Target Information

General Information of This Target
Target ID
PATR0JHCHU
Target Name
DNA topoisomerase 2-alpha (TOP2A)
Gene Name
TOP2A
Gene ID
7153
Synonym
TOP2A; TOP2; DNA topoisomerase II, alpha isozyme
Sequence
MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQ
MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN
NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE
TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV
RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVC
LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK
YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
RKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW
YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE
ELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK
KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA
KGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ
RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA
ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLE
ADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKG
TKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHM
DFDSAVAPRAKSVRAKKPIKYLEESDEDDLF

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Family
the type II topoisomerase family
Function
Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. May play a role in regulating the period length of BMAL1 transcriptional oscillation.

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Uniprot Entry
TOP2A_HUMAN
HGNC ID
HGNC:11989
KEGG ID
hsa:7153
Full List of The ADC Related to This Target
Phase 2 (discontinued)
Click To Hide/Show 1 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
ADC Info
SGN-15
CBR96
Lewis Y
Doxorubicin
Acid-labile linker
Phase 1/2 (discontinued)
Click To Hide/Show 3 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
ADC Info
NBE-002
HuXBR1-402
ROR1
PNU-159682
LPETG-Gly5-EDA
ADC Info
SO-N102
Anti-CLDN18.2 antibody
CLDN18.2
PNU-159682
Pentaglycine-EDA uncleavable linker
ADC Info
Milatuzumab doxorubicin
Milatuzumab
CD74
Doxorubicin
SMCC-hydrazide
Investigative
Click To Hide/Show 34 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
ADC Info
CAC10-Gly5-PNU
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
PNU-159682
Gly5
 [1]
ADC Info
Tras-Gly5-EDA-Pnu
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
Gly5-EDA
 [1]
ADC Info
HuXBR1-402-G5-PNU
Anti-ROR1 mAb huXBR1-402
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
PNU-159682
Gly5-FITC
 [2]
ADC Info
Tras-Gly5-EDA-Dox
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Doxorubicin
Gly5-EDA
 [1]
ADC Info
Tras-Gly5-EDA-Nemo
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Nemorubicin
Gly5-EDA
 [1]
ADC Info
Tras-Gly3-Vakl-Cit-PAB-PNU-159682
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
Gly3-vcPAB
 [1]
ADC Info
Alb-DMBA-SIL-DOX
Alb
Albumin (ALB)
Doxorubicin
DMBA-SIL
 [3]
ADC Info
Trastuzumab-PNU-159682 Antibody-Drug Conjugate
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
Undisclosed
 [4]
ADC Info
Trastuzumab-BCN-HydraSpace-Val-Cit-PABC-PNU-159682
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
BCN-HydraSpace-Val-Cit-PABC
 [5]
ADC Info
Trastuzumab-G5-PNU
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
Gly5-FITC
 [1]
ADC Info
Anti-CD22-NMS249
Pinatuzumab
B-cell receptor CD22 (CD22)
PNU-159682
Mc-Val-Cit-PAB-DEA
 [6]
ADC Info
Anti-CD8-idarubicin conjugate
Anti-CD8 (Ly-2.1) mAb
T-cell surface glycoprotein CD8 alpha chain (CD8A); T-cell surface glycoprotein CD8 alpha chain (CD8A)
Idarubicin
Undisclosed
 [7]
ADC Info
MAb-DMBA-SIL-Dox
Cetuximab
Epidermal growth factor receptor (EGFR)
Doxorubicin
DMBA-SIL
 [3]
ADC Info
Cetuximab-Val-Cit-Dox
Cetuximab
Epidermal growth factor receptor (EGFR)
Doxorubicin
Mc-Val-Cit-PABC
 [8]
ADC Info
NV102
Undisclosed
B-lymphocyte antigen CD19 (CD19)
Doxorubicin
Undisclosed
 [9]
ADC Info
NV101
Undisclosed
CD99 antigen (CD99)
Doxorubicin
Undisclosed
 [10]
ADC Info
CytSCA208
CA208
Pregnancy-specific beta-1-glycoprotein 2 (PSG2)
Cytorhodin S
Undisclosed
 [11]
ADC Info
Trastuzumab-PC4AP-DOX
