Antigen Information

General Information of This Antigen
Antigen ID
TAR0XTCGM
Antigen Name
B-cell receptor CD22 (CD22)
Gene Name
CD22
Gene ID
933
Synonym
B-lymphocyte cell adhesion molecule;Sialic acid-binding Ig-like lectin 2;T-cell surface antigen Leu-14;CD_antigen=CD22
Sequence
MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFH
NPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLR
MESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEG
VPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKH
TPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVT
KDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPL
PTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPK
KVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNT
TIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQ
FFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSM
SPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQ
GTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQG
LQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAES
SEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENV
DYVILKH

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Family
LISCH7 family
Function
Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6- linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

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Uniprot Entry
CD22_HUMAN
HGNC ID
HGNC:1643
KEGG ID
hsa:933
Each Antibody-drug Conjuate AND It's Component Related to This Antigen
Full List of The ADC Related to This Antigen
10F4v3 HC A118C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106714844B ADC-102 [1]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
 ADC Info 
CN106714844B ADC-104 [1]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
 ADC Info 
10F4v3 LC A149C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN106714844B ADC-120 [1]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
 ADC Info 
CN106714844B ADC-122 [1]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Undisclosed
 ADC Info 
CN106714844B ADC-124 [1]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
CN106714844B-ADC-124-linker
 ADC Info 
CN106714844B ADC-126 [1]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
CN106714844B-ADC-126-linker
 ADC Info 
CN107206101B ADC-2 [2]
Dolastatin10
Undisclosed
MC-Sq-CIt-PAB
 ADC Info 
CN107206101B ADC-2-2 [2]
Tubulysin M
Undisclosed
MC-Sq-CIt-PAB
 ADC Info 
Anti- CD22 Disulfide-Tubulysin M [2]
Tubulysin M
Undisclosed
Disulfide linker
 ADC Info 
Anti-CD20 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TRPH-222
DM1
Microtubule (MT)
HIPS-4AP
 ADC Info 
Anti-CD22 10F4 Thiomab (LC:K149C)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-CD22-SN36248 [3]
seco-CBI-dimer
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2
 ADC Info 
Anti-CD22 Anti-ody (LC-K149C)
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-CD22-SPDB-DM4 [4]
Mertansine DM4
Microtubule (MT)
N-succinimidyl 4-(2-pyridyldithio) butanoate (SPDB)
 ADC Info 
Anti-CD22-K149C-MBT-DM4 [4]
Mertansine DM4
Microtubule (MT)
MBT
 ADC Info 
Anti-CD22-K149C-MPEO-DM1 [4]
Mertansine DM1
Microtubule (MT)
MPEO
 ADC Info 
