Antigen Information

General Information of This Antigen
Antigen ID
TAR0MYDAB
Antigen Name
Receptor tyrosine-protein kinase erbB-3 (ERBB3)
Gene Name
ERBB3
Gene ID
2065
Synonym
HER3; Proto-oncogene-like protein c-ErbB-3;Tyrosine kinase-type cell surface receptor HER3
Sequence
MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVM
GNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVM
LNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNG
RSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQD
TDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTS
CVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGN
LDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGG
RSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEE
RLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEP
REFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPI
YKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLG
GTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVF
GTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPG
SSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNV
LLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVT
VWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKE
LANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEED
NLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPR
PVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLL
TPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYM
NRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDY
EYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATD
SAFDNPDYWHSRLFPKANAQRT

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Family
Tyr protein family
Function
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.

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Uniprot Entry
ERBB3_HUMAN
HGNC ID
HGNC:3431
KEGG ID
hsa:2065
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
Anti-Her3 mAb 202-2-1
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Her3-ADC-07 (DAR8)
Her3-ADC-07(DAR8) payload
Undisclosed
Her3-ADC-07(DAR8) linker
 [1]
 ADC Info 
Her3-ADC-07 (DAR4)
Her3-ADC-07(DAR4) payload
Undisclosed
Her3-ADC-07(DAR4) linker
 [1]
 ADC Info 
Her3-ADC-07 (DAR6)
Her3-ADC-07(DAR6) payload
Undisclosed
Her3-ADC-07(DAR6) linker
 [1]
 ADC Info 
Her3-ADC-05 (DAR4)
Her3-ADC-05(DAR4) payload
Undisclosed
Her3-ADC-05(DAR4) linker
 [1]
 ADC Info 
Her3-ADC-15 (DAR8)
Her3-ADC-15(DAR8) payload
Undisclosed
Her3-ADC-15(DAR8) linker
 [1]
 ADC Info 
Her3-ADC-15 (DAR2)
Her3-ADC-15(DAR2) payload
Undisclosed
Her3-ADC-15(DAR2) linker
 [1]
 ADC Info 
Her3-ADC-21 (DAR4)
Her3-ADC-21(DAR4) payload
Undisclosed
Her3-ADC-21(DAR4) linker
 [1]
 ADC Info 
Her3-ADC-23 (DAR4)
Her3-ADC-23(DAR4) payload
Undisclosed
Her3-ADC-23(DAR4) linker
 [1]
 ADC Info 
Her3-ADC-33 (DAR4)
Her3-ADC-33(DAR4) payload
Undisclosed
Her3-ADC-33(DAR4) linker
 [1]
Anti-HER3 mAb 9F7-F11
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
MMAE-9F7-F11 ADC
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [2]
Antibody A
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CN117616052A Antibody A-ADC1