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Doxorubicin
Photocaged C4AP
 [12]
ADC Info
Trastuzumab-PNUEDAGly5
Trastuzumab
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
LPETG-Gly5-EDA
 [13]
ADC Info
Brentuximab-PNUEDAGly5
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
PNU-159682
LPETG-Gly5-EDA
 [13]
ADC Info
WO2007011968A2 cAC10-17
Brentuximab
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)
Doxorubicin
WO2007011968A2_cAC10-17 linker
 [14]
ADC Info
WO2007011968A2 c1F6-17
Anti-CD70 mAb c1F6
CD70 antigen (CD70)
Doxorubicin
WO2007011968A2_c1F6-17 linker
 [14]
ADC Info
PDL1-Dox ADC
Atezolizumab
Programmed cell death 1 ligand 1 (CD274)
Doxorubicin
Undisclosed
 [15]
ADC Info
HCD46-19
Anti-CD46 mAb
Membrane cofactor protein (CD46)
PNU-159682
Hydrophilic cleavable linker 19
 [16]
ADC Info
HuIgG1-19
Undisclosed
Epidermal growth factor receptor (EGFR); Receptor tyrosine-protein kinase erbB-3 (ERBB3)
PNU-159682
Hydrophilic cleavable linker 19
 [16]
ADC Info
HCD46-25
Anti-CD46 mAb
Membrane cofactor protein (CD46)
PNU-159682
Alternative linker without basic amines linker 25
 [16]
ADC Info
HuIgG1-25
Undisclosed
Epidermal growth factor receptor (EGFR); Receptor tyrosine-protein kinase erbB-3 (ERBB3)
PNU-159682
Alternative linker without basic amines linker 25
 [16]
ADC Info
HCD46-26
Anti-CD46 mAb
Membrane cofactor protein (CD46)
PNU-159682
Maleimide based noncleavable linker 26
 [16]
ADC Info
HuIgG1-26
Undisclosed
Epidermal growth factor receptor (EGFR); Receptor tyrosine-protein kinase erbB-3 (ERBB3)
PNU-159682
Maleimide based noncleavable linker 26
 [16]
ADC Info
HCD46-29
Anti-CD46 mAb
Membrane cofactor protein (CD46)
PNU-159682
PNU-thiazole cleavable linker 29
 [16]
ADC Info
HuIgG1-29
Undisclosed
Epidermal growth factor receptor (EGFR); Receptor tyrosine-protein kinase erbB-3 (ERBB3)
PNU-159682
PNU-thiazole cleavable linker 29
 [16]
ADC Info
B12-PEG-G2-DOX
B12
Envelope glycoprotein gp160 (env)
Cis-aconityl-doxorubicin
B12-PEG-G2-DOX linker
 [17]
ADC Info
B12-PEG-G4-DOX
B12
Envelope glycoprotein gp160 (env)
Cis-aconityl-doxorubicin
B12-PEG-G4-DOX linker
 [17]
ADC Info
B12-PEG-G5-DOX
B12
Envelope glycoprotein gp160 (env)
Cis-aconityl-doxorubicin
B12-PEG-G5-DOX linker
 [17]
Investigative(Terminated)
Click To Hide/Show 2 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
ADC Info
Monoclonal antibody 1H10-doxorubicin conjugate
IH10
Tubulin alpha 1B (TUBA1B)
Doxorubicin
Dextran
 [18]
ADC Info
Anti-Laminin receptor monoclonal antibody-liposomal doxorubicin conjugate
Anti-laminin receptor IgM
40S ribosomal protein SA (RPSA)
Doxorubicin
Disulfide bond linker
 [19]
Phase 1
Click To Hide/Show 67 ADC Related to This Stage
ADC Info ADC Name Antibody Antigen Payload Linker Ref
ADC Info
EGFR-EDV-RRM1
Undisclosed
Epidermal growth factor receptor (EGFR)
Doxorubicin
Undisclosed
 [20]
ADC Info
PD0721-DOX ADC
PD0721
Epidermal growth factor receptor variant III (EGFRvIII)
Doxorubicin
dextran T-10
 [21]
ADC Info
ZA202500202A D04-Y180/F404-LP32
D04-Y180/F404
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
PNU-159682
DBCO-L-Cysteic acid-PEG4-Gly
 [22]
ADC Info
ZA202500202A D04-F404-LP32
D04-F404
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
PNU-159682
DBCO-L-Cysteic acid-PEG4-Gly
 [22]
ADC Info
ZA202500202A D04-F404-LP30
D04-F404
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
PNU-159682
DBCO-PEG4-Gly (NH2)
 [22]
ADC Info
ZA202500202A D04-F404-LP31
D04-F404
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
PNU-159682
DBCO-L-Cysteic acid-PEG4 (OH)
 [22]
ADC Info
ZA202500202A D04-F404-LP24
D04-F404
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
PNU-159682
DBCO-nnAA-PEG4
 [22]
ADC Info
ZA202500202A D04-F404-LP25
D04-F404
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
PNU-159682
DBCO-nnAA-PEG4-Gly
 [22]
ADC Info
ZA202500202A D04-F404-LP26
D04-F404
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
PNU-159682
DBCO-nnAA-PEG4-EDA
 [22]
ADC Info
ZA202500202A D04-F404-LP27
D04-F404
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
PNU-159682
DBCO-nnAA-sidechain PEG12-EDA
 [22]
ADC Info
