Antigen Information

General Information of This Antigen (ID: TAR0QHAVI)
Antigen Name
Folate receptor alpha (FOLR1)
Gene Name
FOLR1
Gene ID
2348
Synonym
FOLR; Adult folate-binding protein;Folate receptor 1;Folate receptor, adult;KB cells FBP;Ovarian tumor-associated antigen MOv18
Sequence
MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHKEKPGPEDKLHEQCRPW
RKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQDTCLYECSPNLGPWIQQV
DQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGWNWTSGFNKCAVGAACQPFHF
YFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAAAMSGAGPWA
AWPFLLSLALMLLWLLS

    Click to Show/Hide
Family
Ephrin family
Function
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation.

    Click to Show/Hide
Uniprot Entry
FOLR1_HUMAN
HGNC ID
HGNC:3791
KEGG ID
hsa:2348
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
AMT-151
Duostatin 5
Microtubule (MT)
Pip-Val-Cit linker
 ADC Info 
AB1380026
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AB1380026-SG3932 [1]
(4-NH2)-Exatecan
DNA topoisomerase I (TOP1)
SG3932 Linker
 ADC Info 
AB1380035
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AB1380035-SG3932 [1]
(4-NH2)-Exatecan
DNA topoisomerase I (TOP1)
SG3932 Linker
 ADC Info 
AB1380049
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AB1380049-SG3932 (DAR8) [1]
(4-NH2)-Exatecan
DNA topoisomerase I (TOP1)
SG3932 Linker
 ADC Info 
AB1380049-SG3932 (DAR4) [1]
(4-NH2)-Exatecan
DNA topoisomerase I (TOP1)
SG3932 Linker
 ADC Info 
AB1380083
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AB1380083-SG3932 [1]
(4-NH2)-Exatecan
DNA topoisomerase I (TOP1)
SG3932 Linker
 ADC Info 
AB1380095
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AB1380095-SG3932 [1]
(4-NH2)-Exatecan
DNA topoisomerase I (TOP1)
SG3932 Linker
 ADC Info 
AB1380117
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AB1380117-SG3932 [1]
(4-NH2)-Exatecan
DNA topoisomerase I (TOP1)
SG3932 Linker
 ADC Info 
Anti-FOLR1 huFR1-48
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HuFR1-48-SMCC-DM1 [2]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
Anti-FOLR1 huFR1-49
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HuFR1-49-SMCC-DM1 [2]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
Anti-FOLR1 huFR1-57
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HuFR1-57-SMCC-DM1 [2]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
Anti-FOLR1 huFR1-65
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HuFR1-65-SMCC-DM1 [2]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
Anti-FOLR1 IgG1 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ZW191
ZD06519
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly-AM
 ADC Info 
Anti-FOLR1 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-FOLR1-Ala-Ala-IGN [3]
Indolinobenzodiazepine dimer
Human Deoxyribonucleic acid (hDNA)
Ala-Ala dipeptide
 ADC Info 
Anti-FOLR1-Val-Gln-IGN [3]
Indolinobenzodiazepine dimer
Human Deoxyribonucleic acid (hDNA)
Val-Gln dipeptide linker
 ADC Info 
FOLR1-ADC 13a [4]
PBD dimer 13a
Human Deoxyribonucleic acid (hDNA)
Adipic acid-Val-Ala-PABC
 ADC Info 
FOLR1-ADC 13b [4]
PBD dimer 13b
Human Deoxyribonucleic acid (hDNA)
Adipic acid-Val-Ala-PABC
 ADC Info 
FOLR1-ADC 13c [4]
PBD dimer 13c
Human Deoxyribonucleic acid (hDNA)
Adipic acid-Val-Ala-PABC
 ADC Info 
FOLR1-ADC 15 [4]
PBD dimer 13c
Human Deoxyribonucleic acid (hDNA)
Adipic acid-Val-CIt-PABC
 ADC Info 
Anti-FRα antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
BAT8006
Exatecan
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
GenSci140
GSC5181
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
Anti-FRα mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
SYS6041 [5]
Exatecan
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CN114269749B anti-FolR1 ADC2 [6]
CN114269749B anti-FolR1 ADC1 Payload
Undisclosed
