Antigen Information

General Information of This Antigen
Antigen ID
TAR0QHAVI
Antigen Name
Folate receptor alpha (FOLR1)
Gene Name
FOLR1
Gene ID
2348
Synonym
FOLR; Adult folate-binding protein;Folate receptor 1;Folate receptor, adult;KB cells FBP;Ovarian tumor-associated antigen MOv18
Sequence
MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPW
RKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQV
DQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHF
YFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGAGPWA
AWPFLLSLALMLLWLLS

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Family
Ephrin family
Function
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.

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Uniprot Entry
FOLR1_HUMAN
HGNC ID
HGNC:3791
KEGG ID
hsa:2348
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
AMT-151
Duostatin 5
Microtubule (MT)
Pip-Val-Cit linker
AB1380026
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
AB1380026-SG3932
(4-NH2)-Exatecan
DNA topoisomerase I (TOP1)
SG3932 Linker
 [1]
AB1380035
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
AB1380035-SG3932
(4-NH2)-Exatecan
DNA topoisomerase I (TOP1)
SG3932 Linker
 [1]
AB1380049
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
AB1380049-SG3932 (DAR8)
(4-NH2)-Exatecan
DNA topoisomerase I (TOP1)
SG3932 Linker
 [1]
 ADC Info 
AB1380049-SG3932 (DAR4)
(4-NH2)-Exatecan
DNA topoisomerase I (TOP1)
SG3932 Linker
 [1]
AB1380083
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
AB1380083-SG3932
(4-NH2)-Exatecan
DNA topoisomerase I (TOP1)
SG3932 Linker
 [1]
AB1380095
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
AB1380095-SG3932
(4-NH2)-Exatecan
DNA topoisomerase I (TOP1)
SG3932 Linker
 [1]
AB1380117
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
AB1380117-SG3932
(4-NH2)-Exatecan
DNA topoisomerase I (TOP1)
SG3932 Linker
 [1]
Anti-FOLR1 huFR1-48
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HuFR1-48-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [2]
Anti-FOLR1 huFR1-49
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HuFR1-49-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [2]
Anti-FOLR1 huFR1-57
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HuFR1-57-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [2]
Anti-FOLR1 huFR1-65
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HuFR1-65-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [2]
Anti-FOLR1 IgG1 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ZW191
ZD06519
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly-AM
Anti-FOLR1 mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-FOLR1-Ala-Ala-IGN
Indolinobenzodiazepine dimer
Human Deoxyribonucleic acid (hDNA)
Ala-Ala dipeptide
 [3]
 ADC Info 
Anti-FOLR1-Val-Gln-IGN
Indolinobenzodiazepine dimer
Human Deoxyribonucleic acid (hDNA)
Val-Gln dipeptide linker
 [3]
 ADC Info 
FOLR1-ADC 13a
PBD dimer 13a
Human Deoxyribonucleic acid (hDNA)
Adipic acid-Val-Ala-PABC
 [4]
 ADC Info 
FOLR1-ADC 13b
PBD dimer 13b
Human Deoxyribonucleic acid (hDNA)
Adipic acid-Val-Ala-PABC
 [4]
 ADC Info 
FOLR1-ADC 13c
PBD dimer 13c
Human Deoxyribonucleic acid (hDNA)
Adipic acid-Val-Ala-PABC
 [4]
 ADC Info 
FOLR1-ADC 15
PBD dimer 13c
Human Deoxyribonucleic acid (hDNA)
Adipic acid-Val-CIt-PABC
 [4]
Anti-FRα antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
BAT8006
Exatecan
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
GenSci140
GSC5181
DNA topoisomerase 1 (TOP1)
A cleavable linker
Anti-FRα mAb
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
SYS6041
Exatecan
DNA topoisomerase 1 (TOP1)
A cleavable linker
 [5]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN114269749B anti-FolR1 ADC2
CN114269749B anti-FolR1 ADC1 Payload
Undisclosed
CN114269749B anti-FolR1 ADC1 Linker
 [6]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
F131-LD038
F131-LD038 payload
Undisclosed
F131-LD038 linker
 [7]
 ADC Info 
F131-LD100
F131-LD100 payload
Undisclosed
F131-LD100 linker
 [7]
 ADC Info 
F131-LD111
F131-LD111 payload
Undisclosed
F131-LD111 linker
 [7]
