Antigen Information

General Information of This Antigen (ID: TAR0MYDAB)
Antigen Name
Receptor tyrosine-protein kinase erbB-3 (HER3)
Gene Name
HER3
Gene ID
2065
Synonym
HER3; Proto-oncogene-like protein c-ErbB-3;Tyrosine kinase-type cell surface receptor HER3
Sequence
MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVM
GNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVM
LNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNG
RSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQD
TDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTS
CVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGN
LDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGG
RSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEE
RLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEP
REFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPI
YKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLG
GTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVF
GTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPG
SSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNV
LLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVT
VWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKE
LANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEED
NLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPR
PVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLL
TPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYM
NRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDY
EYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATD
SAFDNPDYWHSRLFPKANAQRT

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Family
Tyr protein family
Function
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. May also be activated by CSPG5. Involved in the regulation of myeloid cell differentiation.

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Uniprot Entry
ERBB3_HUMAN
HGNC ID
HGNC:3431
KEGG ID
hsa:2065
Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens
ADC Name Payload Target Linker ADC Info
AMT-562
Exatecan
DNA topoisomerase 1 (TOP1)
T800
 ADC Info 
Anti-HER3 IgG1 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
DB-1310
P1021
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
YL202
YL0010014
DNA topoisomerase 1 (TOP1)
VK*G-NHCH2-O linker
 ADC Info 
Anti-HER3 mAb
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HMBD-501 [1]
Exatecan
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
SIBP-A13 [2]
DXd
DNA topoisomerase 1 (TOP1)
Mc-VASGFG
 ADC Info 
IBI133
Exatecan
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
SYS6023
Self-developed TOP1 inhibitor
DNA topoisomerase 1 (TOP1)
Undisclosed
 ADC Info 
Anti-Her3 mAb 202-2-1
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Her3-ADC-07 (DAR8) [3]
Her3-ADC-07(DAR8) payload
Undisclosed
Her3-ADC-07(DAR8) linker
 ADC Info 
Her3-ADC-07 (DAR4) [3]
Her3-ADC-07(DAR4) payload
Undisclosed
Her3-ADC-07(DAR4) linker
 ADC Info 
Her3-ADC-07 (DAR6) [3]
Her3-ADC-07(DAR6) payload
Undisclosed
Her3-ADC-07(DAR6) linker
 ADC Info 
Her3-ADC-05 (DAR4) [3]
Her3-ADC-05(DAR4) payload
Undisclosed
Her3-ADC-05(DAR4) linker
 ADC Info 
Her3-ADC-15 (DAR8) [3]
Her3-ADC-15(DAR8) payload
Undisclosed
Her3-ADC-15(DAR8) linker
 ADC Info 
Her3-ADC-15 (DAR2) [3]
Her3-ADC-15(DAR2) payload
Undisclosed
Her3-ADC-15(DAR2) linker
 ADC Info 
Her3-ADC-21 (DAR4) [3]
