Antigen ID	TAR0EBTXG
Antigen Name	B-lymphocyte antigen CD19 (CD19)
Gene Name	CD19
Gene ID	930
Synonym	B-lymphocyte surface antigen B4; Differentiation antigen CD19;T-cell surface antigen Leu-12;CD_antigen=CD19
Sequence	MPPPRLLFFLLFLTPMEVRPEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKP FLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGE LFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSL NQSLSQDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVHPKGPKSLLSLELKDDRPARDMW VMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVLWHWLLRTGGWKVSAVTLAYL IFCLCSLVGILHLQRALVLRRKRKRMTDPTRRFFKVTPPPGSGPQNQYGNVLSLPTPTSG LGRAQRWAAGLGGTAPSYGNPSSDVQADGALGSRSPPGVGPEEEEGEGYEEPDSEEDSEF YENDSNLGQDQLSQDGSGYENPEDEPLGPEDEDSFSNAESYENEDEELTQPVARTMDFLS PHGSAWDPSREATSLGSQSYEDMRGILYAAPQLRSIRGQPGPNHEEDADSYENMDNPDGP DPAWGGGGRMGTWSTR     Click to Show/Hide
Function	Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in response to antigen challenges. Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge.     Click to Show/Hide
Uniprot Entry	CD19_HUMAN
HGNC ID	HGNC:1633
KEGG ID	hsa:930

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	AFM-11-2i	Monomethyl auristatin F	Microtubule (MT)	AFM-11-2i linker	[1]
ADC Info	AFM-11-4i	Monomethyl auristatin F	Microtubule (MT)	AFM-11-4i linker	[1]
ADC Info	AFM-11-3i	Monomethyl auristatin F	Microtubule (MT)	AFM-11-3i linker	[1]
ADC Info	AFM-11-6e	Monomethyl auristatin E	Microtubule (MT)	AFM-11-6e linker	[1]
ADC Info	AFM-11-amanitin	Alpha-amanitin	DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)	AFM-11-amanitin linker	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	AFM-12-2i	Monomethyl auristatin F	Microtubule (MT)	AFM-12-2i linker	[1]
ADC Info	AFM-12-4i	Monomethyl auristatin F	Microtubule (MT)	AFM-12-4i linker	[1]
ADC Info	AFM-12-3i	Monomethyl auristatin F	Microtubule (MT)	AFM-12-3i linker	[1]
ADC Info	AFM-12-6e	Monomethyl auristatin E	Microtubule (MT)	AFM-12-6e linker	[1]
ADC Info	AFM-12-amanitin	Alpha-amanitin	DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)	AFM-12-amanitin linker	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	LCB73	PBD dimer	Human deoxyribonucleic acid (hDNA)	β-glucuronide trigger linker
ADC Info	B43-genistein	Genistein	isoflavone tyrosine kinase	Undisclosed

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	ABBV-319	Glucocorticoid receptor modulator	Glucocorticoid receptor (NR3C1)	MP-Ala-Ala

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	B4-SPP-DC44	DC44	Human Deoxyribonucleic acid (hDNA)	N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)	[2]
ADC Info	B4-SMCC-DC4	Phosphate prodrugs 40 (DC4)	Human Deoxyribonucleic acid (hDNA)	Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)	[2]
ADC Info	B4-SPP-DC4	Phosphate prodrugs 40 (DC4)	Human Deoxyribonucleic acid (hDNA)	N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)	[2]
ADC Info	B4-SPP-DC1	DC1	Human Deoxyribonucleic acid (hDNA)	N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)	[2]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	LCB14-0648	Monomethyl auristatin F	Microtubule (MT)	LCB14-0648 linker	[1]
ADC Info	LCB14-0663	Monomethyl auristatin F	Microtubule (MT)	LCB14-0663 linker	[1]