 ADC Info 
F131-LD101
F131-LD101 payload
Undisclosed
F131-LD101 linker
 [7]
 ADC Info 
F131-LD110
F131-LD110 payload
Undisclosed
F131-LD110 linker
 [7]
Farletuzumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Farletuzumab ecteribulin
Eribulin
Microtubule (MT)
Mal-PEG2-Val-Cit-PABC
 ADC Info 
Farletuzumab-PEG4-Mal-DM1
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 [8]
 ADC Info 
Farletuzumab-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [8]
 ADC Info 
Farletuzumab-SIA-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 [8]
 ADC Info 
Farletuzumab-SPP-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [8]
 ADC Info 
Farletuzumab-sulfo-SPDB-DM4
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [8]
 ADC Info 
Farletuzumab-SPDB-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [8]
 ADC Info 
Farletuzumab-3-sulfo-Mal-DM4
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 [8]
 ADC Info 
Farletuzumab-PEG4-Mal-DM4
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 [8]
 ADC Info 
FOLR1-Mal-PEG2-Val-Cit-PABC-Eribulin
Eribulin
Microtubule (MT)
Mal-PEG2-Val-Cit-PABC
 [9]
 ADC Info 
FOLR1-Mal-PEG8-Val-Cit-PABC-Eribulin
Eribulin
Microtubule (MT)
Mal-PEG8-Val-Cit-PABC
 [9]
 ADC Info 
FOLR1-Mal-Caproyl-Val-Cit-PABC-Eribulin
Eribulin
Microtubule (MT)
Maleimide-Caproyl-Val-Cit-PABC
 [9]
 ADC Info 
FOLR1-Mal-PEG2-Ala-Ala-Asn-PABC-Eribulin
Eribulin
Microtubule (MT)
Mal-PEG2-Ala-Ala-Asn-PABC
 [9]
 ADC Info 
FOLR1-Mal-PEG4-tria-PEG3-Dis-dim-PABC-Eribulin
Eribulin
Microtubule (MT)
Mal-PEG4-triazole-PEG3-Disulfidyl-dimethyl-PABC
 [9]
 ADC Info 
FOLR1-Mal-PEG4-tria-PEG3-Sulfo-Eribulin
Eribulin
Microtubule (MT)
Mal-PEG4-triazole-PEG3-Sulfonamide
 [9]
 ADC Info 
FOLR1-Mal-PEG2-Eribulin
Eribulin
Microtubule (MT)
Mal-PEG2
 [9]
 ADC Info 
FOLR1-Mal-PEG4-Eribulin
Eribulin
Microtubule (MT)
Mal-PEG4
 [9]
 ADC Info 
FOLR1-Suc/SPAAC-PEG4-Val-Cit-PABC-Eribulin
Eribulin
Microtubule (MT)
Succinamide-SPAAC-PEG4-Val-Cit-PABC
 [9]
 ADC Info 
FOLR1-Suc/SPAAC-PEG3-Dis-dim-PABC-Eribulin
Eribulin
Microtubule (MT)
Succinamide-SPAAC-PEG3-Disylfidyl-dimethyl-PABC
 [9]
 ADC Info 
FOLR1-Suc/SPAAC-PEG3-Sulfonamide-Eribulin
Eribulin
Microtubule (MT)
Succinamide-SPAAC-PEG3-Sulfonamide
 [9]
 ADC Info 
FOLR1-Suc/SPAAC-PEG2-Eribulin
Eribulin
Microtubule (MT)
Succinamide-SPAAC-PEG2
 [9]
 ADC Info 
FOLR1-Suc/SPAAC-PEG4-Eribulin
Eribulin
Microtubule (MT)
Succinamide-SPAAC-PEG4
 [9]
 ADC Info 
FOLR1-Mal-PEG-Val-Cit-PABC-Cryptophycin
Cryptophycin
Microtubule (MT)
Mal-PEG-Val-Cit-PABC
 [9]
 ADC Info 
FOLR1-Mal-Caproyl-Val-Cit-PABC-MMAE
Monomethyl auristatin E
Microtubule (MT)
Maleimide-Caproyl-Val-Cit-PABC
 [9]
 ADC Info 
FOLR1-Mal-Caproyl-Val-Cit-PABC-MMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimide-Caproyl-Val-Cit-PABC
 [9]
 ADC Info 
Farletuzumab-sulfo SPDB-DM4
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [9]
 ADC Info 
CN119630431A ADC-6
CN119630431A-ADC-1-PAYLOAD
Undisclosed
Undisclosed
 [10]
 ADC Info 
CN119630431A ADC-7
CN119630431A ADC-51 payload
Undisclosed
Undisclosed
 [10]
 ADC Info 
CN119630431A ADC-8
CN119630431A-ADC-1-PAYLOAD
Undisclosed
CN119630431A-ADC-5-LINKER
 [10]
Fc-silent FRalpha specific humanized IgG1 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
LY-4170156
Exatecan
DNA topoisomerase 1 (TOP1)
Mal-Polysarcosine10-Val-Ala-PABC
FR-alpha antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN115429893A ADC16
CN115429893A ADC1 Payload
Undisclosed
CB07 linker
 [11]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
FR1-21-PEG4-Mal-DM1
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 [8]
 ADC Info 
FR1-21-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [8]
 ADC Info 
FR1-21-SIA-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 [8]
 ADC Info 
FR1-21-SPP-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [8]
 ADC Info 
FR1-21-sulfo-SPDB-DM4
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [8]
 ADC Info 
FR1-21-SPDB-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [8]
 ADC Info 
FR1-21-3-sulfo-Mal-DM4
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 [8]
