Target Information

General Information of This Target (ID: PATR0QBNMQ)
Target Name
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
Gene Name
POLR2B; POLR3G
Gene ID
5431 ; 10622
Synonym 1
DNA-directed RNA polymerase II 140 kDa polypeptide; DNA-directed RNA polymerase II subunit B; RNA polymerase II subunit 2; RNA polymerase II subunit B2
Synonym 2
DNA-directed RNA polymerase III subunit G; RNA polymerase III 32 kDa apha subunit; RNA polymerase III 32 kDa subunit
Sequence 1
MYDADEDMQYDEDDDEITPDLWQEACWIVISSYFDEKGLVRQQLDSFDEFIQMSVQRIVE
DAPPIDLQAEAQHASGEVEEPPRYLLKFEQIYLSKPTHWERDGAPSPMMPNEARLRNLTY
SAPLYVDITKTVIKEGEEQLQTQHQKTFIGKIPIMLRSTYCLLNGLTDRDLCELNECPLD
PGGYFIINGSEKVLIAQEKMATNTVYVFAKKDSKYAYTGECRSCLENSSRPTSTIWVSML
ARGGQGAKKSAIGQRIVATLPYIKQEVPIIIVFRALGFVSDRDILEHIIYDFEDPEMMEM
VKPSLDEAFVIQEQNVALNFIGSRGAKPGVTKEKRIKYAKEVLQKEMLPHVGVSDFCETK
KAYFLGYMVHRLLLAALGRRELDDRDHYGNKRLDLAGPLLAFLFRGMFKNLLKEVRIYAQ
KFIDRGKDFNLELAIKTRIISDGLKYSLATGNWGDQKKAHQARAGVSQVLNRLTFASTLS
HLRRLNSPIGRDGKLAKPRQLHNTLWGMVCPAETPEGHAVGLVKNLALMAYISVGSQPSP
ILEFLEEWSMENLEEISPAAIADATKIFVNGCWVGIHKDPEQLMNTLRKLRRQMDIIVSE
VSMIRDIREREIRIYTDAGRICRPLLIVEKQKLLLKKRHIDQLKEREYNNYSWQDLVASG
VVEYIDTLEEETVMLAMTPDDLQEKEVAYCSTYTHCEIHPSMILGVCASIIPFPDHNQSP
RNTYQSAMGKQAMGVYITNFHVRMDTLAHVLYYPQKPLVTTRSMEYLRFRELPAGINSIV
AIASYTGYNQEDSVIMNRSAVDRGFFRSVFYRSYKEQESKKGFDQEEVFEKPTRETCQGM
RHAIYDKLDDDGLIAPGVRVSGDDVIIGKTVTLPENEDELESTNRRYTKRDCSTFLRTSE
TGIVDQVMVTLNQEGYKFCKIRVRSVRIPQIGDKFASRHGQKGTCGIQYRQEDMPFTCEG
ITPDIIINPHAIPSRMTIGHLIECLQGKVSANKGEIGDATPFNDAVNVQKISNLLSDYGY
HLRGNEVLYNGFTGRKITSQIFIGPTYYQRLKHMVDDKIHSRARGPIQILNRQPMEGRSR
DGGLRFGEMERDCQIAHGAAQFLRERLFEASDPYQVHVCNLCGIMAIANTRTHTYECRGC
RNKTQISLVRMPYACKLLFQELMSMSIAPRMMSV

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Sequence 2
MAGNKGRGRAAYTFNIEAVGFSKGEKLPDVVLKPPPLFPDTDYKPVPLKTGEGEEYMLAL
KQELRETMKRMPYFIETPEERQDIERYSKRYMKVYKEEWIPDWRRLPREMMPRNKCKKAG
PKPKKAKDAGKGTPLTNTEDVLKKMEELEKRGDGEKSDEENEEKEGSKEKSKEGDDDDDD
DAAEQEEYDEEEQEEENDYINSYFEDGDDFGADSDDNMDEATY

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Family
the RNA polymerase beta chain family; the eukaryotic RPC7 RNA polymerase subuni
Function 1
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template.

