Antigen Information

General Information of This Antigen (ID: TAR0EBTXG)
Antigen Name
B-lymphocyte antigen CD19 (CD19)
Gene Name
CD19
Gene ID
930
Synonym
B-lymphocyte surface antigen B4; Differentiation antigen CD19;T-cell surface antigen Leu-12;CD19
Sequence
MPPPRLLFFLLFLTPMEVRPEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKP
FLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGE
LFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSL
NQSLSQDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVHPKGPKSLLSLELKDDRPARDMW
VMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVLWHWLLRTGGWKVSAVTLAYL
IFCLCSLVGILHLQRALVLRRKRKRMTDPTRRFFKVTPPPGSGPQNQYGNVLSLPTPTSG
LGRAQRWAAGLGGTAPSYGNPSSDVQADGALGSRSPPGVGPEEEEGEGYEEPDSEEDSEF
YENDSNLGQDQLSQDGSGYENPEDEPLGPEDEDSFSNAESYENEDEELTQPVARTMDFLS
PHGSAWDPSREATSLGSQSYEDMRGILYAAPQLRSIRGQPGPNHEEDADSYENMDNPDGP
DPAWGGGGRMGTWSTR

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Function
Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens. Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores. Is not required for early steps during B cell differentiation in the blood marrow. Required for normal differentiation of B-1 cells. Required for normal B cell differentiation and proliferation in response to antigen challenges. Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge.

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Uniprot Entry
CD19_HUMAN
HGNC ID
HGNC:1633
KEGG ID
hsa:930
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
AFM-11-2i [1]
Monomethyl auristatin F
Microtubule (MT)
AFM-11-2i linker
 ADC Info 
AFM-11-4i [1]
Monomethyl auristatin F
Microtubule (MT)
AFM-11-4i linker
 ADC Info 
AFM-11-3i [1]
Monomethyl auristatin F
Microtubule (MT)
AFM-11-3i linker
 ADC Info 
AFM-11-6e [1]
Monomethyl auristatin E
Microtubule (MT)
AFM-11-6e linker
 ADC Info 
AFM-11-amanitin [1]
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
AFM-11-amanitin linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
AFM-12-2i [1]
Monomethyl auristatin F
Microtubule (MT)
AFM-12-2i linker
 ADC Info 
AFM-12-4i [1]
Monomethyl auristatin F
Microtubule (MT)
AFM-12-4i linker
 ADC Info 
AFM-12-3i [1]
Monomethyl auristatin F
Microtubule (MT)
AFM-12-3i linker
 ADC Info 
AFM-12-6e [1]
Monomethyl auristatin E
Microtubule (MT)
AFM-12-6e linker
 ADC Info 
AFM-12-amanitin [1]
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
AFM-12-amanitin linker
 ADC Info 
Anti-CD19 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
LCB73
PBD dimer
Human deoxyribonucleic acid (hDNA)
β-glucuronide trigger linker
 ADC Info 
B43-genistein
Genistein
isoflavone tyrosine kinase
Undisclosed
 ADC Info 
Anti-CD19 IgG1 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ABBV-319
Glucocorticoid receptor modulator
Glucocorticoid receptor (NR3C1)
MP-Ala-Ala
 ADC Info 
Anti-CD19 mAb B4
 Antibody Info 
ADC Name Payload Target Linker ADC Info
B4-SPP-DC44 [2]
DC44
Human Deoxyribonucleic acid (hDNA)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
B4-SMCC-DC4 [2]
Phosphate prodrugs 40 (DC4)
Human Deoxyribonucleic acid (hDNA)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
B4-SPP-DC4 [2]
Phosphate prodrugs 40 (DC4)
Human Deoxyribonucleic acid (hDNA)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
B4-SPP-DC1 [2]
DC1
Human Deoxyribonucleic acid (hDNA)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
Anti-CD19 mAb DI-B4
 Antibody Info 
ADC Name Payload Target Linker ADC Info
LCB14-0648 [1]
Monomethyl auristatin F
Microtubule (MT)
LCB14-0648 linker
 ADC Info 
LCB14-0663 [1]
Monomethyl auristatin F
Microtubule (MT)
LCB14-0663 linker
 ADC Info 
LCB14-0664 [1]
Monomethyl auristatin F
Microtubule (MT)
LCB14-0664 linker
 ADC Info 
LCB14-6e [1]
Monomethyl auristatin E
Microtubule (MT)
LCB14-6e linker
 ADC Info 