 ADC Info 
FR1-21-PEG4-Mal-DM4
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 [8]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
FR1-48-PEG4-Mal-DM1
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 [8]
 ADC Info 
FR1-48-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [8]
 ADC Info 
FR1-48-SIA-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 [8]
 ADC Info 
FR1-48-SPP-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [8]
 ADC Info 
FR1-48-sulfo-SPDB-DM4
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [8]
 ADC Info 
FR1-48-SPDB-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [8]
 ADC Info 
FR1-48-3-sulfo-Mal-DM4
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 [8]
 ADC Info 
FR1-48-PEG4-Mal-DM4
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 [8]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
FR1-49-PEG4-Mal-DM1
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 [8]
 ADC Info 
FR1-49-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [8]
 ADC Info 
FR1-49-SIA-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 [8]
 ADC Info 
FR1-49-SPP-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [8]
 ADC Info 
FR1-49-sulfo-SPDB-DM4
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [8]
 ADC Info 
FR1-49-SPDB-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [8]
 ADC Info 
FR1-49-3-sulfo-Mal-DM4
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 [8]
 ADC Info 
FR1-49-PEG4-Mal-DM4
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 [8]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
FR1-57-PEG4-Mal-DM1
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 [8]
 ADC Info 
FR1-57-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [8]
 ADC Info 
FR1-57-SIA-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 [8]
 ADC Info 
FR1-57-SPP-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [8]
 ADC Info 
FR1-57-sulfo-SPDB-DM4
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [8]
 ADC Info 
FR1-57-SPDB-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [8]
 ADC Info 
FR1-57-3-sulfo-Mal-DM4
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 [8]
 ADC Info 
FR1-57-PEG4-Mal-DM4
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 [8]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
FR1-65-PEG4-Mal-DM1
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 [8]
 ADC Info 
FR1-65-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [8]
 ADC Info 
FR1-65-SIA-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 [8]
 ADC Info 
FR1-65-SPP-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [8]
 ADC Info 
FR1-65-sulfo-SPDB-DM4
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [8]
 ADC Info 
FR1-65-SPDB-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [8]
 ADC Info 
FR1-65-3-sulfo-Mal-DM4
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 [8]
 ADC Info 
FR1-65-PEG4-Mal-DM4
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 [8]
H01 Y180F404
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN114269749B anti-FolR1 ADC1
CN114269749B anti-FolR1 ADC1 Payload
Undisclosed
CN114269749B anti-FolR1 ADC1 Linker
 [6]
 ADC Info 
CN114269749B anti-FolR1 ADC3
CN114269749B anti-FolR1 ADC3 Payload
Undisclosed
CN114269749B anti-FolR1 ADC1 Linker
 [6]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HuFR1-21-PEG4-Mal-DM1
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 [8]
 ADC Info 
HuFR1-21-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [8]
 ADC Info 
HuFR1-21-SIA-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 [8]
 ADC Info 
HuFR1-21-SPP-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [8]
 ADC Info 
HuFR1-21-sulfo-SPDB-DM4
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [8]
 ADC Info 
HuFR1-21-SPDB-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [8]
 ADC Info 
HuFR1-21-3-sulfo-Mal-DM4
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 [8]
 ADC Info 
HuFR1-21-PEG4-Mal-DM4
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 [8]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HuFR1-23-PEG4-Mal-DM1
