Antibody Information

General Information of This Antibody

Antibody ID	ANI0GZYGJ
Antibody Name	Anti-HER3 mAb 9F7-F11
Antibody Type	Monoclonal antibody (mAb)
Antibody Subtype	Humanized IgG1-kappa
Antigen Name	Receptor tyrosine-protein kinase erbB-3 (ERBB3)	Antigen Info

Each Antibody-drug Conjugate Related to This Antibody

Full Information of The Activity Data of The ADC(s) Related to This Antibody

MMAE-9F7-F11 ADC [Investigative]

ADC Info

Revealed Based on the Cell Line Data

Click To Hide/Show 1 Activity Data Related to This Level

Experiment 1 Reporting the Activity Date of This ADC					[1]
Efficacy Data	Tumor Growth Inhibition value (TGI)	≈ 1.98 ng/mL±0.74 ng/mL	Positive HER3 expression (HER3+++/++)
Method Description	Cells were plated in 96-well flat-bottom plates the day before starvation in 1% FCS for 24hr. HER3-ADC at different dilutions was then added for 5 days, with 50ng/ml NRG1. In the absence of NRG1 stimulation, cells were maintained in 10% FCS and treated with HER3-ADC.
In Vitro Model	Pancreatic ductal adenocarcinoma	BxPC-3 cells		CVCL_0186

References

Ref 1	An auristatin-based antibody-drug conjugate targeting HER3 enhances the radiation response in pancreatic cancer. Int J Cancer. 2019 Oct 1;145(7):1838-1851. doi: 10.1002/ijc.32273. Epub 2019 Apr 1.

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