LCB14-alpha-amanitin [1]
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
LCB14-alpha-amanitin linker
 ADC Info 
WO2017089895A1 ADC67 [3]
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC67 linker
 ADC Info 
WO2017089895A1 ADC68 [3]
Monomethyl auristatin E
Microtubule (MT)
WO2017089895A1_ADC68 linker
 ADC Info 
WO2017089895A1 ADC69 [3]
Monomethyl auristatin F
Microtubule (MT)
WO2017089895A1_ADC69 linker
 ADC Info 
WO2017089890A1 ADC67 [4]
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC67 linker
 ADC Info 
WO2017089890A1 ADC68 [4]
Monomethyl auristatin E
Microtubule (MT)
WO2017089890A1_ADC68 linker
 ADC Info 
WO2017089890A1 ADC69 [4]
Monomethyl auristatin F
Microtubule (MT)
WO2017089890A1_ADC69 linker
 ADC Info 
Anti-CD19 mAb hA19
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HA19-SN38 antibody-drug conjugate [5]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 ADC Info 
Anti-CD19 mAb hBU12
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HBU12-mc-MMAF [6]
Monomethyl auristatin F
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
CHD37-2i [1]
Monomethyl auristatin F
Microtubule (MT)
cHD37-2i linker
 ADC Info 
CHD37-4i [1]
Monomethyl auristatin F
Microtubule (MT)
cHD37-4i linker
 ADC Info 
CHD37-3i [1]
Monomethyl auristatin F
Microtubule (MT)
cHD37-3i linker
 ADC Info 
CHD37-6e [1]
Monomethyl auristatin E
Microtubule (MT)
cHD37-6e linker
 ADC Info 
CHD37-amanitin [1]
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
cHD37-amanitin linker
 ADC Info 
Coltuximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Coltuximab ravtansine
DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
JP7623413B2 ExampleADC49 [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
JP7560255B2 ControlADC49 [8]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Denintuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Denintuzumab mafodotin
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Denintuzumab-2i [1]
Monomethyl auristatin F
Microtubule (MT)
Denintuzumab-2i linker
 ADC Info 
Denintuzumab-4i [1]
Monomethyl auristatin F
Microtubule (MT)
Denintuzumab-4i linker
 ADC Info 
Denintuzumab-3i [1]
Monomethyl auristatin F
Microtubule (MT)
Denintuzumab-3i linker
 ADC Info 
Denintuzumab-6e [1]
Monomethyl auristatin E
Microtubule (MT)
Denintuzumab-6e linker
 ADC Info 
Denintuzumab-amanitin [1]
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Denintuzumab-amanitin linker
 ADC Info 
hBU12-mcMMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
hBU12-MC-vc-PABC-MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
hBU12-MC-vc-PABC-MMAF DAR4 [9]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
hBU12-1 MMAE DAR4 [9]
Monomethyl auristatin E
Microtubule (MT)
Phe-Dpr-MA
 ADC Info 
hBU12-1 MMAE DAR8 [9]
Monomethyl auristatin E
Microtubule (MT)
Phe-Dpr-MA
 ADC Info 
hBU12-2 MMAE DAR4 [9]
Monomethyl auristatin E
Microtubule (MT)
Phe-Glu-Dpr-MA
 ADC Info 
hBU12-2 MMAE DAR8 [9]
Monomethyl auristatin E
Microtubule (MT)
Phe-Glu-Dpr-MA
 ADC Info 
hBU12-3 MMAE DAR4 [9]
Monomethyl auristatin E
Microtubule (MT)
Thr-Dpr-MA
 ADC Info 
hBU12-3 MMAE DAR8 [9]
Monomethyl auristatin E
Microtubule (MT)
Thr-Dpr-MA
 ADC Info 
hBU12-4 MMAE DAR4 [9]
Monomethyl auristatin E
Microtubule (MT)
Thr-Glu-Dpr-MA
 ADC Info 
hBU12-4 MMAE DAR8 [9]
Monomethyl auristatin E
Microtubule (MT)
Thr-Glu-Dpr-MA
 ADC Info 
hBU12-5 MMAE DAR4 [9]
Monomethyl auristatin E
Microtubule (MT)
Phe-Glu-Dpr-MDpr
 ADC Info 
hBU12-5 MMAE DAR8 [9]
Monomethyl auristatin E
Microtubule (MT)
Phe-Glu-Dpr-MDpr
 ADC Info 
hBU12-6 MMAE DAR4 [9]
Monomethyl auristatin E
Microtubule (MT)
Thr-Glu-Dpr-MDpr
 ADC Info 
hBU12-6 MMAE DAR8 [9]
Monomethyl auristatin E
Microtubule (MT)
Thr-Glu-Dpr-MDpr
 ADC Info 
hBU12-7 MMAE DAR4 [9]
Monomethyl auristatin E