Anti-CD22-K149C-DM1 [4]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
Anti-CD22 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AZD4512
TOP1 inhibitor
DNA topoisomerase 1 (TOP1)
A cleavable linker
 ADC Info 
Anti-CD22 mAb AbBJ
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AbBJ-ConjA [5]
AbBJ-ConjA payload
Undisclosed
AbBJ-ConjA linker
 ADC Info 
AbBJ-ConjB [5]
AbBJ-ConjB payload
Undisclosed
AbBJ-ConjB linker
 ADC Info 
AbBJ-ConjC [5]
AbBJ-ConjC payload
Undisclosed
AbBJ-ConjC linker
 ADC Info 
AbBJ-ConjD [5]
AbBJ-ConjD payload
Undisclosed
AbBJ-ConjD linker
 ADC Info 
AbBJ-ConjE [5]
AbBJ-ConjE payload
Undisclosed
AbBJ-ConjE linker
 ADC Info 
AbBJ-ConjF [5]
AbBJ-ConjF payload
Undisclosed
AbBJ-ConjF linker
 ADC Info 
AbBJ-ConjG [5]
AbBJ-ConjG payload
Undisclosed
AbBJ-ConjG linker
 ADC Info 
AbBJ-ConjH [5]
AbBJ-ConjH payload
Undisclosed
AbBJ-ConjH linker
 ADC Info 
Anti-CD22 mAb AbCJX
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AbCJX-ConjA [5]
AbCJX-ConjA payload
Undisclosed
AbCJX-ConjA linker
 ADC Info 
AbCJX-ConjB [5]
AbCJX-ConjB payload
Undisclosed
AbCJX-ConjB linker
 ADC Info 
AbCJX-ConjC [5]
AbCJX-ConjC payload
Undisclosed
AbCJX-ConjC linker
 ADC Info 
AbCJX-ConjD [5]
AbCJX-ConjD payload
Undisclosed
AbCJX-ConjD linker
 ADC Info 
AbCJX-ConjE [5]
AbCJX-ConjE payload
Undisclosed
AbCJX-ConjE linker
 ADC Info 
AbCJX-ConjF [5]
AbCJX-ConjF payload
Undisclosed
AbCJX-ConjF linker
 ADC Info 
AbCJX-ConjG [5]
AbCJX-ConjG payload
Undisclosed
AbCJX-ConjG linker
 ADC Info 
AbCJX-ConjH [5]
AbCJX-ConjH payload
Undisclosed
AbCJX-ConjH linker
 ADC Info 
Anti-CD22 mAb AbDJ
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AbDJ-ConjA [5]
AbDJ-ConjA payload
Undisclosed
AbDJ-ConjA linker
 ADC Info 
AbDJ-ConjB [5]
AbDJ-ConjB payload
Undisclosed
AbDJ-ConjB linker
 ADC Info 
AbDJ-ConjC [5]
AbDJ-ConjC payload
Undisclosed
AbDJ-ConjC linker
 ADC Info 
AbDJ-ConjD [5]
AbDJ-ConjD payload
Undisclosed
AbDJ-ConjD linker
 ADC Info 
AbDJ-ConjE [5]
AbDJ-ConjE payload
Undisclosed
AbDJ-ConjE linker
 ADC Info 
AbDJ-ConjF [5]
AbDJ-ConjF payload
Undisclosed
AbDJ-ConjF linker
 ADC Info 
AbDJ-ConjG [5]
AbDJ-ConjG payload
Undisclosed
AbDJ-ConjG linker
 ADC Info 
AbDJ-ConjH [5]
AbDJ-ConjH payload
Undisclosed
AbDJ-ConjH linker
 ADC Info 
Anti-CD22 mAb AbHJ
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AbHJ-ConjA [5]
AbHJ-ConjA payload
Undisclosed
AbHJ-ConjA linker
 ADC Info 
AbHJ-ConjB [5]
AbHJ-ConjB payload
Undisclosed
AbHJ-ConjB linker
 ADC Info 
AbHJ-ConjC [5]
AbHJ-ConjC payload
Undisclosed
AbHJ-ConjC linker
 ADC Info 
AbHJ-ConjD [5]
AbHJ-ConjD payload
Undisclosed
AbHJ-ConjD linker
 ADC Info 
AbHJ-ConjE [5]
AbHJ-ConjE payload
Undisclosed
AbHJ-ConjE linker
 ADC Info 
AbHJ-ConjF [5]
AbHJ-ConjF payload
Undisclosed
AbHJ-ConjF linker
 ADC Info 
AbHJ-ConjG [5]
AbHJ-ConjG payload
Undisclosed
AbHJ-ConjG linker
 ADC Info 
AbHJ-ConjH [5]
AbHJ-ConjH payload
Undisclosed
AbHJ-ConjH linker
 ADC Info 
Anti-CD22 mAb AbLJ
 Antibody Info 
ADC Name Payload Target Linker ADC Info
AbLJ-ConjA [5]
AbLJ-ConjA payload
Undisclosed
AbLJ-ConjA linker
 ADC Info 
AbLJ-ConjB [5]
AbLJ-ConjB payload
Undisclosed
