Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0FSTBP
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| ADC Name |
Her3-C3-ADC-05 (DAR4)
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| Synonyms |
Her3 C3 ADC 05 (DAR4)
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| Organization |
Suzhou Medilink Therapeutics Ltd.
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| Drug Status |
Investigative
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| Indication |
In total 2 Indication(s)
Colon cancer [ICD11:2B90]
Investigative
Lung cancer [ICD11:2C25]
Investigative
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| Drug-to-Antibody Ratio |
4.7
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| Structure |
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| Antibody Name |
Her3-C3
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Antibody Info | ||||
| Antigen Name |
Receptor tyrosine-protein kinase erbB-3 (ERBB3)
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Antigen Info | ||||
| Payload Name |
Undisclosed
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| Linker Name |
Her3-C3-ADC-05(DAR4) linker
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General Information of The Activity Data Related to This ADC
Revealed Based on the Cell Line Data
Full List of Activity Data of This Antibody-drug Conjugate
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 32.94 ng/mL | Positive HER3 expression (HER3 +++/++) | ||
| Method Description |
Conjugate in various concentrations was added to cells in a 96 well plate at 1,000 cells per well in 100 pL in complete RPMI medium.
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| In Vitro Model | Esophageal squamous cell carcinoma | KYSE-520 cells | CVCL_1355 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Half Maximal Effective Concentration (EC50) | 65.11 ug/mL | Positive HER3 expression (HER3 +++/++) | ||
| Method Description |
Conjugate in various concentrations was added to cells in a 96 well plate at 1,000 cells per well in 100 pL in complete RPMI medium.
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| In Vitro Model | Minimally invasive lung adenocarcinoma | NCI-H358 cells | CVCL_1559 | ||
References
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