Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0SGXZO
|
|||||
|---|---|---|---|---|---|---|
| ADC Name |
huHEA125-amanitin4
|
|||||
| Synonyms |
huHEA125 Amanitin4
Click to Show/Hide
|
|||||
| Organization |
Heidelberg Pharma AG
|
|||||
| Drug Status |
Investigative
|
|||||
| Indication |
In total 4 Indication(s)
Breast cancer [ICD11:2C60-2C65]
Investigative
Cholangiocarcinoma [ICD11:2C12]
Investigative
Colon adenocarcinoma [ICD11:2B90]
Investigative
Pancreatic ductal adenocarcinoma [ICD11:2C10]
Investigative
|
|||||
| Drug-to-Antibody Ratio |
3
|
|||||
| Antibody Name |
huHEA125
|
Antibody Info | ||||
| Antigen Name |
Epithelial cell adhesion molecule (EPCAM)
|
Antigen Info | ||||
| Payload Name |
Beta-amanitin
|
Payload Info | ||||
| Therapeutic Target |
DNA-directed RNA polymerase II subunit RPB2 (POLR2B); DNA-directed RNA polymerase III subunit RPC7 (POLR3G)
|
Target Info | ||||
| Linker Name |
huHEA125-Amanitin4 linker
|
|||||
| Conjugate Type |
Random conjugation through nucleophilic lysines.
|
|||||
General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Inhibitory Concentration (IC50) | 5.00 pM | Positive EPCAM expression (EPCAM+++/++) | ||
| Method Description |
Cells were added in 50 ul at a density of 50,000 per ml in the experiments with ADCs and at a density of 20,000 per ml in the experiments with huHEA125-Amanitin3. Plates were incubated in a humidified atmosphere at 37°C and 5% CO2 for 72 or 96 h. At 20 h before the end of the assay, 1 uCi of H-thymidine was added.
|
||||
| In Vitro Model | Invasive breast carcinoma | MCF-7 cells | CVCL_0031 | ||
References
If you find any error in data or bug in web service, please kindly report it to Dr. Shen et al.