ADC Info	LCB14-0664	Monomethyl auristatin F	Microtubule (MT)	LCB14-0664 linker	[1]
ADC Info	LCB14-6e	Monomethyl auristatin E	Microtubule (MT)	LCB14-6e linker	[1]
ADC Info	LCB14-alpha-amanitin	Alpha-amanitin	DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)	LCB14-alpha-amanitin linker	[1]
ADC Info	WO2017089895A1 ADC67	Monomethyl auristatin F	Microtubule (MT)	WO2017089895A1_ADC67 linker	[3]
ADC Info	WO2017089895A1 ADC68	Monomethyl auristatin E	Microtubule (MT)	WO2017089895A1_ADC68 linker	[3]
ADC Info	WO2017089895A1 ADC69	Monomethyl auristatin F	Microtubule (MT)	WO2017089895A1_ADC69 linker	[3]
ADC Info	WO2017089890A1 ADC67	Monomethyl auristatin F	Microtubule (MT)	WO2017089890A1_ADC67 linker	[4]
ADC Info	WO2017089890A1 ADC68	Monomethyl auristatin E	Microtubule (MT)	WO2017089890A1_ADC68 linker	[4]
ADC Info	WO2017089890A1 ADC69	Monomethyl auristatin F	Microtubule (MT)	WO2017089890A1_ADC69 linker	[4]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	HA19-SN38 antibody-drug conjugate	Active metabolite of irinotecan SN38	DNA topoisomerase 1 (TOP1)	CL2A	[5]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	HBU12-mc-MMAF	Monomethyl auristatin F	Microtubule (MT)	Mc-Val-Cit-PABC	[6]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	CHD37-2i	Monomethyl auristatin F	Microtubule (MT)	cHD37-2i linker	[1]
ADC Info	CHD37-4i	Monomethyl auristatin F	Microtubule (MT)	cHD37-4i linker	[1]
ADC Info	CHD37-3i	Monomethyl auristatin F	Microtubule (MT)	cHD37-3i linker	[1]
ADC Info	CHD37-6e	Monomethyl auristatin E	Microtubule (MT)	cHD37-6e linker	[1]
ADC Info	CHD37-amanitin	Alpha-amanitin	DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)	cHD37-amanitin linker	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Coltuximab ravtansine	DM4	Microtubule (MT)	N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
ADC Info	JP7623413B2 ExampleADC49	Undisclosed	Undisclosed	Undisclosed	[7]
ADC Info	JP7560255B2 ControlADC49	Undisclosed	Undisclosed	Undisclosed	[8]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Denintuzumab mafodotin	MMAF	Microtubule (MT)	Maleimido-caproyl
ADC Info	Denintuzumab-2i	Monomethyl auristatin F	Microtubule (MT)	Denintuzumab-2i linker	[1]
ADC Info	Denintuzumab-4i	Monomethyl auristatin F	Microtubule (MT)	Denintuzumab-4i linker	[1]
ADC Info	Denintuzumab-3i	Monomethyl auristatin F	Microtubule (MT)	Denintuzumab-3i linker	[1]
ADC Info	Denintuzumab-6e	Monomethyl auristatin E	Microtubule (MT)	Denintuzumab-6e linker	[1]
ADC Info	Denintuzumab-amanitin	Alpha-amanitin	DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)	Denintuzumab-amanitin linker	[1]
ADC Info	hBU12-mcMMAF	Monomethyl auristatin F	Microtubule (MT)	Maleimido-caproyl	[9]
ADC Info	hBU12-MC-vc-PABC-MMAE	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[9]
ADC Info	hBU12-MC-vc-PABC-MMAF DAR4	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[9]
ADC Info	hBU12-1 MMAE DAR4	Monomethyl auristatin E	Microtubule (MT)	Phe-Dpr-MA	[9]
ADC Info	hBU12-1 MMAE DAR8	Monomethyl auristatin E	Microtubule (MT)	Phe-Dpr-MA	[9]
ADC Info	hBU12-2 MMAE DAR4	Monomethyl auristatin E	Microtubule (MT)	Phe-Glu-Dpr-MA	[9]
ADC Info	hBU12-2 MMAE DAR8	Monomethyl auristatin E	Microtubule (MT)	Phe-Glu-Dpr-MA	[9]
