Antigen Information
General Information of This Antigen (ID: TAR0NNHUU)
| Antigen Name | Glypican-3 (GPC3) |
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|---|---|---|---|---|---|---|
| Gene Name | GPC3 |
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| Gene ID | ||||||
| Synonym | OCI5; GTR2-2;Intestinal protein OCI-5;MXR7 |
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| Sequence |
MAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGS
DLQVCLPKGPTCCSRKMEEKYQL.LNMEQLLQSASMELKFLIIQNAAVFQEAFEIVVRHA KNYTNAMFKNNYPSLTPQAFEFVGEFFTDVSLYILGSDINVDDMVNELFDSLFPVIYTQL MNPGLPDSALDINECLRGARRDLKVFGNFPKLIMTQVSKSLQVTRIFLQALNLGIEVINT TDHLKFSKDCGRMLTRMWYCSYCQGLMMVKPCGGYCNVVMQGCMAGVVEIDKYWREYILS LEELVNGMYRIYDMENVLLGLFSTIHDSIQYVQKNAGKLTTTIGKLCAHSQQRQYRSAYY PEDLFIDKKVLKVAHVEHEETLSSRRRELIQKLKSFISFYSALPGYICSHSPVAENDTLC WNGQELVERYSQKAARNGMKNQFNLHELKMKGPEPVVSQIIDKLKHINQLLRTMSMPKGR VLDKNLDEEGFESGDCGDDEDECIGGSGDGMIKVKNQLRFLAELAYDLDVDDAPGNSQQA TPKDNEISTFHNLGNVHSPLKLLTSMAISVVCFFFLVH Click to Show/Hide
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| Family | Glycosyltransferase 29 family |
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| Function |
Cell surface proteoglycan. Negatively regulates the hedgehog signaling pathway when attached via the GPI- anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins. Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation. Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands. Positively regulates the non-canonical Wnt signaling pathway. Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression. Inhibits the dipeptidyl peptidase activity of DPP4. Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4. Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis. Required for coronary vascular development. Plays a role in regulating cell movements during gastrulation.
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Each Antibody-drug Conjugate and Its Component Related to This Antigen
Full List of The ADC Related to This Antigen
| The Numbers of ADCs, Their Three Components, Payload Targets, and Corresponding Diseases for This Antigens | ||||
|---|---|---|---|---|
Adnectins scaffold protein
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Glypican 3 ADC
|
Tubulysin analog Tub |
Undisclosed |
Mal-EBE-Mal |
Anti-GPC3 antibody
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
BMS-986183
|
Tubulysin |
Microtubule (MT) |
Val-Cit dipeptide linker |
|
|
ZW251
[1]
|
ZD06519 |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly-AM |
|
|
BC2027
|
TOP1 inhibitor |
DNA topoisomerase 1 (TOP1) |
A cleavable linker |
Anti-GPC3 mAb
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Anti-GPC3 ADC
[2]
|
Undisclosed |
Undisclosed |
Undisclosed |
|
|
MRG006
|
Novel TOP1 inhibitor |
DNA topoisomerase 1 (TOP1) |
MCC-AAQ |
Anti-GPC3 mAb 4A6
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
Anti-GPC3 mAb 4A6-IIIa-01
[3]
|
Anti-GPC3 mAb 4A6-IIIa-01 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIa-01 linker |
|
|
Anti-GPC3 mAb 4A6-IIIa-02
[3]
|
Anti-GPC3 mAb 4A6-IIIa-02 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIa-02 linker |
|
|
Anti-GPC3 mAb 4A6-IIIa-03
[3]
|
Anti-GPC3 mAb 4A6-IIIa-03 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIa-03 linker |
|
|
Anti-GPC3 mAb 4A6-IIIa-04
[3]
|
Anti-GPC3 mAb 4A6-IIIa-04 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIa-04 linker |
|
|
Anti-GPC3 mAb 4A6-IIIa-05
[3]
|
Anti-GPC3 mAb 4A6-IIIa-05 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIa-05 linker |
|
|
Anti-GPC3 mAb 4A6-IIIa-06
[3]
|
Anti-GPC3 mAb 4A6-IIIa-06 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIa-06 linker |
|
|
Anti-GPC3 mAb 4A6-IIIa-07
[3]
|
Anti-GPC3 mAb 4A6-IIIa-07 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIa-07 linker |
|
|
Anti-GPC3 mAb 4A6-IIIa-08
[3]
|
Anti-GPC3 mAb 4A6-IIIa-08 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIa-08 linker |
|
|
Anti-GPC3 mAb 4A6-IIIb-01
[3]
|
Anti-GPC3 mAb 4A6-IIIb-01 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIb-01 linker |
|
|
Anti-GPC3 mAb 4A6-IIIb-02
[3]
|
Anti-GPC3 mAb 4A6-IIIb-02 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIb-02 linker |
|
|
Anti-GPC3 mAb 4A6-IIIb-03
[3]
|
Anti-GPC3 mAb 4A6-IIIb-03 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIb-03 linker |
|
|
Anti-GPC3 mAb 4A6-IIIb-04
[3]
|
Anti-GPC3 mAb 4A6-IIIb-04 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIb-04 linker |
|
|
Anti-GPC3 mAb 4A6-IIIb-05
[3]
|
Anti-GPC3 mAb 4A6-IIIb-05 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIb-05 linker |
|
|
Anti-GPC3 mAb 4A6-IIIb-06
[3]
|
Anti-GPC3 mAb 4A6-IIIb-06 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIb-06 linker |
|
|
Anti-GPC3 mAb 4A6-IIIb-07
[3]
|
Anti-GPC3 mAb 4A6-IIIb-07 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIb-07 linker |
|
|
Anti-GPC3 mAb 4A6-IIIb-08
[3]
|
Anti-GPC3 mAb 4A6-IIIb-08 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIb-08 linker |
|
|