ZA202500202A D04-F404-LP28
D04-F404
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
PNU-159682
DBCO-nnAA-sidechain PEG12
 [22]
ADC Info
WO2024140927A1-ADC-E (DAR6)
mAb-A
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Doxorubicin
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [23]
ADC Info
WO2024140927A1-ADC-E (DAR2)
mAb-A
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Doxorubicin
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [23]
ADC Info
WO2024140927A1-ADC-G (DAR2)
mAb-D
Vascular endothelial growth factor A (VEGFA)
Doxorubicin
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [23]
ADC Info
WO2024140927A1-ADC-I (DAR2)
mAb-E
B-lymphocyte antigen CD20 (MS4A1)
Doxorubicin
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 [23]
ADC Info
WO2020252015A1 ADCLP-24
mAb42
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
PNU-159682
DBCO-nAA-PEG4
 [24]
ADC Info
WO2020252015A1 ADCLP-25
mAb42
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
PNU-159682
DBCO-nnAA-PEG4-Gly
 [24]
ADC Info
WO2020252015A1 ADCLP-28
mAb42
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
PNU-159682
DBCO-nAA-sidechain PEG12
 [24]
ADC Info
WO2020252015A1 ADCLP-29
mAb42
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
PNU-159682
DBCO-PEG4
 [24]
ADC Info
WO2020252015A1 ADCLP-30
mAb42
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
PNU-159682
DBCO-PEG4-Gly (OH)
 [24]
ADC Info
WO2020252015A1 ADCLP-31
mAb42
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
PNU-159682
DBCO-L-Cysteic acid-PEG4 (OH)
 [24]
ADC Info
WO2020252015A1 ADCLP-32
mAb42
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)
PNU-159682
DBCO-L-Cysteic acid-PEG4-Gly
 [24]
ADC Info
CN106714844B ADC-101
4D5 HC A118C
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
CN106714844B-ADC-101-linker
 [25]
ADC Info
CN106714844B ADC-102
10F4v3 HC A118C
B-cell receptor CD22 (CD22)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-103
4D5 HC A118C
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
CN106714844B-ADC-103-linker
 [25]
ADC Info
CN106714844B ADC-104
10F4v3 HC A118C
B-cell receptor CD22 (CD22)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-105
GM15.33 HC A118C
Myeloid cell surface antigen CD33 (CD33)
PNU-159682
CN106714844B-ADC-105-linker
 [25]
ADC Info
CN106714844B ADC-106
10H1.11B HC A118C
Sodium-dependent phosphate transport protein 2B (SLC34A2)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-107
7C2 HC A118C
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-108
7C2 LC K149C
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-109
7C2 LC K149C
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
CN106714844B-ADC-109-linker
 [25]
ADC Info
CN106714844B ADC-110
15G15.3 LC K149C
Myeloid cell surface antigen CD33 (CD33)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-111
4D5 HC A118C
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-112
4D5 HC A118C
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-113
10H1.11B HC A118C
Sodium-dependent phosphate transport protein 2B (SLC34A2)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-114
7C2 HC A118C
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-115
15G15.3 LC K149C
Myeloid cell surface antigen CD33 (CD33)
PNU-159682
CN106714844B-ADC-115-linker
 [25]
ADC Info
CN106714844B ADC-116
7C2 LC K149C
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-117
6E7.N54A LC K149C
C-type lectin domain family 12 member A (CLEC12A)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-118
6E7.N54A LC K149C
C-type lectin domain family 12 member A (CLEC12A)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-119
4D5 HC A118C
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
CN106714844B-ADC-119-linker
 [25]
ADC Info
CN106714844B ADC-120
10F4v3 LC A149C
B-cell receptor CD22 (CD22)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-121
10H1.11.4B LC A149C
Sodium-dependent phosphate transport protein 2B (SLC34A2)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-122
10F4v3 LC A149C
B-cell receptor CD22 (CD22)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-123