ADC Info	hBU12-3 MMAE DAR4	Monomethyl auristatin E	Microtubule (MT)	Thr-Dpr-MA	[9]
ADC Info	hBU12-3 MMAE DAR8	Monomethyl auristatin E	Microtubule (MT)	Thr-Dpr-MA	[9]
ADC Info	hBU12-4 MMAE DAR4	Monomethyl auristatin E	Microtubule (MT)	Thr-Glu-Dpr-MA	[9]
ADC Info	hBU12-4 MMAE DAR8	Monomethyl auristatin E	Microtubule (MT)	Thr-Glu-Dpr-MA	[9]
ADC Info	hBU12-5 MMAE DAR4	Monomethyl auristatin E	Microtubule (MT)	Phe-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-5 MMAE DAR8	Monomethyl auristatin E	Microtubule (MT)	Phe-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-6 MMAE DAR4	Monomethyl auristatin E	Microtubule (MT)	Thr-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-6 MMAE DAR8	Monomethyl auristatin E	Microtubule (MT)	Thr-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-7 MMAE DAR4	Monomethyl auristatin E	Microtubule (MT)	Thr-Glu-Lys-MDpr	[9]
ADC Info	hBU12-7 MMAE DAR8	Monomethyl auristatin E	Microtubule (MT)	Thr-Glu-Lys-MDpr	[9]
ADC Info	hBU12-8 MMAE	Monomethyl auristatin E	Microtubule (MT)	Thiazole-Glu-Lys-MDpr	[9]
ADC Info	hBU12-9 MMAE	Monomethyl auristatin E	Microtubule (MT)	Phe-Glu-EDA-MDpr	[9]
ADC Info	hBU12-10 MMAE	Monomethyl auristatin E	Microtubule (MT)	Thr-Glu-EDA-MDpr	[9]
ADC Info	hBU12-11 MMAE	Monomethyl auristatin E	Microtubule (MT)	Phe-Ile-EDA-MDpr	[9]
ADC Info	hBU12-12 MMAE DAR4	Monomethyl auristatin E	Microtubule (MT)	Thr-Ile-EDA-MDpr	[9]
ADC Info	hBU12-13 MMAE DAR4	Monomethyl auristatin E	Microtubule (MT)	Thiazole-Glu-EDA-MDpr	[9]
ADC Info	hBU12-14 MMAE	Monomethyl auristatin E	Microtubule (MT)	Asp-Ala-Lys-MDpr	[9]
ADC Info	hBU12-15 MMAE	Monomethyl auristatin E	Microtubule (MT)	Glu-Ala-Lys-MDpr	[9]
ADC Info	hBU12-16 MMAE	Monomethyl auristatin E	Microtubule (MT)	PhosphoThr-Ala-Lys-MDpr	[9]
ADC Info	hBU12-17 MMAE	Monomethyl auristatin E	Microtubule (MT)	Asn-AlaGlu-Dpr-MDpr	[9]
ADC Info	hBU12-18 MMAE	Monomethyl auristatin E	Microtubule (MT)	Glu-Ala-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-19 MMAE	Monomethyl auristatin E	Microtubule (MT)	Asp-AlaGlu-Dpr-MDpr	[9]
ADC Info	hBU12-20 MMAE	Monomethyl auristatin E	Microtubule (MT)	Glu-Ala-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-21 MMAE	Monomethyl auristatin E	Microtubule (MT)	hSer-Ala-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-22 MMAE	Monomethyl auristatin E	Microtubule (MT)	ValoH-AlaGlu-Dpr-MDpr	[9]
ADC Info	hBU12-23 MMAE	Monomethyl auristatin E	Microtubule (MT)	PhosphoThr-Ala-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-24 MMAE	Monomethyl auristatin E	Microtubule (MT)	Pyrazole-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-25 MMAE	Monomethyl auristatin E	Microtubule (MT)	Triazole-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-26 MMAE	Monomethyl auristatin E	Microtubule (MT)	Asn-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-27 MMAE	Monomethyl auristatin E	Microtubule (MT)	Asp-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-28 MMAE	Monomethyl auristatin E	Microtubule (MT)	Fur-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-29 MMAE	Monomethyl auristatin E	Microtubule (MT)	ValOH-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-30 MMAE	Monomethyl auristatin E	Microtubule (MT)	Ser-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-31 MMAE	Monomethyl auristatin E	Microtubule (MT)	hSer-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-32 MMAE	Monomethyl auristatin E	Microtubule (MT)	Thr-IleLeu-Dpr-MDpr	[9]