CN114269749B anti-FolR1 ADC1 Linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
F131-LD038 [7]
F131-LD038 payload
Undisclosed
F131-LD038 linker
 ADC Info 
F131-LD100 [7]
F131-LD100 payload
Undisclosed
F131-LD100 linker
 ADC Info 
F131-LD111 [7]
F131-LD111 payload
Undisclosed
F131-LD111 linker
 ADC Info 
F131-LD101 [7]
F131-LD101 payload
Undisclosed
F131-LD101 linker
 ADC Info 
F131-LD110 [7]
F131-LD110 payload
Undisclosed
F131-LD110 linker
 ADC Info 
Farletuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Farletuzumab ecteribulin
Eribulin
Microtubule (MT)
Mal-PEG2-Val-Cit-PABC
 ADC Info 
Farletuzumab-PEG4-Mal-DM1 [8]
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 ADC Info 
Farletuzumab-SMCC-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
Farletuzumab-SIA-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 ADC Info 
Farletuzumab-SPP-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
Farletuzumab-sulfo-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
Farletuzumab-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
Farletuzumab-3-sulfo-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 ADC Info 
Farletuzumab-PEG4-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 ADC Info 
FOLR1-Mal-PEG2-Val-Cit-PABC-Eribulin [9]
Eribulin
Microtubule (MT)
Mal-PEG2-Val-Cit-PABC
 ADC Info 
FOLR1-Mal-PEG8-Val-Cit-PABC-Eribulin [9]
Eribulin
Microtubule (MT)
Mal-PEG8-Val-Cit-PABC
 ADC Info 
FOLR1-Mal-Caproyl-Val-Cit-PABC-Eribulin [9]
Eribulin
Microtubule (MT)
Maleimide-Caproyl-Val-Cit-PABC
 ADC Info 
FOLR1-Mal-PEG2-Ala-Ala-Asn-PABC-Eribulin [9]
Eribulin
Microtubule (MT)
Mal-PEG2-Ala-Ala-Asn-PABC
 ADC Info 
FOLR1-Mal-PEG4-tria-PEG3-Dis-dim-PABC-Eribulin [9]
Eribulin
Microtubule (MT)
Mal-PEG4-triazole-PEG3-Disulfidyl-dimethyl-PABC
 ADC Info 
FOLR1-Mal-PEG4-tria-PEG3-Sulfo-Eribulin [9]
Eribulin
Microtubule (MT)
Mal-PEG4-triazole-PEG3-Sulfonamide
 ADC Info 
FOLR1-Mal-PEG2-Eribulin [9]
Eribulin
Microtubule (MT)
Mal-PEG2
 ADC Info 
FOLR1-Mal-PEG4-Eribulin [9]
Eribulin
Microtubule (MT)
Mal-PEG4
 ADC Info 
FOLR1-Suc/SPAAC-PEG4-Val-Cit-PABC-Eribulin [9]
Eribulin
Microtubule (MT)
Succinamide-SPAAC-PEG4-Val-Cit-PABC
 ADC Info 
FOLR1-Suc/SPAAC-PEG3-Dis-dim-PABC-Eribulin [9]
Eribulin
Microtubule (MT)
Succinamide-SPAAC-PEG3-Disylfidyl-dimethyl-PABC
 ADC Info 
FOLR1-Suc/SPAAC-PEG3-Sulfonamide-Eribulin [9]
Eribulin
Microtubule (MT)
Succinamide-SPAAC-PEG3-Sulfonamide
 ADC Info 
FOLR1-Suc/SPAAC-PEG2-Eribulin [9]
Eribulin
Microtubule (MT)
Succinamide-SPAAC-PEG2
 ADC Info 
FOLR1-Suc/SPAAC-PEG4-Eribulin [9]
Eribulin
Microtubule (MT)
Succinamide-SPAAC-PEG4
 ADC Info 
FOLR1-Mal-PEG-Val-Cit-PABC-Cryptophycin [9]
Cryptophycin
Microtubule (MT)
Mal-PEG-Val-Cit-PABC
 ADC Info 
FOLR1-Mal-Caproyl-Val-Cit-PABC-MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Maleimide-Caproyl-Val-Cit-PABC
 ADC Info 
FOLR1-Mal-Caproyl-Val-Cit-PABC-MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Maleimide-Caproyl-Val-Cit-PABC
 ADC Info 
Farletuzumab-sulfo SPDB-DM4 [9]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
CN119630431A ADC-6 [10]
CN119630431A-ADC-1-PAYLOAD
Undisclosed
Undisclosed
 ADC Info 
CN119630431A ADC-7 [10]
CN119630431A ADC-51 payload
Undisclosed
Undisclosed
 ADC Info 
CN119630431A ADC-8 [10]
CN119630431A-ADC-1-PAYLOAD
Undisclosed
CN119630431A-ADC-5-LINKER
 ADC Info 
Fc-silent FRalpha specific humanized IgG1 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
LY-4170156
Exatecan
DNA topoisomerase 1 (TOP1)
Mal-Polysarcosine10-Val-Ala-PABC
 ADC Info 
FR-alpha antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN115429893A ADC16 [11]
CN115429893A ADC1 Payload
Undisclosed
CB07 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
FR1-21-PEG4-Mal-DM1 [8]
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 ADC Info 
FR1-21-SMCC-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
FR1-21-SIA-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 ADC Info 