Her3-ADC-21(DAR4) payload
Undisclosed
Her3-ADC-21(DAR4) linker
 ADC Info 
Her3-ADC-23 (DAR4) [3]
Her3-ADC-23(DAR4) payload
Undisclosed
Her3-ADC-23(DAR4) linker
 ADC Info 
Her3-ADC-33 (DAR4) [3]
Her3-ADC-33(DAR4) payload
Undisclosed
Her3-ADC-33(DAR4) linker
 ADC Info 
Anti-HER3 mAb 9F7-F11
 Antibody Info 
ADC Name Payload Target Linker ADC Info
MMAE-9F7-F11 ADC [4]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Antibody A
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN117616052A Antibody A-ADC1 [5]
DX-8951 derivative (DXd)
DNA topoisomerase 1 (TOP1)
DBCO-PEG4-GGFG-aminol
 ADC Info 
Barecetamab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Barecetamab-ADC-Tb4-1 [3]
Barecetamab-ADC-Tb4-1 payload
Undisclosed
Barecetamab-ADC-Tb4-1 linker
 ADC Info 
Barecetamab-ADC-Tb4-2 [3]
Barecetamab-ADC-Tb4-2 payload
Undisclosed
Barecetamab-ADC-Tb4-2 linker
 ADC Info 
Barecetamab-ADC-Tb4-3 [3]
Barecetamab-ADC-Tb4-3 payload
Undisclosed
Barecetamab-ADC-Tb4-3 linker
 ADC Info 
Barecetamab-ADC-Tb4-4 [3]
Barecetamab-ADC-Tb4-4 payload
Undisclosed
Barecetamab-ADC-Tb4-4 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
CDX3379-MMAE [6]
Monomethyl auristatin E
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Duligotuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Duligotuzumab-ADC-Tb4-1 [3]
Duligotuzumab-ADC-Tb4-1 payload
Undisclosed
Duligotuzumab-ADC-Tb4-1 linker
 ADC Info 
Duligotuzumab-ADC-Tb4-2 [3]
Duligotuzumab-ADC-Tb4-2 payload
Undisclosed
Duligotuzumab-ADC-Tb4-2 linker
 ADC Info 
Duligotuzumab-ADC-Tb4-3 [3]
Duligotuzumab-ADC-Tb4-3 payload
Undisclosed
Duligotuzumab-ADC-Tb4-3 linker
 ADC Info 
Duligotuzumab-ADC-Tb4-4 [3]
Duligotuzumab-ADC-Tb4-4 payload
Undisclosed
Duligotuzumab-ADC-Tb4-4 linker
 ADC Info 
Elgemtumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Elgemtumab-ADC-Tb4-1 [3]
Elgemtumab-ADC-Tb4-1 payload
Undisclosed
Elgemtumab-ADC-Tb4-1 linker
 ADC Info 
Elgemtumab-ADC-Tb4-2 [3]
Elgemtumab-ADC-Tb4-2 payload
Undisclosed
Elgemtumab-ADC-Tb4-2 linker
 ADC Info 
Elgemtumab-ADC-Tb4-3 [3]
Elgemtumab-ADC-Tb4-3 payload
Undisclosed
Elgemtumab-ADC-Tb4-3 linker
 ADC Info 
Elgemtumab-ADC-Tb4-4 [3]
Elgemtumab-ADC-Tb4-4 payload
Undisclosed
Elgemtumab-ADC-Tb4-4 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
EV20/NMS-P945 [7]
NMS-P528
Human Deoxyribonucleic acid (hDNA)
Cathepsin-cleavable peptidic linker with self-immolating spacer
 ADC Info 
EV20/MMAF [8]
Monomethyl auristatin F
Microtubule (MT)
Maleimido-caproyl
 ADC Info 
MP-EV-20 [9]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
FDA026-1402 [10]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
FDA026-LE12 [10]
FDA029-LE12 payload
Undisclosed
CN119317630A ADC-C9 Linker
 ADC Info 
FDA026-LE13 [10]
FDA029-LE13 payload
Undisclosed
CN119317630A ADC-C9 Linker
 ADC Info 
FDA026-LE14 [10]
FDA029-LE14 payload
Undisclosed
Mc-Val-Ala-PABC
 ADC Info 
FDA026-LE15 [10]
FDA029-LE14 payload
Undisclosed
FDA026-LE15 linker
 ADC Info 
FDA026-LE16 [10]
FDA029-LE14 payload
Undisclosed
FDA026-LE17 linker
 ADC Info 
FDA026-LE17 [10]
FDA029-LE13 payload
Undisclosed
FDA026-LE17 linker
 ADC Info 
FDA026-LE18 [10]
FDA029-LE14 payload
Undisclosed
FDA026-LE18 linker
 ADC Info 
FDA026-LE19 [10]
FDA029-LE14 payload
Undisclosed
FDA026-LE19 linker
 ADC Info 
FDA026-LE20 [10]
FDA029-LE14 payload
Undisclosed
FDA026-LE20 linker