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
DBCO-PEG4-GGFG-aminol
 [3]
Barecetamab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Barecetamab-ADC-Tb4-1
Barecetamab-ADC-Tb4-1 payload
Undisclosed
Barecetamab-ADC-Tb4-1 linker
 [1]
 ADC Info 
Barecetamab-ADC-Tb4-2
Barecetamab-ADC-Tb4-2 payload
Undisclosed
Barecetamab-ADC-Tb4-2 linker
 [1]
 ADC Info 
Barecetamab-ADC-Tb4-3
Barecetamab-ADC-Tb4-3 payload
Undisclosed
Barecetamab-ADC-Tb4-3 linker
 [1]
 ADC Info 
Barecetamab-ADC-Tb4-4
Barecetamab-ADC-Tb4-4 payload
Undisclosed
Barecetamab-ADC-Tb4-4 linker
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
CDX3379-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 [4]
Duligotuzumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Duligotuzumab-ADC-Tb4-1
Duligotuzumab-ADC-Tb4-1 payload
Undisclosed
Duligotuzumab-ADC-Tb4-1 linker
 [1]
 ADC Info 
Duligotuzumab-ADC-Tb4-2
Duligotuzumab-ADC-Tb4-2 payload
Undisclosed
Duligotuzumab-ADC-Tb4-2 linker
 [1]
 ADC Info 
Duligotuzumab-ADC-Tb4-3
Duligotuzumab-ADC-Tb4-3 payload
Undisclosed
Duligotuzumab-ADC-Tb4-3 linker
 [1]
 ADC Info 
Duligotuzumab-ADC-Tb4-4
Duligotuzumab-ADC-Tb4-4 payload
Undisclosed
Duligotuzumab-ADC-Tb4-4 linker
 [1]
Elgemtumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Elgemtumab-ADC-Tb4-1
Elgemtumab-ADC-Tb4-1 payload
Undisclosed
Elgemtumab-ADC-Tb4-1 linker
 [1]
 ADC Info 
Elgemtumab-ADC-Tb4-2
Elgemtumab-ADC-Tb4-2 payload
Undisclosed
Elgemtumab-ADC-Tb4-2 linker
 [1]
 ADC Info 
Elgemtumab-ADC-Tb4-3
Elgemtumab-ADC-Tb4-3 payload
Undisclosed
Elgemtumab-ADC-Tb4-3 linker
 [1]
 ADC Info 
Elgemtumab-ADC-Tb4-4
Elgemtumab-ADC-Tb4-4 payload
Undisclosed
Elgemtumab-ADC-Tb4-4 linker
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
EV20/NMS-P945
NMS-P528
Human Deoxyribonucleic acid (hDNA)
Cathepsin-cleavable peptidic linker with self-immolating spacer
 [5]
 ADC Info 
EV20/MMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 [6]
 ADC Info 
MP-EV-20
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 [7]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
FDA026-1402
Undisclosed
Undisclosed
Undisclosed
 [8]
 ADC Info 
FDA026-LE12
FDA029-LE12 payload
Undisclosed
CN119317630A ADC-C9 Linker
 [8]
 ADC Info 
FDA026-LE13
FDA029-LE13 payload
Undisclosed
CN119317630A ADC-C9 Linker
 [8]
 ADC Info 
FDA026-LE14
FDA029-LE14 payload
Undisclosed
Mc-Val-Ala-PABC
 [8]
 ADC Info 
FDA026-LE15
FDA029-LE14 payload
Undisclosed
FDA026-LE15 linker
 [8]
 ADC Info 
FDA026-LE16
FDA029-LE14 payload
Undisclosed
FDA026-LE17 linker
 [8]
 ADC Info 
FDA026-LE17
FDA029-LE13 payload
Undisclosed
FDA026-LE17 linker
 [8]
 ADC Info 
FDA026-LE18
FDA029-LE14 payload
Undisclosed
FDA026-LE18 linker
 [8]
 ADC Info 
FDA026-LE19
FDA029-LE14 payload
Undisclosed
FDA026-LE19 linker
 [8]
 ADC Info 
FDA026-LE20
FDA029-LE14 payload
Undisclosed
FDA026-LE20 linker
 [8]
 ADC Info 
FDA026-LE21
FDA026-LE21 payload
Undisclosed
CN119317630A ADC-C9 Linker
 [8]
 ADC Info 
FDA026-LE22
FDA026-LE22 payload
Undisclosed
CN119317630A ADC-C9 Linker
 [8]
 ADC Info 
FDA026-LS13
Undisclosed
Undisclosed
Undisclosed
 [8]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