FR1-21-SPP-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
FR1-21-sulfo-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
FR1-21-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
FR1-21-3-sulfo-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 ADC Info 
FR1-21-PEG4-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 ADC Info 
ADC Name Payload Target Linker ADC Info
FR1-48-PEG4-Mal-DM1 [8]
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 ADC Info 
FR1-48-SMCC-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
FR1-48-SIA-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 ADC Info 
FR1-48-SPP-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
FR1-48-sulfo-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
FR1-48-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
FR1-48-3-sulfo-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 ADC Info 
FR1-48-PEG4-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 ADC Info 
ADC Name Payload Target Linker ADC Info
FR1-49-PEG4-Mal-DM1 [8]
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 ADC Info 
FR1-49-SMCC-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
FR1-49-SIA-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 ADC Info 
FR1-49-SPP-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
FR1-49-sulfo-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
FR1-49-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
FR1-49-3-sulfo-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 ADC Info 
FR1-49-PEG4-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 ADC Info 
ADC Name Payload Target Linker ADC Info
FR1-57-PEG4-Mal-DM1 [8]
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 ADC Info 
FR1-57-SMCC-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
FR1-57-SIA-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 ADC Info 
FR1-57-SPP-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
FR1-57-sulfo-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
FR1-57-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
FR1-57-3-sulfo-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 ADC Info 
FR1-57-PEG4-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 ADC Info 
ADC Name Payload Target Linker ADC Info
FR1-65-PEG4-Mal-DM1 [8]
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 ADC Info 
FR1-65-SMCC-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
FR1-65-SIA-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 ADC Info 
FR1-65-SPP-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
FR1-65-sulfo-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
FR1-65-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
FR1-65-3-sulfo-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 ADC Info 
FR1-65-PEG4-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 ADC Info 
H01 Y180F404
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN114269749B anti-FolR1 ADC1 [6]
CN114269749B anti-FolR1 ADC1 Payload
Undisclosed
CN114269749B anti-FolR1 ADC1 Linker
 ADC Info 
CN114269749B anti-FolR1 ADC3 [6]
CN114269749B anti-FolR1 ADC3 Payload
Undisclosed
CN114269749B anti-FolR1 ADC1 Linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
HuFR1-21-PEG4-Mal-DM1 [8]
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 ADC Info 
HuFR1-21-SMCC-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
HuFR1-21-SIA-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 ADC Info 
HuFR1-21-SPP-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
HuFR1-21-sulfo-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
HuFR1-21-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
HuFR1-21-3-sulfo-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 ADC Info 
HuFR1-21-PEG4-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 ADC Info 
ADC Name Payload Target Linker ADC Info
HuFR1-23-PEG4-Mal-DM1 [8]