 ADC Info 
FDA026-LE21 [10]
FDA026-LE21 payload
Undisclosed
CN119317630A ADC-C9 Linker
 ADC Info 
FDA026-LE22 [10]
FDA026-LE22 payload
Undisclosed
CN119317630A ADC-C9 Linker
 ADC Info 
FDA026-LS13 [10]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
ADC Name Payload Target Linker ADC Info
FDA028-LE12 [10]
FDA029-LE12 payload
Undisclosed
CN119317630A ADC-C9 Linker
 ADC Info 
FDA028-LE13 [10]
FDA029-LE13 payload
Undisclosed
CN119317630A ADC-C9 Linker
 ADC Info 
FDA028-LE14 [10]
FDA029-LE14 payload
Undisclosed
CN119317630A ADC-C9 Linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
FDA029-LE12 [10]
FDA029-LE12 payload
Undisclosed
CN119317630A ADC-C9 Linker
 ADC Info 
FDA029-LE13 [10]
FDA029-LE13 payload
Undisclosed
CN119317630A ADC-C9 Linker
 ADC Info 
FDA029-LE14 [10]
FDA029-LE14 payload
Undisclosed
CN119317630A ADC-C9 Linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
Her3-C3-ADC-05 (DAR4) [3]
Her3-C3-ADC-05(DAR4) payload
Undisclosed
Her3-C3-ADC-05(DAR4) linker
 ADC Info 
Her3-C3-ADC-21 (DAR4) [3]
Her3-C3-ADC-21(DAR4) payload
Undisclosed
Her3-C3-ADC-21(DAR4) linker
 ADC Info 
Her3-C3-ADC-21 (DAR8) [3]
Her3-C3-ADC-21(DAR8) payload
Undisclosed
Her3-C3-ADC-21(DAR8) linker
 ADC Info 
Her3-C3-ADC-23 (DAR4) [3]
Her3-C3-ADC-23(DAR4) payload
Undisclosed
Her3-C3-ADC-23(DAR4) linker
 ADC Info 
Lumretuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Lumretuzumab-ADC-Tb4-1 [3]
Lumretuzumab-ADC-Tb4-1 payload
Undisclosed
Lumretuzumab-ADC-Tb4-1 linker
 ADC Info 
Lumretuzumab-ADC-Tb4-2 [3]
Lumretuzumab-ADC-Tb4-2 payload
Undisclosed
Lumretuzumab-ADC-Tb4-2 linker
 ADC Info 
Lumretuzumab-ADC-Tb4-3 [3]
Lumretuzumab-ADC-Tb4-3 payload
Undisclosed
Lumretuzumab-ADC-Tb4-3 linker
 ADC Info 
Lumretuzumab-ADC-Tb4-4 [3]
Lumretuzumab-ADC-Tb4-4 payload
Undisclosed
Lumretuzumab-ADC-Tb4-4 linker
 ADC Info 
Patritumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Patritumab deruxtecan
DXd
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
ADC3-6 [11]
ADC 3-6 payload
DNA topoisomerase 1 (TOP1)
ADC 3-6 linker
 ADC Info 
ADC3-7 [11]
ADC 3-7 payload
DNA topoisomerase 1 (TOP1)
ADC 3-7 linker
 ADC Info 
ADC3-8 [11]
ADC 3-8 payload
DNA topoisomerase 1 (TOP1)
ADC 3-8 linker
 ADC Info 
ADC3-9 [11]
ADC 3-9 payload
DNA topoisomerase 1 (TOP1)
ADC 3-9 linker
 ADC Info 
ADC3-10 [11]
ADC 3-10 payload
DNA topoisomerase 1 (TOP1)
ADC 3-10 linker
 ADC Info 
ADC3-11 [11]
ADC 3-11 payload
DNA topoisomerase 1 (TOP1)
ADC 3-11 linker
 ADC Info 
ADC3-12 [11]
ADC 3-12 payload
DNA topoisomerase 1 (TOP1)
ADC 3-12 linker
 ADC Info 
ADC3-13 [11]
ADC 3-13 payload
DNA topoisomerase 1 (TOP1)
ADC 3-13 linker
 ADC Info 
ADC3-14 [11]
ADC 3-14 payload
DNA topoisomerase 1 (TOP1)
ADC 3-14 linker
 ADC Info 
ADC3-15 [11]
ADC 3-15 payload
DNA topoisomerase 1 (TOP1)
ADC 3-15 linker
 ADC Info 
ADC3-16 [11]
ADC 3-16 payload
DNA topoisomerase 1 (TOP1)
ADC 3-16 linker
 ADC Info 
ADC3-17 [11]
ADC 3-17 payload
DNA topoisomerase 1 (TOP1)
ADC 3-17 linker
 ADC Info 
ADC3-18 [11]
ADC 3-18 payload
DNA topoisomerase 1 (TOP1)
ADC 3-18 linker
 ADC Info 
ADC3-19 [11]
ADC 3-19 payload
DNA topoisomerase 1 (TOP1)
ADC 3-19 linker
 ADC Info 
ADC3-20 [11]
ADC 3-20 payload
DNA topoisomerase 1 (TOP1)
ADC 3-20 linker
 ADC Info 
ADC-C2 [11]
ADC-C2 payload
DNA topoisomerase 1 (TOP1)
ADC-C2 linker
 ADC Info 
ADC-C3 [11]
ADC-C3 payload