ADC Info	hBU12-33 MMAE	Monomethyl auristatin E	Microtubule (MT)	Phe-Ile-Leu-Dpr-MDpr	[9]
ADC Info	hBU12-34 MMAE	Monomethyl auristatin E	Microtubule (MT)	Glu-Phe-Leu-Dpr-MDpr	[9]
ADC Info	hBU12-35 MMAE	Monomethyl auristatin E	Microtubule (MT)	Thr-LeuPhe-Dpr-MDpr	[9]
ADC Info	hBU12-36 MMAE	Monomethyl auristatin E	Microtubule (MT)	Phe-Leu-Phe-Dpr-MDpr	[9]
ADC Info	hBU12-37 MMAE	Monomethyl auristatin E	Microtubule (MT)	Glu-Phe-Phe-Dpr-MDpr	[9]
ADC Info	hBU12-38 MMAE	Monomethyl auristatin E	Microtubule (MT)	Thr-LysAla-Dpr-MDpr	[9]
ADC Info	hBU12-39 MMAE	Monomethyl auristatin E	Microtubule (MT)	Thr-Lys-Dpr-MDpr	[9]
ADC Info	hBU12-1 MMAF	Monomethyl auristatin F	Microtubule (MT)	Phe-Dpr-MA	[9]
ADC Info	hBU12-2 MMAF	Monomethyl auristatin F	Microtubule (MT)	Phe-Glu-Dpr-MA	[9]
ADC Info	hBU12-3 MMAF	Monomethyl auristatin F	Microtubule (MT)	Thr-Dpr-MA	[9]
ADC Info	hBU12-4 MMAF	Monomethyl auristatin F	Microtubule (MT)	Thr-Glu-Dpr-MA	[9]
ADC Info	hBU12-5 MMAF	Monomethyl auristatin F	Microtubule (MT)	Phe-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-6 MMAF	Monomethyl auristatin F	Microtubule (MT)	Thr-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-7 MMAF	Monomethyl auristatin F	Microtubule (MT)	Thr-Glu-Lys-MDpr	[9]
ADC Info	hBU12-8 MMAF	Monomethyl auristatin F	Microtubule (MT)	Thiazole-Glu-Lys-MDpr	[9]
ADC Info	hBU12-9 MMAF	Monomethyl auristatin F	Microtubule (MT)	Phe-Glu-EDA-MDpr	[9]
ADC Info	hBU12-10 MMAF	Monomethyl auristatin F	Microtubule (MT)	Thr-Glu-EDA-MDpr	[9]
ADC Info	hBU12-11 MMAF	Monomethyl auristatin F	Microtubule (MT)	Phe-Ile-EDA-MDpr	[9]
ADC Info	hBU12-12 MMAF	Monomethyl auristatin F	Microtubule (MT)	Thr-Ile-EDA-MDpr	[9]
ADC Info	hBU12-13 MMAF	Monomethyl auristatin F	Microtubule (MT)	Thiazole-Glu-EDA-MDpr	[9]
ADC Info	hBU12-14 MMAF	Monomethyl auristatin F	Microtubule (MT)	Asp-Ala-Lys-MDpr	[9]
ADC Info	hBU12-15 MMAF	Monomethyl auristatin F	Microtubule (MT)	Glu-Ala-Lys-MDpr	[9]
ADC Info	hBU12-16 MMAF	Monomethyl auristatin F	Microtubule (MT)	PhosphoThr-Ala-Lys-MDpr	[9]
ADC Info	hBU12-17 MMAF	Monomethyl auristatin F	Microtubule (MT)	Asn-AlaGlu-Dpr-MDpr	[9]
ADC Info	hBU12-18 MMAF	Monomethyl auristatin F	Microtubule (MT)	Glu-Ala-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-19 MMAF	Monomethyl auristatin F	Microtubule (MT)	Asp-AlaGlu-Dpr-MDpr	[9]
ADC Info	hBU12-20 MMAF	Monomethyl auristatin F	Microtubule (MT)	Glu-Ala-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-21 MMAF	Monomethyl auristatin F	Microtubule (MT)	hSer-Ala-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-22 MMAF	Monomethyl auristatin F	Microtubule (MT)	ValoH-AlaGlu-Dpr-MDpr	[9]