Microtubule (MT)
Thr-Glu-Lys-MDpr
 ADC Info 
hBU12-7 MMAE DAR8 [9]
Monomethyl auristatin E
Microtubule (MT)
Thr-Glu-Lys-MDpr
 ADC Info 
hBU12-8 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Thiazole-Glu-Lys-MDpr
 ADC Info 
hBU12-9 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Phe-Glu-EDA-MDpr
 ADC Info 
hBU12-10 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Thr-Glu-EDA-MDpr
 ADC Info 
hBU12-11 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Phe-Ile-EDA-MDpr
 ADC Info 
hBU12-12 MMAE DAR4 [9]
Monomethyl auristatin E
Microtubule (MT)
Thr-Ile-EDA-MDpr
 ADC Info 
hBU12-13 MMAE DAR4 [9]
Monomethyl auristatin E
Microtubule (MT)
Thiazole-Glu-EDA-MDpr
 ADC Info 
hBU12-14 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Asp-Ala-Lys-MDpr
 ADC Info 
hBU12-15 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Glu-Ala-Lys-MDpr
 ADC Info 
hBU12-16 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
PhosphoThr-Ala-Lys-MDpr
 ADC Info 
hBU12-17 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Asn-AlaGlu-Dpr-MDpr
 ADC Info 
hBU12-18 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Glu-Ala-Glu-Dpr-MDpr
 ADC Info 
hBU12-19 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Asp-AlaGlu-Dpr-MDpr
 ADC Info 
hBU12-20 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Glu-Ala-Glu-Dpr-MDpr
 ADC Info 
hBU12-21 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
hSer-Ala-Glu-Dpr-MDpr
 ADC Info 
hBU12-22 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
ValoH-AlaGlu-Dpr-MDpr
 ADC Info 
hBU12-23 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
PhosphoThr-Ala-Glu-Dpr-MDpr
 ADC Info 
hBU12-24 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Pyrazole-Glu-Dpr-MDpr
 ADC Info 
hBU12-25 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Triazole-Glu-Dpr-MDpr
 ADC Info 
hBU12-26 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Asn-Glu-Dpr-MDpr
 ADC Info 
hBU12-27 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Asp-Glu-Dpr-MDpr
 ADC Info 
hBU12-28 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Fur-Glu-Dpr-MDpr
 ADC Info 
hBU12-29 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
ValOH-Glu-Dpr-MDpr
 ADC Info 
hBU12-30 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Ser-Glu-Dpr-MDpr
 ADC Info 
hBU12-31 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
hSer-Glu-Dpr-MDpr
 ADC Info 
hBU12-32 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Thr-IleLeu-Dpr-MDpr
 ADC Info 
hBU12-33 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Phe-Ile-Leu-Dpr-MDpr
 ADC Info 
hBU12-34 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Glu-Phe-Leu-Dpr-MDpr
 ADC Info 
hBU12-35 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Thr-LeuPhe-Dpr-MDpr
 ADC Info 
hBU12-36 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Phe-Leu-Phe-Dpr-MDpr
 ADC Info 
hBU12-37 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Glu-Phe-Phe-Dpr-MDpr
 ADC Info 
hBU12-38 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Thr-LysAla-Dpr-MDpr
 ADC Info 
hBU12-39 MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Thr-Lys-Dpr-MDpr
 ADC Info 
hBU12-1 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Phe-Dpr-MA
 ADC Info 
hBU12-2 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Phe-Glu-Dpr-MA
 ADC Info 
hBU12-3 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Thr-Dpr-MA
 ADC Info 
hBU12-4 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Thr-Glu-Dpr-MA
 ADC Info 
hBU12-5 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Phe-Glu-Dpr-MDpr
 ADC Info 
hBU12-6 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Thr-Glu-Dpr-MDpr
 ADC Info 
hBU12-7 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Thr-Glu-Lys-MDpr
 ADC Info 
hBU12-8 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Thiazole-Glu-Lys-MDpr