AbLJ-ConjB linker
 ADC Info 
AbLJ-ConjC [5]
AbLJ-ConjC payload
Undisclosed
AbLJ-ConjC linker
 ADC Info 
AbLJ-ConjD [5]
AbLJ-ConjD payload
Undisclosed
AbLJ-ConjD linker
 ADC Info 
AbLJ-ConjE [5]
AbLJ-ConjE payload
Undisclosed
AbLJ-ConjE linker
 ADC Info 
AbLJ-ConjF [5]
AbLJ-ConjF payload
Undisclosed
AbLJ-ConjF linker
 ADC Info 
AbLJ-ConjG [5]
AbLJ-ConjG payload
Undisclosed
AbLJ-ConjG linker
 ADC Info 
AbLJ-ConjH [5]
AbLJ-ConjH payload
Undisclosed
AbLJ-ConjH linker
 ADC Info 
Anti-CD22 mAb HB22.7
 Antibody Info 
ADC Name Payload Target Linker ADC Info
HB22.7-SAP [6]
Saporin
Microtubule (MT)
Undisclosed
 ADC Info 
Anti-CD22 mAb xCD22
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2013055987A1 xCD22-103 [7]
SG2000
Human Deoxyribonucleic acid (hDNA)
WO2013055987A1_xCD22-103 linker
 ADC Info 
Anti-CD22-HC-A140C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Alpha-CD22-HC-A140C-10 [8]
seco-CBI-dimer
Human Deoxyribonucleic acid (hDNA)
Mc-peptidomimetic based linker 10
 ADC Info 
Alpha-CD22-HC-A140C-11 [8]
seco-CBI-dimer
Human Deoxyribonucleic acid (hDNA)
Mc-PEG2
 ADC Info 
Anti-CD22-LC-K149C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
ACD22-LC-K149C-10 [9]
PA-seco-CBI-dimer
Human Deoxyribonucleic acid (hDNA)
Mc-cBu-Cit
 ADC Info 
Alpha-CD22-LC-K149C-10 [8]
seco-CBI-dimer
Human Deoxyribonucleic acid (hDNA)
Mc-peptidomimetic based linker 10
 ADC Info 
Alpha-CD22-LC-K149C-11 [8]
seco-CBI-dimer
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2
 ADC Info 
Alpha-CD22-LC-K149C-12 [8]
Seco-CBI-dimer 12
Human Deoxyribonucleic acid (hDNA)
Mc-peptidomimetic based linker 12
 ADC Info 
Anti-CD22-LC-V205C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Alpha-CD22-LC-V205C-10 [8]
seco-CBI-dimer
Human Deoxyribonucleic acid (hDNA)
Mc-peptidomimetic based linker 10
 ADC Info 
CD22 Nanobody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CD22 Nanobody DM1 [10]
Mertansine DM1
Microtubule (MT)
Succinimidyl-4- (N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC)
 ADC Info 
CN105828840B_ADC-101 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN105828840B ADC-101 [11]
CN105828840B_ADC-101 payload
Undisclosed
CN105828840B_ADC-101 linker
 ADC Info 
CN105828840B_ADC-104 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN105828840B ADC-104 [11]
CN105828840B_ADC-104 payload
Undisclosed
CN105828840B_ADC-104 linker
 ADC Info 
CN105828840B_ADC-108 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN105828840B ADC-108 [11]
CN105828840B_ADC-108 payload
Undisclosed
CN105828840B_ADC-108 linker
 ADC Info 
CN105828840B_ADC-110 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN105828840B ADC-110 [11]
CN105828840B_ADC-110 payload
Undisclosed
CN105828840B_ADC-110 linker
 ADC Info 
CN105828840B_ADC-111 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN105828840B ADC-111 [11]
CN105828840B_ADC-111 payload
Undisclosed
CN105828840B_ADC-111 linker
 ADC Info 
CN105828840B_ADC-115 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN105828840B ADC-115 [11]
CN105828840B_ADC-115 payload
Undisclosed
CN105828840B_ADC-115 linker
 ADC Info 
CN105828840B_ADC-116 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN105828840B ADC-116 [11]