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Function 2
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF- Kappa-B through the RIG-I pathway

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Uniprot Entry
RPB2_HUMAN ; RPC7_HUMAN
HGNC ID
HGNC:9188 ; HGNC:30075
KEGG ID
hsa:5431 ; hsa:10622
Full List of The ADC Related to This Target
Clinical candidate
Click To Hide/Show 91 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
Trastuzumab-ATAC [1]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Alpha-amanitin
Undisclosed
ADC Info
HuMAB-5B1-ATAC [2]
MVT-5873
Lewis A (LeA)
Alpha-amanitin
Undisclosed
ADC Info
H14A043-ATAC [3]
Human Anti-CDCP1 h14A043-ATAC mAb
CUB domain-containing protein 1 (CDCP1)
Alpha-amanitin
Undisclosed
ADC Info
HuMAB 5B1 targeted amanitin conjugate [4]
5B1
Sialyl Lewis A (sLeA)
Alpha-amanitin
Undisclosed
ADC Info
TAK-ATACs [5]
Undisclosed
Undisclosed
Alpha-amanitin
Undisclosed
ADC Info
Antibody targeted amanitin conjugate [6]
Undisclosed
Undisclosed
Alpha-amanitin
Undisclosed
ADC Info
HDP-103 [7]
Undisclosed
Glutamate carboxypeptidase 2 (FOLH1)
Alpha-amanitin
Undisclosed
ADC Info
Alpha-amanitin antibody-drug conjugate (Agensys) [8]
Undisclosed
Undisclosed
Alpha-amanitin
Undisclosed
ADC Info
T-D265C-CN-Pro-amanitin [9]
Trastuzumab D265C
Receptor tyrosine-protein kinase erbB-2 (HER2)
CN-Pro-dideoxy-alpha-amanitin
Mal-Val-Ala-PAB
ADC Info
CD19-ATAC [10]
Undisclosed
B-lymphocyte antigen CD19 (CD19)
HDP 30.2115
Mal-Val-Ala-PAB
ADC Info
T-D265C-NH2-Pro-amanitin [9]
Trastuzumab D265C
Receptor tyrosine-protein kinase erbB-2 (HER2)
NH2-Pro-dideoxy-alpha-amanitin
Mc-Val-Ala-PABC
ADC Info
T-D265C-OH-Pro-amanitin [9]
Trastuzumab D265C
Receptor tyrosine-protein kinase erbB-2 (HER2)
OH-Pro-dideoxy-alpha-amanitin
Mc-Val-Ala-PABC
ADC Info
OHPAS ADC-1 [11]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Alpha-amanitin
Ortho-hydroxy-protected aryl sulfate
ADC Info
Ab85 D265C/H435A ADC A [12]
Ab85 D265C/H435A
T-cell surface antigen CD2 (CD2)
Amaninamide (thioether)
Mc-Val-Ala-PABC
ADC Info
CD2 RPA2.10 D265C/H435A ADC A [12]
CD2 RPA2.10 D265C/H435A
T-cell surface antigen CD2 (CD2)
Amaninamide (thioether)
Mc-Val-Ala-PABC
ADC Info
CD2 RPA2.10 D265C/H435A ADC C [12]
CD2 RPA2.10 D265C/H435A
T-cell surface antigen CD2 (CD2)
Alpha-amanitin (thioether)
Maleimido-caproyl
ADC Info
CD5 5D7 D265C/H435A ADC A [12]
CD5 5D7 D265C/H435A
T-cell surface glycoprotein CD5 (CD5)
Amaninamide (thioether)
Mc-Val-Ala-PABC
ADC Info
CD5 5D7 D265C/H435A ADC C [12]
CD5 5D7 D265C/H435A
T-cell surface glycoprotein CD5 (CD5)
Alpha-amanitin (thioether)
Maleimido-caproyl
ADC Info
Anti-HER2-D265C-30.2060 [12]
Anti-HER2-D265C
Receptor tyrosine-protein kinase erbB-2 (HER2)
Amanitin 30.206
Mc-Val-Ala-PABC
ADC Info
Anti-HER2-D265C-30.2115 [12]
Anti-HER2-D265C
Receptor tyrosine-protein kinase erbB-2 (HER2)
Amanitin 30.2115
Mc-Val-Ala-PABC
ADC Info
Anti-HER2-D265C-30.2347 [12]
Anti-HER2-D265C
Receptor tyrosine-protein kinase erbB-2 (HER2)
Amanitin 30.2347
Mc-Val-Ala-PABC
ADC Info
Anti-HER2-D265C-30.1699 [12]
Anti-HER2-D265C
Receptor tyrosine-protein kinase erbB-2 (HER2)
Amanitin 30.1699
