtuzumab-ADC-24-10 [17]
Gemtuzumab-ADC-24-10 payload
Undisclosed
Gemtuzumab-ADC-24-10 linker
 ADC Info 
Gemtuzumab-ADC-24-11 [17]
Gemtuzumab-ADC-24-11 payload
Undisclosed
Gemtuzumab-ADC-24-11 linker
 ADC Info 
Gemtuzumab-ADC-24-12 [17]
Gemtuzumab-ADC-24-12 payload
Undisclosed
Gemtuzumab-ADC-24-12 linker
 ADC Info 
Gemtuzumab-ADC-24-13 [17]
Gemtuzumab-ADC-24-13 payload
Undisclosed
Gemtuzumab-ADC-24-13 linker
 ADC Info 
Gemtuzumab-Compound (Ia) [11]
NeoDegrader P1
Protein cereblon (CRBN)
Gemtuzumab-Compound (Ia) linker
 ADC Info 
Gemtuzumab-Compound (Ib) [11]
NeoDegrader P1
Protein cereblon (CRBN)
Gemtuzumab-Compound (Ib) linker
 ADC Info 
Gemtuzumab-Compound (Ic) [11]
NeoDegrader P1
Protein cereblon (CRBN)
Gemtuzumab-Compound (Ic) linker
 ADC Info 
Gemtuzumab-Compound (Ie) [11]
NeoDegrader P1
Protein cereblon (CRBN)
Gemtuzumab-Compound (Ie) linker
 ADC Info 
Gemtuzumab-Compound (Ih) [11]
NeoDegrader P1
Protein cereblon (CRBN)
Gemtuzumab-Compound (Ih) linker
 ADC Info 
Gemtuzumab-Compound (X) [14]
Gemtuzumab-Compound (X) payload
Undisclosed
Gemtuzumab-Compound (X) linker
 ADC Info 
Gemtuzumab-Compound (XI) [14]
Gemtuzumab-Compound (XI) payload
Undisclosed
Gemtuzumab-Compound (XI) linker
 ADC Info 
Gemtuzumab-Compound (XIV) [14]
Gemtuzumab-Compound (XIV) payload
Undisclosed
Gemtuzumab-Compound (XIV) linker
 ADC Info 
Gemtuzumab-Compound (XVIII) [14]
Gemtuzumab-Compound (XVIII) payload
Undisclosed
Gemtuzumab-Compound (XVIII) linker
 ADC Info 
Gemtuzumab-Compound (Ie) [14]
Gemtuzumab-Compound (Ie) payload
Undisclosed
Gemtuzumab-Compound (Ie) linker
 ADC Info 
Gemtuzumab-Compound (XIX) [14]
Gemtuzumab-Compound (XIX) payload
Undisclosed
Gemtuzumab-Compound (XIX) linker
 ADC Info 
Gemtuzumab-Compound (Ii) [14]
Gemtuzumab-Compound (Ii) payload
Undisclosed
Gemtuzumab-Compound (Ii) linker
 ADC Info 
Gemtuzumab-Compound (XLI) [14]
Gemtuzumab-Compound (XLI) payload
Undisclosed
Gemtuzumab-Compound (XLI) linker
 ADC Info 
Gemtuzumab-Compound (XVI) [14]
Gemtuzumab-Compound (XIX) payload
Undisclosed
Gemtuzumab-Compound (XIX) linker
 ADC Info 
Gemtuzumab-Compound (XL) [14]
Gemtuzumab-Compound (XL) payload
Undisclosed
Gemtuzumab-Compound (XL) linker
 ADC Info 
Gemtuzumab-Compound (XLIII) [14]
Gemtuzumab-Compound (XLIII) payload
Undisclosed
Gemtuzumab-Compound (XLIII) linker
 ADC Info 
Gemtuzumab-Compound (XLII) [14]
Gemtuzumab-Compound (XLII) payload
Undisclosed
Gemtuzumab-Compound (XLII) linker
 ADC Info 
Gemtuzumab-Compound (XV) [14]
Gemtuzumab-Compound (XV) payload
Undisclosed
Gemtuzumab-Compound (XV) linker
 ADC Info 
Gemtuzumab-Compound 9 [18]
Mertansine DM1
Microtubule (MT)
Gemtuzumab-Compound 9 linker
 ADC Info 
Gemtuzumab-Compound 17 [18]
Mertansine DM4
Microtubule (MT)
Gemtuzumab-Compound 17 linker
 ADC Info 
Gemtuzumab-Compound 25 [18]
Monomethyl auristatin E
Microtubule (MT)
Gemtuzumab-Compound 25 linker
 ADC Info 
Gemtuzumab-Compound 31 [18]
Auristatin 0101
Microtubule (MT)
Gemtuzumab-Compound 31 linker
 ADC Info 
Gemtuzumab-Compound 36 [18]
Monomethyl auristatin E
Microtubule (MT)
Gemtuzumab-Compound 36 linker
 ADC Info 
Gemtuzumab-Compound 43 [18]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Gemtuzumab-Compound 43 linker
 ADC Info 