CN105828840B_ADC-116 payload
Undisclosed
CN105828840B_ADC-116 linker
 ADC Info 
CN105828840B_ADC-120 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN105828840B ADC-120 [11]
CN105828840B_ADC-120 payload
Undisclosed
CN105828840B_ADC-120 linker
 ADC Info 
CN105828840B_ADC-122 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN105828840B ADC-122 [11]
CN105828840B_ADC-122 payload
Undisclosed
CN105828840B_ADC-122 linker
 ADC Info 
CN105828840B_ADC-124 antibody
 Antibody Info 
ADC Name Payload Target Linker ADC Info
CN105828840B ADC-124 [11]
CN105828840B_ADC-124 payload
Undisclosed
CN105828840B_ADC-124 linker
 ADC Info 
Epratuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Epratuzumab-cys-tesirine
SG3199 (SC-DR002)
Human deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
 ADC Info 
BAY-1862864
227Th
Undisclosed
Undisclosed
 ADC Info 
Emab-CL2E-SN38 [12]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2E
 ADC Info 
RNAse monoclonal antibody-LL2-I-131-conjugate [13]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
HLL2-PBD [14]
SG3199
Human Deoxyribonucleic acid (hDNA)
Mal-PEG8-Val-Ala-PABC
 ADC Info 
Epratuzumab-CL2E-SN-38 [15]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2E
 ADC Info 
Epratuzumab-SN-38 [15]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 ADC Info 
Epratuzumab-SN38 [16]
Active metabolite of irinotecan SN38
DNA topoisomerase 1 (TOP1)
CL2A
 ADC Info 
ADC Name Payload Target Linker ADC Info
CMC-544
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Inotuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Inotuzumab ozogamicin [17]
N-acetyl-gamma-calicheamicin
Human deoxyribonucleic acid (hDNA)
AcButDMH
 ADC Info 
Inotuzumab-ADC-24-1 [18]
Inotuzumab-ADC-24-1 payload
Undisclosed
Inotuzumab-ADC-24-1 linker
 ADC Info 
Inotuzumab-ADC-24-2 [18]
Inotuzumab-ADC-24-2 payload
Undisclosed
Inotuzumab-ADC-24-2 linker
 ADC Info 
Inotuzumab-ADC-24-3 [18]
Inotuzumab-ADC-24-3 payload
Undisclosed
Inotuzumab-ADC-24-3 linker
 ADC Info 
Inotuzumab-ADC-24-4 [18]
Inotuzumab-ADC-24-4 payload
Undisclosed
Inotuzumab-ADC-24-4 linker
 ADC Info 
Inotuzumab-ADC-24-5 [18]
Inotuzumab-ADC-24-5 payload
Undisclosed
Inotuzumab-ADC-24-5 linker
 ADC Info 
Inotuzumab-ADC-24-6 [18]
Inotuzumab-ADC-24-6 payload
Undisclosed
Inotuzumab-ADC-24-6 linker
 ADC Info 
Inotuzumab-ADC-24-7 [18]
Inotuzumab-ADC-24-7 payload
Undisclosed
Inotuzumab-ADC-24-7 linker
 ADC Info 
Inotuzumab-ADC-24-8 [18]
Inotuzumab-ADC-24-8 payload
Undisclosed
Inotuzumab-ADC-24-8 linker
 ADC Info 
Inotuzumab-ADC-24-9 [18]
Inotuzumab-ADC-24-9 payload
Undisclosed
Inotuzumab-ADC-24-9 linker
 ADC Info 
Inotuzumab-ADC-24-10 [18]
Inotuzumab-ADC-24-10 payload
Undisclosed
Inotuzumab-ADC-24-10 linker
 ADC Info 
Inotuzumab-ADC-24-11 [18]
Inotuzumab-ADC-24-11 payload
Undisclosed
Inotuzumab-ADC-24-11 linker
 ADC Info 
Inotuzumab-ADC-24-12 [18]
Inotuzumab-ADC-24-12 payload
Undisclosed
Inotuzumab-ADC-24-12 linker
 ADC Info 
Inotuzumab-ADC-24-13 [18]
Inotuzumab-ADC-24-13 payload
Undisclosed
Inotuzumab-ADC-24-13 linker
 ADC Info 
JP7623413B2 ExampleADC62 [19]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Mozistobart
