General Information of This Antibody-drug Conjugate (ID: DRG0TJYIW)
ADC Name
BMS-986497
Synonyms
ORM-6151; BMS-986497
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Organization
Orum Therapeutics (Originator) (No Rights);Bristol-Myers Squibb (Top20 MNC)
Drug Status
Phase 1
Drug-to-Antibody Ratio
4
Structure
Antibody Name
OR000283
 Antibody Info 
Antigen Name
Myeloid cell surface antigen CD33 (CD33)
 Antigen Info 
Payload Name
SMol006
 Payload Info 
Payload Target
CRBN×GSPT1
 Target Info 
Linker Name
β-glucuronide linker
 Linker Info 
Conjugate Type
Undisclosed
2027 Update
The disease landscape of This ADC
2027 Update
The clinical trial pipelines of This ADC
Disease Name Phase 1 Phase 2 Phase 3 Approved
Myelodysplastic syndrome
1 Trials
Clinical trial identifier
NCT06419634; EudraCT2024-519537-29; EUCT2024-519537-29-00
Acute myeloid leukaemia
1 Trials
Clinical trial identifier
NCT06419634; EudraCT2024-519537-29; EUCT2024-519537-29-00