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 ADC Info 
HuFR1-23-SMCC-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
HuFR1-23-SIA-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 ADC Info 
HuFR1-23-SPP-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
HuFR1-23-sulfo-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
HuFR1-23-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
HuFR1-23-3-sulfo-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 ADC Info 
HuFR1-23-PEG4-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 ADC Info 
ADC Name Payload Target Linker ADC Info
HuMov19-PEG4-Mal-DM1 [8]
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 ADC Info 
HuMov19-SMCC-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
HuMov19-SIA-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 ADC Info 
HuMov19-SPP-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
HuMov19-sulfo-SPDB-DM4 (DAR3.8) [8]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
HuMov19-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
HuMov19-3-sulfo-Mal-DM4 (DAR 3.7) [8]
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 ADC Info 
HuMov19-PEG4-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 ADC Info 
HuMov19-3-sulfo-Mal-DM4 (DAR 8.23) [8]
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 ADC Info 
HuMov19-sulfo-SPDB-DM4 (DAR6.8) [8]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
huMOV19v1.0
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HuMOV19v1.0-PEG4-Mal-DM1 [8]
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 ADC Info 
HuMOV19v1.0-SMCC-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
HuMOV19v1.0-SIA-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 ADC Info 
HuMOV19v1.0-SPP-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
HuMOV19v1.0-sulfo-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
HuMOV19v1.0-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
HuMOV19v1.0-3-sulfo-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 ADC Info 
HuMOV19v1.0-PEG4-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 ADC Info 
huMOV19v1.6
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HuMOV19v1.6-PEG4-Mal-DM1 [8]
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 ADC Info 
HuMOV19v1.6-SMCC-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
HuMOV19v1.6-SIA-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 ADC Info 
HuMOV19v1.6-SPP-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
HuMOV19v1.6-sulfo-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
HuMOV19v1.6-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
HuMOV19v1.6-3-sulfo-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 ADC Info 
HuMOV19v1.6-PEG4-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 ADC Info 
ADC Name Payload Target Linker ADC Info
IKS-01 [12]
FGX2-62
Human Deoxyribonucleic acid (hDNA)
Undisclosed
 ADC Info 
Luveltamab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Luveltamab tazevibulin
SC209
Microtubule (MT)
DBCO-Val-Cit-PABA
 ADC Info 
Mirvetuximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Mirvetuximab soravtansine [13]
DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
Mirvetuximab-SPP-DM1 [2]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
Mirvetuximab-SPDB-DM4 [14]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
Mirvetuximab-SMCC-DM1 [2]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
M9346A Sulfo-SPDB DM4 [2]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
M9346A-CX-DM1 [15]
Mertansine DM1
Microtubule (MT)
triglycyl peptide linker CX
 ADC Info 
M9346A-SMCC-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
M9346A-SPP-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
M9346A-sulfo-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 ADC Info 
M9346A-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
