Antigen Information

General Information of This Antigen
Antigen ID
TAR0NEZUA
Antigen Name
Mesothelin (MSLN)
Gene Name
MSLN
Gene ID
10232
Synonym
MPF; CAK1 antigen;Pre-pro-megakaryocyte-potentiating factor
Sequence
MALP.PLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISSLS
PRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPLDL
LLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEADV
RALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTWSV
STMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKTAC
PSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELYPQ
GYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQAPRRPLPQVATL
IDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLD
VLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPL
TVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLSMQ
EALSGTPCLLGPGPVLTVLALLLASTLA

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Family
LAMP family
Function
Membrane-anchored forms may play a role in cellular adhesion.; Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.

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Uniprot Entry
MSLN_HUMAN
HGNC ID
HGNC:7371
KEGG ID
hsa:10232
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Name Payload Target Linker ADC Info
WO2024105205A1 1m-107 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2024105205A1 1m-107* [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
WO2024105205A1 2m-170 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 3m-170 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 4m-170 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 5m-170 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 6m-170 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 7m-170 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 8m-170 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 11m-170a [1]
KSPI6-1
Undisclosed
WO2024105205A1-11m-170a-Linker
 ADC Info 
WO2024105205A1 11m-170a* [1]
KSPI6-1
Undisclosed
WO2024105205A1-11m-170a-Linker
 ADC Info 
WO2024105205A1 11m-170b [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 12m-170a 1 [1]
KSPI6-1
Undisclosed
WO2024105205A1-12m-170a-Linker
 ADC Info 
WO2024105205A1 12m-170a 2 [1]
KSPI6-1
Undisclosed
WO2024105205A1-12m-170a-Linker
 ADC Info 
WO2024105205A1 13m-170 [1]
KSPI6-1
Undisclosed
Undisclosed
 ADC Info 
WO2024105205A1 14m-170 [1]
KSPI6-1
Undisclosed
WO2024105205A1-14m-170-Linker
 ADC Info 
Amatuximab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
MSLN-Mal-PEG2-Val-Cit-PABC-Eribulin [2]
Eribulin
Microtubule (MT)
Mal-PEG2-Val-Cit-PABC
 ADC Info 
MSLN-Mal-PEG8-Val-Cit-PABC-Eribulin [2]
Eribulin
Microtubule (MT)
Mal-PEG8-Val-Cit-PABC
 ADC Info 
MSLN-Mal-Caproyl-Val-Cit-PABC-Eribulin [2]
Eribulin
Microtubule (MT)
Maleimide-Caproyl-Val-Cit-PABC
 ADC Info 
MSLN-Mal-PEG2-Ala-Ala-Asn-PABC-Eribulin [2]
Eribulin
Microtubule (MT)
Mal-PEG2-Ala-Ala-Asn-PABC
 ADC Info 
MSLN-Mal-PEG4-tria-PEG3-Dis-dim-PABC-Eribulin [2]
Eribulin
Microtubule (MT)
Mal-PEG4-triazole-PEG3-Disulfidyl-dimethyl-PABC
 ADC Info 
MSLN-Mal-PEG4-tria-PEG3-Sulfo-Eribulin [2]
Eribulin
Microtubule (MT)
Mal-PEG4-triazole-PEG3-Sulfonamide
 ADC Info 
MSLN-Mal-PEG2-Eribulin [2]
Eribulin
Microtubule (MT)
Mal-PEG2
 ADC Info 
MSLN-Mal-PEG4-Eribulin [2]
Eribulin
Microtubule (MT)
Mal-PEG4
 ADC Info 
MSLN-Suc/SPAAC-PEG4-Val-Cit-PABC-Eribulin [2]
Eribulin
Microtubule (MT)
Succinamide-SPAAC-PEG4-Val-Cit-PABC
 ADC Info 
MSLN-Suc/SPAAC-PEG3-Dis-dim-PABC-Eribulin [2]
Eribulin
Microtubule (MT)
Succinamide-SPAAC-PEG3-Disylfidyl-dimethyl-PABC
 ADC Info 
MSLN-Suc/SPAAC-PEG3-Sulfonamide-Eribulin [2]
Eribulin
Microtubule (MT)
Succinamide-SPAAC-PEG3-Sulfonamide
 ADC Info 
MSLN-Suc/SPAAC-PEG2-Eribulin [2]
Eribulin
Microtubule (MT)
Succinamide-SPAAC-PEG2
 ADC Info 
MSLN-Suc/SPAAC-PEG4-Eribulin [2]
Eribulin
Microtubule (MT)
Succinamide-SPAAC-PEG4
 ADC Info 
MSLN-Mal-PEG-Val-Cit-PABC-Cryptophycin [2]
Cryptophycin
Microtubule (MT)
Mal-PEG-Val-Cit-PABC
 ADC Info 
MSLN-Mal-Caproyl-Val-Cit-PABC-MMAE [2]
Monomethyl auristatin E
Microtubule (MT)
Maleimide-Caproyl-Val-Cit-PABC
 ADC Info 
MSLN-Mal-Caproyl-Val-Cit-PABC-MMAF [2]
Monomethyl auristatin F
Microtubule (MT)
Maleimide-Caproyl-Val-Cit-PABC
 ADC Info 
Amatuximab-Compound 9 [3]
Mertansine DM1
Microtubule (MT)
Amatuximab-Compound 9 linker
 ADC Info 
Amatuximab-Compound 17 [3]
Mertansine DM4
Microtubule (MT)
Amatuximab-Compound 17 linker
 ADC Info 
Amatuximab-Compound 25 [3]