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 [8]
 ADC Info 
HuFR1-23-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [8]
 ADC Info 
HuFR1-23-SIA-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 [8]
 ADC Info 
HuFR1-23-SPP-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [8]
 ADC Info 
HuFR1-23-sulfo-SPDB-DM4
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [8]
 ADC Info 
HuFR1-23-SPDB-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [8]
 ADC Info 
HuFR1-23-3-sulfo-Mal-DM4
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 [8]
 ADC Info 
HuFR1-23-PEG4-Mal-DM4
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 [8]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HuMov19-PEG4-Mal-DM1
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 [8]
 ADC Info 
HuMov19-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [8]
 ADC Info 
HuMov19-SIA-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 [8]
 ADC Info 
HuMov19-SPP-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [8]
 ADC Info 
HuMov19-sulfo-SPDB-DM4 (DAR3.8)
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [8]
 ADC Info 
HuMov19-SPDB-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [8]
 ADC Info 
HuMov19-3-sulfo-Mal-DM4 (DAR 3.7)
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 [8]
 ADC Info 
HuMov19-PEG4-Mal-DM4
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 [8]
 ADC Info 
HuMov19-3-sulfo-Mal-DM4 (DAR 8.23)
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 [8]
 ADC Info 
HuMov19-sulfo-SPDB-DM4 (DAR6.8)
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [8]
huMOV19v1.0
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HuMOV19v1.0-PEG4-Mal-DM1
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 [8]
 ADC Info 
HuMOV19v1.0-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [8]
 ADC Info 
HuMOV19v1.0-SIA-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 [8]
 ADC Info 
HuMOV19v1.0-SPP-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [8]
 ADC Info 
HuMOV19v1.0-sulfo-SPDB-DM4
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [8]
 ADC Info 
HuMOV19v1.0-SPDB-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [8]
 ADC Info 
HuMOV19v1.0-3-sulfo-Mal-DM4
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 [8]
 ADC Info 
HuMOV19v1.0-PEG4-Mal-DM4
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 [8]
huMOV19v1.6
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HuMOV19v1.6-PEG4-Mal-DM1
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 [8]
 ADC Info 
HuMOV19v1.6-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [8]
 ADC Info 
HuMOV19v1.6-SIA-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 [8]
 ADC Info 
HuMOV19v1.6-SPP-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [8]
 ADC Info 
HuMOV19v1.6-sulfo-SPDB-DM4
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [8]
 ADC Info 
HuMOV19v1.6-SPDB-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [8]
 ADC Info 
HuMOV19v1.6-3-sulfo-Mal-DM4
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 [8]
 ADC Info 
HuMOV19v1.6-PEG4-Mal-DM4
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 [8]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
IKS-01
FGX2-62
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 [12]
Luveltamab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Luveltamab tazevibulin
SC209
Microtubule (MT)
DBCO-Val-Cit-PABA
Mirvetuximab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Mirvetuximab soravtansine
DM4
Microtubule (MT)
Sulfo-SPDB
 [13]
 ADC Info 
Mirvetuximab-SPP-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [2]
 ADC Info 
Mirvetuximab-SPDB-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [14]
 ADC Info 
Mirvetuximab-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [2]
 ADC Info 
M9346A Sulfo-SPDB DM4
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [2]
 ADC Info 
M9346A-CX-DM1
Mertansine DM1
Microtubule (MT)
triglycyl peptide linker CX
 [15]
 ADC Info 
M9346A-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [8]
 ADC Info 
