Antigen Information

General Information of This Antigen
Antigen ID
TAR0BWSFH
Antigen Name
Mucin-1 (MUC1)
Gene Name
MUC1
Gene ID
4582
Synonym
PUM; Breast carcinoma-associated antigen DF3;Cancer antigen 15-3;Carcinoma-associated mucin;Episialin;H23AG;Krebs von den Lungen-6;PEMT;Peanut-reactive urinary mucin;Polymorphic epithelial mucin;Tumor-associated epithelial membrane antigen;Tumor-associated mucin;CD_antigen=CD227
Sequence
MTPGTQSPFFLLLLLTVLTVVTGSGHASSTPGGEKETSATQRSSVPSSTEKNAVSMTSSV
LSSHSPGSGSSTTQGQDVTLAPATEPASGSAATWGQDVTSVPVTRPALGSTTPPAHDVTS
APDNKPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTS
APDTRPAPGSTAPPAHGVTSAPDTRPAPGSTAPPAHGVTSAPDNRPALGSTAPPVHNVTS
ASGSASGSASTLVHNGTSARATTTPASKSTPFSIPSHHSDTPTTLASHSTKTDASSTHHS
SVPPLTSSNHSTSPQLSTGVSFFFLSFHISNLQFNSSLEDPSTDYYQELQRDISEMFLQI
YKQGGFLGLSNIKFRPGSVVVQLTLAFREGTINVHDVETQFNQYKTEAASRYNLTISDVS
VSDVPFPFSAQSGAGVPGWGIALLVLVCVLVALAIVYLIALAVCQCRRKNYGQLDIFPAR
DTYHPMSEYPTYHTHGRYVPPSSTDRSPYEKVSAGNGGSSLSYTNPAVAATSANL

    Click to Show/Hide
Function
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein- protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.

    Click to Show/Hide
Uniprot Entry
MUC1_HUMAN
HGNC ID
HGNC:7508
KEGG ID
hsa:4582
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
28E4-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [1]
Anti-CA6 mAb muDS6
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
MuDS6-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [1]
 ADC Info 
MuDS6-SSNPP-MM1-202
Mertansine DM1
Microtubule (MT)
Sulfosuccinimidyl-N-succinimidyl-4-(5-nitro-2-pyridyldithio) pentanoate (SSNPP)
 [1]
Anti-CD138 mAb C242
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Monoclonal antibody C242-PE conjugate
Pseudomonas exotoxin PE40
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 [2]
Anti-Muc1 antibody
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
DXC005
Tub201
Microtubule (MT)
Undisclosed
 ADC Info 
SBO-154
Undisclosed
Undisclosed
A cleavable linker
Anti-MUC1 mAb DS6
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
DS6-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [3]
Anti-MUC1 mAb hPAM4
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HPAM4-CL2A-SN38
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 [4]
Cantuzumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Cantuzumab ravtansine
DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
Cantuzumab mertansine
DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
Gatipotuzumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
DS-3939
DXd
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Anti-MUC1 ADC
3-aminophenyl-hemiasterlin
Undisclosed
DBCO Val Cit PABA linker
 [5]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HAZcPB-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CMB-401
N-acetyl-gamma-calicheamicin
Human deoxyribonucleic acid (hDNA)
Amide-based linker
huDS6v1.01
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HuDS6v1.01-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [1]
huDS6v1.21
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HuDS6v1.21-DM4
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
MNC2-deruxtecan
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 [6]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HzMUC1-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
40287441 3D1 MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [8]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Pab-001-MMAE
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 [9]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
PAb001-ADC
Undisclosed
Undisclosed
Undisclosed
 [10]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
PnakoMab-ADC
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 [11]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
PM-N54Q-ADC
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 [11]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
SSaPB-DM1
Mertansine DM1
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) pentanoate (SPP)
 [1]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
DAC-005
Undisclosed
Undisclosed
Undisclosed
 [12]
undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
anti MUC1-C ADC
Undisclosed
Undisclosed
Undisclosed
 [13]
References
Ref 1 CA6 antigen-specific cytotoxic conjugate and methods of using the same; 2017-11-21.
Ref 2 Monoclonal antibody C242-Pseudomonas exotoxin A. A specific and potent immunotoxin with antitumor activity on a human colon cancer xenograft in nude mice. J Clin Invest. 1992 Aug;90(2):405-11. doi: 10.1172/JCI115875.
Ref 3 A ca6 antigen-specific cytotoxic conjugate and methods of using the same; 2005-02-03
Ref 4 Antibody-SN-38 immunoconjugates with a CL2A linker.
Ref 5 Bispecific antibody-drug conjugates targeting EGFR and MUC1 and uses thereof
Ref 6 MUC1*-deruxtecan kills tumors that have acquired resistance to trastuzumab containing therapeutics
Ref 7 Therapeutic effect of a MUC1-specific monoclonal antibody-drug conjugates against pancreatic cancer model. Cancer Cell Int. 2022 Dec 27;22(1):417.
Ref 8 MUC1-C dependency in drug resistant HR+/HER2- breast cancer identifies a new target for antibody-drug conjugate treatment
Ref 9 Old target, but new approach: Targeting cancer-associated MUC1 with ADC and Car-T. Cancer Res (2020) 80 (16_Supplement): 6530.
Ref 10 Peptron company product pipeline
Ref 11 Anti-MUC1 antibody-drug conjugate
Ref 12 Introduction to basic information on ADC drug DAC-005.
Ref 13 MUC1-C is a target for antibody-drug conjugate treatment of MRTX1133-resistant KRAS G12D mutant pancreatic ductal adenocarcinomas