 Antibody Info 
ADC Name Payload Target Linker ADC Info
TAC-001
Differentiated TLR-9 agonist (T-CpG)
Undisclosed
Undisclosed
 ADC Info 
Pinatuzumab
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Pinatuzumab vedotin
MMAE
Microtubule (MT)
Mc-Val-Cit-PABC
 ADC Info 
Anti-CD22- (LC:K149C)-SN36248 [3]
seco-CBI-dimer
Human Deoxyribonucleic acid (hDNA)
Mal-PEG2
 ADC Info 
Anti-CD22-NMS249 [20]
PNU-159682
DNA topoisomerase 2-alpha (TOP2A)
Mc-Val-Cit-PAB-DEA
 ADC Info 
Pinatuzumab-ADC-24-1 [18]
Pinatuzumab-ADC-24-1 payload
Undisclosed
Pinatuzumab-ADC-24-1 linker
 ADC Info 
Pinatuzumab-ADC-24-2 [18]
Pinatuzumab-ADC-24-2 payload
Undisclosed
Pinatuzumab-ADC-24-2 linker
 ADC Info 
Pinatuzumab-ADC-24-3 [18]
Pinatuzumab-ADC-24-3 payload
Undisclosed
Pinatuzumab-ADC-24-3 linker
 ADC Info 
Pinatuzumab-ADC-24-4 [18]
Pinatuzumab-ADC-24-4 payload
Undisclosed
Pinatuzumab-ADC-24-4 linker
 ADC Info 
Pinatuzumab-ADC-24-5 [18]
Pinatuzumab-ADC-24-5 payload
Undisclosed
Pinatuzumab-ADC-24-5 linker
 ADC Info 
Pinatuzumab-ADC-24-6 [18]
Pinatuzumab-ADC-24-6 payload
Undisclosed
Pinatuzumab-ADC-24-6 linker
 ADC Info 
Pinatuzumab-ADC-24-7 [18]
Pinatuzumab-ADC-24-7 payload
Undisclosed
Pinatuzumab-ADC-24-7 linker
 ADC Info 
Pinatuzumab-ADC-24-8 [18]
Pinatuzumab-ADC-24-8 payload
Undisclosed
Pinatuzumab-ADC-24-8 linker
 ADC Info 
Pinatuzumab-ADC-24-9 [18]
Pinatuzumab-ADC-24-9 payload
Undisclosed
Pinatuzumab-ADC-24-9 linker
 ADC Info 
Pinatuzumab-ADC-24-10 [18]
Pinatuzumab-ADC-24-10 payload
Undisclosed
Pinatuzumab-ADC-24-10 linker
 ADC Info 
Pinatuzumab-ADC-24-11 [18]
Pinatuzumab-ADC-24-11 payload
Undisclosed
Pinatuzumab-ADC-24-11 linker
 ADC Info 
Pinatuzumab-ADC-24-12 [18]
Pinatuzumab-ADC-24-12 payload
Undisclosed
Pinatuzumab-ADC-24-12 linker
 ADC Info 
Pinatuzumab-ADC-24-13 [18]
Pinatuzumab-ADC-24-13 payload
Undisclosed
Pinatuzumab-ADC-24-13 linker
 ADC Info 
ADC Name Payload Target Linker ADC Info
RFB4-SMPT-dgA
Deglycosylated ricin A-chain (dgA)
Undisclosed
Succynimidyloxycarbonyl-alpha-methyl-alpha- (2-pyridyl-dithio) toluene (SMPT)
 ADC Info 
Thio Anti-CD22 10F4v3 LC V205C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2017214024A1 ADC-101 [21]
WO2017214024A1_ADC-101 payload
Undisclosed
WO2017214024A1_ADC-101 linker
 ADC Info 
Thio hu Anti-CD22 10F43 HC L177C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2017059289A1 ADC-116 [22]
WO2017059289A1_ADC-116 payload
Undisclosed
WO2017059289A1_ADC-116 linker
 ADC Info 
Thio hu Anti-CD22 10F4v3
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2017059289A1 ADC-202 [22]
WO2017059289A1_ADC-202 payload
Undisclosed
WO2017059289A1_ADC-202 linker
 ADC Info 
Thio hu Anti-CD22 10F4v3 HC A118C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2014159981A2 ADC-115 [23]
WO2014159981A2_ADC-115 payload
Undisclosed
WO2014159981A2_ADC-115 linker
 ADC Info 
WO2014159981A2 ADC-125 [23]
WO2014159981A2_ADC-125 payload
Undisclosed
WO2014159981A2_ADC-125 linker
 ADC Info 
WO2014159981A2 ADC-212 [23]
WO2014159981A2_ADC-212 payload
Undisclosed
WO2014159981A2_ADC-212 linker
 ADC Info 
WO2014159981A2 ADC-135 [23]
WO2014159981A2_ADC-135 payload
