Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0VEKFU
ADC Name
LY-4170156
Synonyms
LY-4170156; MBK 103; MBK-103; MBK103
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Organization
Mablink Bioscience
Drug Status
Phase 1
Indication
In total 7 Indication(s)
Breast cancer
Phase 1
Clinical Trial
Cervical cancer
Phase 1
Clinical Trial
Colorectal cancer
Phase 1
Clinical Trial
Endometrial cancer
Phase 1
Clinical Trial
Lung cancer
Phase 1
Clinical Trial
Ovarian cancer
Phase 1
Clinical Trial
Pancreatic cancer
Phase 1
Clinical Trial
Drug-to-Antibody Ratio
8
Structure
Antibody Name
Fc-silent FR specific humanized IgG1 antibody
  Antibody Info 
Antigen Name
Folate receptor alpha (FOLR1)
  Antigen Info 
Payload Name
Exatecan
  Payload Info 
Therapeutic Target
DNA topoisomerase 1 (TOP1)
  Target Info 
Linker Name
Mal-Polysarcosine10-Val-Ala-PABC
  Linker Info 
Conjugate Type
Random Cysteines