Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0JGJDN
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| ADC Name |
HBM9033
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| Synonyms |
HBM9033; YL215; PF-08052666; SGN-MesoC2; MesoC2
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| Organization |
Harbour BioMed (Originator) (No Rights);MediLink Therapeutics (Originator) (No Rights);Seagen (Top20 MNC)
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| Drug Status |
Phase 1 (discontinued)
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| Drug-to-Antibody Ratio |
8
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| Structure |
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| Antibody Name |
Anti-MSLN antibody
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Antibody Info | ||||
| Antigen Name |
Mesothelin (MSLN)
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Antigen Info | ||||
| Payload Name |
YL0010014
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Payload Info | ||||
| Therapeutic Target |
DNA topoisomerase 1 (TOP1)
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Target Info | ||||
| Linker Name |
VK*G-NHCH2-O linker
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Linker Info | ||||
| Conjugate Type |
Reactive Cysteines
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| Combination Type |
pelitecan
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The indication landscape of This ADC(2027 Update)
The clinical trial pipeline of This ADC(2027 Update)
| Indication | Phase 1 | Phase 1/2 | Phase 2 | Phase 2/3 | Phase 3 | New Drug Application | Approved | ||
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| Colorectal cancer |
1 Trials
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| Pancreatic cancer |
1 Trials
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| Lung cancer |
1 Trials
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| Pleura mesothelioma |
1 Trials
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| Ovarian cancer |
1 Trials
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| Endometrial cancer |
1 Trials
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| Unspecific solid tumor |
1 Trials
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