M9346A-SPP-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [8]
 ADC Info 
M9346A-sulfo-Mal-DM4
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 [8]
 ADC Info 
M9346A-SPDB-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [8]
 ADC Info 
37307297 ADC 10
FD-1
Undisclosed
Undisclosed
 [16]
 ADC Info 
37307297 ADC 11
FD-1
Undisclosed
Undisclosed
 [16]
 ADC Info 
37307297 ADC 21
FD-1
Undisclosed
Undisclosed
 [16]
 ADC Info 
37307297 ADC 22
FD-1
Undisclosed
Undisclosed
 [16]
 ADC Info 
37307297 ADC 23
FD-1
Undisclosed
Undisclosed
 [16]
 ADC Info 
37307297 ADC 24
FD-2
Undisclosed
Undisclosed
 [16]
 ADC Info 
37307297 ADC 25
FD-2
Undisclosed
Undisclosed
 [16]
 ADC Info 
37307297 ADC 26
FD-3
Undisclosed
Undisclosed
 [16]
 ADC Info 
37307297 ADC 27
FD-3
Undisclosed
Undisclosed
 [16]
 ADC Info 
37307297 ADC 28
FD-9
Undisclosed
Undisclosed
 [16]
 ADC Info 
37307297 ADC 29
FD-9
Undisclosed
Undisclosed
 [16]
 ADC Info 
37307297 ADC 30
FD-22
Undisclosed
Undisclosed
 [16]
 ADC Info 
37307297 ADC 31
FD-11
Undisclosed
Undisclosed
 [16]
 ADC Info 
37307297 ADC 32
FD-23
Undisclosed
Undisclosed
 [16]
 ADC Info 
37307297 ADC 33
FD-19
Undisclosed
Undisclosed
 [16]
mirvetuximab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
IGAC-91
IG-L-18 Payload
Undisclosed
IG-L-25 linker
 [17]
Mirvetuximab (engineered cysteine HC-C118)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
M9346A-4c-Cxxx-Mal-CX-DM1
Mertansine DM1
Microtubule (MT)
Cxxx-Mal-CX
 [15]
Mirvetuximab (engineered cysteine HC-C239)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
M9346A-4d-Cxxx-Mal-CX-DM1
Mertansine DM1
Microtubule (MT)
Cxxx-Mal-CX
 [15]
Mirvetuximab (engineered cysteine LC-C205)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
M9346A-4a-Cxxx-Mal-CX-DM1
Mertansine DM1
Microtubule (MT)
Cxxx-Mal-CX
 [15]
Mirvetuximab (engineered cysteine LC-C400)
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
M9346A-4b-Cxxx-Mal-CX-DM1
Mertansine DM1
Microtubule (MT)
Cxxx-Mal-CX
 [15]
Morab-003
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
39424599 ADC-10A
Undisclosed
Undisclosed
Electron-deficient sulfonamide-based cleavable linker 10
 [18]
 ADC Info 
39424599 ADC-S32A
Undisclosed
Undisclosed
Electron-deficient Disulfide-based cleavable linker 32
 [18]
MORAb-003
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
MORAb-003 ADC1
Nostocyclopeptide-1
Undisclosed
Maleimidyl - PEG3 - benzyl - disulfide - dimethyl linker
 [19]
 ADC Info 
MORAb-003 ADC2
Nostocyclopeptide-2
Undisclosed
LL2 linker
 [19]
 ADC Info 
MORAb-003 ADC3
Nostocyclopeptide-2
Undisclosed
LL3 linker
 [19]
 ADC Info 
MORAb-003 ADC4
Nostocyclopeptide-2
Undisclosed
VCP linker
 [19]
 ADC Info 
MORAb-003 ADC5
Eribulin
Microtubule (MT)
VCP linker
 [19]
 ADC Info 
MORAb-003 ADC6
ER-001150828
Undisclosed
Maleimidyl- (CH2)5-Val-Cit-pAB linker
 [19]
 ADC Info 
MORAb-003 ADC7
ER-001150828
Undisclosed
Maleimidyl-PEG2-Val-Cit-pAB linker
 [19]
 ADC Info 
MORAb-003 ADC8
Mertansine DM1
Microtubule (MT)
6-Maleimidocaproic acid
 [19]
 ADC Info 
MORAb-003 ADC9
Monomethyl auristatin E
Microtubule (MT)
Maleimidyl- (CH2)5-Val-Cit-pAB linker
 [19]
 ADC Info 
MORAb-003 ADC10
Auristatin F
Microtubule (MT)
NHS-PEG2 linker
 [19]
 ADC Info 
MORAb-003 ADC11
Mertansine DM1
Microtubule (MT)
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [19]
 ADC Info 
MORAb-003 ADC12
Dolicatatin 3
Undisclosed
PEG-pAB linker
 [19]
 ADC Info 
MORAb-003 ADC13
Dolicatatin 5
Microtubule (MT)
Asn-Ala linker
 [19]
 ADC Info 
MORAb-003 ADC14
Dolicatatin 3
Undisclosed
Undisclosed
 [19]
 ADC Info 
MORAb-003 ADC15
Dolicatatin 10
Undisclosed
PEG-pAB linker
 [19]
 ADC Info 
MORAb-003 ADC16
Dolicatatin 14
Undisclosed
Undisclosed
 [19]
 ADC Info 
MORAb-003 ADC17
Dolicatatin 14
Undisclosed
Undisclosed
 [19]
 ADC Info 
MORAb-003 ADC18
Dolicatatin 14
Undisclosed
Undisclosed
 [20]
 ADC Info 
MORAb-003 ADC19
Dolicatatin 14
Undisclosed
Undisclosed
 [20]
 ADC Info 
MORAb-003 ADC20
Polymycin 7
Undisclosed
Undisclosed
 [20]
 ADC Info 
MORAb-003 ADC21
Polymycin 7
Undisclosed
Undisclosed
 [20]
 ADC Info 
MORAb-003 ADC22
Polymycin 7
Undisclosed