DNA topoisomerase 1 (TOP1)
ADC-C3 linker
 ADC Info 
ADC-C4 [11]
ADC-C4 payload
DNA topoisomerase 1 (TOP1)
ADC-C4 linker
 ADC Info 
ADC-C5 [11]
ADC-C5 payload
DNA topoisomerase 1 (TOP1)
ADC-C5 linker
 ADC Info 
ADC-C1 [11]
ADC-C1 payload
DNA topoisomerase 1 (TOP1)
ADC-C1 linker
 ADC Info 
Patritumab-ADC-Tb4-1 [3]
Patritumab-ADC-Tb4-1 payload
Undisclosed
Patritumab-ADC-Tb4-1 linker
 ADC Info 
Patritumab-ADC-Tb4-2 [3]
Patritumab-ADC-Tb4-2 payload
Undisclosed
Patritumab-ADC-Tb4-2 linker
 ADC Info 
Patritumab-ADC-Tb4-3 [3]
Patritumab-ADC-Tb4-3 payload
Undisclosed
Patritumab-ADC-Tb4-3 linker
 ADC Info 
Patritumab-ADC-Tb4-4 [3]
Patritumab-ADC-Tb4-4 payload
Undisclosed
Patritumab-ADC-Tb4-4 linker
 ADC Info 
KHN922 [12]
Exatecan+Triptolide
DNA topoisomerase 1 (TOP1)+RNA polymerase II
Mc-PEG2-VA-PAB+DBCO-PEG4-GGFG
 ADC Info 
US20240245795A1 Antibody Conjugate 9 [13]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
AK138D1
DXd
DNA topoisomerase 1 (TOP1)
Mc-Ala-Ala-Ala
 ADC Info 
Ruzaltatug
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Ruzaltatug rezetecan
SHR9265
DNA topoisomerase 1 (TOP1)
Mc-Gly-Gly-Phe-Gly
 ADC Info 
Seribantumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Seribantumab-ADC-Tb4-1 [3]
Seribantumab-ADC-Tb4-1 payload
Undisclosed
Seribantumab-ADC-Tb4-1 linker
 ADC Info 
Seribantumab-ADC-Tb4-2 [3]
Seribantumab-ADC-Tb4-2 payload
Undisclosed
Seribantumab-ADC-Tb4-2 linker
 ADC Info 
Seribantumab-ADC-Tb4-3 [3]
Seribantumab-ADC-Tb4-3 payload
Undisclosed
Seribantumab-ADC-Tb4-3 linker
 ADC Info 
Seribantumab-ADC-Tb4-4 [3]
Seribantumab-ADC-Tb4-4 payload
Undisclosed
Seribantumab-ADC-Tb4-4 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
EP4494710A2 Antibody-drug conjugate (1) [14]
EP4494710A2 Antibody-drug conjugate (1) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 ADC Info 
EP4494710A2 Antibody-drug conjugate (2) [14]
EP4494710A2 Antibody-drug conjugate (1) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 ADC Info 
EP4494710A2 Antibody-drug conjugate (3) [14]
EP4494710A2 Antibody-drug conjugate (1) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 ADC Info 
EP4494710A2 Antibody-drug conjugate (4) [14]
EP4494710A2 Antibody-drug conjugate (1) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 ADC Info 
EP4494710A2 Antibody-drug conjugate (5) [14]
EP4494710A2 Antibody-drug conjugate (5) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 ADC Info 
EP4494710A2 Antibody-drug conjugate (6) [14]
EP4494710A2 Antibody-drug conjugate (5) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 ADC Info 
EP4494710A2 Antibody-drug conjugate (7) [14]
EP4494710A2 Antibody-drug conjugate (7) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 ADC Info 
EP4494710A2 Antibody-drug conjugate (8) [14]
EP4494710A2 Antibody-drug conjugate (8) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 ADC Info 
EP4494710A2 Antibody-drug conjugate (9) [14]
EP4494710A2 Antibody-drug conjugate (9) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (9) Linker
 ADC Info 
EP4494710A2 Antibody-drug conjugate (10) [14]
EP4494710A2 Antibody-drug conjugate (9) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (9) Linker
 ADC Info 
EP4494710A2 Antibody-drug conjugate (11) [14]
EP4494710A2 Antibody-drug conjugate (9) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (9) Linker