Undisclosed
WO2014159981A2_ADC-135 linker
 ADC Info 
WO2014159981A2 ADC-CD22-41 [23]
WO2014159981A2_ADC-CD22-41 payload
Undisclosed
WO2014159981A2_ADC-CD22-41 linker
 ADC Info 
WO2014159981A2 ADC-CD22-44 [23]
WO2014159981A2_ADC-CD22-44 payload
Undisclosed
WO2014159981A2_ADC-CD22-44 linker
 ADC Info 
WO2014159981A2 ADC-CD22-48 [23]
WO2014159981A2_ADC-CD22-48 payload
Undisclosed
WO2014159981A2_ADC-CD22-48 linker
 ADC Info 
WO2014159981A2 ADC-CD22-22 [23]
WO2014159981A2_ADC-CD22-22 payload
Undisclosed
WO2014159981A2_ADC-CD22-22 linker
 ADC Info 
Thio hu Anti-CD22 10F4v3 HC A140C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2017214024A1 ADC-105 [21]
WO2017214024A1_ADC-105 payload
Undisclosed
WO2017214024A1_ADC-105 linker
 ADC Info 
Thio hu Anti-CD22 10F4v3 HC Y376C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2017059289A1 ADC-118 [22]
WO2017059289A1_ADC-118 payload
Undisclosed
WO2017059289A1_ADC-118 linker
 ADC Info 
Thio hu Anti-CD22 10F4v3 LC K149C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2017059289A1 ADC-103 [22]
WO2017059289A1_ADC-103 payload
Undisclosed
WO2017059289A1_ADC-103 linker
 ADC Info 
WO2017059289A1 ADC-105 [22]
WO2017059289A1_ADC-105 payload
Undisclosed
WO2017059289A1_ADC-105 linker
 ADC Info 
WO2017059289A1 ADC-107 [22]
WO2017059289A1_ADC-107 payload
Undisclosed
WO2017059289A1_ADC-107 linker
 ADC Info 
WO2017059289A1 ADC-110 [22]
WO2017059289A1_ADC-110 payload
Undisclosed
WO2017059289A1_ADC-110 linker
 ADC Info 
WO2017059289A1 ADC-204 [22]
WO2017059289A1_ADC-204 payload
Undisclosed
WO2017059289A1_ADC-204 linker
 ADC Info 
WO2017059289A1 ADC-206 [22]
WO2017059289A1_ADC-206 payload
Undisclosed
WO2017059289A1_ADC-206 linker
 ADC Info 
WO2017059289A1 ADC-207 [22]
WO2017059289A1_ADC-207 payload
Undisclosed
WO2017059289A1_ADC-207 linker
 ADC Info 
WO2017214024A1 ADC-104 [21]
WO2017214024A1_ADC-104 payload
Undisclosed
WO2017214024A1_ADC-104 linker
 ADC Info 
WO2017214024A1 ADC-108 [21]
WO2017214024A1_ADC-108 payload
Undisclosed
WO2017214024A1_ADC-108 linker
 ADC Info 
WO2017214024A1 ADC-110 [21]
WO2017214024A1_ADC-110 payload
Undisclosed
WO2017214024A1_ADC-110 linker
 ADC Info 
Thio hu Anti-CD22 10F4v3 LC K149C HC L177C
 Antibody Info 
ADC Name Payload Target Linker ADC Info
WO2017059289A1 ADC-111 [22]
WO2017059289A1_ADC-111 payload
Undisclosed
WO2017059289A1_ADC-111 linker
 ADC Info 
WO2017059289A1 ADC-112 [22]
WO2017059289A1_ADC-112 payload
Undisclosed
WO2017059289A1_ADC-112 linker
 ADC Info 
Undisclosed
 Antibody Info 
ADC Name Payload Target Linker ADC Info
Anti-CD22 antibody drug-conjugate (Medarex/BMS) [24]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
Anti-CD22 antibody-drug conjugate (Ambrx) [25]
Undisclosed
Undisclosed
Undisclosed
 ADC Info 
References
Ref 1 Anthracycline disulfide intermediates, antibody-drug conjugates and methods
Ref 2 Quaternary ammonium compounds and their antibody-drug conjugates
Ref 3 An Anti-CD22-seco-CBI-Dimer Antibody-Drug Conjugate (ADC) for the Treatment of Non-Hodgkin Lymphoma That Provides a Longer Duration of Response than Auristatin-Based ADCs in Preclinical Models. Mol Cancer Ther. 2021 Feb;20(2):340-346.