Mc-Val-Ala-PABC
ADC Info
Anti-HER2-D265C-30.2371 [12]
Anti-HER2-D265C
Receptor tyrosine-protein kinase erbB-2 (HER2)
Amanitin 30.2371
Mc-Val-Ala-PABC
ADC Info
Anti-HER2-D265C-30.0880 [12]
Anti-HER2-D265C
Receptor tyrosine-protein kinase erbB-2 (HER2)
Amanitin 30.088
Maleimido-caproyl
ADC Info
Anti-HER2-D265C-30.2867 [12]
Anti-HER2-D265C
Receptor tyrosine-protein kinase erbB-2 (HER2)
Amanitin 30.2867
Maleimido-caproyl
ADC Info
Anti-PSMA-D265C-30.2060 [12]
Anti-PSMA-D265C
Glutamate carboxypeptidase 2 (FOLH1)
Amanitin 30.206
Mc-Val-Ala-PABC
ADC Info
Anti-PSMA-D265C-30.2115 [12]
Anti-PSMA-D265C
Glutamate carboxypeptidase 2 (FOLH1)
Amanitin 30.2115
Mc-Val-Ala-PABC
ADC Info
Anti-PSMA-D265C-30.2347 [12]
Anti-PSMA-D265C
Glutamate carboxypeptidase 2 (FOLH1)
Amanitin 30.2347
Mc-Val-Ala-PABC
ADC Info
Anti-PSMA-D265C-30.1699 [12]
Anti-PSMA-D265C
Glutamate carboxypeptidase 2 (FOLH1)
Amanitin 30.1699
Mc-Val-Ala-PABC
ADC Info
Anti-PSMA-D265C-30.2371 [12]
Anti-PSMA-D265C
Glutamate carboxypeptidase 2 (FOLH1)
Amanitin 30.2371
Mc-Val-Ala-PABC
ADC Info
Anti-PSMA-D265C-30.0880 [12]
Anti-PSMA-D265C
Glutamate carboxypeptidase 2 (FOLH1)
Amanitin 30.088
Maleimido-caproyl
ADC Info
Anti-PSMA-D265C-30.2867 [12]
Anti-PSMA-D265C
Glutamate carboxypeptidase 2 (FOLH1)
Amanitin 30.2867
Maleimido-caproyl
ADC Info
T (Anti-HER2)-30.2060 [12]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Amanitin 30.206
Mc-Val-Ala-PABC
ADC Info
H3/F11-Var16 (Anti-PSMA)-30.2060 [12]
Anti-PSMA mAb h3/F11-Var16
Glutamate carboxypeptidase 2 (FOLH1)
Amanitin 30.206
Mc-Val-Ala-PABC
ADC Info
T (Anti-HER2)-30.2867 [12]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Amanitin 30.2867
Maleimido-caproyl
ADC Info
H3/F11-Var16 (Anti-PSMA)-30.2867 [12]
Anti-PSMA mAb h3/F11-Var16
Glutamate carboxypeptidase 2 (FOLH1)
Amanitin 30.2867
Maleimido-caproyl
ADC Info
LCB14-alpha-amanitin [13]
Anti-CD19 mAb DI-B4
B-lymphocyte antigen CD19 (CD19)
Alpha-amanitin
LCB14-alpha-amanitin linker
ADC Info
Anti-CD19(LC)-G7VIM-amanitin [13]
DI-B4-(LC)-GGGGGGG-CVIM
B-lymphocyte antigen CD19 (CD19)
Alpha-amanitin
Anti-CD19(LC)-G7VIM-amanitin linker
ADC Info
Blinatumomab-amanitin [13]
Blinatumomab
B-lymphocyte antigen CD19 (CD19); T-cell surface glycoprotein CD3 delta chain (CD3D)
Alpha-amanitin
Blinatumomab-amanitin linker
ADC Info
Inebilizumab-amanitin [13]
Inebilizumab
B-lymphocyte antigen CD19 (CD19)
Alpha-amanitin
Inebilizumab-amanitin linker
ADC Info
Tafasitamab-amanitin [13]
Tafasitamab
B-lymphocyte antigen CD19 (CD19)
Alpha-amanitin
Tafasitamab-amanitin linker
ADC Info
Obexelimab-amanitin [13]
Obexelimab
B-lymphocyte antigen CD19 (CD19)
Alpha-amanitin
Obexelimab-amanitin linker
ADC Info
MDX-1342-amanitin [13]
MDX-1342
B-lymphocyte antigen CD19 (CD19)
Alpha-amanitin
MDX-1342-amanitin linker
ADC Info
MDX-1435-amanitin [13]
MDX-1435
B-lymphocyte antigen CD19 (CD19)
Alpha-amanitin
MDX-1435-amanitin linker
ADC Info
CHD37-amanitin [13]
cHD37
B-lymphocyte antigen CD19 (CD19)
Alpha-amanitin
cHD37-amanitin linker
ADC Info
AFM-11-amanitin [13]
AFM-11
B-lymphocyte antigen CD19 (CD19)
Alpha-amanitin
AFM-11-amanitin linker
ADC Info
AFM-12-amanitin [13]
