Antigen Information

General Information of This Antigen (ID: TAR0KPFBI)
Antigen Name
CD70 antigen (CD70)
Gene Name
CD70
Gene ID
970
Synonym
CD27L; CD27LG; TNFSF7; CD27 ligand;Tumor necrosis factor ligand superfamily member 7;CD70
Sequence
MPEEGSGCSVRRRPYGCVLRAALVPLVAGLVICLVVCIQRFAQAQQQLPLESLGWDVAEL
QLNHTGPQQDPRLYWQGGPALGRSFLHGPELDKGQLRIHRDGIYMVHIQVTLAICSSTTA
SRHHPTTLAVGICSPASRSISLLRLSFHQGCTIASQRLTPLARGDTLCTNLTGTLLPSRN
TDETFFGVQWVRP

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Family
Tumor necrosis factor family
Function
Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

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Uniprot Entry
CD70_HUMAN
HGNC ID
HGNC:11937
KEGG ID
hsa:970
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
WO2024092067A1 ADC 2E7-LD003 (PA003) [1]
undisclosed
Undisclosed
Drug linker PB003
 ADC Info 
WO2024092067A1 ADC 2E7-LD004 (PA004) [1]
undisclosed
Undisclosed
Drug linker PB004
 ADC Info 
WO2024092067A1 ADC 2E7-LD008 (PA008) [1]
undisclosed
Undisclosed
Drug linker PB008
 ADC Info 
WO2024092067A1 ADC 2E7-LD038 (PA038) [1]
undisclosed
Undisclosed
Drug linker PB038
 ADC Info 
WO2024092067A1 ADC 2E7-LD039 (PA039) [1]
undisclosed
Undisclosed
Drug linker PB039
 ADC Info 
WO2024092067A1 ADC 2E7-LD040 (PA040) [1]
undisclosed
Undisclosed
Drug linker PB040
 ADC Info 
WO2024092067A1 ADC 2E7-LD082 (PA082) [1]
undisclosed
Undisclosed
Drug linker PB082
 ADC Info 
WO2024092067A1 ADC 2E7-LD083 (PA083) [1]
undisclosed
Undisclosed
Drug linker PB083
 ADC Info 
WO2024092067A1 2E7-deruxtecan [1]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
WO2024092067A1 2E7-vedotin [1]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-CD70
 Antibody Info 
ADC Name Payload Target Linker ADC Info
US12186310B2-35 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12186310B2-36 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12186310B2-37 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12186310B2-49 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-CD70 (US12186310B2)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
US12186310B2-10 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
US12186310B2-11 [2]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-CD70 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
PRO1160
Exatecan
DNA topoisomerase 1 (TOP1)
T1000
 ADC Info 
Anti-CD70 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AMG 172
DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
Anti-CD70-45 ADC [3]
Tetrahydroisoquinoline-based PBD dimer 17
Human Deoxyribonucleic acid (hDNA)
Mc-Val-Cit-PABC
 ADC Info 
ARX305
Amberstatin 269 (AS269)
Microtubule (MT)
Oxime-PEG3
 ADC Info 
Anti-CD70 mAb 1F4
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-CD70 mAb 1F4-IIIa-01 [4]
Anti-CD70 mAb 1F4-IIIa-01 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIa-01 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIa-02 [4]
Anti-CD70 mAb 1F4-IIIa-02 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIa-02 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIa-03 [4]
Anti-CD70 mAb 1F4-IIIa-03 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIa-03 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIa-04 [4]
Anti-CD70 mAb 1F4-IIIa-04 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIa-04 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIa-05 [4]
Anti-CD70 mAb 1F4-IIIa-05 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIa-05 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIa-06 [4]
Anti-CD70 mAb 1F4-IIIa-06 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIa-06 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIa-07 [4]