PEG-pAB linker
 [20]
 ADC Info 
MORAb-003 ADC23
Polymycin 7
Undisclosed
Undisclosed
 [20]
 ADC Info 
MORAb-003 ADC24
Dolicatatin 7
Undisclosed
Undisclosed
 [20]
 ADC Info 
MORAb-003 ADC25
Dolicatatin 6
Undisclosed
PEG-pAB linker
 [20]
 ADC Info 
MORAb-003 ADC26
Dolicatatin 10
Undisclosed
Undisclosed
 [20]
 ADC Info 
MORAb-003 ADC27
Dolicatatin 10
Undisclosed
PEG-pAB linker
 [20]
 ADC Info 
MORAb-003 ADC28
Dolicatatin 14
Undisclosed
Undisclosed
 [20]
 ADC Info 
MORAb-003 ADC29
Dolicatatin 14
Undisclosed
Undisclosed
 [20]
 ADC Info 
MORAb-003 ADC30
Dolicatatin 14
Undisclosed
Undisclosed
 [20]
 ADC Info 
MORAb-003 ADC31
Dolicatatin 14
Undisclosed
PEG-pAB linker
 [20]
 ADC Info 
MORAb-003 ADC32
Dolicatatin 14
Undisclosed
Undisclosed
 [20]
 ADC Info 
MORAb-003 ADC33
Dolicatatin 5
Microtubule (MT)
PEG-pAB linker
 [20]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Mov19-PEG4-Mal-DM1
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 [8]
 ADC Info 
Mov19-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [8]
 ADC Info 
Mov19-SIA-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 [8]
 ADC Info 
Mov19-SPP-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [8]
 ADC Info 
Mov19-sulfo-SPDB-DM4
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [8]
 ADC Info 
Mov19-SPDB-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [8]
 ADC Info 
Mov19-3-sulfo-Mal-DM4
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 [8]
 ADC Info 
Mov19-PEG4-Mal-DM4
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 [8]
mu-FR1-13
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
MuFR1-13-PEG4-Mal-DM1
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 [8]
 ADC Info 
MuFR1-13-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [8]
 ADC Info 
MuFR1-13-SIA-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 [8]
 ADC Info 
MuFR1-13-SPP-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [8]
 ADC Info 
MuFR1-13-sulfo-SPDB-DM4
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [8]
 ADC Info 
MuFR1-13-SPDB-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [8]
 ADC Info 
MuFR1-13-3-sulfo-Mal-DM4
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 [8]
 ADC Info 
MuFR1-13-PEG4-Mal-DM4
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 [8]
mu-FR1-21
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
MuFR1-21-PEG4-Mal-DM1
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 [8]
 ADC Info 
MuFR1-21-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [8]
 ADC Info 
MuFR1-21-SIA-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 [8]
 ADC Info 
MuFR1-21-SPP-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [8]
 ADC Info 
MuFR1-21-sulfo-SPDB-DM4
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [8]
 ADC Info 
MuFR1-21-SPDB-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [8]
 ADC Info 
MuFR1-21-3-sulfo-Mal-DM4
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 [8]
 ADC Info 
MuFR1-21-PEG4-Mal-DM4
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 [8]
mu-FR1-22
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
MuFR1-22-PEG4-Mal-DM1
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 [8]
 ADC Info 
MuFR1-22-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [8]
 ADC Info 
MuFR1-22-SIA-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 [8]
 ADC Info 
MuFR1-22-SPP-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [8]
 ADC Info 
MuFR1-22-sulfo-SPDB-DM4
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [8]
 ADC Info 
MuFR1-22-SPDB-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [8]
 ADC Info 
MuFR1-22-3-sulfo-Mal-DM4
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 [8]
 ADC Info 
MuFR1-22-PEG4-Mal-DM4
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 [8]
mu-FR1-23
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
MuFR1-23-PEG4-Mal-DM1
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 [8]
 ADC Info 
MuFR1-23-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [8]
 ADC Info 
MuFR1-23-SIA-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 [8]
 ADC Info 
