General Information of This Antigen
Antigen ID
TAR0MYDAB
Antigen Name
Receptor tyrosine-protein kinase erbB-3 (ERBB3)
Gene Name
ERBB3
Gene ID
2065
Synonym
HER3; Proto-oncogene-like protein c-ErbB-3;Tyrosine kinase-type cell surface receptor HER3
Sequence
MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVM
GNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVM
LNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNG
RSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQD
TDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTS
CVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGN
LDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGG
RSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEE
RLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEP
REFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPI
YKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLG
GTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVF
GTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPG
SSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNV
LLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVT
VWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKE
LANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEED
NLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPR
PVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLL
TPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYM
NRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDY
EYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATD
SAFDNPDYWHSRLFPKANAQRT

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Family
Tyr protein family
Function
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.

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Uniprot Entry
ERBB3_HUMAN
HGNC ID
HGNC:3431
KEGG ID
hsa:2065
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
ADC Info ADC Name Payload Target Linker Ref
AMT-562
Exatecan
DNA topoisomerase 1 (TOP1)
Mc-Val-Ala-PABC
[1]
Anti-HER3 mAb
ADC Info ADC Name Payload Target Linker Ref
SIBP-A13
Undisclosed
Undisclosed
Undisclosed
[2]
Anti-Her3 mAb 202-2-1
ADC Info ADC Name Payload Target Linker Ref
Her3-ADC-07 (DAR8)
Her3-ADC-07(DAR8) payload
Undisclosed
Her3-ADC-07(DAR8) linker
[3]
Her3-ADC-07 (DAR4)
Her3-ADC-07(DAR4) payload
Undisclosed
Her3-ADC-07(DAR4) linker
[3]
Her3-ADC-07 (DAR6)
Her3-ADC-07(DAR6) payload
Undisclosed
Her3-ADC-07(DAR6) linker
[3]
Her3-ADC-05 (DAR4)
Her3-ADC-05(DAR4) payload
Undisclosed
Her3-ADC-05(DAR4) linker
[3]
Her3-ADC-15 (DAR8)
Her3-ADC-15(DAR8) payload
Undisclosed
Her3-ADC-15(DAR8) linker
[3]
Her3-ADC-15 (DAR2)
Her3-ADC-15(DAR2) payload
Undisclosed
Her3-ADC-15(DAR2) linker
[3]
Her3-ADC-21 (DAR4)
Her3-ADC-21(DAR4) payload
Undisclosed
Her3-ADC-21(DAR4) linker
[3]
Her3-ADC-23 (DAR4)
Her3-ADC-23(DAR4) payload
Undisclosed
Her3-ADC-23(DAR4) linker
[3]
Her3-ADC-33 (DAR4)
Her3-ADC-33(DAR4) payload
Undisclosed
Her3-ADC-33(DAR4) linker
[3]
Anti-HER3 mAb 9F7-F11
ADC Info ADC Name Payload Target Linker Ref
MMAE-9F7-F11 ADC
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[4]
Barecetamab
ADC Info ADC Name Payload Target Linker Ref
Barecetamab-ADC-Tb4-1
Barecetamab-ADC-Tb4-1 payload
Undisclosed
Barecetamab-ADC-Tb4-1 linker
[3]
Barecetamab-ADC-Tb4-2
Barecetamab-ADC-Tb4-2 payload
Undisclosed
Barecetamab-ADC-Tb4-2 linker
[3]
Barecetamab-ADC-Tb4-3
Barecetamab-ADC-Tb4-3 payload
Undisclosed
Barecetamab-ADC-Tb4-3 linker
[3]
Barecetamab-ADC-Tb4-4
Barecetamab-ADC-Tb4-4 payload
Undisclosed
Barecetamab-ADC-Tb4-4 linker
[3]
ADC Info ADC Name Payload Target Linker Ref
CDX3379-MMAE
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
[5]
Duligotuzumab
ADC Info ADC Name Payload Target Linker Ref
Duligotuzumab-ADC-Tb4-1
Duligotuzumab-ADC-Tb4-1 payload
Undisclosed
Duligotuzumab-ADC-Tb4-1 linker
[3]
Duligotuzumab-ADC-Tb4-2
Duligotuzumab-ADC-Tb4-2 payload
Undisclosed
Duligotuzumab-ADC-Tb4-2 linker
[3]
Duligotuzumab-ADC-Tb4-3
Duligotuzumab-ADC-Tb4-3 payload
Undisclosed
Duligotuzumab-ADC-Tb4-3 linker
[3]
Duligotuzumab-ADC-Tb4-4
Duligotuzumab-ADC-Tb4-4 payload
Undisclosed
Duligotuzumab-ADC-Tb4-4 linker
[3]
Elgemtumab
ADC Info ADC Name Payload Target Linker Ref
Elgemtumab-ADC-Tb4-1
Elgemtumab-ADC-Tb4-1 payload
Undisclosed
Elgemtumab-ADC-Tb4-1 linker
[3]
Elgemtumab-ADC-Tb4-2
Elgemtumab-ADC-Tb4-2 payload
Undisclosed
Elgemtumab-ADC-Tb4-2 linker
[3]
Elgemtumab-ADC-Tb4-3
Elgemtumab-ADC-Tb4-3 payload
Undisclosed
Elgemtumab-ADC-Tb4-3 linker
[3]
Elgemtumab-ADC-Tb4-4
Elgemtumab-ADC-Tb4-4 payload
Undisclosed
Elgemtumab-ADC-Tb4-4 linker
[3]
ADC Info ADC Name Payload Target Linker Ref
EV20/MMAF
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
[6]
EV20/NMS-P945
NMS-P528
Human Deoxyribonucleic acid (hDNA)
Cathepsin-cleavable peptidic linker with self-immolating spacer
[7]
MP-EV-20
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
[8]
ADC Info ADC Name Payload Target Linker Ref
Her3-C3-ADC-05 (DAR4)
Her3-C3-ADC-05(DAR4) payload
Undisclosed
Her3-C3-ADC-05(DAR4) linker
[3]
Her3-C3-ADC-21 (DAR4)
Her3-C3-ADC-21(DAR4) payload
Undisclosed
Her3-C3-ADC-21(DAR4) linker
[3]
Her3-C3-ADC-23 (DAR4)
Her3-C3-ADC-23(DAR4) payload
Undisclosed
Her3-C3-ADC-23(DAR4) linker
[3]
Her3-C3-ADC-21 (DAR8)
Her3-C3-ADC-21(DAR8) payload
Undisclosed
Her3-C3-ADC-21(DAR8) linker
[3]
Lumretuzumab
ADC Info ADC Name Payload Target Linker Ref
Lumretuzumab-ADC-Tb4-1
Lumretuzumab-ADC-Tb4-1 payload
Undisclosed
Lumretuzumab-ADC-Tb4-1 linker
[3]
Lumretuzumab-ADC-Tb4-2
Lumretuzumab-ADC-Tb4-2 payload
Undisclosed
Lumretuzumab-ADC-Tb4-2 linker
[3]
Lumretuzumab-ADC-Tb4-3
Lumretuzumab-ADC-Tb4-3 payload
Undisclosed
Lumretuzumab-ADC-Tb4-3 linker
[3]
Lumretuzumab-ADC-Tb4-4
Lumretuzumab-ADC-Tb4-4 payload
Undisclosed
Lumretuzumab-ADC-Tb4-4 linker
[3]
Patritumab
ADC Info ADC Name Payload Target Linker Ref
Patritumab deruxtecan
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
[9]
ADC3-6
ADC 3-6 payload
DNA topoisomerase 1 (TOP1)
ADC 3-6 linker
[10]
ADC3-7
ADC 3-7 payload
DNA topoisomerase 1 (TOP1)
ADC 3-7 linker
[10]
ADC3-8
ADC 3-8 payload
DNA topoisomerase 1 (TOP1)
ADC 3-8 linker
[10]
ADC3-9
ADC 3-9 payload
DNA topoisomerase 1 (TOP1)
ADC 3-9 linker
[10]
ADC3-10
ADC 3-10 payload
DNA topoisomerase 1 (TOP1)
