Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0JNPOI
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| ADC Name |
HPAM4-CL2A-SN38
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| Synonyms |
HPAM4-SN38
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| Organization |
Immunomedics, Inc.; Gilead Sciences, Inc.
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| Drug Status |
Investigative
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| Indication |
In total 1 Indication(s)
Solid tumors [ICD11:2A00-2A0Z|2B50-2F9Z]
Investigative
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| Drug-to-Antibody Ratio |
5-6
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| Structure |
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| Antibody Name |
Anti-MUC1 mAb hPAM4
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Antibody Info | ||||
| Antigen Name |
Mucin-1 (MUC1)
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Antigen Info | ||||
| Payload Name |
Active metabolite of irinotecan SN38
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Payload Info | ||||
| Therapeutic Target |
DNA topoisomerase 1 (TOP1)
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Target Info | ||||
| Linker Name |
CL2A
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Linker Info | ||||
| Conjugate Type |
Inter-chain cysteine.
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| Combination Type |
Govitecan
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