Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0KJQRS
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| ADC Name |
CD5 5D7 D265C/H435A ADC C
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| Synonyms |
CD5-5D7-D265C/H435A-ADC-C
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| Organization |
Heidelberg Pharma Research GmbH
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| Drug Status |
Investigative
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| Indication |
In total 1 Indication(s)
Acute myeloid leukaemia [ICD11:2A60]
Investigative
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| Drug-to-Antibody Ratio |
2
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| Structure |
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| Antibody Name |
CD5 5D7 D265C/H435A
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Antibody Info | ||||
| Antigen Name |
T-cell surface glycoprotein CD5 (CD5)
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Antigen Info | ||||
| Payload Name |
Alpha-amanitin (thioether)
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Payload Info | ||||
| Therapeutic Target |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
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Target Info | ||||
| Linker Name |
Maleimido-caproyl
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Linker Info | ||||
| Conjugate Type |
Site-specific conjugation through the engineered cysteine (THIOMAB).
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