Ref 4 Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates. Chem Sci. 2017 Jan 1;8(1):366-370. doi: 10.1039/c6sc01831a. Epub 2016 Aug 22.
Ref 5 Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using.
Ref 6 The HB22.7 Anti-CD22 Monoclonal Antibody Is an Effective Platform for CD22-Targeted Antibody Drug Conjugates for Treatment of Lymphoma and Acute Lymphoblastic Leukemia. Blood. 2012 ;120(21):-. doi: 10.1182/blood.V120.21.1653.1653.
Ref 7 Pyrrolobenzodiazepines and conjugates thereof; 2013-04-18.
Ref 8 Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo. Bioconjug Chem. 2019 May 15;30(5):1356-1370. doi: 10.1021/acs.bioconjchem.9b00133. Epub 2019 Apr 22.
Ref 9 Antibody-Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo. Bioconjug Chem. 2019 May 15;30(5):1356-1370. doi: 10.1021/acs.bioconjchem.9b00133. Epub 2019 Apr 22.
Ref 10 Production and characterization of a camelid single domain anti-CD22 antibody conjugated to DM1
Ref 11 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment.
Ref 12 Epratuzumab-SN-38: a new antibody-drug conjugate for the therapy of hematologic malignancies. Mol Cancer Ther. 2012 Jan;11(1):224-34.
Ref 13 Potent and specific antitumor effects of an anti-CD22-targeted cytotoxic ribonuclease: potential for the treatment of non-Hodgkin lymphoma. Blood. 2001 Jan 15;97(2):528-35. doi: 10.1182/blood.v97.2.528.
Ref 14 Preclinical activity of hLL2-PBD, a novel anti-CD22 antibody-pyrrolobenzodiazepine (PBD) conjugate in models of non-Hodgkin lymphoma. Cancer Res (2015) 75 (15_Supplement): 637.
Ref 15 Epratuzumab-SN-38: a new antibody-drug conjugate for the therapy of hematologic malignancies. Mol Cancer Ther. 2012 Jan;11(1):224-34. doi: 10.1158/1535-7163.MCT-11-0632. Epub 2011 Oct 28.
Ref 16 ADC review: basic information about Epratuzumab-SN-38.
Ref 17 Inotuzumab Ozogamicin: First Global Approval
Ref 18 Ligand-drug conjugate of exatecan analogue, preparation method therefor and application thereof; 2020-04-02.
Ref 19 Antibody-drug complexes containing hemiasterlin derivatives
Ref 20 A Novel Anti-CD22 Anthracycline-Based Antibody-Drug Conjugate (ADC) That Overcomes Resistance to Auristatin-Based ADCs. Clin Cancer Res. 2015 Jul 15;21(14):3298-306. doi: 10.1158/1078-0432.CCR-14-2035. Epub 2015 Apr 3.
Ref 21 Silvestrol antibody-drug conjugates and methods of use; 2017-12-14.
Ref 22 Pyrrolobenzodiazepine antibody drug conjugates and methods of use; 2017-04-06.
Ref 23 Pyrrolobenzodiazepines and conjugates thereof; 2015-04-09.
Ref 24 Introduction to basic information on anti-CD22 antibody drug-conjugates(Medarex/BMS).
Ref 25 Introduction to basic information on anti-CD22 antibody-drug conjugate(Ambrx).