Gemtuzumab-Compound 49 [18]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Gemtuzumab-Compound 49 linker
 ADC Info 
Gemtuzumab-Compound 55 [18]
Mertansine DM1
Microtubule (MT)
Gemtuzumab-Compound 55 linker
 ADC Info 
Gemtuzumab-Compound 59 [18]
Mertansine DM4
Microtubule (MT)
Gemtuzumab-Compound 59 linker
 ADC Info 
Gemtuzumab-Compound 64 [18]
Monomethyl auristatin E
Microtubule (MT)
Gemtuzumab-Compound 64 linker
 ADC Info 
Gemtuzumab-Compound 69 [18]
Monomethyl auristatin E
Microtubule (MT)
Gemtuzumab-Compound 69 linker
 ADC Info 
Gemtuzumab-Compound 74 [18]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Gemtuzumab-Compound 74 linker
 ADC Info 
Gemtuzumab-Compound 75 [18]
Monomethyl auristatin E
Microtubule (MT)
Gemtuzumab-Compound 75 linker
 ADC Info 
Gemtuzumab-Compound 76 [18]
Monomethyl auristatin E
Microtubule (MT)
Gemtuzumab-Compound 76 linker
 ADC Info 
Gemtuzumab-Compound 77 [18]
Mertansine DM1
Microtubule (MT)
Gemtuzumab-Compound 77 linker
 ADC Info 
Gemtuzumab-Compound 78 [18]
Auristatin 0101
Microtubule (MT)
Gemtuzumab-Compound 78 linker
 ADC Info 
Gemtuzumab-Compound 79 [18]
Auristatin 0101
Microtubule (MT)
Gemtuzumab-Compound 79 linker
 ADC Info 
Gemtuzumab-Compound 80 [18]
Mertansine DM4
Microtubule (MT)
Gemtuzumab-Compound 80 linker
 ADC Info 
JP7623413B2 ExampleADC46 [19]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
IGAC-89 [20]
IG-L-18 Payload
Undisclosed
IG-L-25 linker
 ADC Info 
gemtuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
IGAC-26 [20]
Smol006
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)
MP-Ala-Ala-PAB
 ADC Info 
IGAC-28 [20]
IG-L-1 Payload
Undisclosed
IG-L-1 linker
 ADC Info 
IGAC-32 [20]
IG-L-1 Payload
Undisclosed
IG-L-1 linker
 ADC Info 
JP7560255B2 ControlADC46 [21]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
GM15.33 HC A118C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106714844B ADC-105 [2]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
CN106714844B-ADC-105-linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CD33-ADC [22]
SG3199
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 ADC Info 
TW201803600A ADC-1 [23]
PBD
Undisclosed
Mc-Val-Ala
 ADC Info 
ADC Name Payload Target Linker ADC Info
TW201803600A ADC-2 [23]
PBD
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
AVE9633
DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
huMy9-6 IgG1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HuMy9-6IgG1-Compound (la) DAR 8 [24]
NeoDegrader P1
Protein cereblon (CRBN)
huMy9-6IgG1-Compound (la) DAR 8 linker
 ADC Info 
HuMy9-6 IgG1-Compound (la) DAR 1.9 [24]
NeoDegrader P1
Protein cereblon (CRBN)
huMy9-6 IgG1-Compound (la) DAR 1.9 linker
 ADC Info 
HuMy9-6IgG1-Compound (la) DAR3.9 [24]
NeoDegrader P1
Protein cereblon (CRBN)
huMy9-6IgG1-Compound (la) DAR3.9 linker
 ADC Info 
HuMy9-6IgG1-Compound(la) DAR 5.5 [24]
NeoDegrader P1
Protein cereblon (CRBN)
huMy9-6IgG1-Compound(la) DAR 5.5 linker
 ADC Info 
HuMy9-6IgG1-Compound (ld) DAR 8 [24]
NeoDegrader P1
Protein cereblon (CRBN)
huMy9-6IgG1-Compound (ld) DAR 8 linker
 ADC Info 
huMy9-6-IgG4-S228P
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HuMy9-6-IgG4-S228P-Compound (Ia) [11]
NeoDegrader P1
Protein cereblon (CRBN)
huMy9-6-IgG4-S228P-Compound (Ia) linker