Anti-CD70 mAb 1F4-IIIa-07 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIa-07 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIa-08 [4]
Anti-CD70 mAb 1F4-IIIa-08 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIa-08 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIb-01 [4]
Anti-CD70 mAb 1F4-IIIb-01 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIb-01 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIb-02 [4]
Anti-CD70 mAb 1F4-IIIb-02 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIb-02 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIb-03 [4]
Anti-CD70 mAb 1F4-IIIb-03 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIb-03 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIb-04 [4]
Anti-CD70 mAb 1F4-IIIb-04 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIb-04 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIb-05 [4]
Anti-CD70 mAb 1F4-IIIb-05 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIb-05 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIb-06 [4]
Anti-CD70 mAb 1F4-IIIb-06 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIb-06 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIb-07 [4]
Anti-CD70 mAb 1F4-IIIb-07 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIb-07 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIb-08 [4]
Anti-CD70 mAb 1F4-IIIb-08 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIb-08 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIb-09 [4]
Anti-CD70 mAb 1F4-IIIb-09 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIb-09 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIc-01 [4]
Anti-CD70 mAb 1F4-IIIc-01 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIc-01 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIc-02 [4]
Anti-CD70 mAb 1F4-IIIc-02 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIc-02 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIc-03 [4]
Anti-CD70 mAb 1F4-IIIc-03 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIc-03 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIc-04 [4]
Anti-CD70 mAb 1F4-IIIc-04 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIc-04 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIc-05 [4]
Anti-CD70 mAb 1F4-IIIc-05 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIc-05 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIc-06 [4]
Anti-CD70 mAb 1F4-IIIc-06 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIc-06 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIc-07 [4]
Anti-CD70 mAb 1F4-IIIc-07 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIc-07 linker
 ADC Info 
Anti-CD70 mAb 1F4-IIIc-08 [4]
Anti-CD70 mAb 1F4-IIIc-08 payload
Undisclosed
Anti-CD70 mAb 1F4-IIIc-08 linker
 ADC Info 
Anti-CD70 mAb 1F4-A [4]
Anti-CD70 mAb 1F4-A payload
Undisclosed
Anti-CD70 mAb 1F4 linker
 ADC Info 
Anti-CD70 mAb 2H5
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-CD70 ADC 12-2 [5]
Anti-CD70 ADC 12-2 payload
Undisclosed
Anti-CD70 ADC 12-2 linker
 ADC Info 
Anti-CD70 ADC 2-7 [5]
Anti-CD70 ADC 2-7 payload
Undisclosed
Anti-CD70 ADC 2-7 linker
 ADC Info 
Anti-CD70 ADC 3-4 [5]
Anti-CD70 ADC 3-4 payload
Undisclosed
Anti-CD70 ADC 3-4 linker
 ADC Info 
Anti-CD70 ADC 4-3 [5]
Anti-CD70 ADC 4-3 payload
Undisclosed
Anti-CD70 ADC 4-3 linker
 ADC Info 
Anti-CD70 ADC 5-3 [5]
Anti-CD70 ADC 5-3 payload
Undisclosed
Anti-CD70 ADC 5-3 linker
 ADC Info 
Anti-CD70 ADC 6-2 [5]
Anti-CD70 ADC 6-2 payload
Undisclosed
Anti-CD70 ADC 6-2 linker
 ADC Info 
Anti-CD70 ADC 7-1 [5]
Anti-CD70 ADC 7-1 payload
Undisclosed
Anti-CD70 ADC 7-1 linker
 ADC Info 
Anti-CD70 ADC 8-5 [5]
Anti-CD70 ADC 8-5 payload
Undisclosed
Anti-CD70 ADC 8-5 linker
 ADC Info 
Anti-CD70 ADC 9-4 [5]
Anti-CD70 ADC 9-4 payload
Undisclosed