ADC 3-10 linker
[10]
ADC3-11
ADC 3-11 payload
DNA topoisomerase 1 (TOP1)
ADC 3-11 linker
[10]
ADC3-12
ADC 3-12 payload
DNA topoisomerase 1 (TOP1)
ADC 3-12 linker
[10]
ADC3-13
ADC 3-13 payload
DNA topoisomerase 1 (TOP1)
ADC 3-13 linker
[10]
ADC3-14
ADC 3-14 payload
DNA topoisomerase 1 (TOP1)
ADC 3-14 linker
[10]
ADC3-15
ADC 3-15 payload
DNA topoisomerase 1 (TOP1)
ADC 3-15 linker
[10]
ADC3-16
ADC 3-16 payload
DNA topoisomerase 1 (TOP1)
ADC 3-16 linker
[10]
ADC3-17
ADC 3-17 payload
DNA topoisomerase 1 (TOP1)
ADC 3-17 linker
[10]
ADC3-18
ADC 3-18 payload
DNA topoisomerase 1 (TOP1)
ADC 3-18 linker
[10]
ADC3-19
ADC 3-19 payload
DNA topoisomerase 1 (TOP1)
ADC 3-19 linker
[10]
ADC3-20
ADC 3-20 payload
DNA topoisomerase 1 (TOP1)
ADC 3-20 linker
[10]
ADC-C2
ADC-C2 payload
DNA topoisomerase 1 (TOP1)
ADC-C2 linker
[10]
ADC-C3
ADC-C3 payload
DNA topoisomerase 1 (TOP1)
ADC-C3 linker
[10]
ADC-C4
ADC-C4 payload
DNA topoisomerase 1 (TOP1)
ADC-C4 linker
[10]
ADC-C5
ADC-C5 payload
DNA topoisomerase 1 (TOP1)
ADC-C5 linker
[10]
ADC-C1
ADC-C1 payload
DNA topoisomerase 1 (TOP1)
ADC-C1 linker
[10]
Patritumab-ADC-Tb4-1
Patritumab-ADC-Tb4-1 payload
Undisclosed
Patritumab-ADC-Tb4-1 linker
[3]
Patritumab-ADC-Tb4-2
Patritumab-ADC-Tb4-2 payload
Undisclosed
Patritumab-ADC-Tb4-2 linker
[3]
Patritumab-ADC-Tb4-3
Patritumab-ADC-Tb4-3 payload
Undisclosed
Patritumab-ADC-Tb4-3 linker
[3]
Patritumab-ADC-Tb4-4
Patritumab-ADC-Tb4-4 payload
Undisclosed
Patritumab-ADC-Tb4-4 linker
[3]
Seribantumab
ADC Info ADC Name Payload Target Linker Ref
Seribantumab-ADC-Tb4-1
Seribantumab-ADC-Tb4-1 payload
Undisclosed
Seribantumab-ADC-Tb4-1 linker
[3]
Seribantumab-ADC-Tb4-2
Seribantumab-ADC-Tb4-2 payload
Undisclosed
Seribantumab-ADC-Tb4-2 linker
[3]
Seribantumab-ADC-Tb4-3
Seribantumab-ADC-Tb4-3 payload
Undisclosed
Seribantumab-ADC-Tb4-3 linker
[3]
Seribantumab-ADC-Tb4-4
Seribantumab-ADC-Tb4-4 payload
Undisclosed
Seribantumab-ADC-Tb4-4 linker
[3]
Undisclosed
ADC Info ADC Name Payload Target Linker Ref
SHR-A2009
Undisclosed
Undisclosed
Undisclosed
[11]
MP-HER3-ADC
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
[12]
HMBD-501
Exatecan
DNA topoisomerase 1 (TOP1)
Undisclosed
[13]
DB-1310
Proprietary DNA topoisomerase I inhibitor
DNA topoisomerase 1 (TOP1)
Maleimide tetrapeptide-based cleavable linker
[14]
HER3-ADC9 (Jiangsu Hengrui)
Undisclosed
Undisclosed
Undisclosed
[15]
STI-A050X
Undisclosed
Undisclosed
Undisclosed
[16]
Tissue/Disease specific Abundances of This Antigen
Tissue specific Abundances of This Antigen
ICD Disease Classification 01
Click to Show/Hide the 1 Disease of This Class
Bacterial infection [ICD-11: 1A00-1C4Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Gingival
The Specific Disease Bacterial infection of gingival
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 7.80E-07; Fold-change: -0.322401576; Z-score: -0.715309242
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 02
Click to Show/Hide the 22 Disease of This Class
Brain cancer [ICD-11: 2A00]
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Differential expression pattern of antigen in diseases
The Studied Tissue Brainstem
The Specific Disease Glioma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.4075402; Fold-change: -0.195282798; Z-score: -0.755278016
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue White matter
The Specific Disease Glioma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 6.27E-05; Fold-change: -0.844103329; Z-score: -2.427450581
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Brainstem
The Specific Disease Neuroectodermal tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 6.57E-08; Fold-change: -2.237221981; Z-score: -4.667713711
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Nervous
The Specific Disease Brain cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 8.64E-76; Fold-change: -0.597811565; Z-score: -1.155941675
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic myeloid leukemia [ICD-11: 2A20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Polycythemia vera
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 7.99E-07; Fold-change: 0.165461279; Z-score: 0.99624091
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Whole blood
The Specific Disease Myelofibrosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.164177223; Fold-change: 0.057993732; Z-score: 0.342258485
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
MyeloDysplastic syndromes [ICD-11: 2A37]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Myelodysplastic syndromes
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.386618293; Fold-change: 0.026275604; Z-score: 0.12210698
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.905178196; Fold-change: 0.003783842; Z-score: 0.03693325
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Lymphoma [ICD-11: 2A90- 2A85]
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Differential expression pattern of antigen in diseases
The Studied Tissue Tonsil
The Specific Disease Lymphoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.146544693; Fold-change: -0.068901528; Z-score: -0.517089327
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Gastric cancer [ICD-11: 2B72]
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Differential expression pattern of antigen in diseases
The Studied Tissue Gastric
The Specific Disease Gastric cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.777367798; Fold-change: -0.183038638; Z-score: -0.427818213
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.139205963; Fold-change: 0.087533963; Z-score: 0.270061841
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Colon cancer [ICD-11: 2B90]
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Differential expression pattern of antigen in diseases
The Studied Tissue Colon
The Specific Disease Colon cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000136754; Fold-change: -0.255089061; Z-score: -0.42909424
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 7.41E-07; Fold-change: 0.408304975; Z-score: 0.691336013
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pancreatic cancer [ICD-11: 2C10]