AFM-12
B-lymphocyte antigen CD19 (CD19)
Alpha-amanitin
AFM-12-amanitin linker
ADC Info
GBR401-amanitin [13]
GBR401
B-lymphocyte antigen CD19 (CD19)
Alpha-amanitin
GBR401-amanitin linker
ADC Info
Denintuzumab-amanitin [13]
Denintuzumab
B-lymphocyte antigen CD19 (CD19)
Alpha-amanitin
Denintuzumab-amanitin linker
ADC Info
Cetuximab (LC) G7-CVIM-amanitin [14]
Cetuximab (LC) G7-CVIM
Epidermal growth factor receptor (EGFR)
Alpha-amanitin
Cetuximab(LC) G7-CVIM-amanitin linker
ADC Info
Cetuximab (LV) G7-CVIM-amanitin [14]
Cetuximab (LV) G7-CVIM
Epidermal growth factor receptor (EGFR)
Alpha-amanitin
Cetuximab(LV) G7-CVIM-amanitin linker
ADC Info
Cetuximab (LC)-amanitin [14]
Cetuximab (LC)
Epidermal growth factor receptor (EGFR)
Alpha-amanitin
Cetuximab(LC)-amanitin linker
ADC Info
WO2017089895A1 ADC21 [15]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Alpha-amanitin
WO2017089895A1_ADC21 linker
ADC Info
WO2017089895A1 ADC22 [15]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Alpha-amanitin
WO2017089895A1_ADC22 linker
ADC Info
WO2017089895A1 ADC56 [15]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Alpha-amanitin
WO2017089895A1_ADC56 linker
ADC Info
WO2017089895A1 ADC57 [15]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Alpha-amanitin
WO2017089895A1_ADC57 linker
ADC Info
huHEA125-amanitin1 [16]
huHEA125
Epithelial cell adhesion molecule (EPCAM)
Beta-amanitin
huHEA125-Amanitin1 linker
ADC Info
Omalizumab-amanitin 1 [16]
Omalizumab
High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A)
Beta-amanitin
Omalizumab-Amanitin1 linker
ADC Info
Trastuzumab-amanitin 1 [16]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Beta-amanitin
Trastuzumab-Amanitin1 linker
ADC Info
Trastuzumab-alpha-amanitin conjugate 3 [16]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Alpha-amanitin
Trastuzumab-alpha-amanitin conjugate 3 linker
ADC Info
huHEA125-alpha-amanitin conjugate 3 [16]
huHEA125
Epithelial cell adhesion molecule (EPCAM)
Alpha-amanitin
huHEA125-alpha-amanitin conjugate 3 linker
ADC Info
Omalizumab-alpha-amanitin conjugate 3 [16]
Omalizumab
High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A)
Alpha-amanitin
Omalizumab-alpha-amanitin conjugate 3 linker
ADC Info
Trastuzumab-alpha-amanitin conjugate 4 [16]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Alpha-amanitin
Trastuzumab-alpha-amanitin conjugate 4 linker
ADC Info
huHEA125-alpha-amanitin conjugate 4 [16]
huHEA125
Epithelial cell adhesion molecule (EPCAM)
Alpha-amanitin
huHEA125-alpha-amanitin conjugate 4 linker
ADC Info
Omalizumab-alpha-amanitin conjugate 4 [16]
Omalizumab
High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A)
Alpha-amanitin
Omalizumab-alpha-amanitin conjugate 4 linker
ADC Info
Trastuzumab-alpha-amanitin conjugate 7 [16]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Alpha-amanitin
Trastuzumab-alpha-amanitin conjugate 7 linker
ADC Info
huHEA125-alpha-amanitin conjugate 7 [16]
huHEA125
Epithelial cell adhesion molecule (EPCAM)
Alpha-amanitin
huHEA125-alpha-amanitin conjugate 7 linker
ADC Info
Omalizumab-alpha-amanitin conjugate 7 [16]
Omalizumab