Anti-CD70 ADC 9-4 linker
 ADC Info 
Anti-CD70 ADC 10-1 [5]
Anti-CD70 ADC 10-1 payload
Undisclosed
Anti-CD70 ADC 10-1 linker
 ADC Info 
Anti-CD70 ADC 11-5 [5]
Anti-CD70 ADC 11-5 payload
Undisclosed
Anti-CD70 ADC 11-5 linker
 ADC Info 
Anti-CD70 ADC 12-3 [5]
Anti-CD70 ADC 12-3 payload
Undisclosed
Anti-CD70 ADC 12-3 linker
 ADC Info 
Anti-CD70 ADC 13-7 [5]
Anti-CD70 ADC 13-7 payload
Undisclosed
Anti-CD70 ADC 13-7 linker
 ADC Info 
Anti-CD70 ADC 14-5 [5]
Anti-CD70 ADC 14-5 payload
Undisclosed
Anti-CD70 ADC 14-5 linker
 ADC Info 
Anti-CD70 ADC 15-5 [5]
Anti-CD70 ADC 15-5 payload
Undisclosed
Anti-CD70 ADC 15-5 linker
 ADC Info 
Anti-CD70 ADC 16-5 [5]
Anti-CD70 ADC 16-5 payload
Undisclosed
Anti-CD70 ADC 16-5 linker
 ADC Info 
Anti-CD70 ADC 17-2 [5]
Anti-CD70 ADC 17-2 payload
Undisclosed
Anti-CD70 ADC 17-2 linker
 ADC Info 
Anti-CD70 ADC 18-3 [5]
Anti-CD70 ADC 18-3 payload
Undisclosed
Anti-CD70 ADC 18-3 linker
 ADC Info 
Anti-CD70 ADC 19-5 [5]
Anti-CD70 ADC 19-5 payload
Undisclosed
Anti-CD70 ADC 19-5 linker
 ADC Info 
Anti-CD70 ADC 20-5 [5]
Anti-CD70 ADC 20-5 payload
Undisclosed
Anti-CD70 ADC 20-5 linker
 ADC Info 
Anti-CD70 ADC 21-5 [5]
Anti-CD70 ADC 21-5 payload
Undisclosed
Anti-CD70 ADC 21-5 linker
 ADC Info 
Anti-CD70 mAb c1F6
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2007011968A2 c1F6-9a [6]
Monomethyl auristatin E
Microtubule (MT)
WO2007011968A2_c1F6-9a linker
 ADC Info 
WO2007011968A2 c1F6-9b [6]
Monomethyl auristatin F
Microtubule (MT)
WO2007011968A2_c1F6-9b linker
 ADC Info 
WO2007011968A2 c1F6-17 [6]
Doxorubicin
DNA topoisomerase 2-alpha (TOP2A)
WO2007011968A2_c1F6-17 linker
 ADC Info 
Anti-CD70 mAb h1F6
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2015095755A1 h1F6-1.3 [7]
Monomethyl auristatin E
Microtubule (MT)
WO2015095755A1_h1F6-1.3 linker
 ADC Info 
WO2015095755A1 h1F6-1006 [7]
WO2015095755A1_h1F6-1006 payload
Undisclosed
WO2015095755A1_h1F6-1006 linker
 ADC Info 
WO2015095755A1 h1F6-2.0 [7]
Monomethyl auristatin E
Microtubule (MT)
WO2015095755A1_h1F6-2.0 linker
 ADC Info 
WO2015095755A1 h1F6-5.6 [7]
WO2015095755A1_h1F6-5.6 payload
Undisclosed
WO2015095755A1_h1F6-5.6 linker
 ADC Info 
WO2015095755A1 h1F6-6.4 [7]
WO2015095755A1_h1F6-6.4 payload
Undisclosed
WO2015095755A1_h1F6-6.4 linker
 ADC Info 
WO2015095755A1 h1F6-7.7 [7]
WO2015095755A1_h1F6-7.7 payload
Undisclosed
WO2015095755A1_h1F6-7.7 linker
 ADC Info 
Anti-CD70 mAb humanized 1F6
 Antibody Info 
ADC Name Payload Target Linker ADC Info
h1F6-Compound 1 [8]
h1F6-compound 1 payload
Undisclosed
h1F6-compound 1 linker
 ADC Info 
h1F6-Compound 2 [8]
h1F6-compound 2 payload
Undisclosed
h1F6-compound 2 linker
 ADC Info 
h1F6-Compound 3 [8]
h1F6-compound 3 payload
Undisclosed
h1F6-compound 3 linker
 ADC Info 
Anti-CD70 mAb IF6
 Antibody Info 
ADC Name Payload Target Linker ADC Info
1F6-Val-Cit-PABC-MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Mal-Val-Cit-PABC
 ADC Info 
1F6-Ile-Pro-AF [9]
Auristatin F
Microtubule (MT)
Mal-Ile-Pro
 ADC Info 
1F6-Me3-Lys-Pro-AF [9]
Auristatin F
Microtubule (MT)
Mal-Me3Lys-Pro
 ADC Info 
1F6-NorVal- (D)Asp-AF [9]
Auristatin F
Microtubule (MT)
Mal-NorVal-D-Asp
 ADC Info 
1F6-beta-Ala- (D)Asp-AF [9]
Auristatin F
Microtubule (MT)
Mal-bata-Ala-D-Asp
 ADC Info 
1F6-PhenylGly- (D)Lys-AF [9]
Auristatin F
Microtubule (MT)
Mal-PhenylGly-D-Lys
 ADC Info 
1F6-Met- (D)Lys-AF [9]
Auristatin F
Microtubule (MT)
Mal-Met-D-Lys
 ADC Info 
1F6-Asn- (D)Lys-AM [9]
Auristatin M
Microtubule (MT)
Mal-Asn-D-Lys
 ADC Info 
1F6-Met- (D)Lys-AW [9]
L-Alanyl-L-tryptophan
Microtubule (MT)
Mal-Met-D-Lys
 ADC Info 
1F6-Ile-Val-AF [9]
Auristatin F
Microtubule (MT)
Mal-Ile-Val
 ADC Info 
1F6-Asp-Val-AF [9]
Auristatin F
Microtubule (MT)
Mal-Asp-Val