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Differential expression pattern of antigen in diseases
The Studied Tissue Pancreas
The Specific Disease Pancreatic cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.39318219; Fold-change: 0.109606213; Z-score: 0.180522631
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.785430879; Fold-change: -0.211145867; Z-score: -0.472597608
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Liver cancer [ICD-11: 2C12]
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Differential expression pattern of antigen in diseases
The Studied Tissue Liver
The Specific Disease Liver cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.158076337; Fold-change: -0.035146607; Z-score: -0.08217277
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 1.85E-09; Fold-change: 0.212789479; Z-score: 0.678232569
The Expression Level of Disease Section Compare with the Other Disease Section p-value: 0.557641599; Fold-change: 0.041029886; Z-score: 0.317633443
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Lung cancer [ICD-11: 2C25]
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Differential expression pattern of antigen in diseases
The Studied Tissue Lung
The Specific Disease Lung cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 7.21E-05; Fold-change: -0.321694755; Z-score: -0.619125272
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.002969306; Fold-change: -0.145654383; Z-score: -0.30487295
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Melanoma [ICD-11: 2C30]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Melanoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000139654; Fold-change: 1.472155713; Z-score: 1.500125799
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sarcoma [ICD-11: 2C35]
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Differential expression pattern of antigen in diseases
The Studied Tissue Muscle
The Specific Disease Sarcoma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 8.84E-86; Fold-change: -0.596522932; Z-score: -1.891867884
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.000840394; Fold-change: -0.711778794; Z-score: -6.584059626
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Breast cancer [ICD-11: 2C60]
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Differential expression pattern of antigen in diseases
The Studied Tissue Breast
The Specific Disease Breast cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.351295896; Fold-change: 0.101303707; Z-score: 0.165085819
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.002363699; Fold-change: 0.166499592; Z-score: 0.394814294
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ovarian cancer [ICD-11: 2C73]
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Differential expression pattern of antigen in diseases
The Studied Tissue Ovarian
The Specific Disease Ovarian cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000584153; Fold-change: 0.627265171; Z-score: 2.010820501
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 4.41E-06; Fold-change: 0.401921008; Z-score: 1.645091107
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Cervical cancer [ICD-11: 2C77]
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Differential expression pattern of antigen in diseases
The Studied Tissue Cervical
The Specific Disease Cervical cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.27E-06; Fold-change: -0.171146606; Z-score: -1.49659741
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Uterine cancer [ICD-11: 2C78]
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Differential expression pattern of antigen in diseases
The Studied Tissue Endometrium
The Specific Disease Uterine cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 4.23E-21; Fold-change: -0.490721314; Z-score: -1.1831257
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 2.16E-09; Fold-change: 0.955970651; Z-score: 12.48256318
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Prostate cancer [ICD-11: 2C82]
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Differential expression pattern of antigen in diseases
The Studied Tissue Prostate
The Specific Disease Prostate cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.165867953; Fold-change: -0.749722161; Z-score: -0.726862856
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Bladder cancer [ICD-11: 2C94]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bladder
The Specific Disease Bladder cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.003475716; Fold-change: 0.516556613; Z-score: 1.872759634
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Retina cancer [ICD-11: 2D02]
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Differential expression pattern of antigen in diseases
The Studied Tissue Uvea
The Specific Disease Retinoblastoma tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 5.42E-09; Fold-change: 0.934750996; Z-score: 7.213643493
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Thyroid cancer [ICD-11: 2D10]
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Differential expression pattern of antigen in diseases
The Studied Tissue Thyroid
The Specific Disease Thyroid cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000125129; Fold-change: 0.133712954; Z-score: 0.476007924
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.979645469; Fold-change: 0.042027504; Z-score: 0.164256376
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Adrenal cancer [ICD-11: 2D11]
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Differential expression pattern of antigen in diseases
The Studied Tissue Adrenal cortex
The Specific Disease Adrenocortical carcinoma
The Expression Level of Disease Section Compare with the Other Disease Section p-value: 0.002364709; Fold-change: -0.097731445; Z-score: -0.863594037
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Head and neck cancer [ICD-11: 2D42]
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Differential expression pattern of antigen in diseases
The Studied Tissue Head and neck
The Specific Disease Head and neck cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 8.46E-10; Fold-change: -0.1968635; Z-score: -0.660981102