 ADC Info 
HuMy9-6-IgG4-S228P-Compound (Ib) [11]
NeoDegrader P1
Protein cereblon (CRBN)
huMy9-6-IgG4-S228P-Compound (Ib) linker
 ADC Info 
HuMy9-6-IgG4-S228P-Compound (Ic) [11]
NeoDegrader P1
Protein cereblon (CRBN)
huMy9-6-IgG4-S228P-Compound (Ic) linker
 ADC Info 
HuMy9-6-IgG4-S228P-Compound (Ie) [11]
NeoDegrader P1
Protein cereblon (CRBN)
huMy9-6-IgG4-S228P-Compound (Ie) linker
 ADC Info 
HuMy9-6-IgG4-S228P-Compound (Ih) [11]
NeoDegrader P1
Protein cereblon (CRBN)
huMy9-6-IgG4-S228P-Compound (Ih) linker
 ADC Info 
Lintuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Lintuzumab Ac-225
AC225
Undisclosed
DOTA-P-toluene isothiocyanate
 ADC Info 
Lintuzumab IgG1-Compound (la) DAR 8 [24]
NeoDegrader P1
Protein cereblon (CRBN)
Lintuzumab IgG1-Compound (la) DAR 8 linker
 ADC Info 
Lintuzumab IgG1-Compound (ld) DAR 8 [24]
NeoDegrader P1
Protein cereblon (CRBN)
Lintuzumab IgG1-Compound (ld) DAR 8 linker
 ADC Info 
GLK-33 [25]
Glucuronyl-monomethyl-auristatin E (MMAU)
Microtubule (MT)
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
OR000213-Compound (Ia) [24]
NeoDegrader P1
Protein cereblon (CRBN)
OR000213-Compound (Ia) linker
 ADC Info 
OR000213-Compound(la) DAR 8 [24]
NeoDegrader P1
Protein cereblon (CRBN)
OR000213-Compound(la) DAR 8 linker
 ADC Info 
OR000213-Compound (la) DAR 1.2 [24]
NeoDegrader P1
Protein cereblon (CRBN)
OR000213-Compound (la) DAR 1.2 linker
 ADC Info 
OR000213-Compound(la) DAR 1.8 [24]
NeoDegrader P1
Protein cereblon (CRBN)
OR000213-Compound(la) DAR 1.8 linker
 ADC Info 
OR000213-Compound(la) DAR 2.3 [24]
NeoDegrader P1
Protein cereblon (CRBN)
OR000213-Compound(la) DAR 2.3 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
BMS-986497 [26]
SMol006
CRBN×GSPT1
β-glucuronide linker
 ADC Info 
Thio hu Anti-CD33 GM15.33 HC A118C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2014159981A2 ADC-203 [27]
WO2014159981A2_ADC-203 payload
Undisclosed
WO2014159981A2_ADC-203 linker
 ADC Info 
WO2014159981A2 ADC-213 [27]
WO2014159981A2_ADC-213 payload
Undisclosed
WO2014159981A2_ADC-213 linker
 ADC Info 
WO2014159981A2 ADC-222 [27]
WO2014159981A2_ADC-222 payload
Undisclosed
WO2014159981A2_ADC-222 linker
 ADC Info 
WO2014159981A2 ADC-CD33-24 [27]
WO2014159981A2_ADC-CD33-24 payload
Undisclosed
WO2014159981A2_ADC-CD33-24 linker
 ADC Info 
WO2014159981A2 ADC-CD33-25 [27]
WO2014159981A2_ADC-CD33-25 payload
Undisclosed
WO2014159981A2_ADC-CD33-25 linker
 ADC Info 
WO2014159981A2 ADC-CD33-33 [27]
WO2014159981A2_ADC-CD33-33 payload
Undisclosed
WO2014159981A2_ADC-CD33-33 linker
 ADC Info 
WO2014159981A2 ADC-CD33-37 [27]
WO2014159981A2_ADC-CD33-37 payload
Undisclosed
WO2014159981A2_ADC-CD33-37 linker
 ADC Info 
WO2014159981A2 ADC-CD33-41 [27]
WO2014159981A2_ADC-CD33-41 payload
Undisclosed
WO2014159981A2_ADC-CD33-41 linker
 ADC Info 
WO2014159981A2 ADC-CD33-44 [27]
WO2014159981A2_ADC-CD33-44 payload
Undisclosed
WO2014159981A2_ADC-CD33-44 linker
 ADC Info 
Vadastuximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Vadastuximab talirine
SGD-1882
Human deoxyribonucleic acid (hDNA)
Mc-Val-Ala
 ADC Info 
JP7623413B2 ExampleADC54 [19]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
IMGN779
DGN462
Human deoxyribonucleic acid (hDNA)
Sulfo-SPDB
