Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ID: DRG0WOBTH)
| ADC Name |
DS-3939
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| Synonyms |
DS-3939; GT-00A ADC; DS-3939a
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| Organization |
Daiichi Sankyo (Originator)
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| Drug Status |
Phase 1/2
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| Drug-to-Antibody Ratio |
7.9
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| Structure |
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| Antibody Name |
Gatipotuzumab
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Antibody Info | ||||
| Antigen Name |
Mucin-1 (MUC1)
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Antigen Info | ||||
| Payload Name |
DXd
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Payload Info | ||||
| Payload Target |
DNA topoisomerase 1 (TOP1)
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Target Info | ||||
| Linker Name |
Mc-Gly-Gly-Phe-Gly
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Linker Info | ||||
| Conjugate Type |
Random Cysteines
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| Combination Type |
deruxtecan
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2027 Update
The disease landscape of This ADC
2027 Update
The clinical trial pipelines of This ADC
| Indication | Phase 1 | Phase 2 | Phase 3 | Approved | ||
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| Unspecific solid tumor |
1 Trials
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General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Identified from the Human Clinical Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Patients Enrolled |
Eligible patients (ECOG 0-1, LVEF ≥50%, measurable disease) must provide tumor samples for MUC1 analysis; exclusions include prior MUC1 therapy, active CNS metastases, uncontrolled infections (HIV/HBV/HCV), interstitial lung disease, or thromboembolic/autoimmune disorders within 6 months.
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| Administration Dosage |
One IV infusion Q3W on Day 1 of each 21-day cycle.
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| Related Clinical Trial | |||||
| NCT Number | NCT05875168 | Clinical Status | PHASE1|||PHASE2 | ||
| Clinical Description | Phase 1/2, Open-label, Multicenter, First-in-Human Study of DS-3939a in Subjects With Advanced Solid Tumors | ||||
| Primary Endpoint |
The study assesses dose-limiting toxicities (DLTs) within 3 months and tracks treatment-emergent adverse events (AEs) with objective response rates over ~31 months.
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| Other Endpoint |
Efficacy is evaluated via objective response rate, disease control rate, duration of response, and survival outcomes (PFS, OS) over ~31 months, alongside pharmacokinetic (AUC, Cmax, Tmax, T1/2) and immunogenicity (anti-drug antibodies) profiling extending up to 47 months, with TA-MUC1 expression analyzed at baseline.
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