FDA028-LE12
FDA029-LE12 payload
Undisclosed
CN119317630A ADC-C9 Linker
 [8]
 ADC Info 
FDA028-LE13
FDA029-LE13 payload
Undisclosed
CN119317630A ADC-C9 Linker
 [8]
 ADC Info 
FDA028-LE14
FDA029-LE14 payload
Undisclosed
CN119317630A ADC-C9 Linker
 [8]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
FDA029-LE12
FDA029-LE12 payload
Undisclosed
CN119317630A ADC-C9 Linker
 [8]
 ADC Info 
FDA029-LE13
FDA029-LE13 payload
Undisclosed
CN119317630A ADC-C9 Linker
 [8]
 ADC Info 
FDA029-LE14
FDA029-LE14 payload
Undisclosed
CN119317630A ADC-C9 Linker
 [8]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Her3-C3-ADC-05 (DAR4)
Her3-C3-ADC-05(DAR4) payload
Undisclosed
Her3-C3-ADC-05(DAR4) linker
 [1]
 ADC Info 
Her3-C3-ADC-21 (DAR4)
Her3-C3-ADC-21(DAR4) payload
Undisclosed
Her3-C3-ADC-21(DAR4) linker
 [1]
 ADC Info 
Her3-C3-ADC-21 (DAR8)
Her3-C3-ADC-21(DAR8) payload
Undisclosed
Her3-C3-ADC-21(DAR8) linker
 [1]
 ADC Info 
Her3-C3-ADC-23 (DAR4)
Her3-C3-ADC-23(DAR4) payload
Undisclosed
Her3-C3-ADC-23(DAR4) linker
 [1]
Lumretuzumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Lumretuzumab-ADC-Tb4-1
Lumretuzumab-ADC-Tb4-1 payload
Undisclosed
Lumretuzumab-ADC-Tb4-1 linker
 [1]
 ADC Info 
Lumretuzumab-ADC-Tb4-2
Lumretuzumab-ADC-Tb4-2 payload
Undisclosed
Lumretuzumab-ADC-Tb4-2 linker
 [1]
 ADC Info 
Lumretuzumab-ADC-Tb4-3
Lumretuzumab-ADC-Tb4-3 payload
Undisclosed
Lumretuzumab-ADC-Tb4-3 linker
 [1]
 ADC Info 
Lumretuzumab-ADC-Tb4-4
Lumretuzumab-ADC-Tb4-4 payload
Undisclosed
Lumretuzumab-ADC-Tb4-4 linker
 [1]
Patritumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
ADC3-6
ADC 3-6 payload
DNA topoisomerase 1 (TOP1)
ADC 3-6 linker
 [9]
 ADC Info 
ADC3-7
ADC 3-7 payload
DNA topoisomerase 1 (TOP1)
ADC 3-7 linker
 [9]
 ADC Info 
ADC3-8
ADC 3-8 payload
DNA topoisomerase 1 (TOP1)
ADC 3-8 linker
 [9]
 ADC Info 
ADC3-9
ADC 3-9 payload
DNA topoisomerase 1 (TOP1)
ADC 3-9 linker
 [9]
 ADC Info 
ADC3-10
ADC 3-10 payload
DNA topoisomerase 1 (TOP1)
ADC 3-10 linker
 [9]
 ADC Info 
ADC3-11
ADC 3-11 payload
DNA topoisomerase 1 (TOP1)
ADC 3-11 linker
 [9]
 ADC Info 
ADC3-12
ADC 3-12 payload
DNA topoisomerase 1 (TOP1)
ADC 3-12 linker
 [9]
 ADC Info 
ADC3-13
ADC 3-13 payload
DNA topoisomerase 1 (TOP1)
ADC 3-13 linker
 [9]
 ADC Info 
ADC3-14
ADC 3-14 payload
DNA topoisomerase 1 (TOP1)
ADC 3-14 linker
 [9]
 ADC Info 
ADC3-15
ADC 3-15 payload
DNA topoisomerase 1 (TOP1)
ADC 3-15 linker
 [9]
 ADC Info 
ADC3-16
ADC 3-16 payload
DNA topoisomerase 1 (TOP1)
ADC 3-16 linker
 [9]
 ADC Info 
ADC3-17
ADC 3-17 payload
DNA topoisomerase 1 (TOP1)
ADC 3-17 linker
 [9]
 ADC Info 
ADC3-18
ADC 3-18 payload
DNA topoisomerase 1 (TOP1)
ADC 3-18 linker
 [9]
 ADC Info 
ADC3-19
ADC 3-19 payload
DNA topoisomerase 1 (TOP1)
ADC 3-19 linker
 [9]
 ADC Info 
ADC3-20
ADC 3-20 payload
DNA topoisomerase 1 (TOP1)
ADC 3-20 linker
 [9]
 ADC Info 
ADC-C2
ADC-C2 payload
DNA topoisomerase 1 (TOP1)
ADC-C2 linker
 [9]
 ADC Info 
ADC-C3
ADC-C3 payload
DNA topoisomerase 1 (TOP1)
ADC-C3 linker
 [9]
 ADC Info 
ADC-C4
ADC-C4 payload
DNA topoisomerase 1 (TOP1)
ADC-C4 linker
 [9]
 ADC Info 