High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A)
Alpha-amanitin
Omalizumab-alpha-amanitin conjugate 7 linker
ADC Info
Trastuzumab-alpha-amanitin conjugate 10 [16]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Alpha-amanitin
Trastuzumab-alpha-amanitin conjugate 10 linker
ADC Info
huHEA125-alpha-amanitin conjugate 10 [16]
huHEA125
Epithelial cell adhesion molecule (EPCAM)
Alpha-amanitin
huHEA125-alpha-amanitin conjugate 10 linker
ADC Info
Omalizumab-alpha-amanitin conjugate 10 [16]
Omalizumab
High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A)
Alpha-amanitin
Omalizumab-alpha-amanitin conjugate 10 linker
ADC Info
Trastuzumab-alpha-amanitin conjugate 11 [16]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Alpha-amanitin
Trastuzumab-alpha-amanitin conjugate 11 linker
ADC Info
huHEA125-alpha-amanitin conjugate 11 [16]
huHEA125
Epithelial cell adhesion molecule (EPCAM)
Alpha-amanitin
huHEA125-alpha-amanitin conjugate 11 linker
ADC Info
Omalizumab-alpha-amanitin conjugate 11 [16]
Omalizumab
High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A)
Alpha-amanitin
Omalizumab-alpha-amanitin conjugate 11 linker
ADC Info
Trastuzumab-alpha-amanitin conjugate 14 [16]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Alpha-amanitin
Trastuzumab-alpha-amanitin conjugate 14 linker
ADC Info
huHEA125-alpha-amanitin conjugate 14 [16]
huHEA125
Epithelial cell adhesion molecule (EPCAM)
Alpha-amanitin
huHEA125-alpha-amanitin conjugate 14 linker
ADC Info
Omalizumab-alpha-amanitin conjugate 14 [16]
Omalizumab
High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A)
Alpha-amanitin
Omalizumab-alpha-amanitin conjugate 14 linker
ADC Info
Trastuzumab-alpha-amanitin conjugate 15 [16]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Alpha-amanitin
Trastuzumab-alpha-amanitin conjugate 15 linker
ADC Info
huHEA125-alpha-amanitin conjugate 15 [16]
huHEA125
Epithelial cell adhesion molecule (EPCAM)
Alpha-amanitin
huHEA125-alpha-amanitin conjugate 15 linker
ADC Info
Omalizumab-alpha-amanitin conjugate 15 [16]
Omalizumab
High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A)
Alpha-amanitin
Omalizumab-alpha-amanitin conjugate 15 linker
ADC Info
huHEA125-amanitin3 [16]
huHEA125
Epithelial cell adhesion molecule (EPCAM)
Beta-amanitin
huHEA125-Amanitin3 linker
ADC Info
Omalizumab-amanitin 3 [16]
Omalizumab
High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A)
Beta-amanitin
Omalizumab-Amanitin3 linker
ADC Info
Trastuzumab-amanitin 3 [16]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Beta-amanitin
Trastuzumab-Amanitin3 linker
ADC Info
huHEA125-amanitin4 [16]
huHEA125
Epithelial cell adhesion molecule (EPCAM)
Beta-amanitin
huHEA125-Amanitin4 linker
ADC Info
Omalizumab-amanitin 4 [16]
Omalizumab
High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A)
Beta-amanitin
Omalizumab-Amanitin4 linker
ADC Info
Trastuzumab-amanitin 4 [16]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Beta-amanitin
Trastuzumab-Amanitin4 linker
ADC Info
Her-30.0643 [17]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
HDP 30.0643
Her-30.0643 linker
ADC Info