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pituitary cancer [ICD-11: 2F37]
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Differential expression pattern of antigen in diseases
The Studied Tissue Pituitary
The Specific Disease Pituitary gonadotrope tumor
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.005518949; Fold-change: -0.523468084; Z-score: -1.805365916
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Pituitary
The Specific Disease Pituitary cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.001575386; Fold-change: -0.482758038; Z-score: -1.956107682
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 03
Click to Show/Hide the 1 Disease of This Class
Thrombocytopenia [ICD-11: 3B64]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Thrombocytopenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.935246539; Fold-change: -0.003316367; Z-score: -0.017512856
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 04
Click to Show/Hide the 2 Disease of This Class
Lupus erythematosus [ICD-11: 4A40]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Lupus erythematosus
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.133453789; Fold-change: -0.05365248; Z-score: -0.131851316
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Autoimmune disease [ICD-11: 4A4Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral monocyte
The Specific Disease Autoimmune uveitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.422980091; Fold-change: -0.042300611; Z-score: -0.453531462
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 05
Click to Show/Hide the 1 Disease of This Class
Hyperlipoproteinaemia [ICD-11: 5C80]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Familial hypercholesterolemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.001042452; Fold-change: -0.189572611; Z-score: -0.669644317
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 06
Click to Show/Hide the 1 Disease of This Class
Schizophrenia [ICD-11: 6A20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Superior temporal cortex
The Specific Disease Schizophrenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.105062958; Fold-change: -0.067730966; Z-score: -0.271727241
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 08
Click to Show/Hide the 3 Disease of This Class
Multiple sclerosis [ICD-11: 8A40]
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Differential expression pattern of antigen in diseases
The Studied Tissue Spinal cord
The Specific Disease Multiple sclerosis
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.577737054; Fold-change: -0.436557413; Z-score: -0.901391595
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Plasmacytoid dendritic cells
The Specific Disease Multiple sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.294698044; Fold-change: 0.03801617; Z-score: 0.155415869
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Epilepsy [ICD-11: 8A60]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peritumoral cortex
The Specific Disease Epilepsy
The Expression Level of Disease Section Compare with the Other Disease Section p-value: 0.14221503; Fold-change: 0.085777967; Z-score: 0.587382695
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Cerebral ischaemic stroke [ICD-11: 8B11]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Cardioembolic Stroke
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.009767022; Fold-change: -0.221169009; Z-score: -0.691337875
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Peripheral blood
The Specific Disease Ischemic stroke
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.028938171; Fold-change: 0.026369894; Z-score: 0.232763644
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 1
Click to Show/Hide the 6 Disease of This Class
HIV [ICD-11: 1C60-1C62]
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Differential expression pattern of antigen in diseases
The Studied Tissue White matter
The Specific Disease HIV
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.391150881; Fold-change: 0.084550363; Z-score: 0.359289596
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Influenza [ICD-11: 1E30]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Influenza
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.016463642; Fold-change: 0.415113609; Z-score: 5.451922695
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic hepatitis C [ICD-11: 1E51.1]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Chronic hepatitis C
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.215504856; Fold-change: 0.225627846; Z-score: 1.003708503
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sepsis [ICD-11: 1G40-1G41]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Sepsis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.062911669; Fold-change: -0.034639276; Z-score: -0.147733422
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Septic shock [ICD-11: 1G41]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Septic shock
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.079757279; Fold-change: 0.038438506; Z-score: 0.151995675
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pediatric respiratory syncytial virus infection [ICD-11: CA40.11]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Pediatric respiratory syncytial virus infection
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.220859891; Fold-change: -0.018928135; Z-score: -0.18344425
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 11
Click to Show/Hide the 6 Disease of This Class
Essential hypertension [ICD-11: BA00]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Essential hypertension
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.197356696; Fold-change: 0.475290933; Z-score: 1.853125216
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Myocardial infarction [ICD-11: BA41]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Myocardial infarction
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.909269533; Fold-change: -0.037534412; Z-score: -0.069932936
