Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0CKMPP
|
|||||
|---|---|---|---|---|---|---|
| ADC Name |
C46-PE24
|
|||||
| Synonyms |
C46 PE24; C46PE24
Click to Show/Hide
|
|||||
| Drug Status |
Investigative
|
|||||
| Indication |
In total 1 Indication(s)
Hepatocellular carcinoma [ICD11:2C12]
Investigative
|
|||||
| Antibody Name |
Anti-GPC3 mAb C46
|
Antibody Info | ||||
| Antigen Name |
Glypican-3 (GPC3)
|
Antigen Info | ||||
| Payload Name |
Pseudomonas exotoxin PE24
|
Payload Info | ||||
| Therapeutic Target |
Eukaryotic elongation factor 2 (EEF2)
|
Target Info | ||||
| Linker Name |
Undisclosed
|
|||||
General Information of The Activity Data Related to This ADC
Discovered Using Cell Line-derived Xenograft Model
| Standard Type | Value | Units | Cell Line | Disease Model |
|---|---|---|---|---|
| Tumor Growth Inhibition value (TGI) |
≈ 75
|
%
|
Hepatocellular carcinoma cells
|
Hepatocellular carcinoma
|
Revealed Based on the Cell Line Data
| Standard Type | Value | Units | Cell Line | Disease Model |
|---|---|---|---|---|
| Inhibitory Concentration 5% (IC5) |
110
|
ng/mL
|
G1LG cells
|
Hepatocellular carcinoma
|
Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 75.00% (Day 48) | Positive GPC3 expression (GPC3+++/++) | ||
| Method Description |
C46-PE24induces efficient tumor cell killing in cell line-derived models of immunotherapy of hepatocellular carcinoma cells.
|
||||
| In Vivo Model | Hepatocellular carcinoma CDX model | ||||
| In Vitro Model | Hepatocellular carcinoma | Hepatocellular carcinoma cells | Homo sapiens | ||
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Inhibitory Concentration 5% (IC5) | 110.00 ng/mL | Positive GPC3 expression (GPC3+++/++) | ||
| Method Description |
Ten thousand cells were seeded in a 96-well cell culture plate (200 l per well), supplemented with purified immunotoxins at the indicated final concentrations, and incubated at 37°C for 3 days. Cell viability was determined by quantifying the enzymatic activity of the intracellular luciferase that was released by two rounds of freezing-thawing.
Click to Show/Hide
|
||||
| In Vitro Model | Hepatocellular carcinoma | G1LG cells | Homo sapiens | ||
References
If you find any error in data or bug in web service, please kindly report it to Dr. Shen et al.