Antibody Information
General Information of This Antibody
| Antibody ID | ANI0ZAZLK |
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| Antibody Name | Obexelimab |
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| Organization | Xencor, Inc.; Zenas Biopharma Usa LLC |
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| Indication | Systemic lupus erythematosus; Rheumatoid arthritis; Autoimmune diseases; IgG4-related disease |
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| Synonyms |
XmAb-5871; XmAb5871; XMAB5871; OBEXELIMAB
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Chimeric IgG1-kappa |
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| Antigen Name | B-lymphocyte antigen CD19 (CD19) |
Antigen Info | ||||
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| Heavy Chain Varible Domain |
EVQLVESGGGLVKPGGSLKLSCAASGYTFTSYVMHWVRQAPGKGLEWIGYINPYNDGTKY
NEKFQGRVTISSDKSISTAYMELSSLRSEDTAMYYCARGTYYYGTRVFDYWGQGTLVTVS S Click to Show/Hide
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| Heavy Chain Constant Domain 1 |
ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSS
GLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKV Click to Show/Hide
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| Heavy Chain Constant Domain 2 |
APELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVEHEDPEVKFNWYVDGVEVHNAKTK
PREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKAFPAPIEKTISKAK Click to Show/Hide
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| Heavy Chain Constant Domain 3 |
GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDS
DGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK Click to Show/Hide
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| Heavy Chain Hinge Region |
EPKSCDKTHTCPPCP
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| Heavy Chain CDR 1 |
GYTFTSYV
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| Heavy Chain CDR 2 |
INPYNDGT
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| Heavy Chain CDR 3 |
ARGTYYYGTRVFDY
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| Light Chain Varible Domain |
DIVMTQSPATLSLSPGERATLSCRSSKSLQNVNGNTYLYWFQQKPGQSPQLLIYRMSNLN
SGVPDRFSGSGSGTEFTLTISSLEPEDFAVYYCMQHLEYPITFGAGTKLEIK Click to Show/Hide
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| Light Chain Constant Domain |
RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQD
SKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC Click to Show/Hide
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| Light Chain CDR 1 |
KSLQNVNGNTY
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| Light Chain CDR 2 |
RMS
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| Light Chain CDR 3 |
MQHLEYPIT
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Each Antibody-drug Conjugate Related to This Antibody
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