37307297 ADC 10 [16]
FD-1
Undisclosed
Undisclosed
 ADC Info 
37307297 ADC 11 [16]
FD-1
Undisclosed
Undisclosed
 ADC Info 
37307297 ADC 21 [16]
FD-1
Undisclosed
Undisclosed
 ADC Info 
37307297 ADC 22 [16]
FD-1
Undisclosed
Undisclosed
 ADC Info 
37307297 ADC 23 [16]
FD-1
Undisclosed
Undisclosed
 ADC Info 
37307297 ADC 24 [16]
FD-2
Undisclosed
Undisclosed
 ADC Info 
37307297 ADC 25 [16]
FD-2
Undisclosed
Undisclosed
 ADC Info 
37307297 ADC 26 [16]
FD-3
Undisclosed
Undisclosed
 ADC Info 
37307297 ADC 27 [16]
FD-3
Undisclosed
Undisclosed
 ADC Info 
37307297 ADC 28 [16]
FD-9
Undisclosed
Undisclosed
 ADC Info 
37307297 ADC 29 [16]
FD-9
Undisclosed
Undisclosed
 ADC Info 
37307297 ADC 30 [16]
FD-22
Undisclosed
Undisclosed
 ADC Info 
37307297 ADC 31 [16]
FD-11
Undisclosed
Undisclosed
 ADC Info 
37307297 ADC 32 [16]
FD-23
Undisclosed
Undisclosed
 ADC Info 
37307297 ADC 33 [16]
FD-19
Undisclosed
Undisclosed
 ADC Info 
mirvetuximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
IGAC-91 [17]
IG-L-18 Payload
Undisclosed
IG-L-25 linker
 ADC Info 
Mirvetuximab (engineered cysteine HC-C118)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
M9346A-4c-Cxxx-Mal-CX-DM1 [15]
Mertansine DM1
Microtubule (MT)
Cxxx-Mal-CX
 ADC Info 
Mirvetuximab (engineered cysteine HC-C239)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
M9346A-4d-Cxxx-Mal-CX-DM1 [15]
Mertansine DM1
Microtubule (MT)
Cxxx-Mal-CX
 ADC Info 
Mirvetuximab (engineered cysteine LC-C205)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
M9346A-4a-Cxxx-Mal-CX-DM1 [15]
Mertansine DM1
Microtubule (MT)
Cxxx-Mal-CX
 ADC Info 
Mirvetuximab (engineered cysteine LC-C400)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
M9346A-4b-Cxxx-Mal-CX-DM1 [15]
Mertansine DM1
Microtubule (MT)
Cxxx-Mal-CX
 ADC Info 
Morab-003
 Antibody Info 
ADC Name Payload Target Linker ADC Info
39424599 ADC-10A [18]
Undisclosed
Undisclosed
Electron-deficient sulfonamide-based cleavable linker 10
 ADC Info 
39424599 ADC-S32A [18]
Undisclosed
Undisclosed
Electron-deficient Disulfide-based cleavable linker 32
 ADC Info 
MORAb-003
 Antibody Info 
ADC Name Payload Target Linker ADC Info
MORAb-003 ADC1 [19]
Nostocyclopeptide-1
Undisclosed
Maleimidyl - PEG3 - benzyl - disulfide - dimethyl linker
 ADC Info 
MORAb-003 ADC2 [19]
Nostocyclopeptide-2
Undisclosed
LL2 linker
 ADC Info 
MORAb-003 ADC3 [19]
Nostocyclopeptide-2
Undisclosed
LL3 linker
 ADC Info 
MORAb-003 ADC4 [19]
Nostocyclopeptide-2
Undisclosed
VCP linker
 ADC Info 
MORAb-003 ADC5 [19]
Eribulin
Microtubule (MT)
VCP linker
 ADC Info 
MORAb-003 ADC6 [19]
ER-001150828
Undisclosed
Maleimidyl- (CH2)5-Val-Cit-pAB linker
 ADC Info 
MORAb-003 ADC7 [19]
ER-001150828
Undisclosed
Maleimidyl-PEG2-Val-Cit-pAB linker
 ADC Info 
MORAb-003 ADC8 [19]
Mertansine DM1
Microtubule (MT)
6-Maleimidocaproic acid
 ADC Info 
MORAb-003 ADC9 [19]
Monomethyl auristatin E
Microtubule (MT)
Maleimidyl- (CH2)5-Val-Cit-pAB linker
 ADC Info 
MORAb-003 ADC10 [19]
Auristatin F
Microtubule (MT)
NHS-PEG2 linker
 ADC Info 
MORAb-003 ADC11 [19]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
MORAb-003 ADC12 [19]
Dolicatatin 3
Undisclosed
PEG-pAB linker
 ADC Info 
MORAb-003 ADC13 [19]
Dolicatatin 5
Microtubule (MT)
Asn-Ala linker
 ADC Info 
MORAb-003 ADC14 [19]
Dolicatatin 3
Undisclosed
Undisclosed
 ADC Info 
MORAb-003 ADC15 [19]
Dolicatatin 10
Undisclosed
PEG-pAB linker
 ADC Info 
MORAb-003 ADC16 [19]
Dolicatatin 14
Undisclosed
Undisclosed
 ADC Info 
MORAb-003 ADC17 [19]
Dolicatatin 14
Undisclosed
Undisclosed
 ADC Info 
MORAb-003 ADC18 [20]
Dolicatatin 14
Undisclosed
Undisclosed
 ADC Info 
MORAb-003 ADC19 [20]
Dolicatatin 14
Undisclosed
Undisclosed
 ADC Info 
MORAb-003 ADC20 [20]
Polymycin 7
Undisclosed
Undisclosed
 ADC Info 
MORAb-003 ADC21 [20]
Polymycin 7
Undisclosed
Undisclosed
 ADC Info 
MORAb-003 ADC22 [20]
Polymycin 7
Undisclosed