ADC-C5
ADC-C5 payload
DNA topoisomerase 1 (TOP1)
ADC-C5 linker
 [9]
 ADC Info 
ADC-C1
ADC-C1 payload
DNA topoisomerase 1 (TOP1)
ADC-C1 linker
 [9]
 ADC Info 
Patritumab-ADC-Tb4-1
Patritumab-ADC-Tb4-1 payload
Undisclosed
Patritumab-ADC-Tb4-1 linker
 [1]
 ADC Info 
Patritumab-ADC-Tb4-2
Patritumab-ADC-Tb4-2 payload
Undisclosed
Patritumab-ADC-Tb4-2 linker
 [1]
 ADC Info 
Patritumab-ADC-Tb4-3
Patritumab-ADC-Tb4-3 payload
Undisclosed
Patritumab-ADC-Tb4-3 linker
 [1]
 ADC Info 
Patritumab-ADC-Tb4-4
Patritumab-ADC-Tb4-4 payload
Undisclosed
Patritumab-ADC-Tb4-4 linker
 [1]
 ADC Info 
US20240245795A1 Antibody Conjugate 9
Undisclosed
Undisclosed
Undisclosed
 [10]
Seribantumab
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Seribantumab-ADC-Tb4-1
Seribantumab-ADC-Tb4-1 payload
Undisclosed
Seribantumab-ADC-Tb4-1 linker
 [1]
 ADC Info 
Seribantumab-ADC-Tb4-2
Seribantumab-ADC-Tb4-2 payload
Undisclosed
Seribantumab-ADC-Tb4-2 linker
 [1]
 ADC Info 
Seribantumab-ADC-Tb4-3
Seribantumab-ADC-Tb4-3 payload
Undisclosed
Seribantumab-ADC-Tb4-3 linker
 [1]
 ADC Info 
Seribantumab-ADC-Tb4-4
Seribantumab-ADC-Tb4-4 payload
Undisclosed
Seribantumab-ADC-Tb4-4 linker
 [1]
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
EP4494710A2 Antibody-drug conjugate (1)
EP4494710A2 Antibody-drug conjugate (1) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 [11]
 ADC Info 
EP4494710A2 Antibody-drug conjugate (2)
EP4494710A2 Antibody-drug conjugate (1) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 [11]
 ADC Info 
EP4494710A2 Antibody-drug conjugate (3)
EP4494710A2 Antibody-drug conjugate (1) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 [11]
 ADC Info 
EP4494710A2 Antibody-drug conjugate (4)
EP4494710A2 Antibody-drug conjugate (1) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 [11]
 ADC Info 
EP4494710A2 Antibody-drug conjugate (5)
EP4494710A2 Antibody-drug conjugate (5) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 [11]
 ADC Info 
EP4494710A2 Antibody-drug conjugate (6)
EP4494710A2 Antibody-drug conjugate (5) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 [11]
 ADC Info 
EP4494710A2 Antibody-drug conjugate (7)
EP4494710A2 Antibody-drug conjugate (7) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 [11]
 ADC Info 
EP4494710A2 Antibody-drug conjugate (8)
EP4494710A2 Antibody-drug conjugate (8) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 [11]
 ADC Info 
EP4494710A2 Antibody-drug conjugate (9)
EP4494710A2 Antibody-drug conjugate (9) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (9) Linker
 [11]
 ADC Info 
EP4494710A2 Antibody-drug conjugate (10)
EP4494710A2 Antibody-drug conjugate (9) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (9) Linker
 [11]
 ADC Info 
EP4494710A2 Antibody-drug conjugate (11)
EP4494710A2 Antibody-drug conjugate (9) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (9) Linker
 [11]
 ADC Info 
EP4494710A2 Antibody-drug conjugate (12)
EP4494710A2 Antibody-drug conjugate (12) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 [11]
 ADC Info 
EP4494710A2 Antibody-drug conjugate (13)