 ADC Info 
EP4494710A2 Antibody-drug conjugate (12) [14]
EP4494710A2 Antibody-drug conjugate (12) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 ADC Info 
EP4494710A2 Antibody-drug conjugate (13) [14]
EP4494710A2 Antibody-drug conjugate (12) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 ADC Info 
EP4494710A2 Antibody-drug conjugate (14) [14]
EP4494710A2 Antibody-drug conjugate (12) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 ADC Info 
EP4494710A2 Antibody-drug conjugate (15) [14]
EP4494710A2 Antibody-drug conjugate (12) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 ADC Info 
EP4494710A2 Antibody-drug conjugate (16a) [14]
EP4494710A2 Antibody-drug conjugate (12) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 ADC Info 
EP4494710A2 Antibody-drug conjugate (16b) [14]
EP4494710A2 Antibody-drug conjugate (12) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 ADC Info 
EP4494710A2 Antibody-drug conjugate (16c) [14]
EP4494710A2 Antibody-drug conjugate (12) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 ADC Info 
EP4494710A2 Antibody-drug conjugate (16d) [14]
EP4494710A2 Antibody-drug conjugate (12) Payload
Undisclosed
EP4494710A2 Antibody-drug conjugate (1) Linker
 ADC Info 
FI3789042T3Antibody-drug conjugate (1) [15]
Antibody-drug conjugate (1)payload
Undisclosed
Antibody-drug conjugate (1)Linker
 ADC Info 
FI3789042T3Antibody-drug conjugate (2) [15]
Antibody-drug conjugate (1)payload
Undisclosed
Antibody-drug conjugate (1)Linker
 ADC Info 
FI3789042T3Antibody-drug conjugate (3) [15]
Antibody-drug conjugate (1)payload
Undisclosed
Antibody-drug conjugate (1)Linker
 ADC Info 
FI3789042T3Antibody-drug conjugate (4) [15]
Antibody-drug conjugate (1)payload
Undisclosed
Antibody-drug conjugate (1)Linker
 ADC Info 
FI3789042T3Antibody-drug conjugate (5) [15]
Antibody-drug conjugate (1)payload
Undisclosed
Antibody-drug conjugate (5)Linker
 ADC Info 
FI3789042T3Antibody-drug conjugate (6) [15]
Undisclosed
Undisclosed
Antibody-drug conjugate (5)Linker
 ADC Info 
FI3789042T3Antibody-drug conjugate (7) [15]
Antibody-drug conjugate (7)payload
Undisclosed
Antibody-drug conjugate (7)Linker
 ADC Info 
FI3789042T3Antibody-drug conjugate (8) [15]
Undisclosed
Undisclosed
Antibody-drug conjugate (7)Linker
 ADC Info 
FI3789042T3Antibody-drug conjugate (9) [15]
Undisclosed
Undisclosed
Antibody-drug conjugate (9)Linker
 ADC Info 
FI3789042T3Antibody-drug conjugate (10) [15]
Undisclosed
Undisclosed
Antibody-drug conjugate (9)Linker
 ADC Info 
FI3789042T3Antibody-drug conjugate (11) [15]
Undisclosed
Undisclosed
Antibody-drug conjugate (9)Linker
 ADC Info 
FI3789042T3Antibody-drug conjugate (12) [15]
Antibody-drug conjugate (12)payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
FI3789042T3Antibody-drug conjugate (13) [15]
Antibody-drug conjugate (12)payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
FI3789042T3Antibody-drug conjugate (14) [15]
Antibody-drug conjugate (12)payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
FI3789042T3Antibody-drug conjugate (15) [15]
Antibody-drug conjugate (12)payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
FI3789042T3Antibody-drug conjugate (16a) [15]
Antibody-drug conjugate (12)payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
FI3789042T3Antibody-drug conjugate (16b) [15]
