Antigen Information

General Information of This Antigen (ID: TAR0BWSFH)
Antigen Name
Mucin-1 (MUC1)
Gene Name
MUC1
Gene ID
4582
Synonym
PUM; Breast carcinoma-associated antigen DF3;Cancer antigen 15-3;Carcinoma-associated mucin;Episialin;H23AG;Krebs von den Lungen-6;PEMT;Peanut-reactive urinary mucin;Polymorphic epithelial mucin;Tumor-associated epithelial membrane antigen;Tumor-associated mucin;CD227
Sequence
MTPGTQSPFFLLLLLTVLTVVTGSGHASSTPGGEKETSATQRSSVPSSTEKNAVSMTSSV
LSSHSPGSGSSTTQGQDVTLAPATEPASGSAATWGQDVTSVPVTRPALGSTTPPAHDVTS
APDNKPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDNRPALGSTAPPVHNVTS
ASGSASGSASTLVHNGTSARATTTPASKSTPFSIPSHHSDTPTTLASHSTKTDASSTHHS
SVPPLTSSNHSTSPQLSTGVSFFFLSFHISNLQFNSSLEDPSTDYYQELQRDISEMFLQI
YKQGGFLGLSNIKFRPGSVVVQLTLAFREGTINVHDVETQFNQYKTEAASRYNLTISDVS
VSDVPFPFSAQSGAGVPGWGIALLVLVCVLVALAIVYLIALAVCQCRRKNYGQLDIFPAR
DTYHPMSEYPTYHTHGRYVPPSSTDRSPYEKVSAGNGGSSLSYTNPAVAATSANL

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Function
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein- protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.

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Uniprot Entry
MUC1_HUMAN
HGNC ID
HGNC:7508
KEGG ID
hsa:4582
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
28E4-DM1 [1]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
Anti-CA6 mAb muDS6
 Antibody Info 
ADC Name Payload Target Linker ADC Info
MuDS6-DM1 [1]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
MuDS6-SSNPP-MM1-202 [1]
Mertansine DM1
Microtubule (MT)
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
 ADC Info 
Anti-CD138 mAb C242
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Monoclonal antibody C242-PE conjugate [2]
Pseudomonas exotoxin PE40
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 ADC Info 
Anti-Muc1 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
DXC005
Tub201
Microtubule (MT)
Undisclosed
 ADC Info 
SBO-154
Undisclosed
Undisclosed
A cleavable linker
 ADC Info 
Anti-MUC1 mAb DS6
 Antibody Info 
ADC Name Payload Target Linker ADC Info
DS6-DM1 [3]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
Anti-MUC1 mAb hPAM4
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HPAM4-CL2A-SN38 [4]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 ADC Info 
Cantuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Cantuzumab ravtansine
DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
Cantuzumab mertansine
DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
Gatipotuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
DS-3939
DXd
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ADC Name Payload Target Linker ADC Info
Anti-MUC1 ADC [5]
3-aminophenyl-hemiasterlin
Undisclosed
DBCO Val Cit PABA linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
HAZcPB-DM1 [1]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
ADC Name Payload Target Linker ADC Info
CMB-401
N-acetyl-gamma-calicheamicin
Human deoxyribonucleic acid (hDNA)
Amide-based linker
 ADC Info 
huDS6v1.01
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HuDS6v1.01-DM4 [1]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
huDS6v1.21
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HuDS6v1.21-DM4 [1]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
ADC Name Payload Target Linker ADC Info
MNC2-deruxtecan [6]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ADC Name Payload Target Linker ADC Info
HzMUC1-MMAE [7]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
40287441 3D1 MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
Pab-001-MMAE [9]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
PAb001-ADC [10]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
PnakoMab-ADC [11]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ADC Name Payload Target Linker ADC Info
PM-N54Q-ADC [11]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ADC Name Payload Target Linker ADC Info
SSaPB-DM1 [1]
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
DAC-005 [12]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
anti MUC1-C ADC [13]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 CA6 antigen-specific cytotoxic conjugate and methods of using the same; 2017-11-21.
Ref 2 Monoclonal antibody C242-Pseudomonas exotoxin A. A specific and potent immunotoxin with antitumor activity on a human colon cancer xenograft in nude mice. J Clin Invest. 1992 Aug;90(2):405-11. doi: 10.1172/JCI115875.
Ref 3 A ca6 antigen-specific cytotoxic conjugate and methods of using the same; 2005-02-03
Ref 4 Antibody-SN-38 immunoconjugates with a CL2A linker.
Ref 5 Bispecific antibody-drug conjugates targeting EGFR and MUC1 and uses thereof
Ref 6 MUC1*-deruxtecan kills tumors that have acquired resistance to trastuzumab containing therapeutics
Ref 7 Therapeutic effect of a MUC1-specific monoclonal antibody-drug conjugates against pancreatic cancer model. Cancer Cell Int. 2022 Dec 27;22(1):417.
Ref 8 MUC1-C dependency in drug resistant HR+/HER2- breast cancer identifies a new target for antibody-drug conjugate treatment
Ref 9 Old target, but new approach: Targeting cancer-associated MUC1 with ADC and Car-T. Cancer Res (2020) 80 (16_Supplement): 6530.
Ref 10 Peptron company product pipeline
Ref 11 Anti-MUC1 antibody-drug conjugate
Ref 12 Introduction to basic information on ADC drug DAC-005.
Ref 13 MUC1-C is a target for antibody-drug conjugate treatment of MRTX1133-resistant KRAS G12D mutant pancreatic ductal adenocarcinomas