ADC Info	hBU12-23 MMAF	Monomethyl auristatin F	Microtubule (MT)	PhosphoThr-Ala-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-24 MMAF	Monomethyl auristatin F	Microtubule (MT)	Pyrazole-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-25 MMAF	Monomethyl auristatin F	Microtubule (MT)	Triazole-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-26 MMAF	Monomethyl auristatin F	Microtubule (MT)	Asn-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-27 MMAF	Monomethyl auristatin F	Microtubule (MT)	Asp-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-28 MMAF	Monomethyl auristatin F	Microtubule (MT)	Fur-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-29 MMAF	Monomethyl auristatin F	Microtubule (MT)	ValOH-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-30 MMAF	Monomethyl auristatin F	Microtubule (MT)	Ser-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-31 MMAF	Monomethyl auristatin F	Microtubule (MT)	hSer-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-32 MMAF	Monomethyl auristatin F	Microtubule (MT)	Thr-IleLeu-Dpr-MDpr	[9]
ADC Info	hBU12-33 MMAF	Monomethyl auristatin F	Microtubule (MT)	Phe-Ile-Leu-Dpr-MDpr	[9]
ADC Info	hBU12-34 MMAF	Monomethyl auristatin F	Microtubule (MT)	Glu-Phe-Leu-Dpr-MDpr	[9]
ADC Info	hBU12-35 MMAF	Monomethyl auristatin F	Microtubule (MT)	Thr-LeuPhe-Dpr-MDpr	[9]
ADC Info	hBU12-36 MMAF	Monomethyl auristatin F	Microtubule (MT)	Phe-Leu-Phe-Dpr-MDpr	[9]
ADC Info	hBU12-37 MMAF	Monomethyl auristatin F	Microtubule (MT)	Glu-Phe-Phe-Dpr-MDpr	[9]
ADC Info	hBU12-38 MMAF	Monomethyl auristatin F	Microtubule (MT)	Thr-LysAla-Dpr-MDpr	[9]
ADC Info	hBU12-39 MMAF	Monomethyl auristatin F	Microtubule (MT)	Thr-Lys-Dpr-MDpr	[9]
ADC Info	hBU12-MC-vc-PABC-MMAF DAR8	Monomethyl auristatin E	Microtubule (MT)	Mc-Val-Cit-PABC	[9]
ADC Info	hBU12-13 MMAE DAR8	Monomethyl auristatin E	Microtubule (MT)	Thiazole-Glu-EDA-MDpr	[9]
ADC Info	hBU12-12 MMAE DAR8	Monomethyl auristatin E	Microtubule (MT)	Thr-Ile-EDA-MDpr	[9]
ADC Info	hBU12-11 MMAE DAR8	Monomethyl auristatin E	Microtubule (MT)	Phe-Ile-EDA-MDpr	[9]
ADC Info	hBU12-17 MMAE DAR4	Monomethyl auristatin E	Microtubule (MT)	Asn-AlaGlu-Dpr-MDpr	[9]
ADC Info	hBU12-20 MMAE DAR4	Monomethyl auristatin E	Microtubule (MT)	Glu-Ala-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-24 MMAE DAR4	Monomethyl auristatin E	Microtubule (MT)	Pyrazole-Glu-Dpr-MDpr	[9]
ADC Info	hBU12-29 MMAE DAR4	Monomethyl auristatin E	Microtubule (MT)	ValOH-Glu-Dpr-MDpr	[9]
ADC Info	JP7623413B2 ExampleADC50	Undisclosed	Undisclosed	Undisclosed	[7]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Anti-CD19(LC)-G7VIM-2i	Monomethyl auristatin F	Microtubule (MT)	Anti-CD19(LC)-G7VIM-2i linker	[1]
ADC Info	Anti-CD19(LC)-G7VIM-4i	Monomethyl auristatin F	Microtubule (MT)	Anti-CD19(LC)-G7VIM-4i linker	[1]
ADC Info	Anti-CD19(LC)-G7VIM-3i	Monomethyl auristatin F	Microtubule (MT)	Anti-CD19(LC)-G7VIM-3i linker	[1]
ADC Info	Anti-CD19(LC)-G7VIM-6e	Monomethyl auristatin E	Microtubule (MT)	Anti-CD19(LC)-G7VIM-6e linker	[1]
ADC Info	Anti-CD19(LC)-G7VIM-amanitin	Alpha-amanitin	DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)	Anti-CD19(LC)-G7VIM-amanitin linker	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	GBR401-2i	Monomethyl auristatin F	Microtubule (MT)	GBR401-2i linker	[1]
ADC Info	GBR401-4i	Monomethyl auristatin F	Microtubule (MT)	GBR401-4i linker	[1]
ADC Info	GBR401-3i	Monomethyl auristatin F	Microtubule (MT)	GBR401-3i linker	[1]
ADC Info	GBR401-6e	Monomethyl auristatin E	Microtubule (MT)	GBR401-6e linker	[1]