PEG-pAB linker
 ADC Info 
MORAb-003 ADC23 [20]
Polymycin 7
Undisclosed
Undisclosed
 ADC Info 
MORAb-003 ADC24 [20]
Dolicatatin 7
Undisclosed
Undisclosed
 ADC Info 
MORAb-003 ADC25 [20]
Dolicatatin 6
Undisclosed
PEG-pAB linker
 ADC Info 
MORAb-003 ADC26 [20]
Dolicatatin 10
Undisclosed
Undisclosed
 ADC Info 
MORAb-003 ADC27 [20]
Dolicatatin 10
Undisclosed
PEG-pAB linker
 ADC Info 
MORAb-003 ADC28 [20]
Dolicatatin 14
Undisclosed
Undisclosed
 ADC Info 
MORAb-003 ADC29 [20]
Dolicatatin 14
Undisclosed
Undisclosed
 ADC Info 
MORAb-003 ADC30 [20]
Dolicatatin 14
Undisclosed
Undisclosed
 ADC Info 
MORAb-003 ADC31 [20]
Dolicatatin 14
Undisclosed
PEG-pAB linker
 ADC Info 
MORAb-003 ADC32 [20]
Dolicatatin 14
Undisclosed
Undisclosed
 ADC Info 
MORAb-003 ADC33 [20]
Dolicatatin 5
Microtubule (MT)
PEG-pAB linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
Mov19-PEG4-Mal-DM1 [8]
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 ADC Info 
Mov19-SMCC-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
Mov19-SIA-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 ADC Info 
Mov19-SPP-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
Mov19-sulfo-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
Mov19-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
Mov19-3-sulfo-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 ADC Info 
Mov19-PEG4-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 ADC Info 
mu-FR1-13
 Antibody Info 
ADC Name Payload Target Linker ADC Info
MuFR1-13-PEG4-Mal-DM1 [8]
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 ADC Info 
MuFR1-13-SMCC-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
MuFR1-13-SIA-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 ADC Info 
MuFR1-13-SPP-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
MuFR1-13-sulfo-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
MuFR1-13-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
MuFR1-13-3-sulfo-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 ADC Info 
MuFR1-13-PEG4-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 ADC Info 
mu-FR1-21
 Antibody Info 
ADC Name Payload Target Linker ADC Info
MuFR1-21-PEG4-Mal-DM1 [8]
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 ADC Info 
MuFR1-21-SMCC-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
MuFR1-21-SIA-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 ADC Info 
MuFR1-21-SPP-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
MuFR1-21-sulfo-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
MuFR1-21-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
MuFR1-21-3-sulfo-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 ADC Info 
MuFR1-21-PEG4-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 ADC Info 
mu-FR1-22
 Antibody Info 
ADC Name Payload Target Linker ADC Info
MuFR1-22-PEG4-Mal-DM1 [8]
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 ADC Info 
MuFR1-22-SMCC-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
MuFR1-22-SIA-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 ADC Info 
MuFR1-22-SPP-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
MuFR1-22-sulfo-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
MuFR1-22-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
MuFR1-22-3-sulfo-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 ADC Info 
MuFR1-22-PEG4-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 ADC Info 
mu-FR1-23
 Antibody Info 
ADC Name Payload Target Linker ADC Info
MuFR1-23-PEG4-Mal-DM1 [8]
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 ADC Info 
MuFR1-23-SMCC-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
MuFR1-23-SIA-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 ADC Info 
MuFR1-23-SPP-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
MuFR1-23-sulfo-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