MuFR1-23-SPP-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [8]
 ADC Info 
MuFR1-23-sulfo-SPDB-DM4
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [8]
 ADC Info 
MuFR1-23-SPDB-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [8]
 ADC Info 
MuFR1-23-3-sulfo-Mal-DM4
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 [8]
 ADC Info 
MuFR1-23-PEG4-Mal-DM4
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 [8]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
MuFR1-9-PEG4-Mal-DM1
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 [8]
 ADC Info 
MuFR1-9-SMCC-DM1
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [8]
 ADC Info 
MuFR1-9-SIA-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 [8]
 ADC Info 
MuFR1-9-SPP-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [8]
 ADC Info 
MuFR1-9-sulfo-SPDB-DM4
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 [8]
 ADC Info 
MuFR1-9-SPDB-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [8]
 ADC Info 
MuFR1-9-3-sulfo-Mal-DM4
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 [8]
 ADC Info 
MuFR1-9-PEG4-Mal-DM4
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 [8]
Opugotamig
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Opugotamig olatansine
DM21-C
Microtubule (MT)
Stable cleavable peptide linker
Rinatabart
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Rinatabart sesutecan
Exatecan
DNA topoisomerase 1 (TOP1)
T1000
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
SIBP-A19
DXd
DNA topoisomerase 1 (TOP1)
Mc-VASGFG
Sofetabart
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
sofetabart mipitecan
Exatecan
DNA topoisomerase 1 (TOP1)
Mal-Polysarcosine10-Val-Ala-PABC
Torvutatug
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Torvutatug samrotecan
AZ14170132 (AZ0132)
DNA topoisomerase 1 (TOP1)
Mal-PEG8-Val-Ala
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HuIgG1-SPDB-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [2]
 ADC Info 
Anti-FolRa Iadc
Undisclosed
Undisclosed
Undisclosed
 [21]
 ADC Info 
FOLR1 maytansinoid based antibody-drug conjugate
Undisclosed
Undisclosed
Undisclosed
 [22]
 ADC Info 
M-DGN549
Undisclosed
Undisclosed
Undisclosed
 [23]
 ADC Info 
DNA-alkylating anti-FRalpha antibody-drug conjugate
Undisclosed
Undisclosed
Undisclosed
 [24]
 ADC Info 
IKS-012
Undisclosed
Undisclosed
Undisclosed
 [25]
 ADC Info 
ALT-Q5
Undisclosed
Undisclosed
Undisclosed
 [26]
 ADC Info 
BB-17
Undisclosed
Undisclosed
Undisclosed
 [27]
 ADC Info 
Isumab01-C1a
Undisclosed
Undisclosed
Undisclosed
 [29]
 ADC Info 
Isumab01-C1b
Undisclosed
Undisclosed
Undisclosed
 [29]
 ADC Info 
Isumab01-C2a
WO2025015586A1, ADC25, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Undisclosed
 [29]
 ADC Info 
Isumab01-C2b
WO2025015586A1, ADC25, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Undisclosed
 [29]
 ADC Info 
Isumab01-C3
WO2025015586A1, ADC23, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Undisclosed
 [29]
 ADC Info 
Isumab01-C4
compound 4
DNA topoisomerase I (TOP1)
Undisclosed
 [29]
 ADC Info 
Isumab01-C5
compound 5
DNA topoisomerase I (TOP1)
Undisclosed
 [29]
 ADC Info 
Isumab01-C6
WO2025015586A1, ADC24, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Undisclosed
 [29]
 ADC Info 
Isumab01-C7
WO2025015586A1, ADC34, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Undisclosed
 [29]
 ADC Info 
Isumab01-C8
WO2025015586A1, ADC35, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Undisclosed
 [29]
undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
39424599 ADC-S35A
Undisclosed
Undisclosed
S35 linker
 [18]
 ADC Info 
CN115429893A ADC17
CN115429893A ADC1 Payload
Undisclosed
CB07 linker
 [11]
 ADC Info 
anti-FOLR1-151-K-LOCK-D5
AU2023267043A1 ADC-5 Payload
Undisclosed
AU2023267043A1 ADC-5 Linker
 [28]
 ADC Info 
anti-FOLR1-151-C-LOCK-D5
Undisclosed
Undisclosed
Undisclosed
 [28]
References
Ref 1 Binding molecules against FR alpha
Ref 2 IMGN853, a Folate Receptor- (FR)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FR-Expressing Tumors. Mol Cancer Ther. 2015 Jul;14(7):1605-13.