ADC Info	GBR401-amanitin	Alpha-amanitin	DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)	GBR401-amanitin linker	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	TW201803600A ADC-5	PBD	Undisclosed	Undisclosed	[10]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	SGN-CD19B	SGD-1882	Human deoxyribonucleic acid (hDNA)	Mc-Val-Ala

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Inebilizumab-2i	Monomethyl auristatin F	Microtubule (MT)	Inebilizumab-2i linker	[1]
ADC Info	Inebilizumab-4i	Monomethyl auristatin F	Microtubule (MT)	Inebilizumab-4i linker	[1]
ADC Info	Inebilizumab-3i	Monomethyl auristatin F	Microtubule (MT)	Inebilizumab-3i linker	[1]
ADC Info	Inebilizumab-6e	Monomethyl auristatin E	Microtubule (MT)	Inebilizumab-6e linker	[1]
ADC Info	Inebilizumab-amanitin	Alpha-amanitin	DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)	Inebilizumab-amanitin linker	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Loncastuximab tesirine	SG3199 (SC-DR002)	Human deoxyribonucleic acid (hDNA)	Mal-PEG8-Val-Ala-PABC

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	IGAC-88	IG-L-18 Payload	Undisclosed	IG-L-25 linker	[11]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	MDX-1342-2i	Monomethyl auristatin F	Microtubule (MT)	MDX-1342-2i linker	[1]
ADC Info	MDX-1342-4i	Monomethyl auristatin F	Microtubule (MT)	MDX-1342-4i linker	[1]
ADC Info	MDX-1342-3i	Monomethyl auristatin F	Microtubule (MT)	MDX-1342-3i linker	[1]
ADC Info	MDX-1342-6e	Monomethyl auristatin E	Microtubule (MT)	MDX-1342-6e linker	[1]
ADC Info	MDX-1342-amanitin	Alpha-amanitin	DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)	MDX-1342-amanitin linker	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	MDX-1435-2i	Monomethyl auristatin F	Microtubule (MT)	MDX-1435-2i linker	[1]
ADC Info	MDX-1435-4i	Monomethyl auristatin F	Microtubule (MT)	MDX-1435-4i linker	[1]
ADC Info	MDX-1435-3i	Monomethyl auristatin F	Microtubule (MT)	MDX-1435-3i linker	[1]
ADC Info	MDX-1435-6e	Monomethyl auristatin E	Microtubule (MT)	MDX-1435-6e linker	[1]
ADC Info	MDX-1435-amanitin	Alpha-amanitin	DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)	MDX-1435-amanitin linker	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	37788373 ADC1	(R)-Budesonide	Undisclosed	MC-Val-Cit-RG-1	[12]
ADC Info	37788373 ADC2	(R)-Budesonide	Undisclosed	MC-Val-Ala-RG-1	[12]
ADC Info	37788373 ADC3	(R)-Budesonide	Undisclosed	MC-Ala-Ala-RG-1	[12]
ADC Info	37788373 ADC4	(R)-Budesonide	Undisclosed	Mc-Val-Glu-RG-1	[12]
ADC Info	37788373 ADC5	(R)-Budesonide	Undisclosed	MC-Ser-Cit-RG-1	[12]
ADC Info	37788373 ADC6	(R)-Budesonide	Undisclosed	MP-Ala-Ala-RG-1	[12]
ADC Info	37788373 ADC7	(R)-Budesonide	Undisclosed	MP-Asn-Cit-RG-1	[12]
ADC Info	37788373 ADC8	(R)-Budesonide	Undisclosed	MP-Gln-Cit-RG-1	[12]
ADC Info	37788373 ADC9	Triamcinolone acetonide	Undisclosed	MC-Ala-Ala-RG-1	[12]
ADC Info	37788373 ADC10	(S)-Budesonide	Undisclosed	MC-Ala-Ala-RG-1	[12]
ADC Info	37788373 ADC11	(R)-Budesonide	Undisclosed	MC-Ala-Ala-RG-2	[12]
ADC Info	37788373 ADC12	(R)-Budesonide	Undisclosed	MC-Ala-Ala-RG-4	[12]
ADC Info	37788373 ADC13	(R)-Budesonide	Undisclosed	MC-Ala-Ala-RG-6	[12]
ADC Info	37788373 ADC14	(R)-Budesonide	Undisclosed	MC-Val-Cit-RG-7	[12]
