Antibody-drug Conjugate Information

General Information of This Antibody-drug Conjugate (ADC)
ADC ID
DRG0WBMKZ
ADC Name
WO2017214024A1 ADC-110
Synonyms
WO2017214024A1 ADC-110
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Organization
Genentech, Inc.
Drug Status
Investigative
Indication
In total 1 Indication(s)
Diffuse large B-cell lymphoma [ICD11:2A81]
Investigative
Drug-to-Antibody Ratio
2.01
Antibody Name
Thio hu Anti-CD22 10F4v3 LC K149C
  Antibody Info 
Antigen Name
B-cell receptor CD22 (CD22)
  Antigen Info 
Payload Name
Undisclosed
Linker Name
WO2017214024A1_ADC-110 linker
General Information of The Activity Data Related to This ADC
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 3 Activity Data Related to This Level
Standard Type Value Units Cell Line Disease Model
Tumor Growth Inhibition value (TGI) 
≈ 51.05
%
BJAB cells
Burkitt lymphoma
Tumor Growth Inhibition value (TGI) 
≈ 68.38
%
BJAB cells
Burkitt lymphoma
Tumor Growth Inhibition value (TGI) 
≈ 72.44
%
BJAB cells
Burkitt lymphoma
Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Cell Line-derived Xenograft Model
Click To Hide/Show 3 Activity Data Related to This Level
Experiment 1 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 51.05% (Day 10) Moderate CD22 expression (CD22++)
Method Description
Inoculate 150 mice with BJAB cells at 3 million cells/mouse suspended in HBSS/matrigel, in the thoracic mammary fat pad at a volume of 0.2 ml. When tumors have reached a mean tumor volume of 100-250 mm3, they will be grouped out into 10 groups of 8-10 mice each. A single treatment will be administered intravenously (3 mg/kg) via the tail vein on Day 0.

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In Vivo Model BJAB CDX model
In Vitro Model Burkitt lymphoma BJAB cells CVCL_5711
Experiment 2 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 68.38% (Day 10) Moderate CD22 expression (CD22++)
Method Description
Inoculate 150 mice with BJAB cells at 3 million cells/mouse suspended in HBSS/matrigel, in the thoracic mammary fat pad at a volume of 0.2 ml. When tumors have reached a mean tumor volume of 100-250 mm3, they will be grouped out into 10 groups of 8-10 mice each. A single treatment will be administered intravenously (6 mg/kg) via the tail vein on Day 0.

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In Vivo Model BJAB CDX model
In Vitro Model Burkitt lymphoma BJAB cells CVCL_5711
Experiment 3 Reporting the Activity Date of This ADC [1]
Efficacy Data Tumor Growth Inhibition value (TGI) ≈ 72.44% (Day 10) Moderate CD22 expression (CD22++)
Method Description
Inoculate 150 mice with BJAB cells at 3 million cells/mouse suspended in HBSS/matrigel, in the thoracic mammary fat pad at a volume of 0.2 ml. When tumors have reached a mean tumor volume of 100-250 mm3, they will be grouped out into 10 groups of 8-10 mice each. A single treatment will be administered intravenously (10 mg/kg) via the tail vein on Day 0.

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In Vivo Model BJAB CDX model
In Vitro Model Burkitt lymphoma BJAB cells CVCL_5711
References
Ref 1 Silvestrol antibody-drug conjugates and methods of use; 2017-12-14.

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