Antibody Information
General Information of This Antibody
| Antibody ID | ANI0JBWHZ |
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| Antibody Name | Seribantumab |
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| Organization | Merrimack Pharmaceuticals, Inc.; Sanofi; Elevation Oncology, Inc. |
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| Indication | Adenocarcinoma; Bile duct tumors; Bladder cancer |
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| Synonyms |
MM121; SAR256212; SERIBANTUMAB; MM-121; SAR-256212
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Humanized IgG2-lambda |
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| Antigen Name | Receptor tyrosine-protein kinase erbB-3 (ERBB3) |
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| Click to Show/Hide the Sequence Information of This Antibody | ||||||
| Heavy Chain Sequence |
EVQLLESGGGLVQPGGSLRLSCAASGFTFSHYVMAWVRQAPGKGLEWVSSISSSGGWTLY
ADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCTRGLKMATIFDYWGQGTLVTVSSA STKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSG LYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTVERKCCVECPPCPAPPVAGPSVFL FPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTFRV VSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTKGQPREPQVYTLPPSREEMTKNQ VSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDSDGSFFLYSKLTVDKSRWQQGNV FSCSVMHEALHNHYTQKSLSLSPGK Click to Show/Hide
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| Heavy Chain Varible Domain |
EVQLLESGGGLVQPGGSLRLSCAASGFTFSHYVMAWVRQAPGKGLEWVSSISSSGGWTLY
ADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCTRGLKMATIFDYWGQGTLVTVSS Click to Show/Hide
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| Heavy Chain Constant Domain 1 |
ASTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSS
GLYSLSSVVTVPSSNFGTQTYTCNVDHKPSNTKVDKTV Click to Show/Hide
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| Heavy Chain Constant Domain 2 |
APPVAGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVQFNWYVDGVEVHNAKTKP
REEQFNSTFRVVSVLTVVHQDWLNGKEYKCKVSNKGLPAPIEKTISKTK Click to Show/Hide
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| Heavy Chain Constant Domain 3 |
GQPREPQVYTLPPSREEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPMLDS
DGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK Click to Show/Hide
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| Heavy Chain Hinge Region |
ERKCCVECPPCP
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| Heavy Chain CDR 1 |
GFTFSHYV
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| Heavy Chain CDR 2 |
ISSSGGWT
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| Heavy Chain CDR 3 |
TRGLKMATIFDY
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| Light Chain Sequence |
QSALTQPASVSGSPGQSITISCTGTSSDVGSYNVVSWYQQHPGKAPKLIIYEVSQRPSGV
SNRFSGSKSGNTASLTISGLQTEDEADYYCCSYAGSSIFVIFGGGTKVTVLGQPKAAPSV TLFPPSSEELQANKATLVCLVSDFYPGAVTVAWKADGSPVKVGVETTKPSKQSNNKYAAS SYLSLTPEQWKSHRSYSCRVTHEGSTVEKTVAPAECS Click to Show/Hide
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| Light Chain Varible Domain |
QSALTQPASVSGSPGQSITISCTGTSSDVGSYNVVSWYQQHPGKAPKLIIYEVSQRPSGV
SNRFSGSKSGNTASLTISGLQTEDEADYYCCSYAGSSIFVIFGGGTKVTVL Click to Show/Hide
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| Light Chain Constant Domain |
GQPKAAPSVTLFPPSSEELQANKATLVCLVSDFYPGAVTVAWKADGSPVKVGVETTKPSK
QSNNKYAASSYLSLTPEQWKSHRSYSCRVTHEGSTVEKTVAPAECS Click to Show/Hide
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| Light Chain CDR 1 |
SSDVGSYNV
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| Light Chain CDR 2 |
EVS
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| Light Chain CDR 3 |
CSYAGSSIFVI
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Each Antibody-drug Conjugate Related to This Antibody
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