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Coronary artery disease [ICD-11: BA8Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Coronary artery disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.110866129; Fold-change: -0.103384719; Z-score: -0.918715325
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Aortic stenosis [ICD-11: BB70]
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Differential expression pattern of antigen in diseases
The Studied Tissue Calcified aortic valve
The Specific Disease Aortic stenosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.271988867; Fold-change: -0.21765627; Z-score: -0.507300363
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Arteriosclerosis [ICD-11: BD40]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Arteriosclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.423076831; Fold-change: 0.09172998; Z-score: 0.667810522
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Aneurysm [ICD-11: BD50]
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Differential expression pattern of antigen in diseases
The Studied Tissue Intracranial artery
The Specific Disease Aneurysm
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 2.48E-06; Fold-change: -0.790016737; Z-score: -3.069241725
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 12
Click to Show/Hide the 8 Disease of This Class
Immunodeficiency [ICD-11: 4A00-4A20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Immunodeficiency
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.300887259; Fold-change: 0.014524841; Z-score: 0.135028731
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Apnea [ICD-11: 7A40]
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Differential expression pattern of antigen in diseases
The Studied Tissue Hyperplastic tonsil
The Specific Disease Apnea
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.315563964; Fold-change: -0.014531008; Z-score: -0.047339313
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Olive pollen allergy [ICD-11: CA08.00]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Olive pollen allergy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.428575494; Fold-change: -0.104183603; Z-score: -0.184050824
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic rhinosinusitis [ICD-11: CA0A]
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Differential expression pattern of antigen in diseases
The Studied Tissue Sinus mucosa
The Specific Disease Chronic rhinosinusitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.391128078; Fold-change: -0.008172554; Z-score: -0.025197105
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Chronic obstructive pulmonary disease [ICD-11: CA22]
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Differential expression pattern of antigen in diseases
The Studied Tissue Lung
The Specific Disease Chronic obstructive pulmonary disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.212360538; Fold-change: 0.112762024; Z-score: 0.376693945
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Small airway epithelium
The Specific Disease Chronic obstructive pulmonary disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.019265566; Fold-change: -0.221400667; Z-score: -0.645657356
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Asthma [ICD-11: CA23]
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Differential expression pattern of antigen in diseases
The Studied Tissue Nasal and bronchial airway
The Specific Disease Asthma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.013604765; Fold-change: -0.154784102; Z-score: -0.329278808
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Human rhinovirus infection [ICD-11: CA42]
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Differential expression pattern of antigen in diseases
The Studied Tissue Nasal Epithelium
The Specific Disease Human rhinovirus infection
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.723218355; Fold-change: 0.024452521; Z-score: 0.10497088
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Idiopathic pulmonary fibrosis [ICD-11: CB03.4]
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Differential expression pattern of antigen in diseases
The Studied Tissue Lung
The Specific Disease Idiopathic pulmonary fibrosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.736332751; Fold-change: -0.011655968; Z-score: -0.048159129
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 13
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Periodontal disease [ICD-11: DA0C]
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Differential expression pattern of antigen in diseases
The Studied Tissue Gingival
The Specific Disease Periodontal disease
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.000423311; Fold-change: -0.165882782; Z-score: -0.389774716
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Eosinophilic gastritis [ICD-11: DA42.2]
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Differential expression pattern of antigen in diseases
The Studied Tissue Gastric antrum
The Specific Disease Eosinophilic gastritis
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.672060272; Fold-change: -0.035991699; Z-score: -0.275102962
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Liver failure [ICD-11: DB99.7-DB99.8]
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Differential expression pattern of antigen in diseases
The Studied Tissue Liver
The Specific Disease Liver failure
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.255865837; Fold-change: -0.08567336; Z-score: -0.54133859
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ulcerative colitis [ICD-11: DD71]
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Differential expression pattern of antigen in diseases
The Studied Tissue Colon mucosal
The Specific Disease Ulcerative colitis
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.247520189; Fold-change: 0.148265343; Z-score: 0.504090398
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Irritable bowel syndrome [ICD-11: DD91.0]
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Differential expression pattern of antigen in diseases
