Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0GXGKO
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| ADC Name |
huHEA125-alpha-amanitin conjugate 3
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| Synonyms |
huHEA125 alpha-amanitin conjugate 3
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| Organization |
Heidelberg Pharma AG
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| Drug Status |
Investigative
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| Indication |
In total 4 Indication(s)
Breast cancer [ICD11:2C60-2C65]
Investigative
Cholangiocarcinoma [ICD11:2C12]
Investigative
Colon adenocarcinoma [ICD11:2B90]
Investigative
Pancreatic ductal adenocarcinoma [ICD11:2C10]
Investigative
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| Drug-to-Antibody Ratio |
2
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| Antibody Name |
huHEA125
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Antibody Info | ||||
| Antigen Name |
Epithelial cell adhesion molecule (EPCAM)
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Antigen Info | ||||
| Payload Name |
Alpha-amanitin
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Payload Info | ||||
| Therapeutic Target |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
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Target Info | ||||
| Linker Name |
huHEA125-alpha-amanitin conjugate 3 linker
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| Conjugate Type |
Random conjugation through nucleophilic lysines.
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