Antibody-drug Conjugate Information
General Information of This Antibody-drug Conjugate (ADC)
| ADC ID |
DRG0DEOYK
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|---|---|---|---|---|---|---|
| ADC Name |
A43-PE24
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| Synonyms |
A43 PE24; A43PE24
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| Drug Status |
Investigative
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| Indication |
In total 1 Indication(s)
Hepatocellular carcinoma [ICD11:2C12]
Investigative
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| Antibody Name |
Anti-GPC3 mAb A43
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Antibody Info | ||||
| Antigen Name |
Glypican-3 (GPC3)
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Antigen Info | ||||
| Payload Name |
Pseudomonas exotoxin PE24
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Payload Info | ||||
| Therapeutic Target |
Eukaryotic elongation factor 2 (EEF2)
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Target Info | ||||
| Linker Name |
Undisclosed
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General Information of The Activity Data Related to This ADC
Discovered Using Cell Line-derived Xenograft Model
| Standard Type | Value | Units | Cell Line | Disease Model |
|---|---|---|---|---|
| Tumor Growth Inhibition value (TGI) |
≈ 50
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%
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Hepatocellular carcinoma cells
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Hepatocellular carcinoma
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Revealed Based on the Cell Line Data
| Standard Type | Value | Units | Cell Line | Disease Model |
|---|---|---|---|---|
| Inhibitory Concentration 5% (IC5) |
110
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ng/mL
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G1LG cells
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Hepatocellular carcinoma
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Full List of Activity Data of This Antibody-drug Conjugate
Discovered Using Cell Line-derived Xenograft Model
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Tumor Growth Inhibition value (TGI) | ≈ 50.00% (Day 48) | Positive GPC3 expression (GPC3+++/++) | ||
| Method Description |
A43-PE24 induces efficient tumor cell killing in cell line-derived models of immunotherapy of hepatocellular carcinoma cells.
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| In Vivo Model | Hepatocellular carcinoma CDX model | ||||
| In Vitro Model | Hepatocellular carcinoma | Hepatocellular carcinoma cells | Homo sapiens | ||
Revealed Based on the Cell Line Data
| Experiment 1 Reporting the Activity Date of This ADC | [1] | ||||
| Efficacy Data | Inhibitory Concentration 5% (IC5) | 110.00 ng/mL | Positive GPC3 expression (GPC3+++/++) | ||
| Method Description |
Ten thousand cells were seeded in a 96-well cell culture plate (200 l per well), supplemented with purified immunotoxins at the indicated final concentrations, and incubated at 37°C for 3 days. Cell viability was determined by quantifying the enzymatic activity of the intracellular luciferase that was released by two rounds of freezing-thawing.
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| In Vitro Model | Hepatocellular carcinoma | G1LG cells | Homo sapiens | ||
References
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