Antibody Information
General Information of This Antibody
| Antibody ID | ANI0HGNYZ |
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| Antibody Name | Anti-CD22 mAb xCD22 |
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| Antibody Type | Monoclonal antibody (mAb) |
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| Antibody Subtype | Humanized IgG1 |
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| Antigen Name | B-cell receptor CD22 (CD22) |
Antigen Info | ||||
Each Antibody-drug Conjugate Related to This Antibody
Full Information of The Activity Data of The ADC(s) Related to This Antibody
WO2013055987A1 xCD22-103 [Investigative]
Obtained from the Model Organism Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 81.10% (Day 11) | High HER2 expression (HER2 +++) | ||
| Method Description |
Before being used for an in vivo efficacy study, the MMTV-HER2 Fo5 transgenic mammary tumor was surgically transplanted into the mammary fat pad of nu/nu mice in fragments that measured approximately 2x2 mm. When tumor sreached desired volumes, the tumor-bearing mice were randomized and given a single dose by IV 10 mg/kg injection of the ADC.
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| In Vivo Model | Breast cancer model MMTV-HER2 Fo5 | ||||
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