 ADC Info 
hBU12-9 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Phe-Glu-EDA-MDpr
 ADC Info 
hBU12-10 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Thr-Glu-EDA-MDpr
 ADC Info 
hBU12-11 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Phe-Ile-EDA-MDpr
 ADC Info 
hBU12-12 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Thr-Ile-EDA-MDpr
 ADC Info 
hBU12-13 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Thiazole-Glu-EDA-MDpr
 ADC Info 
hBU12-14 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Asp-Ala-Lys-MDpr
 ADC Info 
hBU12-15 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Glu-Ala-Lys-MDpr
 ADC Info 
hBU12-16 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
PhosphoThr-Ala-Lys-MDpr
 ADC Info 
hBU12-17 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Asn-AlaGlu-Dpr-MDpr
 ADC Info 
hBU12-18 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Glu-Ala-Glu-Dpr-MDpr
 ADC Info 
hBU12-19 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Asp-AlaGlu-Dpr-MDpr
 ADC Info 
hBU12-20 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Glu-Ala-Glu-Dpr-MDpr
 ADC Info 
hBU12-21 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
hSer-Ala-Glu-Dpr-MDpr
 ADC Info 
hBU12-22 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
ValoH-AlaGlu-Dpr-MDpr
 ADC Info 
hBU12-23 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
PhosphoThr-Ala-Glu-Dpr-MDpr
 ADC Info 
hBU12-24 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Pyrazole-Glu-Dpr-MDpr
 ADC Info 
hBU12-25 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Triazole-Glu-Dpr-MDpr
 ADC Info 
hBU12-26 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Asn-Glu-Dpr-MDpr
 ADC Info 
hBU12-27 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Asp-Glu-Dpr-MDpr
 ADC Info 
hBU12-28 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Fur-Glu-Dpr-MDpr
 ADC Info 
hBU12-29 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
ValOH-Glu-Dpr-MDpr
 ADC Info 
hBU12-30 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Ser-Glu-Dpr-MDpr
 ADC Info 
hBU12-31 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
hSer-Glu-Dpr-MDpr
 ADC Info 
hBU12-32 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Thr-IleLeu-Dpr-MDpr
 ADC Info 
hBU12-33 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Phe-Ile-Leu-Dpr-MDpr
 ADC Info 
hBU12-34 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Glu-Phe-Leu-Dpr-MDpr
 ADC Info 
hBU12-35 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Thr-LeuPhe-Dpr-MDpr
 ADC Info 
hBU12-36 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Phe-Leu-Phe-Dpr-MDpr
 ADC Info 
hBU12-37 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Glu-Phe-Phe-Dpr-MDpr
 ADC Info 
hBU12-38 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Thr-LysAla-Dpr-MDpr
 ADC Info 
hBU12-39 MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Thr-Lys-Dpr-MDpr
 ADC Info 
hBU12-MC-vc-PABC-MMAF DAR8 [9]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
hBU12-13 MMAE DAR8 [9]
Monomethyl auristatin E
Microtubule (MT)
Thiazole-Glu-EDA-MDpr
 ADC Info 
hBU12-12 MMAE DAR8 [9]
Monomethyl auristatin E
Microtubule (MT)
Thr-Ile-EDA-MDpr
 ADC Info 
hBU12-11 MMAE DAR8 [9]
Monomethyl auristatin E
Microtubule (MT)
Phe-Ile-EDA-MDpr
 ADC Info 
hBU12-17 MMAE DAR4 [9]
Monomethyl auristatin E
Microtubule (MT)
Asn-AlaGlu-Dpr-MDpr
 ADC Info 
hBU12-20 MMAE DAR4 [9]
Monomethyl auristatin E
Microtubule (MT)
Glu-Ala-Glu-Dpr-MDpr
 ADC Info 
hBU12-24 MMAE DAR4 [9]
Monomethyl auristatin E
Microtubule (MT)
Pyrazole-Glu-Dpr-MDpr
 ADC Info 
hBU12-29 MMAE DAR4 [9]
Monomethyl auristatin E
Microtubule (MT)
ValOH-Glu-Dpr-MDpr
 ADC Info 
JP7623413B2 ExampleADC50 [7]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
DI-B4-(LC)-GGGGGGG-CVIM