Antibody-drug conjugate (12)payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
FI3789042T3Antibody-drug conjugate (16c) [15]
Antibody-drug conjugate (12)payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
FI3789042T3Antibody-drug conjugate (16d) [15]
Antibody-drug conjugate (12)payload
Undisclosed
Mc-Gly-Gly-Phe-Gly
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HER3-ADC9 (Jiangsu Hengrui) [16]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
MP-HER3-ADC [17]
Monomethyl auristatin F
Microtubule (MT)
Undisclosed
 ADC Info 
STI-A050X [18]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Patritumab-eribulin-D2 [19]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Patritumab-eribulin-D8 [19]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Patritumab-DDDXd-D8 [19]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Patritumab-eribulin-D4 [19]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
BR122024023391 antibody-drug conjugate (2) [20]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
Production of the antibody-drug conjugate (2) [21]
undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 HMBD-501 - a novel Fc engineered, exatecan-based next generation HER3 targeting antibody drug conjugate shows robust efficacy and tolerability in pre-clinical solid tumor models. Cancer Res (2023) 83 (7_Supplement): 2660.
Ref 2 Introduction to basic information on ADC drug SIBP-A13
Ref 3 Bioactive substance conjugate, preparation method therefor and use thereof; 2022-08-18.
Ref 4 An auristatin-based antibody-drug conjugate targeting HER3 enhances the radiation response in pancreatic cancer. Int J Cancer. 2019 Oct 1;145(7):1838-1851. doi: 10.1002/ijc.32273. Epub 2019 Apr 1.
Ref 5 Antibody-drug conjugates and applications thereof
Ref 6 Monomethyl auristatin antibody and peptide drug conjugates for trimodal cancer chemo-radio-immunotherapy. Nat Commun. 2022 Jul 5;13(1):3869. doi: 10.1038/s41467-022-31601-z.
Ref 7 EV20/NMS-P945, a Novel Thienoindole Based Antibody-Drug Conjugate Targeting HER-3 for Solid Tumors. Pharmaceutics. 2021 Apr 2;13(4):483. doi: 10.3390/pharmaceutics13040483.
Ref 8 EV20-mediated delivery of cytotoxic auristatin MMAF exhibits potent therapeutic efficacy in cutaneous melanoma. J Control Release. 2018 May 10;277:48-56. doi: 10.1016/j.jconrel.2018.03.016. Epub 2018 Mar 14.
Ref 9 Mediapharma product pipeline
Ref 10 Antibody-drug conjugates, intermediates, preparation methods and uses
Ref 11 Antibody drug conjugates; 2023-07-06.
Ref 12 A novel dual-payload HER3-directed antibody-drug conjugate, shows potent antitumor efficacy in HER3-low in vivo tumor models
Ref 13 Preparation method and application of antibody drug conjugate
Ref 14 Pharmaceutical composition comprising an anti-HER3 antibody-drug conjugate for use in treating breast cancers
Ref 15 Methods for preparing anti-HER3 antibody-drug conjugates
Ref 16 Introduction to basic information on HER3-ADC9(Jiangsu Hengrui).
Ref 17 MP-EV20-ADC: humanized anti-HER3 antibody drug conjugate
Ref 18 Sorrento therapeutics next-generation cancer therapeutics; November 2013
Ref 19 Anti-HER3 antibody drug conjugate, composition thereof, and use thereof
Ref 20 Use of an antibody-drug conjugate, pharmaceutical composition and pharmaceutical combination
Ref 21 Combination of antibody-drug conjugate with anti-SIRPα antibody