Monomethyl auristatin E
Microtubule (MT)
Amatuximab-Compound 25 linker
 ADC Info 
Amatuximab-Compound 31 [3]
Auristatin 0101
Microtubule (MT)
Amatuximab-Compound 31 linker
 ADC Info 
Amatuximab-Compound 36 [3]
Monomethyl auristatin E
Microtubule (MT)
Amatuximab-Compound 36 linker
 ADC Info 
Amatuximab-Compound 43 [3]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Amatuximab-Compound 43 linker
 ADC Info 
Amatuximab-Compound 49 [3]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Amatuximab-Compound 49 linker
 ADC Info 
Amatuximab-Compound 55 [3]
Mertansine DM1
Microtubule (MT)
Amatuximab-Compound 55 linker
 ADC Info 
Amatuximab-Compound 59 [3]
Mertansine DM4
Microtubule (MT)
Amatuximab-Compound 59 linker
 ADC Info 
Amatuximab-Compound 64 [3]
Monomethyl auristatin E
Microtubule (MT)
Amatuximab-Compound 64 linker
 ADC Info 
Amatuximab-Compound 69 [3]
Monomethyl auristatin E
Microtubule (MT)
Amatuximab-Compound 69 linker
 ADC Info 
Amatuximab-Compound 74 [3]
PBD dimer
Human Deoxyribonucleic acid (hDNA)
Amatuximab-Compound 74 linker
 ADC Info 
Amatuximab-Compound 75 [3]
Monomethyl auristatin E
Microtubule (MT)
Amatuximab-Compound 75 linker
 ADC Info 
Amatuximab-Compound 76 [3]
Monomethyl auristatin E
Microtubule (MT)
Amatuximab-Compound 76 linker
 ADC Info 
Amatuximab-Compound 77 [3]
Mertansine DM1
Microtubule (MT)
Amatuximab-Compound 77 linker
 ADC Info 
Amatuximab-Compound 78 [3]
Auristatin 0101
Microtubule (MT)
Amatuximab-Compound 78 linker
 ADC Info 
Amatuximab-Compound 79 [3]
Auristatin 0101
Microtubule (MT)
Amatuximab-Compound 79 linker
 ADC Info 
Amatuximab-Compound 80 [3]
Mertansine DM4
Microtubule (MT)
Amatuximab-Compound 80 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
Anetumab ravtansine
DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
Anetumab corixetan [4]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anetuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
JP7623413B2 ExampleADC52 [5]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-MSLN Anti-ody Fab fragment
 Antibody Info 
ADC Name Payload Target Linker ADC Info
RG7787 [6]
Pseudomonas exotoxin PE24
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 ADC Info 
Anti-MSLN antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HBM9033
YL0010014
DNA topoisomerase 1 (TOP1)
VK*G-NHCH2-O linker
 ADC Info 
Anti-MSLN IgG1-ALA12
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ALA12-Val-Cit-MMAE [7]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-MSLN IgG1-CHS5
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CHS5-Val-Cit-MMAE [7]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-MSLN IgG1-CHS7
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CHS7-Val-Cit-MMAE [7]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-MSLN IgG1-CHS8
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CHS8-Val-Cit-MMAE [7]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-MSLN IgG1-SS1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
SS1-Val-Cit-MMAE [7]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-MSLN mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
RC88-Mc-Val-Cit-PAB-MMAD [8]
Monomethyl auristatin D
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
RC88-Mc-Val-Cit-PAB-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
RC88-PY-MAA-Val-Cit-PAB-MMAD [8]
Monomethyl auristatin D
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
RC88-PY-MAA-Val-Cit-PAB-MMAE [8]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-MSLN-45 ADC [9]
Tetrahydroisoquinoline-based PBD dimer 17
Human Deoxyribonucleic acid (hDNA)
Mc-Val-Cit-PABC
 ADC Info 
Anti-MSLN-46 ADC [9]
Tetrahydroisoquinoline-based PBD dimer 17
Human Deoxyribonucleic acid (hDNA)
PEG2-Val-Cit-PABC
 ADC Info 
Anti-MSLN-47 ADC [9]
Tetrahydroisoquinoline-based PBD dimer 17
Human Deoxyribonucleic acid (hDNA)
PEG4-Val-Cit-PABC
 ADC Info 
Anti-MSLN-48 ADC [9]
Tetrahydroisoquinoline-based PBD dimer 17
Human Deoxyribonucleic acid (hDNA)
PEG8-Val-Cit-PABC
 ADC Info 
Anti-MSLN-44 ADC [9]
Tetrahydroisoquinoline-based PBD dimer 14
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Cit-PABC
 ADC Info 
Anti-MSLN mAb 6A4
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-MSLN mAb 6A4-IIIa-01 [10]
Anti-MSLN mAb 6A4-IIIa-01 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIa-01 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIa-02 [10]