ADC Info	37788373 ADC15	(R)-Budesonide	Undisclosed	MC-Val-Ala-RG-8	[12]
ADC Info	37788373 ADC16	(R)-Budesonide	Undisclosed	MC-Val-Ala-RG-9	[12]
ADC Info	37788373 ADC17	(R)-Budesonide	Undisclosed	MC-Val-Cit-RG-10	[12]
ADC Info	37788373 ADC18	(R)-Budesonide	Undisclosed	MC-Val-Cit-RG-11	[12]
ADC Info	37788373 ADC19	(R)-Budesonide	Undisclosed	MC-Val-Ala-RG-12	[12]
ADC Info	37788373 ADC20	(R)-Budesonide	Undisclosed	MC-Val-Ala-RG-13	[12]
ADC Info	37788373 ADC21	(R)-Budesonide	Undisclosed	MC-Val-Ala-RG-14	[12]
ADC Info	37788373 ADC22	(R)-Budesonide	Undisclosed	MC-Val-Ala-RG-15	[12]
ADC Info	37788373 ADC23	(R)-Budesonide	Undisclosed	MP-Ala-Ala-RG-9	[12]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Obexelimab-2i	Monomethyl auristatin F	Microtubule (MT)	Obexelimab-2i linker	[1]
ADC Info	Obexelimab-4i	Monomethyl auristatin F	Microtubule (MT)	Obexelimab-4i linker	[1]
ADC Info	Obexelimab-3i	Monomethyl auristatin F	Microtubule (MT)	Obexelimab-3i linker	[1]
ADC Info	Obexelimab-6e	Monomethyl auristatin E	Microtubule (MT)	Obexelimab-6e linker	[1]
ADC Info	Obexelimab-amanitin	Alpha-amanitin	DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)	Obexelimab-amanitin linker	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	RC58-ADC-1	Dumycin-7	Human Deoxyribonucleic acid (hDNA)	Bis-bromine linker-PEG4-Asn-Ala-ethylenediamine	[13]
ADC Info	RC58-ADC-3	Duostain 3	Undisclosed	Bis-bromine linker-mono-glycine-PEG12-PAB	[13]
ADC Info	RC58-ADC-2	Duostain 3	Undisclosed	Bis-bromine linker-PEG2-VC-PAB	[13]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	Tafasitamab-2i	Monomethyl auristatin F	Microtubule (MT)	Tafasitamab-2i linker	[1]
ADC Info	Tafasitamab-4i	Monomethyl auristatin F	Microtubule (MT)	Tafasitamab-4i linker	[1]
ADC Info	Tafasitamab-3i	Monomethyl auristatin F	Microtubule (MT)	Tafasitamab-3i linker	[1]
ADC Info	Tafasitamab-6e	Monomethyl auristatin E	Microtubule (MT)	Tafasitamab-6e linker	[1]
ADC Info	Tafasitamab-amanitin	Alpha-amanitin	DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)	Tafasitamab-amanitin linker	[1]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	LCB-73	Undisclosed	Undisclosed	Undisclosed	[14]
ADC Info	NI-2201	Undisclosed	Undisclosed	Undisclosed	[15]
ADC Info	TE-1522	Undisclosed	Undisclosed	Undisclosed	[16]
ADC Info	HuB4-DGN462	DGN462	Human Deoxyribonucleic acid (hDNA)	Sulfo-SPDB	[17]
ADC Info	Anti-B4 monoclonal antibody-DC1 conjugate	DC1	Human Deoxyribonucleic acid (hDNA)	Undisclosed	[18]
ADC Info	NV102	Doxorubicin	DNA topoisomerase 2-alpha (TOP2A)	Undisclosed	[19]
ADC Info	CD19-ATAC	HDP 30.2115	DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)	Mal-Val-Ala-PAB	[20]
ADC Info	Anti-CD19 monoclonal antibody-liposomal sodium butyrate conjugate	Sodium butyrate	Histone deacetylase 1 (HDAC1)	Undisclosed	[21]
ADC Info	CO-1008	Undisclosed	Undisclosed	Undisclosed	[22]
ADC Info	B cell High Density Microparticles	Undisclosed	Undisclosed	Undisclosed	[23]

ADC Info	ADC Name	Payload	Target	Linker	Ref
ADC Info	CD19 mAb-TP	Triptolide	Nuclear factor NF-kappa-B p105 subunit (NFKB1)	PEG2000-NHS	[24]
ADC Info	CN119365219A+ADC	Undisclosed	Undisclosed	Mc-Gly-Gly-Phe-Gly	[25]

Ref 1	Compositions and methods related to anti-cd19 antibody drug conjugates; 2017-03-30.