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-CD19(LC)-G7VIM-2i [1]
Monomethyl auristatin F
Microtubule (MT)
Anti-CD19(LC)-G7VIM-2i linker
 ADC Info 
Anti-CD19(LC)-G7VIM-4i [1]
Monomethyl auristatin F
Microtubule (MT)
Anti-CD19(LC)-G7VIM-4i linker
 ADC Info 
Anti-CD19(LC)-G7VIM-3i [1]
Monomethyl auristatin F
Microtubule (MT)
Anti-CD19(LC)-G7VIM-3i linker
 ADC Info 
Anti-CD19(LC)-G7VIM-6e [1]
Monomethyl auristatin E
Microtubule (MT)
Anti-CD19(LC)-G7VIM-6e linker
 ADC Info 
Anti-CD19(LC)-G7VIM-amanitin [1]
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Anti-CD19(LC)-G7VIM-amanitin linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
GBR401-2i [1]
Monomethyl auristatin F
Microtubule (MT)
GBR401-2i linker
 ADC Info 
GBR401-4i [1]
Monomethyl auristatin F
Microtubule (MT)
GBR401-4i linker
 ADC Info 
GBR401-3i [1]
Monomethyl auristatin F
Microtubule (MT)
GBR401-3i linker
 ADC Info 
GBR401-6e [1]
Monomethyl auristatin E
Microtubule (MT)
GBR401-6e linker
 ADC Info 
GBR401-amanitin [1]
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
GBR401-amanitin linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
TW201803600A ADC-5 [10]
PBD
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
SGN-CD19B
SGD-1882
Human deoxyribonucleic acid (hDNA)
Mc-Val-Ala
 ADC Info 
Inebilizumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Inebilizumab-2i [1]
Monomethyl auristatin F
Microtubule (MT)
Inebilizumab-2i linker
 ADC Info 
Inebilizumab-4i [1]
Monomethyl auristatin F
Microtubule (MT)
Inebilizumab-4i linker
 ADC Info 
Inebilizumab-3i [1]
Monomethyl auristatin F
Microtubule (MT)
Inebilizumab-3i linker
 ADC Info 
Inebilizumab-6e [1]
Monomethyl auristatin E
Microtubule (MT)
Inebilizumab-6e linker
 ADC Info 
Inebilizumab-amanitin [1]
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Inebilizumab-amanitin linker
 ADC Info 
Loncastuximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Loncastuximab tesirine
SG3199 (SC-DR002)
Human deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
 ADC Info 
loncastuximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
IGAC-88 [11]
IG-L-18 Payload
Undisclosed
IG-L-25 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
MDX-1342-2i [1]
Monomethyl auristatin F
Microtubule (MT)
MDX-1342-2i linker
 ADC Info 
MDX-1342-4i [1]
Monomethyl auristatin F
Microtubule (MT)
MDX-1342-4i linker
 ADC Info 
MDX-1342-3i [1]
Monomethyl auristatin F
Microtubule (MT)
MDX-1342-3i linker
 ADC Info 
MDX-1342-6e [1]
Monomethyl auristatin E
Microtubule (MT)
MDX-1342-6e linker
 ADC Info 
MDX-1342-amanitin [1]
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
MDX-1342-amanitin linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
MDX-1435-2i [1]
Monomethyl auristatin F
Microtubule (MT)
MDX-1435-2i linker
 ADC Info 
MDX-1435-4i [1]
Monomethyl auristatin F
Microtubule (MT)
MDX-1435-4i linker
 ADC Info 
MDX-1435-3i [1]
Monomethyl auristatin F
Microtubule (MT)
MDX-1435-3i linker
 ADC Info 
MDX-1435-6e [1]
Monomethyl auristatin E
Microtubule (MT)
MDX-1435-6e linker
 ADC Info 
MDX-1435-amanitin [1]
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
MDX-1435-amanitin linker
 ADC Info 
Mouse CD19 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
37788373 ADC1 [12]
(R)-Budesonide
Undisclosed
MC-Val-Cit-RG-1
 ADC Info 
37788373 ADC2 [12]
(R)-Budesonide
Undisclosed
MC-Val-Ala-RG-1
 ADC Info 
37788373 ADC3 [12]
(R)-Budesonide
Undisclosed
MC-Ala-Ala-RG-1
 ADC Info 
37788373 ADC4 [12]
(R)-Budesonide
Undisclosed
Mc-Val-Glu-RG-1
 ADC Info 
37788373 ADC5 [12]
(R)-Budesonide
Undisclosed
MC-Ser-Cit-RG-1
 ADC Info 
37788373 ADC6 [12]
(R)-Budesonide
Undisclosed
MP-Ala-Ala-RG-1
 ADC Info 
37788373 ADC7 [12]
(R)-Budesonide
Undisclosed
MP-Asn-Cit-RG-1
 ADC Info 
37788373 ADC8 [12]
(R)-Budesonide
Undisclosed
MP-Gln-Cit-RG-1
