Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0KVTZM
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| ADC Name |
CD33-D Antibody-Compound (XL)
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| Synonyms |
CD33-D Antibody Compound (XL)
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| Organization |
Orum Therapeutics, Inc.
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| Drug Status |
Investigative
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| Indication |
In total 1 Indication(s)
Acute myeloid leukaemia [ICD11:2A60]
Investigative
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| Drug-to-Antibody Ratio |
1-2
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| Structure |
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| Antibody Name |
CD33-D Anti-ody
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Antibody Info | ||||
| Antigen Name |
Myeloid cell surface antigen CD33 (CD33)
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Antigen Info | ||||
| Payload Name |
Undisclosed
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| Linker Name |
CD33-D Antibody-Compound (XL) linker
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General Information of The Activity Data Related to This ADC
Discovered Using Cell Line-derived Xenograft Model
| Standard Type | Value | Units | Cell Line | Disease Model |
|---|---|---|---|---|
| Tumor Growth Inhibition value (TGI) |
≈ 38.56
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%
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MV4-11 cells
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Childhood acute monocytic leukemia
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Revealed Based on the Cell Line Data
| Standard Type | Value | Units | Cell Line | Disease Model |
|---|---|---|---|---|
| Half Maximal Inhibitory Concentration (IC50) |
0.27
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nM
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MV4-11 cells
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Childhood acute monocytic leukemia
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Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 38.56% (Day 15) | Positive CD33 expression (CD33+++/++) | ||
| Method Description |
Mice were orthotopically implanted with 1x107 MV411 cells suspended in amixture of Matrigel and culture media in the inguinal fat pad. Following group allocation, mice were treated with a single 10 ml/kg lateral tail vein injection of a CD33-D antibody-Compound (XL) conjugate at 10 mg/kg QWx2.
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| In Vivo Model | MV411 CDX model | ||||
| In Vitro Model | Childhood acute monocytic leukemia | MV4-11 cells | CVCL_0064 | ||
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | 0.27 nM | Positive CD33 expression (CD33+++/++) | ||
| Method Description |
The cells, at a predetermined concentration, were plated into 96 well plates, and, after overnight incubation at 37°C/5% CO2, serial dilutions of each test article (TA) were added to the cells. Cells were incubated with test articles for 72 hours. and viability was detected with CellTiter-Gloreagent.
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| In Vitro Model | Childhood acute monocytic leukemia | MV4-11 cells | CVCL_0064 | ||
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