Anti-MSLN mAb 6A4-IIIa-02 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIa-02 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIa-03 [10]
Anti-MSLN mAb 6A4-IIIa-03 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIa-03 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIa-04 [10]
Anti-MSLN mAb 6A4-IIIa-04 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIa-04 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIa-05 [10]
Anti-MSLN mAb 6A4-IIIa-05 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIa-05 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIa-06 [10]
Anti-MSLN mAb 6A4-IIIa-06 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIa-06 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIa-07 [10]
Anti-MSLN mAb 6A4-IIIa-07 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIa-07 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIa-08 [10]
Anti-MSLN mAb 6A4-IIIa-08 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIa-08 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIb-01 [10]
Anti-MSLN mAb 6A4-IIIb-01 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIb-01 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIb-02 [10]
Anti-MSLN mAb 6A4-IIIb-02 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIb-02 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIb-03 [10]
Anti-MSLN mAb 6A4-IIIb-03 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIb-03 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIb-04 [10]
Anti-MSLN mAb 6A4-IIIb-04 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIb-04 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIb-05 [10]
Anti-MSLN mAb 6A4-IIIb-05 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIb-05 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIb-06 [10]
Anti-MSLN mAb 6A4-IIIb-06 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIb-06 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIb-07 [10]
Anti-MSLN mAb 6A4-IIIb-07 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIb-07 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIb-08 [10]
Anti-MSLN mAb 6A4-IIIb-08 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIb-08 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIb-09 [10]
Anti-MSLN mAb 6A4-IIIb-09 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIb-09 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIc-01 [10]
Anti-MSLN mAb 6A4-IIIc-01 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIc-01 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIc-02 [10]
Anti-MSLN mAb 6A4-IIIc-02 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIc-02 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIc-03 [10]
Anti-MSLN mAb 6A4-IIIc-03 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIc-03 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIc-04 [10]
Anti-MSLN mAb 6A4-IIIc-04 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIc-04 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIc-05 [10]
Anti-MSLN mAb 6A4-IIIc-05 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIc-05 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIc-06 [10]
Anti-MSLN mAb 6A4-IIIc-06 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIc-06 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIc-07 [10]
Anti-MSLN mAb 6A4-IIIc-07 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIc-07 linker
 ADC Info 
Anti-MSLN mAb 6A4-IIIc-08 [10]
Anti-MSLN mAb 6A4-IIIc-08 payload
Undisclosed
Anti-MSLN mAb 6A4-IIIc-08 linker
 ADC Info 
Anti-MSLN mAb 6A4-A [10]
Anti-MSLN mAb 6A4-A payload
Undisclosed
Anti-MSLN mAb 6A4 linker
 ADC Info 
Anti-MSLN scFv
 Antibody Info 
ADC Name Payload Target Linker ADC Info
LMB-100 [11]
Pseudomonas exotoxin LO10R456A
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 ADC Info 
LMB-12 [11]
Pseudomonas exotoxin PE24
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 ADC Info 
LMB-164 [11]
Pseudomonas exotoxin PE24
Eukaryotic elongation factor 2 kinase (EEF2K)
Undisclosed
 ADC Info 
BMS-986021
 Antibody Info 
ADC Name Payload Target Linker ADC Info
BMS-986148
Tubulysin
Microtubule (MT)
Mc-Val-Cit
 ADC Info 
ADC Name Payload Target Linker ADC Info
RG7600 [12]
MMAE
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Humanized IgG1 Anti-MSLN mAb h7D9.v3
 Antibody Info 
ADC Name Payload Target Linker ADC Info
RG-7600 [13]
Monomethyl auristatin E
Microtubule (MT)
Protease-labile valine-citrulline linker
 ADC Info 
Misitatug