The Studied Tissue Rectal colon
The Specific Disease Irritable bowel syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.668471875; Fold-change: 0.009659003; Z-score: 0.040686981
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 14
Click to Show/Hide the 5 Disease of This Class
Atopic dermatitis [ICD-11: EA80]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Atopic dermatitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.468163003; Fold-change: 0.005069775; Z-score: 0.015238151
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Psoriasis [ICD-11: EA90]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Psoriasis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 6.18E-05; Fold-change: -0.331486187; Z-score: -0.750717775
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 7.92E-25; Fold-change: 0.852955476; Z-score: 1.878455719
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Vitiligo [ICD-11: ED63.0]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Vitiligo
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.035894218; Fold-change: 0.418525806; Z-score: 1.122304633
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Alopecia [ICD-11: ED70]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin from scalp
The Specific Disease Alopecia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.537664845; Fold-change: -0.082781846; Z-score: -0.389754019
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sensitive skin [ICD-11: EK0Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Sensitive skin
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.442770502; Fold-change: 0.181716135; Z-score: 0.570375176
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 15
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Osteoarthritis [ICD-11: FA00-FA0Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Synovial
The Specific Disease Osteoarthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.022267605; Fold-change: -0.248324584; Z-score: -1.428270082
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Arthropathy [ICD-11: FA00-FA5Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Arthropathy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.151433417; Fold-change: 0.053539316; Z-score: 0.483495694
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Arthritis [ICD-11: FA20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Arthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.16289099; Fold-change: -0.055576177; Z-score: -0.229866292
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Rheumatoid arthritis [ICD-11: FA20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Synovial
The Specific Disease Rheumatoid arthritis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 1.02E-05; Fold-change: -0.563096132; Z-score: -4.500823082
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ankylosing spondylitis [ICD-11: FA92.0Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Pheripheral blood
The Specific Disease Ankylosing spondylitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.457722773; Fold-change: -0.036830749; Z-score: -0.236653911
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Osteoporosis [ICD-11: FB83]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Osteoporosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.638026748; Fold-change: -0.088279953; Z-score: -0.698376106
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 16
Click to Show/Hide the 2 Disease of This Class
Endometriosis [ICD-11: GA10]
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Differential expression pattern of antigen in diseases
The Studied Tissue Endometrium
The Specific Disease Endometriosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.700931979; Fold-change: -0.060801171; Z-score: -0.084681011
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Interstitial cystitis [ICD-11: GC00.3]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bladder
The Specific Disease Interstitial cystitis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.007174122; Fold-change: -0.848288435; Z-score: -2.101127413
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 19
Click to Show/Hide the 1 Disease of This Class
Preterm birth [ICD-11: KA21.4Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Myometrium
The Specific Disease Preterm birth
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.365937152; Fold-change: 0.136699949; Z-score: 0.562871352
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 2
Click to Show/Hide the 8 Disease of This Class
Acute myelocytic leukemia [ICD-11: 2A60]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Acute myelocytic leukemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.154694558; Fold-change: -0.014190819; Z-score: -0.06341144
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Myeloma [ICD-11: 2A83]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Myeloma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.001030185; Fold-change: -0.434172727; Z-score: -2.127910015
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Peripheral blood
The Specific Disease Myeloma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.087020745; Fold-change: 0.10517238; Z-score: 0.778696638
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Oral cancer [ICD-11: 2B6E]
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Differential expression pattern of antigen in diseases
The Studied Tissue Oral
The Specific Disease Oral cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.038777561; Fold-change: -0.270613501; Z-score: -0.610659743
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.053333887; Fold-change: -0.075365547; Z-score: -0.179044214
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Esophagal cancer [ICD-11: 2B70]
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Differential expression pattern of antigen in diseases
The Studied Tissue Esophagus
The Specific Disease Esophagal cancer
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.461625553; Fold-change: -0.095714861; Z-score: -0.336434857
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Rectal cancer [ICD-11: 2B92]