Ref 2	Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82.
Ref 3	Antibody-drug conjugates comprising branched linkers and methods related thereto; 2017-06-01.
Ref 4	Conjugates comprising self-immolative groups and methods related thereto.
Ref 5	Introduction to basic information on ADC drug hA19-SN-38 antibody-drug conjugate - Immunomedics.
Ref 6	A coiled-coil masking domain for selective activation of therapeutic antibodies. Nat Biotechnol. 2019 Jul;37(7):761-765. doi: 10.1038/s41587-019-0135-x. Epub 2019 May 27.
Ref 7	Antibody-drug complexes containing hemiasterlin derivatives
Ref 8	Pharmaceuticals containing antibody-drug complexes containing hemiasterin derivatives
Ref 9	Hydrophilic antibody-drug conjugates; 2015-08-20.
Ref 10	Antibody-drug conjugates mainly based on PBD and combinations with FLT3 inhibitors
Ref 11	Isoindolinone-glutarimide antibody conjugates, and uses thereof
Ref 12	Self-Immolative Carbamate Linkers for CD19-Budesonide Antibody-Drug Conjugates
Ref 13	Development of novel anti-CD19 antibody-drug conjugates for B-cell lymphoma treatment. Int Immunopharmacol. 2018 Sep;62:299-308. doi: 10.1016/j.intimp.2018.06.034. Epub 2018 Jul 23.
Ref 14	LegoChem Biosciences and Iksuda enter Licensing Agreement for Antibody Drug Conjugate program; 27 Jan 2021.
Ref 15	Lightchain biosciences biotechnology company product pipeline
Ref 16	Introduction to basic information on ADC drug TE-1522.
Ref 17	The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models. Haematologica. 2019 Aug;104(8):1633-1639. doi: 10.3324/haematol.2018.211011. Epub 2019 Feb 7.
Ref 18	Introduction to basic information on anti-B4 monoclonal antibody-DC1 conjugate (Anti-B4-DC1).
Ref 19	ADC review: basic information about NV102 (Doxorubicin-Anti-CD19).
Ref 20	CD19 - a potential target for Amanitin-based ADCs. Cancer Res (2017) 77 (13_Supplement): 62.
Ref 21	Effect of liposomes containing sodium butyrate conjugated with anti-CD19 monoclonal antibody on in vitro and in vivo growth of malignant lymphoma. Cancer Res. 1990 Jun 1;50(11):3245-8.
Ref 22	Progression towards the clinic by 2025 with a strategy for rapid FIH data acquisition.
Ref 23	Effective purging of autologous hematopoietic stem cells using anti-B-cell monoclonal antibody-coated high-density microparticles prior to high-dose therapy for patients with non-Hodgkin's lymphoma. Biol Blood Marrow Transplant. 2002;8(8):429-34. doi: 10.1053/bbmt.2002.v8.pm12234168.
Ref 24	A rationally designed CD19 monoclonal antibody-triptolide conjugate for the treatment of systemic lupus erythematosus
Ref 25	Anti-CD19 antibody-drug conjugates