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Misitatug blivedotin
MMAE
Microtubule (MT)
PY-MAA-Val-Cit-PABC
 ADC Info 
ADC Name Payload Target Linker ADC Info
RC88-Mc-Val-Cit-PAB-MMAD [14]
Monomethyl auristatin D
Undisclosed
Mc-Val-Cit-PABC
 ADC Info 
RC88-Mc-Val-Cit-PAB-MMAE [14]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
RC88-Py-MAA-Val-Cit-PAB-MMAD [14]
Monomethyl auristatin D
Undisclosed
PY-MAA-Val-Cit-PABC
 ADC Info 
RC88-Py-MAA-Val-Cit-PAB-MMAE [14]
Monomethyl auristatin E
Microtubule (MT)
PY-MAA-Val-Cit-PABC
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Immunoconjugate (Bayer AG)
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
NAV-001 [15]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
LCB14-17nn [16]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-mesothelin antibody-drug conjugate (Bristol Myers Squibb) [17]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
MSLN ADC (Development Center for Biotechnology) [18]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
MSLN MMAE [19]
Monomethyl auristatin E
Microtubule (MT)
Undisclosed
 ADC Info 
undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Tubulysin-aMeso ADC (Lysine-conjugated random ADCs) [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Deacetyl tubulysin-aMeso ADC (Lysine-conjugated random ADCs) [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Hinge-cysteine ADC [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
N297Q ADC [20]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
CN105899515B I [21]
CN105899515B I payload
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Antibody-drug conjugates (A2DCs) with enzymatically cleavable groups
Ref 2 MORAb-202, an Antibody-Drug Conjugate Utilizing Humanized Anti-human FR Farletuzumab and the Microtubule-targeting Agent Eribulin, has Potent Antitumor Activity. Mol Cancer Ther. 2018 Dec;17(12):2665-2675. doi: 10.1158/1535-7163.MCT-17-1215. Epub 2018 Sep 27.
Ref 3 Covalent linkers in antibody-drug conjugates and methods of making and using the same.
Ref 4 ADC review: basic information about Anetumab corixetan.
Ref 5 Antibody-drug complexes containing hemiasterlin derivatives
Ref 6 Anticancer Effects of Mesothelin-Targeted Immunotoxin Therapy Are Regulated by Tyrosine Kinase DDR1. Cancer Res. 2016 Mar 15;76(6):1560-8. doi: 10.1158/0008-5472.CAN-15-2401. Epub 2015 Dec 30.
Ref 7 Eradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody-drug conjugates from synthetic antibody libraries. Sci Rep. 2021 Jul 29;11(1):15430. doi: 10.1038/s41598-021-94902-1.
Ref 8 Anti-mesothelin antibody and antibody-drug conjugate thereof; 2019-11-28.
Ref 9 Design, Synthesis, and Structure-Activity Relationships of Novel Tetrahydroisoquinolino Benzodiazepine Dimer Antitumor Agents and Their Application in Antibody-Drug Conjugates. J Med Chem. 2020 Nov 25;63(22):13913-13950. doi: 10.1021/acs.jmedchem.0c01385.
Ref 10 Benzodiazepine dimers, conjugates thereof, and methods of making and using.
Ref 11 Anti-Mesothelin Recombinant Immunotoxin Therapy for Colorectal Cancer. Clin Colorectal Cancer. 2019 Sep;18(3):192-199.e1. doi: 10.1016/j.clcc.2019.06.006. Epub 2019 Jul 2.
Ref 12 89Zr-MMOT PET Imaging in Pancreatic and Ovarian Cancer Patients
Ref 13 Phase I Study of DMOT4039A, an Antibody-Drug Conjugate Targeting Mesothelin, in Patients with Unresectable Pancreatic or Platinum-Resistant Ovarian Cancer. Mol Cancer Ther. 2016 Mar;15(3):439-47. doi: 10.1158/1535-7163.MCT-15-0693.
Ref 14 Anti-mesothelin antibody and antibody drug conjugate thereof
Ref 15 NAV-001, a high-efficacy antibody-drug conjugate targeting mesothelin with improved delivery of a potent payload by counteracting MUC16/CA125 inhibitory effects. PLoS One. 2023 May 17;18(5):e0285161. doi: 10.1371/journal.pone.0285161.
Ref 16 ADC review: basic information about LCB14-17NN.
Ref 17 Introduction to basic information on anti-mesothelin antibody-drug conjugate(Bristol Myers Squibb).
Ref 18 Anti-MSLN ADC against cancer; institute of pharmaceutics development center for biotechnology; 2020
Ref 19 A clinical candidate anti-mesothelin-MMAE antibody-drug conjugate (ADC) for therapy of mesothelin-expressing cancers. Cancer Res (2014) 74 (19_Supplement): 4494.
Ref 20 The Impact of Conjugation Mode and Site on Tubulysin Antibody-Drug-Conjugate Efficacy and Stability
Ref 21 Derivatives of uncialamycin, methods of synthesis and uses as antitumor agents