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Differential expression pattern of antigen in diseases
The Studied Tissue Rectal colon
The Specific Disease Rectal cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.04795117; Fold-change: 0.450706063; Z-score: 1.154459123
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.945918695; Fold-change: 0.042051702; Z-score: 0.22043818
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Skin cancer [ICD-11: 2C30-2C3Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Skin cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000864162; Fold-change: 0.110835857; Z-score: 0.173478703
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 2.81E-29; Fold-change: 0.972896342; Z-score: 1.632726074
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Renal cancer [ICD-11: 2C90-2C91]
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Differential expression pattern of antigen in diseases
The Studied Tissue Kidney
The Specific Disease Renal cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.029720273; Fold-change: -0.709009952; Z-score: -1.267571875
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 8.49E-15; Fold-change: -0.993088233; Z-score: -1.542123896
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Ureter cancer [ICD-11: 2C92]
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Differential expression pattern of antigen in diseases
The Studied Tissue Urothelium
The Specific Disease Ureter cancer
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.06703473; Fold-change: -0.138430894; Z-score: -0.383569792
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 20
Click to Show/Hide the 2 Disease of This Class
Simpson golabi behmel syndrome [ICD-11: LD2C]
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Differential expression pattern of antigen in diseases
The Studied Tissue Adipose
The Specific Disease Simpson golabi behmel syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.559515928; Fold-change: -0.008971057; Z-score: -0.056132976
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Tuberous sclerosis complex [ICD-11: LD2D.2]
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Differential expression pattern of antigen in diseases
The Studied Tissue Perituberal
The Specific Disease Tuberous sclerosis complex
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.556018696; Fold-change: 0.066332397; Z-score: 1.237164472
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 3
Click to Show/Hide the 3 Disease of This Class
Anemia [ICD-11: 3A00-3A9Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Bone marrow
The Specific Disease Anemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.146985214; Fold-change: 0.198063105; Z-score: 0.797365822
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sickle cell disease [ICD-11: 3A51.0-3A51.3]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Sickle cell disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.670580395; Fold-change: 0.095962608; Z-score: 0.374772966
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Thrombocythemia [ICD-11: 3B63]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Thrombocythemia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.00209457; Fold-change: 0.226497225; Z-score: 1.589489561
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 4
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Scleroderma [ICD-11: 4A42.Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Scleroderma
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.423787007; Fold-change: -0.05771096; Z-score: -0.364746787
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Sjogren syndrome [ICD-11: 4A43]
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Differential expression pattern of antigen in diseases
The Studied Tissue Salivary gland
The Specific Disease Sjogren syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.103120577; Fold-change: -0.289146057; Z-score: -1.325639651
The Expression Level of Disease Section Compare with the Adjacent Tissue p-value: 0.402173647; Fold-change: -0.131929756; Z-score: -0.738353869
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Behcet disease [ICD-11: 4A62]
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Differential expression pattern of antigen in diseases
The Studied Tissue Peripheral blood
The Specific Disease Behcet disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.581333855; Fold-change: -0.066661849; Z-score: -0.613625797
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Autosomal dominant monocytopenia [ICD-11: 4B04]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Autosomal dominant monocytopenia
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.570835969; Fold-change: 0.033290946; Z-score: 0.285226964
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 5
Click to Show/Hide the 5 Disease of This Class
Type 2 diabetes [ICD-11: 5A11]
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Differential expression pattern of antigen in diseases
The Studied Tissue Liver
The Specific Disease Type 2 diabetes
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.624191315; Fold-change: -0.100560515; Z-score: -0.233932628
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Polycystic ovary syndrome [ICD-11: 5A80.1]
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Differential expression pattern of antigen in diseases
The Studied Tissue Vastus lateralis muscle
The Specific Disease Polycystic ovary syndrome
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.618095699; Fold-change: -0.004199947; Z-score: -0.017973221
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Obesity [ICD-11: 5B81]
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Differential expression pattern of antigen in diseases
The Studied Tissue Subcutaneous Adipose
The Specific Disease Obesity
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.091692087; Fold-change: -0.169140193; Z-score: -0.640883627
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Pompe disease [ICD-11: 5C51.3]
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Differential expression pattern of antigen in diseases