 ADC Info 
37788373 ADC9 [12]
Triamcinolone acetonide
Undisclosed
MC-Ala-Ala-RG-1
 ADC Info 
37788373 ADC10 [12]
(S)-Budesonide
Undisclosed
MC-Ala-Ala-RG-1
 ADC Info 
37788373 ADC11 [12]
(R)-Budesonide
Undisclosed
MC-Ala-Ala-RG-2
 ADC Info 
37788373 ADC12 [12]
(R)-Budesonide
Undisclosed
MC-Ala-Ala-RG-4
 ADC Info 
37788373 ADC13 [12]
(R)-Budesonide
Undisclosed
MC-Ala-Ala-RG-6
 ADC Info 
37788373 ADC14 [12]
(R)-Budesonide
Undisclosed
MC-Val-Cit-RG-7
 ADC Info 
37788373 ADC15 [12]
(R)-Budesonide
Undisclosed
MC-Val-Ala-RG-8
 ADC Info 
37788373 ADC16 [12]
(R)-Budesonide
Undisclosed
MC-Val-Ala-RG-9
 ADC Info 
37788373 ADC17 [12]
(R)-Budesonide
Undisclosed
MC-Val-Cit-RG-10
 ADC Info 
37788373 ADC18 [12]
(R)-Budesonide
Undisclosed
MC-Val-Cit-RG-11
 ADC Info 
37788373 ADC19 [12]
(R)-Budesonide
Undisclosed
MC-Val-Ala-RG-12
 ADC Info 
37788373 ADC20 [12]
(R)-Budesonide
Undisclosed
MC-Val-Ala-RG-13
 ADC Info 
37788373 ADC21 [12]
(R)-Budesonide
Undisclosed
MC-Val-Ala-RG-14
 ADC Info 
37788373 ADC22 [12]
(R)-Budesonide
Undisclosed
MC-Val-Ala-RG-15
 ADC Info 
37788373 ADC23 [12]
(R)-Budesonide
Undisclosed
MP-Ala-Ala-RG-9
 ADC Info 
Obexelimab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Obexelimab-2i [1]
Monomethyl auristatin F
Microtubule (MT)
Obexelimab-2i linker
 ADC Info 
Obexelimab-4i [1]
Monomethyl auristatin F
Microtubule (MT)
Obexelimab-4i linker
 ADC Info 
Obexelimab-3i [1]
Monomethyl auristatin F
Microtubule (MT)
Obexelimab-3i linker
 ADC Info 
Obexelimab-6e [1]
Monomethyl auristatin E
Microtubule (MT)
Obexelimab-6e linker
 ADC Info 
Obexelimab-amanitin [1]
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Obexelimab-amanitin linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
RC58-ADC-1 [13]
Dumycin-7
Human Deoxyribonucleic acid (hDNA)
Bis-bromine linker-PEG4-Asn-Ala-ethylenediamine
 ADC Info 
RC58-ADC-3 [13]
Duostain 3
Undisclosed
Bis-bromine linker-mono-glycine-PEG12-PAB
 ADC Info 
RC58-ADC-2 [13]
Duostain 3
Undisclosed
Bis-bromine linker-PEG2-VC-PAB
 ADC Info 
Tafasitamab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Tafasitamab-2i [1]
Monomethyl auristatin F
Microtubule (MT)
Tafasitamab-2i linker
 ADC Info 
Tafasitamab-4i [1]
Monomethyl auristatin F
Microtubule (MT)
Tafasitamab-4i linker
 ADC Info 
Tafasitamab-3i [1]
Monomethyl auristatin F
Microtubule (MT)
Tafasitamab-3i linker
 ADC Info 
Tafasitamab-6e [1]
Monomethyl auristatin E
Microtubule (MT)
Tafasitamab-6e linker
 ADC Info 
Tafasitamab-amanitin [1]
Alpha-amanitin
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Tafasitamab-amanitin linker
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
LCB-73 [14]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
NI-2201 [15]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
TE-1522 [16]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
HuB4-DGN462 [17]
DGN462
Human Deoxyribonucleic acid (hDNA)
Sulfo-SPDB
 ADC Info 
Anti-B4 monoclonal antibody-DC1 conjugate [18]
DC1
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 ADC Info 
NV102 [19]
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
 ADC Info 
CD19-ATAC [20]
HDP 30.2115
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Mal-Val-Ala-PAB
 ADC Info 
Anti-CD19 monoclonal antibody-liposomal sodium butyrate conjugate [21]
Sodium butyrate
Histone deacetylase 1 (HDAC1)
Undisclosed
 ADC Info 
CO-1008 [22]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
B cell High Density Microparticles [23]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD19 mAb-TP [24]
Triptolide
Nuclear factor NF-kappa-B p105 subunit (NFKB1)
PEG2000-NHS
 ADC Info 
CN119365219A+ADC [25]
Undisclosed
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
References
Ref 1 Compositions and methods related to anti-cd19 antibody drug conjugates; 2017-03-30.