MuFR1-23-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
MuFR1-23-3-sulfo-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 ADC Info 
MuFR1-23-PEG4-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 ADC Info 
ADC Name Payload Target Linker ADC Info
MuFR1-9-PEG4-Mal-DM1 [8]
Mertansine DM1
Microtubule (MT)
PEG4-Mal
 ADC Info 
MuFR1-9-SMCC-DM1 [8]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
MuFR1-9-SIA-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl iodoacetate (SIA)
 ADC Info 
MuFR1-9-SPP-DM1 [8]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
MuFR1-9-sulfo-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
Sulfo-SPDB
 ADC Info 
MuFR1-9-SPDB-DM4 [8]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
MuFR1-9-3-sulfo-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
3-sulfo-Mal
 ADC Info 
MuFR1-9-PEG4-Mal-DM4 [8]
Mertansine DM4
Microtubule (MT)
PEG4-Mal
 ADC Info 
Opugotamig
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Opugotamig olatansine
DM21-C
Microtubule (MT)
Stable cleavable peptide linker
 ADC Info 
Rinatabart
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Rinatabart sesutecan
Exatecan
DNA topoisomerase 1 (TOP1)
T1000
 ADC Info 
ADC Name Payload Target Linker ADC Info
SIBP-A19
DXd
DNA topoisomerase 1 (TOP1)
Mc-VASGFG
 ADC Info 
Sofetabart
 Antibody Info 
ADC Name Payload Target Linker ADC Info
sofetabart mipitecan
Exatecan
DNA topoisomerase 1 (TOP1)
Mal-Polysarcosine10-Val-Ala-PABC
 ADC Info 
Torvutatug
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Torvutatug samrotecan
AZ14170132 (AZ0132)
DNA topoisomerase 1 (TOP1)
Mal-PEG8-Val-Ala
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HuIgG1-SPDB-DM4 [2]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
Anti-FolRa Iadc [21]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
FOLR1 maytansinoid based antibody-drug conjugate [22]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
M-DGN549 [23]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
DNA-alkylating anti-FRalpha antibody-drug conjugate [24]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
IKS-012 [25]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ALT-Q5 [26]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
BB-17 [27]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
39424599 ADC-S35A [18]
Undisclosed
Undisclosed
S35 linker
 ADC Info 
CN115429893A ADC17 [11]
CN115429893A ADC1 Payload
Undisclosed
CB07 linker
 ADC Info 
anti-FOLR1-151-K-LOCK-D5 [28]
AU2023267043A1 ADC-5 Payload
Undisclosed
AU2023267043A1 ADC-5 Linker
 ADC Info 
anti-FOLR1-151-C-LOCK-D5 [28]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Isumab01-C1a [29]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Isumab01-C1b [29]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Isumab01-C2a [29]
WO2025015586A1, ADC25, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Undisclosed
 ADC Info 
Isumab01-C2b [29]
WO2025015586A1, ADC25, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Undisclosed
 ADC Info 
Isumab01-C3 [29]
WO2025015586A1, ADC23, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Undisclosed
 ADC Info 
Isumab01-C4 [29]
compound 4
DNA topoisomerase I (TOP1)
Undisclosed
 ADC Info 
Isumab01-C5 [29]
compound 5
DNA topoisomerase I (TOP1)
Undisclosed
 ADC Info 
Isumab01-C6 [29]
WO2025015586A1, ADC24, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Undisclosed
 ADC Info 
Isumab01-C7 [29]
WO2025015586A1, ADC34, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Undisclosed
 ADC Info 
Isumab01-C8 [29]
WO2025015586A1, ADC35, Payload
Toll-like receptor 7 (TLR7); Toll-like receptor 8 (TLR8)
Undisclosed
 ADC Info 
References
Ref 1 Binding molecules against FR alpha
Ref 2 IMGN853, a Folate Receptor- (FR)-Targeting Antibody-Drug Conjugate, Exhibits Potent Targeted Antitumor Activity against FR-Expressing Tumors. Mol Cancer Ther. 2015 Jul;14(7):1605-13.