The Studied Tissue Biceps muscle
The Specific Disease Pompe disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.49517273; Fold-change: -0.063072743; Z-score: -0.235672229
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Batten disease [ICD-11: 5C56.1]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Batten disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.793773274; Fold-change: 0.03444657; Z-score: 0.42306702
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 6
Click to Show/Hide the 2 Disease of This Class
Autism [ICD-11: 6A02]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Autism
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.006190545; Fold-change: -0.165867379; Z-score: -0.58366212
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Anxiety disorder [ICD-11: 6B00-6B0Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Anxiety disorder
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.17537909; Fold-change: -0.110061157; Z-score: -0.302092086
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
ICD Disease Classification 8
Click to Show/Hide the 7 Disease of This Class
Parkinson disease [ICD-11: 8A00]
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Differential expression pattern of antigen in diseases
The Studied Tissue Substantia nigra
The Specific Disease Parkinson disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.497422023; Fold-change: 0.025549458; Z-score: 0.066367406
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Huntington disease [ICD-11: 8A01]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Huntington disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.387513999; Fold-change: 0.09168742; Z-score: 0.522064954
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Alzheimer disease [ICD-11: 8A20]
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Differential expression pattern of antigen in diseases
The Studied Tissue Entorhinal cortex
The Specific Disease Alzheimer disease
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.917148806; Fold-change: 0.003172074; Z-score: 0.006821178
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Seizure [ICD-11: 8A60-8A6Z]
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Differential expression pattern of antigen in diseases
The Studied Tissue Whole blood
The Specific Disease Seizure
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.848995004; Fold-change: 0.005784188; Z-score: 0.027093532
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Lateral sclerosis [ICD-11: 8B60.4]
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Differential expression pattern of antigen in diseases
The Studied Tissue Skin
The Specific Disease Lateral sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.024006049; Fold-change: 0.120046152; Z-score: 1.747309325
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
The Studied Tissue Cervical spinal cord
The Specific Disease Lateral sclerosis
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.383643507; Fold-change: -0.016331101; Z-score: -0.03868759
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Muscular atrophy [ICD-11: 8C70]
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Differential expression pattern of antigen in diseases
The Studied Tissue Muscle
The Specific Disease Muscular atrophy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.001161704; Fold-change: 0.231565306; Z-score: 0.80605852
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
Myopathy [ICD-11: 8C70.6]
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Differential expression pattern of antigen in diseases
The Studied Tissue Muscle
The Specific Disease Myopathy
The Expression Level of Disease Section Compare with the Healthy Individual Tissue p-value: 0.000551983; Fold-change: 0.473056049; Z-score: 2.600369306
Disease-specific Antigen Abundances Click to View the Clearer Original Diagram
References
Ref 1 AMT-562, a novel HER3-targeting antibody drug conjugate, demonstrates a potential to broaden therapeutic opportunities for HER3-expressing tumors. Mol Cancer Ther. 2023 Jun 11:MCT-23-0198. doi: 10.1158/1535-7163.MCT-23-0198. Online ahead of print.
Ref 2 Introduction to basic information on ADC drug SIBP-A13
Ref 3 Bioactive substance conjugate, preparation method therefor and use thereof; 2022-08-18.
Ref 4 An auristatin-based antibody-drug conjugate targeting HER3 enhances the radiation response in pancreatic cancer. Int J Cancer. 2019 Oct 1;145(7):1838-1851. doi: 10.1002/ijc.32273. Epub 2019 Apr 1.
Ref 5 Monomethyl auristatin antibody and peptide drug conjugates for trimodal cancer chemo-radio-immunotherapy. Nat Commun. 2022 Jul 5;13(1):3869. doi: 10.1038/s41467-022-31601-z.
Ref 6 EV20-mediated delivery of cytotoxic auristatin MMAF exhibits potent therapeutic efficacy in cutaneous melanoma. J Control Release. 2018 May 10;277:48-56. doi: 10.1016/j.jconrel.2018.03.016. Epub 2018 Mar 14.
Ref 7 EV20/NMS-P945, a Novel Thienoindole Based Antibody-Drug Conjugate Targeting HER-3 for Solid Tumors. Pharmaceutics. 2021 Apr 2;13(4):483. doi: 10.3390/pharmaceutics13040483.
Ref 8 Mediapharma product pipeline
Ref 9 Efficacy and Safety of Patritumab Deruxtecan (HER3-DXd) in EGFR Inhibitor-Resistant, EGFR-Mutated Non-Small Cell Lung Cancer. Cancer Discov. 2022 Jan;12(1):74-89.
Ref 10 Antibody drug conjugates; 2023-07-06.
Ref 11 A Phase I Clinical Study of SHR-A2009 for Injection in Patients With Advanced Solid Tumors; NCT05114759.
Ref 12 MP-EV20-ADC: humanized anti-HER3 antibody drug conjugate
Ref 13 HMBD-501 - a novel Fc engineered, exatecan-based next generation HER3 targeting antibody drug conjugate shows robust efficacy and tolerability in pre-clinical solid tumor models. Cancer Res (2023) 83 (7_Supplement): 2660.
Ref 14 DB-1310, a novel Her3 targeting antibody-drug conjugate, exhibits therapeutic efficacy for solid tumors. Cancer Res (2023) 83 (7_Supplement): 1884.
Ref 15 Introduction to basic information on HER3-ADC9(Jiangsu Hengrui).
Ref 16 Sorrento therapeutics next-generation cancer therapeutics; November 2013

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