Ref 2 Synthesis and biological evaluation of antibody conjugates of phosphate prodrugs of cytotoxic DNA alkylators for the targeted treatment of cancer. J Med Chem. 2012 Jan 26;55(2):766-82.
Ref 3 Antibody-drug conjugates comprising branched linkers and methods related thereto; 2017-06-01.
Ref 4 Conjugates comprising self-immolative groups and methods related thereto.
Ref 5 Introduction to basic information on ADC drug hA19-SN-38 antibody-drug conjugate - Immunomedics.
Ref 6 A coiled-coil masking domain for selective activation of therapeutic antibodies. Nat Biotechnol. 2019 Jul;37(7):761-765. doi: 10.1038/s41587-019-0135-x. Epub 2019 May 27.
Ref 7 Antibody-drug complexes containing hemiasterlin derivatives
Ref 8 Pharmaceuticals containing antibody-drug complexes containing hemiasterin derivatives
Ref 9 Hydrophilic antibody-drug conjugates; 2015-08-20.
Ref 10 Antibody-drug conjugates mainly based on PBD and combinations with FLT3 inhibitors
Ref 11 Isoindolinone-glutarimide antibody conjugates, and uses thereof
Ref 12 Self-Immolative Carbamate Linkers for CD19-Budesonide Antibody-Drug Conjugates
Ref 13 Development of novel anti-CD19 antibody-drug conjugates for B-cell lymphoma treatment. Int Immunopharmacol. 2018 Sep;62:299-308. doi: 10.1016/j.intimp.2018.06.034. Epub 2018 Jul 23.
Ref 14 LegoChem Biosciences and Iksuda enter Licensing Agreement for Antibody Drug Conjugate program; 27 Jan 2021.
Ref 15 Lightchain biosciences biotechnology company product pipeline
Ref 16 Introduction to basic information on ADC drug TE-1522.
Ref 17 The novel CD19-targeting antibody-drug conjugate huB4-DGN462 shows improved anti-tumor activity compared to SAR3419 in CD19-positive lymphoma and leukemia models. Haematologica. 2019 Aug;104(8):1633-1639. doi: 10.3324/haematol.2018.211011. Epub 2019 Feb 7.
Ref 18 Introduction to basic information on anti-B4 monoclonal antibody-DC1 conjugate (Anti-B4-DC1).
Ref 19 ADC review: basic information about NV102 (Doxorubicin-Anti-CD19).
Ref 20 CD19 - a potential target for Amanitin-based ADCs. Cancer Res (2017) 77 (13_Supplement): 62.
Ref 21 Effect of liposomes containing sodium butyrate conjugated with anti-CD19 monoclonal antibody on in vitro and in vivo growth of malignant lymphoma. Cancer Res. 1990 Jun 1;50(11):3245-8.
Ref 22 Progression towards the clinic by 2025 with a strategy for rapid FIH data acquisition.
Ref 23 Effective purging of autologous hematopoietic stem cells using anti-B-cell monoclonal antibody-coated high-density microparticles prior to high-dose therapy for patients with non-Hodgkin's lymphoma. Biol Blood Marrow Transplant. 2002;8(8):429-34. doi: 10.1053/bbmt.2002.v8.pm12234168.
Ref 24 A rationally designed CD19 monoclonal antibody-triptolide conjugate for the treatment of systemic lupus erythematosus
Ref 25 Anti-CD19 antibody-drug conjugates