Ref 3 Optimizing Lysosomal Activation of Antibody-Drug Conjugates (ADCs) by Incorporation of Novel Cleavable Dipeptide Linkers. Mol Pharm. 2019 Dec 2;16(12):4817-4825. doi: 10.1021/acs.molpharmaceut.9b00696. Epub 2019 Oct 29.
Ref 4 Synthesis of Highly Potent N-10 Amino-Linked DNA-Alkylating Indolinobenzodiazepine Antibody-Drug Conjugates (ADCs). ACS Med Chem Lett. 2019 Jul 22;10(8):1211-1215. doi: 10.1021/acsmedchemlett.9b00254. eCollection 2019 Aug 8.
Ref 5 SYS6041, a next-generation Folate Receptor α-targeted antibody-drug conjugates for the treatment of FRα-expressing malignancies
Ref 6 5H-pyrrolo[3,2-d]pyrimidine-2,4-diamine compounds and their antibody-drug conjugates
Ref 7 Linkers, drug linkers and conjugates thereof and methods of using the same; 2023-02-16.
Ref 8 Folate receptor 1 antibodies and immunoconjugates and uses thereof; 2011-09-01.
Ref 9 MORAb-202, an Antibody-Drug Conjugate Utilizing Humanized Anti-human FR Farletuzumab and the Microtubule-targeting Agent Eribulin, has Potent Antitumor Activity. Mol Cancer Ther. 2018 Dec;17(12):2665-2675. doi: 10.1158/1535-7163.MCT-17-1215. Epub 2018 Sep 27.
Ref 10 Antibody-drug conjugates
Ref 11 Drug conjugates and uses thereof
Ref 12 IKS01, a next generation antibody drug conjugate, shows target-dependent efficacy in a platinum-resistant tumor model with low levels of folate receptor alpha expression. Mol Cancer Ther (2019) 18 (12_Supplement): C023.
Ref 13 Mirvetuximab Soravtansine: First Approval
Ref 14 Introduction to basic information on ADC drug anti-FR (clone M9346A)-SPDB-DM4.
Ref 15 A Case Study Comparing Heterogeneous Lysine- and Site-Specific Cysteine-Conjugated Maytansinoid Antibody-Drug Conjugates (ADCs) Illustrates the Benefits of Lysine Conjugation. Mol Pharm. 2019 Sep 3;16(9):3926-3937. doi: 10.1021/acs.molpharmaceut.9b00529. Epub 2019 Jul 31.
Ref 16 Structure-Activity Relationships of Bis-Intercalating Peptides and Their Application as Antibody-Drug Conjugate Payloads
Ref 17 Isoindolinone-glutarimide antibody conjugates, and uses thereof
Ref 18 A Novel Concept for Cleavable Linkers Applicable to Conjugation Chemistry - Design, Synthesis and Characterization
Ref 19 Antibody-drug conjugates based on eribulin and methods of use
Ref 20 Fan bracket
Ref 21 Next-generation immunostimulatory antibody-drug conjugate (iADC) combines direct tumor killing and innate immune stimulation to provide protective anti-tumor immunity;
Ref 22 Introduction to basic information on maytansinoid based antibody-drug conjugate.
Ref 23 Preclinical evaluation of M-DGN549, a folate receptor alpha-targeting antibodydrug conjugate (ADC) with a DNA-alkylating payload. December 2016 European journal of cancer 69(1):S145.
Ref 24 A new class of DNA alkylating indolino-benzodiazepine agents (BIAs) linked with a DNA binding moiety for use with antibody-drug conjugates (ADCs). Cancer Res (2018) 78 (13_Supplement): 747.
Ref 25 Iksuda therapeutics product pipeline
Ref 26 Alteogen biotechnology company product pipeline
Ref 27 Introduction to basic information on ADC drug BB-17.
Ref 28 Antibody-drug conjugates comprising an anti-FOLR1 antibody
Ref 29 Antibody-drug conjugate compounds, and methods of use and treatment