Anti-GPC3 mAb 4A6-IIIb-09
[3]
|
Anti-GPC3 mAb 4A6-IIIb-09 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIb-09 linker |
|
|
Anti-GPC3 mAb 4A6-IIIc-01
[3]
|
Anti-GPC3 mAb 4A6-IIIc-01 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIc-01 linker |
|
|
Anti-GPC3 mAb 4A6-IIIc-02
[3]
|
Anti-GPC3 mAb 4A6-IIIc-02 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIc-02 linker |
|
|
Anti-GPC3 mAb 4A6-IIIc-03
[3]
|
Anti-GPC3 mAb 4A6-IIIc-03 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIc-03 linker |
|
|
Anti-GPC3 mAb 4A6-IIIc-04
[3]
|
Anti-GPC3 mAb 4A6-IIIc-04 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIc-04 linker |
|
|
Anti-GPC3 mAb 4A6-IIIc-05
[3]
|
Anti-GPC3 mAb 4A6-IIIc-05 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIc-05 linker |
|
|
Anti-GPC3 mAb 4A6-IIIc-06
[3]
|
Anti-GPC3 mAb 4A6-IIIc-06 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIc-06 linker |
|
|
Anti-GPC3 mAb 4A6-IIIc-07
[3]
|
Anti-GPC3 mAb 4A6-IIIc-07 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIc-07 linker |
|
|
Anti-GPC3 mAb 4A6-IIIc-08
[3]
|
Anti-GPC3 mAb 4A6-IIIc-08 payload |
Undisclosed |
Anti-GPC3 mAb 4A6-IIIc-08 linker |
Anti-GPC3 mAb A18
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
A18-PE24
[4]
|
Pseudomonas exotoxin PE24 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
Anti-GPC3 mAb A43
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
A43-PE24
[4]
|
Pseudomonas exotoxin PE24 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
Anti-GPC3 mAb A5
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
A5-PE24
[4]
|
Pseudomonas exotoxin PE24 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
Anti-GPC3 mAb C46
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
C46-PE24
[4]
|
Pseudomonas exotoxin PE24 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
Anti-GPC3 mAb F5
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
F5-PE24
[4]
|
Pseudomonas exotoxin PE24 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
Anti-GPC3 mAb F67
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
F67-PE24
[4]
|
Pseudomonas exotoxin PE24 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
Anti-GPC3 mAb G15
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
G15-PE24
[4]
|
Pseudomonas exotoxin PE24 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
Anti-GPC3 mAb H49
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
H49-PE24
[4]
|
Pseudomonas exotoxin PE24 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
Anti-GPC3 mAb HN3
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
HN3-PE24
[4]
|
Pseudomonas exotoxin PE24 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
Anti-GPC3 mAb I34
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
I34-PE24
[4]
|
Pseudomonas exotoxin PE24 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
Anti-GPC3 mAb I82
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
I82-PE24
[4]
|
Pseudomonas exotoxin PE24 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
Anti-GPC3 mAb I88
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
I88-PE24
[4]
|
Pseudomonas exotoxin PE24 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
Anti-GPC3 mAb J58
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
J58-PE24
[4]
|
Pseudomonas exotoxin PE24 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
Anti-GPC3 mAb J80A
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
J80A-PE24
[4]
|
Pseudomonas exotoxin PE24 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
Anti-GPC3 mAb J80B
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
J80B-PE24
[4]
|
Pseudomonas exotoxin PE24 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
Anti-GPC3 mAb R6
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
R6-PE24
[4]
|
Pseudomonas exotoxin PE24 |
Eukaryotic elongation factor 2 kinase (EEF2K) |
Undisclosed |
FS001-huVH3-huVL2
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
FS001-VH3-VL2-Vc-MMAE
[5]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
FS001-VH3-VL2-Dxd
[5]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
FS001-huVH4-huVL1
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
FS001-VH4-VL1-VC-MMAE
[5]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
FS001-huVH4-huVL2
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
FS001-VH4-VL2-vc-MMAE
[5]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
FS001-huVH4-huVL3
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
FS001-VH4-VL3-VC-MMAE
[5]
|
Monomethyl auristatin E |
Microtubule (MT) |
Mc-Val-Cit-PABC |
|
|
FS001-VH4-VL3-Dxd
[5]
|
DX-8951 derivative (DXd) |
DNA topoisomerase 1 (TOP1) |
Mc-Gly-Gly-Phe-Gly |
Humanized GPC3-specific Anti-ody YP7
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
HYP7-DC
[6]
|
Duocarmycin Sa |
Human Deoxyribonucleic acid (hDNA) |
Mal-PEG4-Val-Cit-PABC-DMAE |
Undisclosed
| ADC Name | Payload | Target | Linker | ADC Info |
|---|---|---|---|---|
|
CN105899515B II
[7]
|
Undisclosed |
Undisclosed |
Undisclosed |
References