Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0CMIBA
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| ADC Name |
MDX-1342-amanitin
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| Synonyms |
MDX-1342 amanitin
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| Organization |
LegoChem Biosciences, Inc.
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| Drug Status |
Investigative
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| Indication |
In total 1 Indication(s)
Burkitt lymphoma [ICD11:2A85]
Investigative
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| Drug-to-Antibody Ratio |
2
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| Antibody Name |
MDX-1342
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Antibody Info | ||||
| Antigen Name |
B-lymphocyte antigen CD19 (CD19)
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Antigen Info | ||||
| Payload Name |
Alpha-amanitin
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Payload Info | ||||
| Therapeutic Target |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
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Target Info | ||||
| Linker Name |
MDX-1342-amanitin linker
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| Conjugate Type |
Site-specific conjugation through the CaaX sequence at the C-terminal.
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