Ref 3 Optimizing Lysosomal Activation of Antibody-Drug Conjugates (ADCs) by Incorporation of Novel Cleavable Dipeptide Linkers. Mol Pharm. 2019 Dec 2;16(12):4817-4825. doi: 10.1021/acs.molpharmaceut.9b00696. Epub 2019 Oct 29.
Ref 4 Synthesis of Highly Potent N-10 Amino-Linked DNA-Alkylating Indolinobenzodiazepine Antibody-Drug Conjugates (ADCs). ACS Med Chem Lett. 2019 Jul 22;10(8):1211-1215. doi: 10.1021/acsmedchemlett.9b00254. eCollection 2019 Aug 8.
Ref 5 SYS6041, a next-generation Folate Receptor α-targeted antibody-drug conjugates for the treatment of FRα-expressing malignancies
Ref 6 5H-pyrrolo[3,2-d]pyrimidine-2,4-diamine compounds and their antibody-drug conjugates
Ref 7 Linkers, drug linkers and conjugates thereof and methods of using the same; 2023-02-16.
Ref 8 Folate receptor 1 antibodies and immunoconjugates and uses thereof; 2011-09-01.
Ref 9 MORAb-202, an Antibody-Drug Conjugate Utilizing Humanized Anti-human FR Farletuzumab and the Microtubule-targeting Agent Eribulin, has Potent Antitumor Activity. Mol Cancer Ther. 2018 Dec;17(12):2665-2675. doi: 10.1158/1535-7163.MCT-17-1215. Epub 2018 Sep 27.
Ref 10 Antibody-drug conjugates
Ref 11 Drug conjugates and uses thereof
Ref 12 IKS01, a next generation antibody drug conjugate, shows target-dependent efficacy in a platinum-resistant tumor model with low levels of folate receptor alpha expression. Mol Cancer Ther (2019) 18 (12_Supplement): C023.
Ref 13 Mirvetuximab Soravtansine: First Approval
Ref 14 Introduction to basic information on ADC drug anti-FR (clone M9346A)-SPDB-DM4.
Ref 15 A Case Study Comparing Heterogeneous Lysine- and Site-Specific Cysteine-Conjugated Maytansinoid Antibody-Drug Conjugates (ADCs) Illustrates the Benefits of Lysine Conjugation. Mol Pharm. 2019 Sep 3;16(9):3926-3937. doi: 10.1021/acs.molpharmaceut.9b00529. Epub 2019 Jul 31.
Ref 16 Structure-Activity Relationships of Bis-Intercalating Peptides and Their Application as Antibody-Drug Conjugate Payloads
Ref 17 Isoindolinone-glutarimide antibody conjugates, and uses thereof
Ref 18 A Novel Concept for Cleavable Linkers Applicable to Conjugation Chemistry - Design, Synthesis and Characterization
Ref 19 Antibody-drug conjugates based on eribulin and methods of use
Ref 20 Fan bracket
Ref 21 Next-generation immunostimulatory antibody-drug conjugate (iADC) combines direct tumor killing and innate immune stimulation to provide protective anti-tumor immunity;
Ref 22 Introduction to basic information on maytansinoid based antibody-drug conjugate.
Ref 23 Preclinical evaluation of M-DGN549, a folate receptor alpha-targeting antibodydrug conjugate (ADC) with a DNA-alkylating payload. December 2016 European journal of cancer 69(1):S145.
Ref 24 A new class of DNA alkylating indolino-benzodiazepine agents (BIAs) linked with a DNA binding moiety for use with antibody-drug conjugates (ADCs). Cancer Res (2018) 78 (13_Supplement): 747.
Ref 25 Iksuda therapeutics product pipeline
Ref 26 Alteogen biotechnology company product pipeline
Ref 27 Introduction to basic information on ADC drug BB-17.
Ref 28 Antibody-drug conjugates comprising an anti-FOLR1 antibody
Ref 29 Antibody-drug conjugate compounds, and methods of use and treatment