EP4494710A2 Antibody-drug conjugate (12) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 [11]
 ADC Info 
EP4494710A2 Antibody-drug conjugate (14)
EP4494710A2 Antibody-drug conjugate (12) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 [11]
 ADC Info 
EP4494710A2 Antibody-drug conjugate (15)
EP4494710A2 Antibody-drug conjugate (12) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 [11]
 ADC Info 
EP4494710A2 Antibody-drug conjugate (16a)
EP4494710A2 Antibody-drug conjugate (12) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 [11]
 ADC Info 
EP4494710A2 Antibody-drug conjugate (16b)
EP4494710A2 Antibody-drug conjugate (12) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 [11]
 ADC Info 
EP4494710A2 Antibody-drug conjugate (16c)
EP4494710A2 Antibody-drug conjugate (12) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 [11]
 ADC Info 
EP4494710A2 Antibody-drug conjugate (16d)
EP4494710A2 Antibody-drug conjugate (12) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 [11]
 ADC Info 
FI3789042T3Antibody-drug conjugate (1)
Antibody-drug conjugate (1)payload
Undisclosed
Antibody-drug conjugate (1)Linker
 [12]
 ADC Info 
FI3789042T3Antibody-drug conjugate (2)
Antibody-drug conjugate (1)payload
Undisclosed
Antibody-drug conjugate (1)Linker
 [12]
 ADC Info 
FI3789042T3Antibody-drug conjugate (3)
Antibody-drug conjugate (1)payload
Undisclosed
Antibody-drug conjugate (1)Linker
 [12]
 ADC Info 
FI3789042T3Antibody-drug conjugate (4)
Antibody-drug conjugate (1)payload
Undisclosed
Antibody-drug conjugate (1)Linker
 [12]
 ADC Info 
FI3789042T3Antibody-drug conjugate (5)
Antibody-drug conjugate (1)payload
Undisclosed
Antibody-drug conjugate (5)Linker
 [12]
 ADC Info 
FI3789042T3Antibody-drug conjugate (6)
Undisclosed
Undisclosed
Antibody-drug conjugate (5)Linker
 [12]
 ADC Info 
FI3789042T3Antibody-drug conjugate (7)
Antibody-drug conjugate (7)payload
Undisclosed
Antibody-drug conjugate (7)Linker
 [12]
 ADC Info 
FI3789042T3Antibody-drug conjugate (8)
Undisclosed
Undisclosed
Antibody-drug conjugate (7)Linker
 [12]
 ADC Info 
FI3789042T3Antibody-drug conjugate (9)
Undisclosed
Undisclosed
Antibody-drug conjugate (9)Linker
 [12]
 ADC Info 
FI3789042T3Antibody-drug conjugate (10)
Undisclosed
Undisclosed
Antibody-drug conjugate (9)Linker
 [12]
 ADC Info 
FI3789042T3Antibody-drug conjugate (11)
Undisclosed
Undisclosed
Antibody-drug conjugate (9)Linker
 [12]
 ADC Info 
FI3789042T3Antibody-drug conjugate (12)
Antibody-drug conjugate (12)payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 [12]
 ADC Info 
FI3789042T3Antibody-drug conjugate (13)
Antibody-drug conjugate (12)payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 [12]
 ADC Info 
FI3789042T3Antibody-drug conjugate (14)
Antibody-drug conjugate (12)payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 [12]
 ADC Info 
FI3789042T3Antibody-drug conjugate (15)
Antibody-drug conjugate (12)payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 [12]
 ADC Info 
FI3789042T3Antibody-drug conjugate (16a)
Antibody-drug conjugate (12)payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 [12]