WO2017089890A1 ADC21 [18]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Alpha-amanitin
WO2017089890A1_ADC21 linker
ADC Info
WO2017089890A1 ADC22 [18]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Alpha-amanitin
WO2017089890A1_ADC22 linker
ADC Info
WO2017089890A1 ADC56 [18]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Alpha-amanitin
WO2017089890A1_ADC56 linker
ADC Info
WO2017089890A1 ADC57 [18]
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (HER2)
Alpha-amanitin
WO2017089890A1_ADC57 linker
ADC Info
Investigative
Click To Hide/Show 2 ADC Related to This Stage
ADC Name Antibody Antigen Payload Linker ADC Info
hRS7 ATAC 1 [19]
hRS7
Tumor-associated calcium signal transducer 2 (TACSTD2)
Alpha-amanitin
Mal-Val-Ala-PAB
ADC Info
hRS7 ATAC 2 [19]
hRS7
Tumor-associated calcium signal transducer 2 (TACSTD2)
Alpha-amanitin
Maleimide-noncleavable-C6-linker
ADC Info
References
Ref 1 Payload diversification: a key step in the development of antibody-drug conjugates. J Hematol Oncol. 2023 Jan 17;16(1):3. doi: 10.1186/s13045-022-01397-y.
Ref 2 Heidelberg pharma: expanding the ADC landscape with a new payload targeting RNA polymerase 2; 2017
Ref 3 Antibody drug conjugate using a novel anti-CDCP1 antibody with low hematopoietic stem-cell binding and rapid internalization showed high efficacy for solid cancer. Cancer Res (2023) 83 (7_Supplement): 438.
Ref 4 Heidelberg pharma: ATACing cancer; 2017
Ref 5 Heidelberg pharma ATACs fighting cancer; 2020
Ref 6 Combination of antibody-targeted amanitin conjugates (ATAC) with immune checkpoint inhibitors shows synergistic therapeutic effect in vitro and in vivo. Cancer Res (2021) 81 (13_Supplement): 921.
Ref 7 Heidelberg pharma product pipeline
Ref 8 Introduction to basic information on alpha-amanitin antibody-drug conjugates(Agensys).
Ref 9 Design, Synthesis, and Biochemical Evaluation of Alpha-Amanitin Derivatives Containing Analogs of the trans-Hydroxyproline Residue for Potential Use in Antibody-Drug Conjugates. Chemistry. 2021 Jul 16;27(40):10282-10292. doi: 10.1002/chem.202101373. Epub 2021 Jun 18.
Ref 10 CD19 - a potential target for Amanitin-based ADCs. Cancer Res (2017) 77 (13_Supplement): 62.
Ref 11 Aryl Sulfate is a Useful Motif for Conjugating and Releasing Phenolic Molecules: Sulfur Fluorine Exchange Click Chemistry Enables Discovery of Ortho-Hydroxy-Protected Aryl Sulfate Linker. Bioconjug Chem. 2019 Jul 17;30(7):1957-1968. doi: 10.1021/acs.bioconjchem.9b00340. Epub 2019 Jun 28.
Ref 12 Amatoxin antibody-drug conjugates and uses thereof; 2020-10-29.
Ref 13 Compositions and methods related to anti-cd19 antibody drug conjugates; 2017-03-30.
Ref 14 Compositions and methods related to anti-egfr antibody drug conjugates; 2017-03-30.
Ref 15 Antibody-drug conjugates comprising branched linkers and methods related thereto; 2017-06-01.
Ref 16 Amatoxin-armed therapeutic cell surface binding components designed for tumour therapy.
Ref 17 Amatoxin derivatives.
Ref 18 Conjugates comprising self-immolative groups and methods related thereto.
Ref 19 Novel Amanitin-Based Antibody-Drug Conjugates Targeting TROP2 for the Treatment of Pancreatic Cancer