Antibody Information
General Information of This Antibody
| Antibody ID | ANI0KUFWC |
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| Antibody Name | Tafasitamab |
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| Brand Name | MONJUVI |
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| Organization | Xencor, Inc.; Incyte Corp.; MorphoSys AG |
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| Indication | Diffuse large B-cell lymphoma |
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| Approval Date | Jul. 2020 |
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| Synonyms |
MOR00208; MOR-00208; MOR208; MOR-208; TAFASITAMAB; TAFASITAMAB CXIX; TAFASITAMAB-CXIX; XmAb5574; XMAB5574; XMAB-5574; MOR208; XmAb5574,MOR-00208; MOR-208; XENP-5574; XMP-5574; XmAb-5574; Xmab-CD19; Xmab5574; tafasitamab-cxix
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Humanized IgG2-kappa |
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| Antigen Name | B-lymphocyte antigen CD19 (CD19) |
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| Click to Show/Hide the Sequence Information of This Antibody | ||||||
| Heavy Chain Sequence |
EVQLVESGGGLVKPGGSLKLSCAASGYTFTSYVMHWVRQAPGKGLEWIGYINPYNDGTKY
NEKFQGRVTISSDKSISTAYMELSSLRSEDTAMYYCARGTYYYGTRVFDYWGQGTLVTVS SASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQS SGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCPAPELLG GPDVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQF NSTFRVVSVLTVVHQDWLNGKEYKCKVSNKALPAPEEKTISKTKGQPREPQVYTLPPSRE EMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSR WQQGNVFSCSVMHEALHNHYTQKSLSLSPGK Click to Show/Hide
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| Heavy Chain Varible Domain |
EVQLVESGGGLVKPGGSLKLSCAASGYTFTSYVMHWVRQAPGKGLEWIGYINPYNDGTKY
NEKFQGRVTISSDKSISTAYMELSSLRSEDTAMYYCARGTYYYGTRVFDYWGQGTLVTVS S Click to Show/Hide
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| Heavy Chain Constant Domain 1 |
ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSS
GLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKV Click to Show/Hide
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| Heavy Chain Constant Domain 2 |
APELLGGPDVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTK
PREEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKALPAPEEKTISKTK Click to Show/Hide
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| Heavy Chain Constant Domain 3 |
GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDS
DGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK Click to Show/Hide
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| Heavy Chain Hinge Region |
EPKSCDKTHTCPPCP
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| Heavy Chain CDR 1 |
GYTFTSYV
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| Heavy Chain CDR 2 |
INPYNDGT
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| Heavy Chain CDR 3 |
ARGTYYYGTRVFDY
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| Light Chain Sequence |
DIVMTQSPATLSLSPGERATLSCRSSKSLQNVNGNTYLYWFQQKPGQSPQLLIYRMSNLN
SGVPDRFSGSGSGTEFTLTISSLEPEDFAVYYCMQHLEYPITFGAGTKLEIKRTVAAPSV FIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSL SSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC Click to Show/Hide
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| Light Chain Varible Domain |
DIVMTQSPATLSLSPGERATLSCRSSKSLQNVNGNTYLYWFQQKPGQSPQLLIYRMSNLN
SGVPDRFSGSGSGTEFTLTISSLEPEDFAVYYCMQHLEYPITFGAGTKLEIK Click to Show/Hide
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| Light Chain Constant Domain |
RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQD
SKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC Click to Show/Hide
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| Light Chain CDR 1 |
KSLQNVNGNTY
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| Light Chain CDR 2 |
RMS
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| Light Chain CDR 3 |
MQHLEYPIT
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Each Antibody-drug Conjugate Related to This Antibody
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