 ADC Info 
FI3789042T3Antibody-drug conjugate (16b)
Antibody-drug conjugate (12)payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 [12]
 ADC Info 
FI3789042T3Antibody-drug conjugate (16c)
Antibody-drug conjugate (12)payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 [12]
 ADC Info 
FI3789042T3Antibody-drug conjugate (16d)
Antibody-drug conjugate (12)payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 [12]
Undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
HER3-ADC9 (Jiangsu Hengrui)
Undisclosed
Undisclosed
Undisclosed
 [13]
 ADC Info 
MP-HER3-ADC
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 [14]
 ADC Info 
STI-A050X
Undisclosed
Undisclosed
Undisclosed
 [15]
 ADC Info 
BR122024023391 antibody-drug conjugate (2)
undisclosed
Undisclosed
Undisclosed
 [17]
undisclosed
 Antibody Info 
ADC Info ADC Name Payload Target Linker Ref
 ADC Info 
Patritumab-eribulin-D2
Undisclosed
Undisclosed
Undisclosed
 [16]
 ADC Info 
Patritumab-eribulin-D8
Undisclosed
Undisclosed
Undisclosed
 [16]
 ADC Info 
Patritumab-DDDXd-D8
Undisclosed
Undisclosed
Undisclosed
 [16]
 ADC Info 
Patritumab-eribulin-D4
Undisclosed
Undisclosed
Undisclosed
 [16]
 ADC Info 
Production of the antibody-drug conjugate (2)
undisclosed
Undisclosed
Undisclosed
 [18]
References
Ref 1 Bioactive substance conjugate, preparation method therefor and use thereof; 2022-08-18.
Ref 2 An auristatin-based antibody-drug conjugate targeting HER3 enhances the radiation response in pancreatic cancer. Int J Cancer. 2019 Oct 1;145(7):1838-1851. doi: 10.1002/ijc.32273. Epub 2019 Apr 1.
Ref 3 Antibody-drug conjugates and applications thereof
Ref 4 Monomethyl auristatin antibody and peptide drug conjugates for trimodal cancer chemo-radio-immunotherapy. Nat Commun. 2022 Jul 5;13(1):3869. doi: 10.1038/s41467-022-31601-z.
Ref 5 EV20/NMS-P945, a Novel Thienoindole Based Antibody-Drug Conjugate Targeting HER-3 for Solid Tumors. Pharmaceutics. 2021 Apr 2;13(4):483. doi: 10.3390/pharmaceutics13040483.
Ref 6 EV20-mediated delivery of cytotoxic auristatin MMAF exhibits potent therapeutic efficacy in cutaneous melanoma. J Control Release. 2018 May 10;277:48-56. doi: 10.1016/j.jconrel.2018.03.016. Epub 2018 Mar 14.
Ref 7 Mediapharma product pipeline
Ref 8 Antibody-drug conjugates, intermediates, preparation methods and uses
Ref 9 Antibody drug conjugates; 2023-07-06.
Ref 10 Preparation method and application of antibody drug conjugate
Ref 11 Pharmaceutical composition comprising an anti-HER3 antibody-drug conjugate for use in treating breast cancers
Ref 12 Methods for preparing anti-HER3 antibody-drug conjugates
Ref 13 Introduction to basic information on HER3-ADC9(Jiangsu Hengrui).
Ref 14 MP-EV20-ADC: humanized anti-HER3 antibody drug conjugate
Ref 15 Sorrento therapeutics next-generation cancer therapeutics; November 2013
Ref 16 Anti-HER3 antibody drug conjugate, composition thereof, and use thereof
Ref 17 Use of an antibody-drug conjugate, pharmaceutical composition and pharmaceutical combination
Ref 18 Combination of antibody-drug conjugate with anti-SIRPα antibody