Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0QQBMI
|
|||||
|---|---|---|---|---|---|---|
| ADC Name |
WO2017059289A1 ADC-112
|
|||||
| Synonyms |
Thio Hu Anti-CD22 10F4v3 LC K149C HC L177C-51
Click to Show/Hide
|
|||||
| Organization |
Genentech, Inc.
|
|||||
| Drug Status |
Investigative
|
|||||
| Indication |
In total 1 Indication(s)
Diffuse large B-cell lymphoma [ICD11:2A81]
Investigative
|
|||||
| Drug-to-Antibody Ratio |
5.4
|
|||||
| Antibody Name |
Thio hu Anti-CD22 10F4v3 LC K149C HC L177C
|
Antibody Info | ||||
| Antigen Name |
B-cell receptor CD22 (CD22)
|
Antigen Info | ||||
| Payload Name |
Undisclosed
|
|||||
| Linker Name |
WO2017059289A1_ADC-112 linker
|
|||||
General Information of The Activity Data Related to This ADC
Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 52.89% (Day 14) | Positive CD22 expression (CD22+++/++) | ||
| Method Description |
Inoculate 150 mice with WSU-DLCL2 cells at 3 million cells/mouse suspended in HBSS/matrigel, in the thoracic mammary fat pad at a volume of 0.2 ml. When tumors have reached a mean tumor volume of 100-250 mm3, they will be grouped out into 10 groups of 8-10 mice each. A single treatment will be administered intravenously (2.2 mg/kg) via the tail vein on Day 0.
Click to Show/Hide
|
||||
| In Vivo Model | WSU-DLCL2 CDX model | ||||
| In Vitro Model | Diffuse large B-cell lymphoma | WSU-DLCL2 cells | CVCL_1902 | ||
| Experiment 2 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 79.85% (Day 14) | Positive CD22 expression (CD22+++/++) | ||
| Method Description |
Inoculate 150 mice with WSU-DLCL2 cells at 3 million cells/mouse suspended in HBSS/matrigel, in the thoracic mammary fat pad at a volume of 0.2 ml. When tumors have reached a mean tumor volume of 100-250 mm3, they will be grouped out into 10 groups of 8-10 mice each. A single treatment will be administered intravenously (6 mg/kg) via the tail vein on Day 0.
Click to Show/Hide
|
||||
| In Vivo Model | WSU-DLCL2 CDX model | ||||
| In Vitro Model | Diffuse large B-cell lymphoma | WSU-DLCL2 cells | CVCL_1902 | ||
If you find any error in data or bug in web service, please kindly report it to Dr. Shen et al.