 ADC Info 
1F6-His-Val-AF [9]
Auristatin F
Microtubule (MT)
Mal-His-Val
 ADC Info 
1F6-Met-Lys-AF [9]
Auristatin F
Microtubule (MT)
Mal-Met-Lys
 ADC Info 
1F6-Asn-Lys-AF [9]
Auristatin F
Microtubule (MT)
Mal-Asn-Lys
 ADC Info 
1F6-Pro- (D)Lys-AF [9]
Auristatin F
Microtubule (MT)
Mal-Pro-D-Lys
 ADC Info 
1F6-Met- (D)Lys-MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Mal-Met-D-Lys
 ADC Info 
1F6-Asn- (D)Lys-MMAF [9]
Monomethyl auristatin F
Microtubule (MT)
Mal-Asn-D-Lys
 ADC Info 
1F6-Met- (D)Lys-AM [9]
Auristatin M
Microtubule (MT)
Mal-Met-D-Lys
 ADC Info 
1F6-Asn- (D)Lys-AW [9]
L-Alanyl-L-tryptophan
Microtubule (MT)
Mal-Asn-D-Lys
 ADC Info 
1F6-Asn- (D)Lys-AF [9]
Auristatin F
Microtubule (MT)
Mal-Asn-D-Lys
 ADC Info 
Anti-CD70 mAb murine 1F6
 Antibody Info 
ADC Name Payload Target Linker ADC Info
m1F6-Compound 1 [8]
m1F6-compound 1 payload
Undisclosed
m1F6-compound 1 linker
 ADC Info 
m1F6-Compound 2 [8]
m1F6-compound 2 payload
Undisclosed
m1F6-compound 2 linker
 ADC Info 
m1F6-Compound 3 [8]
m1F6-compound 3 payload
Undisclosed
m1F6-compound 3 linker
 ADC Info 
Chimeric Anti-CD70 Anti-ody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Alpha-CD70-Mc-MMAF [10]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
TW201803600A ADC-6 [11]
PBD
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
SGN-CD70A
PBD dimer
Human deoxyribonucleic acid (hDNA)
dipeptide linker
 ADC Info 
Humanized anti-CD70 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ARX-305
Monomethyl auristatin F
Microtubule (MT)
Oxime-PEG3
 ADC Info 
ADC Name Payload Target Linker ADC Info
BMS-936561
seco-MED-A
Human deoxyribonucleic acid (hDNA)
Mal-Val-Cit
 ADC Info 
Vorsetuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Vorsetuzumab mafodotin
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
CD70-MMAF-ADC [12]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-CD70 antibody-drug conjugate (XDCExplorer) [13]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CD70-glucocorticoid ADC [14]
Fluticasone propionate
Glucocorticoid receptor (NR3C1)
Pyrophosphate linker
 ADC Info 
CN105899515B III [15]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 CD70 antibody drug conjugates and methods of using the same
Ref 2 Antibody-drug conjugate
Ref 3 Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates. J Med Chem. 2020 Nov 25;63(22):13913-13950. doi: 10.1021/acs.jmedchem.0c01385.
Ref 4 Benzodiazepine dimers, conjugates thereof, and methods of making and using.
Ref 5 Phosphate based linkers for intracellular delivery of drug conjugates; 2015-10-08.
Ref 6 Beta-glucuronide-linker drug conjugates; 2007-10-25.
Ref 7 Methylene carbamate linkers for use with targeted-drug conjugates; 2015-06-25.
Ref 8 Cyclodextrin and antibody-drug conjugate formulations.
Ref 9 Novel peptide linkers for highly potent antibody-auristatin conjugate. Bioconjug Chem. 2008 Oct;19(10):1960-3. doi: 10.1021/bc800289a. Epub 2008 Sep 20.
Ref 10 Introduction to basic information on ADC drug Alpha-CD70-Mc-MMAF
Ref 11 Antibody-drug conjugates mainly based on PBD and combinations with FLT3 inhibitors
Ref 12 CD70 antibody-drug conjugate as a potential therapeutic agent for uterine leiomyosarcoma. Am J Obstet Gynecol. 2021 Feb;224(2):197.e1-197.e23. doi: 10.1016/j.ajog.2020.08.028. Epub 2020 Aug 19.
Ref 13 Introduction to basic information on anti-CD70 antibody-drug conjugate(XDCExplorer).
Ref 14 Discovery of Pyrophosphate Diesters as Tunable, Soluble, and Bioorthogonal Linkers for Site-Specific Antibody-Drug Conjugates. J Am Chem Soc. 2016 Feb 3;138(4):1430-45. doi: 10.1021/jacs.5b12547. Epub 2016 Jan 25.
Ref 15 Derivatives of uncialamycin, methods of synthesis and uses as antitumor agents