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-CD33 next-generation DNA-targeting payload ADC (Pfizer) [28]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Indolino-benzodiazepine antibody drug conjugate [29]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-CD3 single-chain immunotoxin [30]
DT390-scFvUCHT1
Undisclosed
Undisclosed
 ADC Info 
Anti-Human CD33 BETd ADCs [31]
BETd drug
Undisclosed
US20250000993A1 ADC Linker
 ADC Info 
References
Ref 1 Antibody-drug conjugate
Ref 2 Anthracycline disulfide intermediates, antibody-drug conjugates and methods
Ref 3 Anti-graft-versus-host disease effect of DT390-anti-CD3sFv, a single-chain Fv fusion immunotoxin specifically targeting the CD3 epsilon moiety of the T-cell receptor. Blood. 1996 Sep 15;88(6):2342-53.
Ref 4 Antibody-drug conjugate
Ref 5 Neodegrader-anti-cd33 antibody conjugates; 2022-12-08.
Ref 6 Development of Highly Optimized Antibody-Drug Conjugates against CD33 and CD123 for Acute Myeloid Leukemia. Clin Cancer Res. 2021 Jan 15;27(2):622-631. doi: 10.1158/1078-0432.CCR-20-2149. Epub 2020 Nov 4.
Ref 7 anti-CD33/BET degrader ADC ABBV-787
Ref 8 Peptidomimetic compounds and antibody-drug conjugates thereof; 2015-09-03.
Ref 9 Cyclodextrin and antibody-drug conjugate formulations.
Ref 10 Heteroaryl sulfone-based conjugation handles, methods for their preparation, and their use in synthesizing antibody drug conjugates
Ref 11 Neodegrader conjugates; 2021-10-07.
Ref 12 Calicheamicin derivatives and antibody drug conjugates thereof
Ref 13 Bifunctional cytotoxic agents containing the CTI pharmacophore
Ref 14 Linkers for use in antibody drug conjugates; 2023-03-16.
Ref 15 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment.
Ref 16 Approval summary: gemtuzumab ozogamicin in relapsed acute myeloid leukemia
Ref 17 Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof; 2020-04-02.
Ref 18 Covalent linkers in antibody-drug conjugates and methods of making and using the same.
Ref 19 Antibody-drug complexes containing hemiasterlin derivatives
Ref 20 Isoindolinone-glutarimide antibody conjugates, and uses thereof
Ref 21 Pharmaceuticals containing antibody-drug complexes containing hemiasterin derivatives
Ref 22 KK2845, a PBD dimer-containing antibody-drug conjugate targeting TIM-3-expressing AML
Ref 23 Antibody-drug conjugates mainly based on PBD and combinations with FLT3 inhibitors
Ref 24 Neodegrader conjugates; 2021-10-07.
Ref 25 Targeting CD33+ Acute Myeloid Leukemia with GLK-33, a Lintuzumab-Auristatin Conjugate with a Wide Therapeutic Window
Ref 26 Abstract 2700: ORM-6151: A first-in-class CD33-antibody enabled GSPT1 degrader for AML
Ref 27 Pyrrolobenzodiazepines and conjugates thereof; 2015-04-09.
Ref 28 Introduction to basic information on anti-CD33 targeting next-generation DNA-targeting payload antibody-drug conjugates(Pfizer).
Ref 29 Characterization of the taxol structure-activity profile for the locus of the a-ring side-chain. Bioorg Med Chem Lett. 1994;4(12):1531-1536.
Ref 30 Expression of an anti-CD3 single-chain immunotoxin with a truncated diphtheria toxin in a mutant CHO cell line. Protein Expr Purif. 2000 Jul;19(2):304-11. doi: 10.1006/prep.2000.1255.
Ref 31 Anti-human CD33 BET degrader antibody-drug conjugates