10H1.11.4B LC A149C
Sodium-dependent phosphate transport protein 2B (SLC34A2)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-124
10F4v3 LC A149C
B-cell receptor CD22 (CD22)
PNU-159682
CN106714844B-ADC-124-linker
 [25]
ADC Info
CN106714844B ADC-125
10H1.11.4B LC A149C
Sodium-dependent phosphate transport protein 2B (SLC34A2)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-126
10F4v3 LC A149C
B-cell receptor CD22 (CD22)
PNU-159682
CN106714844B-ADC-126-linker
 [25]
ADC Info
CN106714844B ADC-127
10H1.11.4B LC A149C
Sodium-dependent phosphate transport protein 2B (SLC34A2)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-128
4D5 HC A140C
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-129
4D5 LC A149C
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-130
4D5 LC V205C
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-131
4D5 HC A118C
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-132
4D5 LC S121C
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-133
6E7.N54A LC K149C
C-type lectin domain family 12 member A (CLEC12A)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-134
7C2 LC K149C
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
CN106714844B-ADC-134-linker
 [25]
ADC Info
CN106714844B ADC-135
7C2 LC K149C
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
CN106714844B-ADC-135-linker
 [25]
ADC Info
CN106714844B ADC-136
7C2 LC K149C
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
Undisclosed
 [25]
ADC Info
CN106714844B ADC-137
7C2 LC K149C
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
Ethylmaleimide linker
 [25]
ADC Info
CN106714844B ADC-138
7C2 LC K149C
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
Ethylmaleimide linker
 [25]
ADC Info
CN106714844B ADC-139
15G15.3 LC K149C
Myeloid cell surface antigen CD33 (CD33)
PNU-159682
Ethylmaleimide linker
 [25]
ADC Info
CN106714844B ADC-140
7C2 HC K118C
Receptor tyrosine-protein kinase erbB-2 (ERBB2)
PNU-159682
Ethylmaleimide linker
 [25]
ADC Info
CN113286618A ADC-1
alpha-HMGB1Ab
High mobility group box 1 protein (HMGB1)
Doxorubicin
CN113286618A-ADC-1-linker
 [26]
ADC Info
CN113286618A ADC-2
alpha-KLHAb
Hemocyanin 1 (KLH1)
Doxorubicin
Undisclosed
 [26]
ADC Info
CN114450324B ADC-39
undisclosed
Interleukin-1 beta (IL1B)
Doxorubicin
CN114450324B-ADC-39-linker
 [27]
ADC Info
CN114450324B ADC-41
undisclosed
Interleukin-1 beta (IL1B)
Doxorubicin
CN114450324B-ADC-41-linker
 [27]
ADC Info
PNU-159682-P1C1TM
undisclosed
Cellular tumor antigen p53 (TP53)
PNU-159682
Undisclosed
References
Ref 1 Highly Potent, Anthracycline-based Antibody-Drug Conjugates Generated by Enzymatic, Site-specific Conjugation. Mol Cancer Ther. 2017 May;16(5):879-892.
Ref 2 The ROR1 antibody-drug conjugate huXBR1-402-G5-PNU effectively targets ROR1+ leukemia. Blood Adv. 2021 Aug 24;5(16):3152-3162.
Ref 3 Radiation Cleaved Drug-Conjugate Linkers Enable Local Payload Release. Bioconjug Chem. 2022 Aug 17;33(8):1474-1484.
Ref 4 A novel anti-HER2 anthracycline-based antibody-drug conjugate induces adaptive anti-tumor immunity and potentiates PD-1 blockade in breast cancer. J Immunother Cancer. 2019 Jan 21;7(1):16. doi: 10.1186/s40425-018-0464-1.
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Ref 20 Introduction to basic information on antibody-drug nanocell conjugates(EnGeneIC Pty Ltd.).
Ref 21 Preparation and evaluation of the PD0721-DOX antibody-drug conjugate targeting EGFRvIII to inhibit glioblastoma
Ref 22 Anti-ROR1 antibodies and antibody conjugates, compositions comprising Anti-ROR1 antibodies or antibody conjugates, and methods of making and using Anti-ROR1 antibodies and antibody conjugates
Ref 23 Use of hydroxypropyl-β-cyclodextrin in stabilizing antibody-drug conjugate formulations
Ref 24 Immunomodulator antibody drug conjugates and uses thereof
Ref 25 Anthracycline disulfide intermediates, antibody-drug conjugates and methods
Ref 26 Antibody-drug conjugates and applications in antibody-mediated drug delivery
Ref 27 Heterobifunctional monodisperse polyethylene glycol with peptide linkers